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Elsevier

Assessments, Treatments and Modeling in Aging and Neurological Disease

The Neuroscience of Aging

  • 1st Edition - June 1, 2021
  • Latest edition
  • Editors: Colin R. Martin, Victor R. Preedy, Rajkumar Rajendram
  • Language: English

Assessments, Treatments and Modeling in Aging and Neurological Disease: The Neuroscience of Aging is a comprehensive reference on the diagnosis and management of neurologi… Read more

Description

Assessments, Treatments and Modeling in Aging and Neurological Disease: The Neuroscience of Aging is a comprehensive reference on the diagnosis and management of neurological aging and associated disorders. The book discusses the mechanisms underlying neurological aging and provides readers with a detailed introduction to the aging of neural connections and complexities in biological circuitries, as well as the interactions between genetics, epigenetics and other micro-environmental processes. It also examines pharmacological and non-pharmacological interventions of age-related conditions that affect the brain, including Alzheimer’s, stroke and multiple sclerosis.

Key features

  • Provides the most comprehensive coverage of the broad range of topics related to the neuroscience of aging
  • Features sections on diagnosis and biomarkers of neurological aging, Alzheimer’s and stroke
  • Contains an abstract, key facts, a mini dictionary of terms, and summary points in each chapter
  • Focuses on neurological diseases and conditions linked to aging, environmental factors and clinical recommendations
  • Includes more than 500 illustrations and tables

Readership

Neuroscientists, geriatricians, neurobiologists, experimental biologists, clinicians, graduate students, and post-doctoral fellows

Table of contents

Part I Introductory chapters: Setting the scene for the neuroscience of aging

1. The concept of productive agingPremchand Dommaraju and Shawn Wong

2. Quality of life in older peopleTimo E. Strandberg

3. Successful aging and dietEkavi N. Georgousopoulou, Duane D. Mellor and Demosthenes B. Panagiotakos

4. The impact of positive social relations on the quality of life of older people. An alternative to medicalization from an integralperspectiveLuis Miguel Rondo

5. The brain in life span: use of phase functional magnetic resonanceimagingZikuan Chen, Zeyuan Chen and Bihong T. Chen

6. Neuronal structure in aging:cytoskeleton in health and diseaseDaniele Cartelli

7. Sporadic Alzheimer’s triad: age, sex, and ApoEXin Zhang, Punam Rawal, Long Wu and Liqin Zhao

8. The moderating effect of BDNF Val66Met polymorphism oninhibitory control in elderly individualsMichel Audiffren, Nathalie Andre´, Delphine Fagot, Christian Chicherio and Ce´dric Albinet

9. Alcohol use disorder pharmacotherapy options for postmenopausal females: age and gender issues and considerationsJelena Milic, Janko Zekovic, Dunja Stankic, Ed van Beeck and Janko Samardzic

10. The aging brain and brain bankingR.C. Jezewski, G.M. Halliday and C.E. Shepherd

Part II Impairments and diseases

11. Dementia or no dementia in the elderly. Why?Lewis H. Kuller

12. Neuropsychology, social cognition, and loss of insight infrontotemporal dementia Fiadhnait O’Keeffe and Derval McCormack

13. Neuroinflammation and agingJoaeo O. Malva, Ricardo Moreira, Beatriz Martins, Joaeo Novo, Frederico C. Pereira, Ramon Raposo, Reinaldo B. Oria´ and Carlos Fontes Ribeiro

14. Cortical microinfarcts and the aging brainEniko Kovari and Gabriel Gold

15. Cerebrovascular and neuro>degenerative racial/ethnic healthdisparitiesAstrid M. Suchy-Dicey

16. Hearing loss among the elderlyGary Jek Chong LEE

17. Aging auditory cortex: the impact of reduced inhibition on functionBjo€rn Herrmann and Blake E. Butler

18. Aging and vestibular disordersAugusto Pietro Casani and Elena Navari

19. Brain aging in HIV and retroviralsJasmina Boban, Majda M. Thurnher and Dusko Kozic

20. Methylmercury exposure and its implications for agingAndrew N. Shen and M. Christopher Newland

21. Alcohol and the aging brain: increased alcohol sensitivity potentially magnifying oxidative stressCandice E. Van Skike and Douglas B. Matthews

Part IIIBiomarkers and diagnosis

22. Brain aging: radiological biomarkersBanu Alicioglu and Hakki Muammer Karakas

23. ADAM10 as a biomarker for Alzheimer’s diseaseMariana Luciano de Almeida, Izabela Pereira Vatanabe, Patricia Regina Manzine, Rafaela Peron, Carlos Roberto Bueno Ju´nior and Ma´rcia Regina Cominetti

24. Circulating microRNAs as biomarkers of health in elderlyindividualsJonas Mengel-From

25. DHEA as a biomarker of aging in humans and nonhuman primates:synthesis, neuroprotection, and cognitive functionHenryk F. Urbanski

26. Evaluation of subjective memory abilities in elderly peopleLuigi Trojano, Gabriella Santangelo and Simona Raimo

27. The functional activities questionnaire: applications to agingOndrej Bezdicek

28. Autobiographical memory as a diagnostic tool in agingJuan C. Mele´ndez and Encarnacio´n Satorres

29. Assessment tools for subjective memory abilities in elderly peopleSimona Raimo, Gabriella Santangelo and Luigi Trojano

30. The Knowledge of Memory Aging QuestionnaireCelinda Reese-Melancon, Katie E. Cherry and Erin E. Harrington

Part IVManagement and treatments

31. Pharmacological use of transient receptor potential (TRP) ionchannel agonists in neurological disease and aging: effects on swallowing and implications for nutritionNoemı´ Tomsen and Pere Clave´

32. Aripiprazole: features and use in the agedUnax Lertxundi, Rafael Herna´ndez and Juan Medrano

33. Cognition-enhancing drugs and applications to agingJelena Mili

34. Creatine supplementation in the aging brainMarina Yazigi Solis, Eimear Dolan, Guilherme Giannini Artioli and Bruno Gualano

35. Photobiomodulation as a brain-boosting strategy in agingFarzad Salehpour, Marvin H. Berman and Saeed Sadigh-Eteghad

36. Innovations in deep brain stimulation in aging: a focus onParkinson diseasePaolo Amami

37. Exergames: what they are and how they can be used to successfulaging?Renato Sobral Monteiro-Junior, Ana Carolina de Mello Alves Rodrigues, Laı´s Francielle Francisca Felı´cio, Luiz Felipe da Silva Figueiredo and Tu´lio Brandaeo Xavier-Rocha

38. Linking cognitive decline and ballroom dance as a therapeuticintervention in the elderlyJacqueline C. Dominguez, Maria Clarissa O. del Moral, Ma Fe P. de Guzman and Jeshya A. Chio

39. Training the functionality of daily life. A new neuroscientific paradigm of cognitive trainingCarmen Requena, Paula A´lvarez-Merino and Francisco Javier Belchı´

40. Integrated medical and psychiatric self-management smartphonetechnologies for older adults with serious mental illnessKaren L. Fortuna and Cynthia Bianco

41. Psychosocial interventions for suicide prevention in the elderly:advances and future directionsTheresa Ebo, Hannah Reich, Elizabeth Arslanoglou, Claudia Heidenreich, Jody Monkovic and Dimitris Kiosses

Part VModels and modelling

42. D-galactose-induced aging and brain mitochondriaFereshteh Farajdokht, Saeed Sadigh-Eteghad and Javad Mahmoudi

43. Drosophila models of neuronal aging Vı´ctor Lo´pez del Amo, Andrea Tapia and Ma´ximo Ibo Galindo

44. The zebrafish (Danio rerio) and its uses for understanding theneuroscience of aging: applications and observationDilan Celebi-Birand, Melek Umay Tuz-Sasik, Narin Ilgim Ardic-Avci, Hande Ozge Aydogan, Begun Erbaba, Elif Tugce Karoglu-Eravsar, Hulusi Kafaligonul and Michelle M. Adams

45. Murine models of tauopathies: a platform to study neurodegenerative diseases associated with agingGhazaleh Eskandari-Sedighi and David Westaway

46. Modeling nutrition and brain aging in rodentsDevin Wahl, Rahul Gokarn, Samantha M. Solon-Biet, Victoria C. Cogger, Thomas J. LaRocca, David Raubenheimer, Stephen J. Simpsonand David G. Le Couteur

47. Nonhuman primates as models for aging and Alzheimer’s diseaseMelissa K. Edler, Emily L. Munger, Hayley Groetz and Mary Ann Raghanti

48. Linking aging and animal models to neurodegeneration: the striatum, substantia nigra, and Parkinson’s diseaseRodrigo Portes Ureshino and Ana Lo´pez Ramı´rez

49. Behavioral evaluation of aging in experimental animalsAna Perez-Villalba and Isabel Farin˜as

Part VIResources

50. Recommended resources on the neuroscience of agingRajkumar Rajendram and Victor R. Preedy

Review quotes

"This book is unique in its approach to a myriad of topics in aging. I agree with the authors that most books tend to be highly specialized and do not cover the valuable number of topics addressed by this book. I commend them for achieving their objectives. They do so at the expense of not fully tackling any specific topic(s), but this makes the book very useful for a larger audience. I am not aware of a comparable book in this sense."—© Doody’s Review Service, 2021, Sasha Alick-Lindstrom, MD, reviewer, expert opinion

Product details

  • Edition: 1
  • Latest edition
  • Published: June 25, 2021
  • Language: English

About the editors

CM

Colin R. Martin

Colin R. Martin RN, BSc, MSc, PhD, MBA, YCAP, FHEA, C.Psychol, AFBPsS, C.Sci is Professor of Clinical Psychobiology and Applied Psychoneuroimmunology and Clinical Director of the Institute of Health and Wellbeing at the University of Suffolk, UK. He is a Chartered Health Psychologist and a Chartered Scientist. He also trained in analytical biochemistry, this aspect reflecting the psychobiological focus of much of his research within mental health. He has published or has in press well over 300 research papers and book chapters. He is a keen book author and editor having written and/or edited more than 50 books. These outputs include the prophetic insight into the treatment of neurological disease, Handbook of Behavior, Food and Nutrition (2011), Nanomedicine and the Nervous System (2012), Oxidative Stress and Dietary Antioxidants in Neurological Disease (2020), Zika Virus Impact, Diagnosis, Control and Models (2021), Factors Affecting Neurodevelopment: Genetics, Neurology, Behavior and Diet (2021), Diagnosis and Treatment of Spinal Cord Injury (2022), The Neurobiology, Physiology, and Psychology of Pain (2022) and The Handbook of Lifespan Cognitive Behavioral Therapy: Childhood, Adolescence, Pregnancy, Adulthood, and Aging (2023). Professor Martin is particularly interested in all aspects of the relationship between underlying physiological substrates and behavior, particularly in how these relationships manifest in both acute and chronic psychiatric disorder. He has published original research germane to significant mental health disorders including the areas of schizophrenia, anxiety, depression, self-esteem, alcohol and drug dependency, high secure forensic mental health and personality disorder. He has a keen interest in the impact of postviral illness and is actively involved in clinical research post-Covid pandemic and in particular, the impact of Long Covid on psychological, neurological, physiological and social functioning. He is involved in collaborative International research with many European and Non-European countries.
Affiliations and expertise
Visiting Professor of Perinatal Wellbeing, Institute for Health and Wellbeing, University of Suffolk, Ipswich, UK

VP

Victor R. Preedy

Victor R. Preedy BSc, PhD, DSc, FRSB, FRSPH, FRSC, FRCPath graduated with an Honours Degree in Biology and Physiology with Pharmacology. After gaining his University of London PhD, he received his Membership of the Royal College of Pathologists. He was later awarded his second doctorate (DSc), for his contribution to protein metabolism in health and disease. He is Professor of Clinical Biochemistry (Hon) at King’s College Hospital and Emeritus Professor of Nutritional Biochemistry at King’s College London. He has Honorary Professorships at the University of Hull, and the University of Suffolk. Professor Preedy was the Founding Director and then long-term Director of the Genomics Centre at King’s College London from 2006 to 2020. Professor Preedy has been awarded fellowships of the Royal Society of Biology, the Royal College of Pathologists, the Royal Society for the Promotion of Health, the Royal Institute of Public Health, the Royal Society for Public Health, the Royal Society of Chemistry and the Royal Society of Medicine. He carried out research when attached to the National Heart Hospital (part of Imperial College London), The School of Pharmacy (now part of University College London) and the MRC Centre at Northwick Park Hospital. He has collaborated with international research groups in Finland, Japan, Australia, USA, and Germany. To his credit, Professor Preedy has published over 750 articles, which includes peer-reviewed manuscripts based on original research, abstracts and symposium presentations, reviews and edited books.
Affiliations and expertise
Professor, Department of Clinical Biochemistry, King’s College Hospital, London, UK; Emeritus Professor, Faculty of Life Sciences and Medicine, King’s College London, UK; Visiting Professor, University of Hull, UK

RR

Rajkumar Rajendram

Dr Rajkumar Rajendram is a clinician scientist with a focus on internal medicine, anaesthesia, intensive care and peri-operative medicine. He graduated with distinctions from Guy’s, King’s and St. Thomas Medical School, King’s College London in 2001. As an undergraduate he was awarded several prizes, merits and distinctions in pre-clinical and clinical subjects.

Dr Rajendram began his post-graduate medical training in general medicine and intensive care in Oxford. He attained membership of the Royal College of Physicians (MRCP) in 2004 and completed specialist training in acute and general medicine in Oxford in 2010. Dr Rajendram subsequently practiced as a Consultant in Acute General Medicine at the John Radcliffe Hospital, Oxford.

Dr Rajendram also trained in anaesthesia and intensive care in London and was awarded a fellowship of the Royal College of Anaesthetists (FRCA) in 2009. He completed advanced training in regional anaesthesia and intensive care. He was awarded a fellowship of the Faculty of Intensive Care Medicine (FFICM) in 2013 and obtained the European diploma of intensive care medicine (EDIC) in 2014. He then moved to the Royal Free London Hospitals as a Consultant in Intensive Care, Anaesthesia and Peri-operative Medicine. He has been a fellow of the Royal College of Physicians of Edinburgh (FRCP Edin) and the Royal College of Physicians of London (FRCP Lond) since 2017 and 2019 respectively. He is currently a Consultant in Internal Medicine at King Abdulaziz Medical City, National Guard Heath Affairs, Riyadh, Saudi Arabia.

Dr Rajendram’s focus on improving outcomes from Coronavirus Disease 2019 (COVID-19) has involved research on point of care ultrasound and phenotypes of COVID-19. Dr Rajendram also recognises that nutritional support is a fundamental aspect of medical care. This is particularly important for patients with COVID-19. As a clinician scientist he has therefore devoted significant time and effort into nutritional science research and education. He is an affiliated member of the Nutritional Sciences Research Division of King’s College London and has published over 400 textbook chapters, review articles, peer-reviewed papers and abstracts.

Affiliations and expertise
Consultant, Medical Protocol Department, King Abdulaziz Medical City, Ministry of National Guard Heath Affairs, Riyadh, Saudi Arabia

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