Laboratory Animal Medicine
- 4th Edition - December 1, 2025
- Imprint: Academic Press
- Editors: James G. Fox, F. Claire Hankenson, Kelly A. Metcalf Pate, Kathleen R. Pritchett-Corning, Mark A. Suckow
- Language: English
- Hardback ISBN:9 7 8 - 0 - 4 4 3 - 1 3 7 2 1 - 1
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 1 3 7 2 2 - 8
Laboratory Animal Medicine, Fourth Edition—a volume in the American College of Laboratory Animal Medicine (ACLAM) blue book series—is the authoritative reference on the biology, he… Read more
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Laboratory Animal Medicine, Fourth Edition—a volume in the American College of Laboratory Animal Medicine (ACLAM) blue book series—is the authoritative reference on the biology, health, and care for species involved in research. Edited by recognized veterinary, operational, and research experts and endorsed as the official material for veterinary specialty certification by ACLAM, this work defines the standard for all aspects of humane laboratory animal care and science with animal models.
This new edition contains significant changes in content and organization to reflect the evolution of the field. The animal welfare chapter has been moved to the beginning of the book to highlight this subject’s importance. Other chapters have either been consolidated to encourage the reader to recognize commonalities such as those between guinea pigs, gerbils and hamsters, or separated out in recognition of expansions in knowledge and cross-species complexity as illustrated by separate new and old world primate chapters. Advances in practice, technology, and knowledge are highlighted in the chapters on genetically modified organisms, with updates on new techniques in genetic engineering and consideration of non-rodent genetically modified models; microbiological monitoring, with an increased emphasis on environmental monitoring and sentinel free colony health monitoring methods; regulatory compliance, with a comprehensive chapter on birds; employee health and safety, with expanded consideration of compassion fatigue; and animal models in biomedical research, with increased emphasis on experimental design and rigor. New chapters on animal models for microbiome, infectious disease, and transplant research have been added to serve as a reference for the community.
This book is an excellent reference for veterinarians and research scientists, as well as program directors and facility managers employed in a variety of academic and corporate settings. This edition continues the tradition of this text in setting standards for the research animal science community as well as expanding and updating relevant and essential topics for this specialty field.
- Covers the most important species used in life sciences research focusing on biology, diseases, and management
- Provides a renewed focus on animal welfare and expanded coverage of non-human primates, fishes, avian models
- Includes guidance on laboratory animal program and human resources management
- Presents regulations, policies, and laws for laboratory animal management worldwide
Laboratory Animal Scientists and Veterinarians, Life science researchers using animal models in their experiments
1. Laboratory Animal Medicine Historical Perspectives
2. Animal Welfare (incl euthanasia)
3. Laws, Regulations, and Policies Affecting the Use of Laboratory Animals
4. Biology and Diseases of Mice
5. Biology and Diseases of Rats
6. Guinea Pigs, Hamsters & Gerbils
7. Biology and Diseases of Other Rodents
8. Biology and Diseases of Rabbits
9. Microbiological Quality Control for Laboratory Rodents and Lagomorphs
10. Biology and Diseases of Dogs
11. Biology and Diseases of Cats
12. Biology and Diseases of Ferrets
13. Biology and Diseases of Ruminants
14. Biology and Diseases of Swine
15. New World Primates
16. Old World Primates
17. The Biology and Management of the Zebrafish and Other Fish
18. Other Fish
19. Biology and Diseases of Amphibians
20. Biology and Diseases of Reptiles
21. Biology and Diseases of Avian Models in Research
22. Animal Models in Biomedical Research
23. Techniques of Experimentation
24. Pre-anesthesia, Anesthesia, Analgesia
25. Factors that Influence Animal Research
26. Design and Management of Research Facilities & Lab Animal Programs
27. Working Safely with Experimental Animals Exposed to Biohazards
28. Zoonoses
29. Genetically Modified Animals
30. Gnotobiotics
31. Microbiome Research
32. Infectious Disease Research and Biocontainment
33. Transplant Medicine
33. Program Management
34. Lab Animal Behavior
Appendix
1. In Vitro Alternatives
2. Invertebrates and Cephalopods
2. Animal Welfare (incl euthanasia)
3. Laws, Regulations, and Policies Affecting the Use of Laboratory Animals
4. Biology and Diseases of Mice
5. Biology and Diseases of Rats
6. Guinea Pigs, Hamsters & Gerbils
7. Biology and Diseases of Other Rodents
8. Biology and Diseases of Rabbits
9. Microbiological Quality Control for Laboratory Rodents and Lagomorphs
10. Biology and Diseases of Dogs
11. Biology and Diseases of Cats
12. Biology and Diseases of Ferrets
13. Biology and Diseases of Ruminants
14. Biology and Diseases of Swine
15. New World Primates
16. Old World Primates
17. The Biology and Management of the Zebrafish and Other Fish
18. Other Fish
19. Biology and Diseases of Amphibians
20. Biology and Diseases of Reptiles
21. Biology and Diseases of Avian Models in Research
22. Animal Models in Biomedical Research
23. Techniques of Experimentation
24. Pre-anesthesia, Anesthesia, Analgesia
25. Factors that Influence Animal Research
26. Design and Management of Research Facilities & Lab Animal Programs
27. Working Safely with Experimental Animals Exposed to Biohazards
28. Zoonoses
29. Genetically Modified Animals
30. Gnotobiotics
31. Microbiome Research
32. Infectious Disease Research and Biocontainment
33. Transplant Medicine
33. Program Management
34. Lab Animal Behavior
Appendix
1. In Vitro Alternatives
2. Invertebrates and Cephalopods
- Edition: 4
- Published: December 1, 2025
- Imprint: Academic Press
- Language: English
JF
James G. Fox
Prof. James G. Fox obtained his Doctor of Veterinary Medicine at Colorado State University, Fort Collins, and, as an NIH postdoctoral fellow, received a Master of Science in Medical Microbiology at Stanford University. Dr. Fox is an adjunct professor at Tufts University School of Veterinary Medicine. He is a diplomate and a past president of the American College of Laboratory Animal Medicine, as well as a past president of the Massachusetts Society for Medical Research and the American Association of Veterinary Medical Colleges. Additionally, he has served as past chairman of the AAALAC Council and the NCCR/NIH Comparative Medicine Study Section. He is also an elected fellow of the Infectious Disease Society of America and the American Gastroenterological Association. He was recruited to MIT and created the Division of Comparative Medicine, which he directed from 1974 until 2021. As a faculty member in the MIT Department of Biological Engineering, Professor Fox received numerous scientific awards and was elected to the National Academy of Medicine in 2004. Dr. Fox has been the principal investigator of an NIH postdoctoral training grant for veterinarians for 30 years and has trained 90 veterinarians for careers in biomedical research. The NIH has continuously funded him to study infectious diseases of the gastrointestinal tract, where he has studied the gastrointestinal microbiome and how it interfaces with and influences the host’s immune response to gastrointestinal pathogens, particularly oncogenic Helicobacter species. He has authored over 600 papers, 84 chapters, holds 4 patents and has authored or edited 18 comparative medicine texts.
Affiliations and expertise
Division of Comparative Medicine, Department of Biological Engineering, MIT, Cambridge, MA, USAFH
F. Claire Hankenson
Dr. F. Claire Hankenson is the Associate Vice Provost for Research and Executive Director of University Laboratory Animal Resources at the University of Pennsylvania. She serves as the Attending Veterinarian and holds a faculty position as Professor and Division Chief of Comparative Medicine & Research within the Department of Pathobiology at the School of Veterinary Medicine. Dr. Hankenson obtained her veterinary degree from Purdue University, completed her graduate work and residency at the University of Washington and became certified as a Diplomate of the American College of Laboratory Animal Medicine (ACLAM) in 2002. Dr. Hankenson has been active on committees within AALAS, including the AALAS Editorial Review Board, has served on the Executive Board for ACLAM and as ACLAM President, and is an ad-hoc specialist and Member Organization Delegate with AAALAC. She is a past Chair of the Board of Directors for Public Responsibility in Medicine & Research (PRIM&R), a nationally recognized nonprofit organization that provides education and professional resources to scientific and research oversight communities for both animal and human patients.
Affiliations and expertise
Executive Director, Attending Veterinarian and Division Chief of Comparative Medicine & Research; Professor of Comparative Medicine, University of Pennsylvania, Philadelphia, USAKM
Kelly A. Metcalf Pate
Dr. Kelly A. Metcalf Pate is Director of the Division of Comparative Medicine and faculty of Biological Engineering at Massachusetts Institute of Technology, as well as adjunct faculty at Tufts Cummings School of Veterinary Medicine and at Johns Hopkins School f of Medicine. She is a veterinarian-scientist with over 15 years of experience and more than 40 peer reviewed publications spanning the disciplines of comparative medicine, virology, and immunology. She obtained her D.V.M. from Purdue University College of Veterinary Medicine, and pursued both veterinary specialty training in laboratory animal medicine and her Ph.D. at Johns Hopkins School of Medicine. Dr. Metcalf Pate is a Diplomate of the American College of Laboratory Animal Medicine, acts as an Ad Hoc Specialist for AAALAC International, and has served on multiple national committees, including in the past, as chair on the Scientific Advisory Committee for the American Association of Laboratory Animal Science (AALAS), as chair for the Animal Welfare Advisory Board of Morris Animal Foundation, as a member on the National Academies of Science, Engineering and Medicine committee on the Nonhuman Primate Model Systems, and as a member on the NIH Advisory Committee to the Director Working Group on Catalyzing the Development and Use of Novel Alternative Methods to Advance Biomedical Research.
Affiliations and expertise
Director, Division of Comparative Medicine, Associate Professor of Biological Engineering, MIT, USAKP
Kathleen R. Pritchett-Corning
Dr. Pritchett-Corning is Attending Veterinarian and Director of the Office of Animal Resources at the Harvard University Faculty of Arts and Sciences and an Affiliate Assistant Professor in the Department of Comparative Medicine at the University of Washington. She has more than 30 years of experience in laboratory animal science and medicine, with a focus on rodents and animal-based husbandry research. Dr. Pritchett-Corning received her BS and her DVM from Washington State University and completed her post-doctoral training in laboratory animal medicine at the University of Washington. She has authored more than 80 peer-reviewed publications and book chapters. She is the Chair of the Laboratory Animal Working Group of the AVMA Panel on Euthanasia and the AVMA Panel on Depopulation, as well as a member of the FELASA Working Group on Health Monitoring, and the joint AALAS/FELASA Working Group on Health Monitoring of Rodents for Animal Transfer. Dr. Pritchett-Corning has held positions at the University of Washington, the Jackson Laboratory, and Charles River.
Affiliations and expertise
Director, Office of Animal Resources, Attending Veterinarian, Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA, USAMS
Mark A. Suckow
Mark A. Suckow is a private consultant in laboratory animal medicine and Professor (Emeritus) in Biomedical Engineering at the University of Kentucky where he previously served as Attending Veterinarian and Associate Vice President for Research. He received his DVM from the University of Wisconsin and subsequently completed a post-doctoral residency in laboratory animal medicine at the University of Michigan. Dr. Suckow has 35 years of experience in laboratory animal medicine, regulatory compliance, and animal facility management. With an interest in the use of animal models for cancer research, vaccinology, and biomaterials development, Dr. Suckow has published greater than 115 papers in refereed journals and has seven issued patents related to vaccine adjuvants and cancer vaccines. He has written or edited over 20 books on topics related to research and laboratory animal medicine. Further, he served as the 2006 President of the American Association for Laboratory Animal Science and the 2011 President of the American Society of Laboratory Animal Practitioners; and he currently serves as an emeritus member of the Council on Accreditation of AAALAC, International and as Editor in Chief for the Journal of the American Association for Laboratory Animal Science.
Affiliations and expertise
Private Consultant