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Elsevier

Neurobiology of Aging

Exploring Cognitive Decline and Neurodegeneration

  • 1st Edition - November 28, 2025
  • Latest edition
  • Editor: Sachchida Nand Rai
  • Language: English

Neurobiology of Aging: Exploring Cognitive Decline and Neurodegeneration is a comprehensive reference exploring the complexities of the aging brain. This book examines the intric… Read more

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Description

Neurobiology of Aging: Exploring Cognitive Decline and Neurodegeneration is a comprehensive reference exploring the complexities of the aging brain. This book examines the intricate processes driving cognitive decline and neurodegeneration. From the gradual loss of neurons and synapses to the formation of protein aggregates characteristic of Alzheimer's disease, each chapter reviews key aspects of brain aging. Chapters dissect the mechanisms driving neuronal loss, synaptic dysfunction, and protein misfolding, shedding light on the intricate interplay of oxidative stress, inflammation, and mitochondrial dysfunction. This book also navigates through strategies for healthy brain aging, from the impact of diet and exercise to the role of cognitive stimulation.

Key features

  • Reviews the complex interplay of various molecular, cellular, and systemic processes that contribute to cognitive decline and neurodegeneration
  • Discusses genetic influences on aging and neurodegenerative diseases
  • Outlines various therapeutic approaches to age-related cognitive decline and neurodegenerative diseases

Readership

Researchers and graduate students in neuroscience, psychology, aging, neurobiology, cognitive decline, and neurodegenerative diseases

Table of contents

Part 1: Mechanisms of Brain Aging

1. Introduction to the Neurobiology of Aging

2. Neuronal Loss and Synaptic Dysfunction

3. Protein Misfolding and Aggregation and its role in dementia with Lewy bodies

4. Oxidative Stress and Aging

5. Inflammation: Chronic Inflammation in Aging

Part 2: Factors Influencing Brain Aging

6. Mitochondrial Dysfunction and Aging

7. Neurotransmitter Systems in Aging

8. Genetic Influences on Aging and Neurodegenerative Diseases

9. Environmental and Lifestyle Factors in Brain Aging

10. The Role of Diet in Brain Health

Part 3: Interventions and Strategies for Healthy Brain Aging

11. Exercise and Cognitive Function in Aging

12. Unlocking Cognitive Vitality: The Interplay of Stimulation, Sleep, and Brain Aging

13. Exploring the Multifaceted Links Between Comorbidities and Cognitive Aging

14. Therapeutic Approaches to Age-Related Cognitive Decline and Neurodegenerative Diseases

15. Exploring Promising Pharmaceutical Candidates for Anti-Aging

Product details

  • Edition: 1
  • Latest edition
  • Published: November 28, 2025
  • Language: English

About the editor

SR

Sachchida Nand Rai

Dr. Sachchida Nand Rai is an Associate Professor at Saveetha Institute of Basic Medical Sciences (SIBMS), Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University . He obtained his MSc in Biochemistr from Purvanchal University, India, and his PhD in Biochemistry from Banaras Hindu University, India. Dr. Rai researches the anti-oxidative and anti-neuroinflammatory properties of phytochemicals for the treatment of neurodegenerative diseases. He is a lifetime member of the Indian Academy of Neuroscience.

Affiliations and expertise
Assistant Professor

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