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Books in Life sciences

  • Chronic Obstructive Pulmonary Disease (COPD) Diagnosis using Electromyography (EMG)

    • 1st Edition
    • January 16, 2022
    • Archana Bajirao Kanwade + 1 more
    • English
    Chronic Obstructive Pulmonary Disease (COPD) Diagnosis using Electromyography (EMG) presents a new and innovative method of COPD diagnosis using EMG to analyze sternomastoid muscle activity using features extraction and classification. The book describes the methodology of EMG analysis, the slope-based onset detection algorithm and SEMG analysis in time, frequency and time frequency domain analyses. It also explores the identification of frequencies for single frequency Continuous Wavelet Transform (CWT) analysis and feature extraction and selection for successful classification COPD into its severity grades. The book provides a compilation of all techniques used in the literatures and emphasizes newly proposed techniques for the early detection of COPD. Fully comprehensive, the book includes discussion of limitations of existing methods for COPD diagnosis and introduces new efficient methods for COPD identification, classification and early diagnosis.

  • Biomarkers in Bipolar Disorders

    • 1st Edition
    • January 16, 2022
    • Rodrigo Machado-Vieira + 1 more
    • English
    Biomarkers in Bipolar Disorders summarizes cutting-edge findings in biomarkers' research, emphasizing the most promising findings, tools and technologies relevant to drug development and personalized medicine. Key findings cover different levels of evidence such as genes, molecules, cells, systems, brain and behavior related to diagnosis (state and trait/endophenotypes... prediction of treatment response and follow-up outcomes, along with the most promising perspectives in each area. Each section includes a comprehensive and focused overview on the state-of-the-art and perspectives. The book concludes with a section on practical applications, encompassing diagnostics development (genetic testing, biomarkers), and new drug development. Edited by Dr. Rodrigo Machado-Vieira and Dr. Jair C. Soares, and contributed by leading experts in the field of biomarker research, this book will be become the leading tool for all researchers and clinicians in Bipolar Disorder.

  • Antiangiogenic Drugs as Chemosensitizers in Cancer Therapy

    • 1st Edition
    • Volume 18
    • January 14, 2022
    • English
    Anti-angiogenic Drugs as Chemosensitizers in Cancer Therapy, Volume 19 focuses on the use of anti-angiogenic drugs as sensitizers of tumor cells to the inhibitory activity of antitumor agents. Conventional and novel anti-neoplastic agents (cytotoxic molecules, hormones/antihormone... immunotherapies) are taken into consideration, along with advances made in combination therapies. The book encompasses examples of studies on the use of antiangiogenic compounds—molecules that inhibit the growth of vessels inside a tumor—together with antineoplastic drugs in order to sensitize the resistant tumor to their cytotoxic effects, thus reducing adverse side reactions and resistance and improving the therapeutic response of cancer patients. In addition, the book discusses clinical applications in various types of cancer, such as colorectal, lung, breast, renal, genitourinary, skin and brain and circulating tumors. It is a valuable resource for cancer researchers, clinicians and members of the biomedical field who wants to be up-to-date on the most recent and promising developments in the field.

  • Neuroplasticity

    From Bench to Bedside
    • 1st Edition
    • Volume 184
    • January 14, 2022
    • Angelo Quartarone + 2 more
    • English
    Neuroplasticity: From Bench to Bedside, Volume 184 in the Handbook of Clinical Neurology series, provides a comprehensive multidisciplinary guide to neuroplasticity. Sections summarize the basic mechanisms of neuroplasticity, focus on neuroplasticity in movement disorders, discuss brain oscillations in neurological disorders, segue into plasticity in neurorehabilitation, and cover issues of inflammation and autoimmunity in neuroplasticity. The book concludes with a section on neuroplasticity and psychiatric disorders.

  • Advances in Protein Molecular and Structural Biology Methods

    • 1st Edition
    • January 14, 2022
    • Timir Tripathi + 1 more
    • English
    Advances in Protein Molecular and Structural Biology Methods offers a complete overview of the latest tools and methods applicable to the study of proteins at the molecular and structural level. The book begins with sections exploring tools to optimize recombinant protein expression and biophysical techniques such as fluorescence spectroscopy, NMR, mass spectrometry, cryo-electron microscopy, and X-ray crystallography. It then moves towards computational approaches, considering structural bioinformatics, molecular dynamics simulations, and deep machine learning technologies. The book also covers methods applied to intrinsically disordered proteins (IDPs)followed by chapters on protein interaction networks, protein function, and protein design and engineering. It provides researchers with an extensive toolkit of methods and techniques to draw from when conducting their own experimental work, taking them from foundational concepts to practical application.

  • Formulation and Device Lifecycle Management of Biotherapeutics

    A Guidance for Researchers and Drug Developers
    • 1st Edition
    • January 14, 2022
    • Beate Bittner + 1 more
    • English
    Today, the pressure on healthcare costs and resources is increasing, and especially for biopharmaceuticals that require parenteral administration, the inherent complex and invasive dosing procedure adds to the demand for efficient medical management. In light of the COVID-19 pandemic the value of drug delivery technologies in enabling a flexible care setting is broadly recognized. In such a setting, patients and their caregivers can choose the place of drug administration based on individual preferences and capabilities. This includes not only dosing in the clinic but also supervised at-home dosing and self-administration for eligible patients. Formulation and Device Lifecycle Management of Biotherapeutics: A Guidance for Researchers and Drug Developers covers the various aspects of improving drug delivery of biological medicines with the ultimate goal to reduce dosing complexity associated with parenteral administration and, thus, enhance patient experience and drug administration-relat... healthcare capacity. The target audience are multidisciplinary researchers and drug developers in the pharmaceutical industry, biotech companies, and academia involved in formulation and device development. This includes pharmacology and medical experts in charge of generating nonclinical and clinical data to support approval of novel dosing regimens, and drug delivery scientists and engineers responsible for technical particulars of product optimizations. Moreover, professionals in market access and commercial functions are expected to benefit from the discussions about the impact of patient and healthcare provider needs and country-specific reimbursement models on realizing a truly convenient and cost and resource efficient drug delivery solution.

  • Hormones

    • 4th Edition
    • January 13, 2022
    • Gerald Litwack
    • English
    Hormones, Fourth Edition provides a report on the field of human hormones viewed in light of our current understanding of cellular and subcellular architecture, along with the molecular details of their modes of action. Comprehensive information about hormone action on canonical and non-canonical signaling pathways at cellular and subcellular level and effects on architecture and function of organ systems are discussed. All chapters in this new edition have been completely updated to cover advances in endocrinology research, which has expanded significantly in the last few years. Vast coverage of hormones not previously covered and newly discovered aspects of hormone action are also included. This new fourth edition is intended to be used by advanced undergraduates and graduate students in the biological sciences. It will also provide useful background information for health professionals, clinicians and researchers in the field of endocrinology, metabolism and biochemistry.

  • Advances in Agronomy

    • 1st Edition
    • Volume 171
    • January 13, 2022
    • Donald L. Sparks
    • English
    Advances in Agronomy, Volume 171, the latest release in this leading reference, contains a variety of updates and new advances in the field, including updates on Elevated CO2 in Semi-arid Cropping Systems: A Synthesis of Research from the Australian Grains Free Air CO2 Enrichment (AGFACE) Research Program, Simultaneous Effects of Legume Cultivation on Carbon and Nitrogen Accumulation in Soil, Growing Small Grains Organically in the Semiarid West: A Review of Markets and Management Practices to Optimize Productivity and Sustainability, Principles and Applications of Topography in Precision Agriculture, Retention of Heavy Metals by Dredged Sediments and their Management Following Land Application, and more. Other chapters focus on Genetic Diversity for Developing Climate-resilient Wheats to Achieve Food Security Goals and A Century of Subclover: Lessons for Sustainable Intensification from a Historical Review of Innovations in Subterranean Clover Seed Production.

  • Membrane Proteins

    • 1st Edition
    • Volume 128
    • January 13, 2022
    • Rossen Donev
    • English
    Membrane Proteins, Volume 128 in the Advances in Protein Chemistry and Structural Biology series highlights new advances in the field, with this new volume presenting interesting chapters written by an international board of authors.

  • Micro/Nanofluidics and Lab-on-Chip Based Emerging Technologies for Biomedical and Translational Research Applications - Part A

    • 1st Edition
    • Volume 186
    • January 13, 2022
    • English
    Micro/Nanofluidics and Lab-on-Chip Based Emerging Technologies for Biomedical and Translational Research Applications, Volume 185, Part A represents the collation of chapters written by eminent scientists worldwide. Chapters in this updated release include An introduction to microfluidics and their applications, Design and fabrication of Micro/Nanofluidics devices and systems, Detection and separation of proteins using Micro/Nanofluidics devices, Micro/Nanofluidics devices for DNA/RNA detection and separation, Paper based microfluidics a forecast towards the most affordable and rapid point-of-care devices, Paper based micro/Nanofluidics devices for biomedical applications, Advances of Microfluidics Devices and their Applications in Personalized Medicine, and much more. Additional chapters cover Microfluidics for single cell analysis, Fluorescence Based Miniaturized Microfluidic and Nanofluidic Systems for Biomedical Applications, Active Matter Dynamics in Confined Microfluidic Environments, Challenges and opportunities in micro/nanofluidics and lab-on-a-chip, and Paper-microfluidic signal-enhanced immunoassays.

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