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Elsevier

Books in Life sciences

  • Endotoxin in Critical Illness

    • 1st Edition
    • John Kellum + 1 more
    • English
    Endotoxin in Critical Illness intricately explores the theme of endotoxin and sepsis through the lenses of basic, clinical, and translational science. This work consolidates and synthesizes novel clinical insights and groundbreaking scientific discoveries into one comprehensive resource on endotoxic septic shock and sheds light on cutting-edge approaches in treatment. Beginning with a historical journey, the book traces the evolution of understanding from ancient concepts to modern molecular insights. It covers the physiological aspects of endotoxin sensitivity, tolerance, and human response variation. The crucial role of the gut microbiome in critical illness serves as a translational link between foundational science and clinical implications, and the complex language of bacterial communication is introduced, merging basic science with potential translational applications. In the clinical arena, chapters cover the critical role of endotoxin in septic shock, trauma, and its relevance in COVID-19, providing a translational bridge between laboratory findings and real-world clinical scenarios. The historical context of anti-endotoxin drug development is revisited, emphasizing the translational challenges faced in bridging basic science discoveries to clinical applications. The discussion on quantifying endotoxin concentration as well as the exploration of therapeutic rationale and clinical experiences with endotoxin removal therapy serve as a culmination of basic understanding translated into practical applications. The book concludes by contemplating the complexity of sepsis and acknowledging the challenges in achieving personalized medicine and underscoring the dynamic nature of the translational journey. In essence, this comprehensive exploration provides clinicians, researchers, and scientists with a holistic understanding of endotoxin and sepsis and potential advancements in patient care.

  • Harnessing Endogenous Mechanisms for Targeted Drug Delivery

    • 1st Edition
    • Anisha A. D’Souza + 2 more
    • English
    Harnessing Endogenous Mechanisms for Targeted Drug Delivery presents a comprehensive exploration of the evolving landscape of targeted drug delivery, emphasizing the strategic utilization of the body's intrinsic biological pathways. This authoritative two-volume reference addresses the critical need for precision in therapeutic delivery, overcoming physiological, anatomical, and immunological barriers through innovative endogenous mechanisms. By integrating foundational concepts with advanced methodologies, the work underscores the transition from traditional passive and active targeting to sophisticated endogenous strategies that enhance drug specificity and efficacy.The text systematically examines the multifaceted challenges inherent in drug delivery, including detailed analyses of in vivo barriers such as the blood-tumor barrier, blood-brain barrier, ocular, pulmonary, and gastrointestinal obstacles, as well as cellular and intracellular impediments. It further elucidates endogenous stimuli-responsive systems, nutrient transporter exploitation, glyco-targeting, and stealth peptide modifications. Comprehensive coverage extends to drug conjugates, protein corona phenomena, and cell-based delivery platforms encompassing stem cells, leukocytes, erythrocytes, and platelets. The series also addresses extracellular vesicles, viral vectors, and plant virus-based carriers, culminating in critical discussions on manufacturing complexities, regulatory considerations, and clinical translation challenges.This definitive resource is indispensable for graduate students, postdoctoral researchers, and professionals in academia and industry engaged in targeted drug delivery research and development. By providing an in-depth understanding of endogenous targeting mechanisms and their translational potential, the book fosters innovation and supports the advancement of precision therapeutics with the goal of improving patient outcomes.

  • Microbial Stress Survival

    • 1st Edition
    • Ashutosh Kumar
    • English
    Microbial Stress Survival explores the diversity of microbes, the microbe-host relationship, and the various strategies employed by microbes that enable them to adapt to stressful environments and persist in hostile conditions. The book aims to cover critical pathogen biology, microbial adaptation and survival strategies, and the impact of microbial resilience on therapeutic efforts. Topics include the modulation of host pathways by pathogens for their adaptation and survival; their drug tolerance and antimicrobial resistance; role of proteins in microbial stress survival; and evolutionary adaptative mechanisms of extremophiles. Microbial Stress Survival is an insightful resource for those interested in pathogen biology and the different adaptive features and resilience of microbes.

  • Plant Proteins

    Farm to Table
    • 1st Edition
    • Dilek Uzunalioglu + 2 more
    • English
    Plant Proteins: Farm to Table addresses all aspects of plant proteins, including plant science, chemistry, processing, formulations, nutrition, and trends. This important reference also covers cereal and pulse plant-based and soy proteins and presents protein extraction and processing techniques, as well as ingredient principles and their application in formulating plant-based products, from ingredient interactions to processing to measurement science, including sensory. The book addresses not only the different types of plant proteins and their nutritional aspects but also plant protein processing and ingredients and formulating plant proteins to develop plant-based foods.It will be a welcomed addition to the libraries of food technologists, research scientists, product developers, process engineers, students and educators.

  • Stem Cells and Tissue Regeneration

    Bridging Research and Clinical Practice
    • 1st Edition
    • Wen Zeng + 2 more
    • English
    Stem Cells and Tissue Regeneration: Bridging Research and Clinical Practice delves into the latest advancements in the dynamic field of tissue regeneration. This comprehensive book begins with an introduction that reviews stem cell classifications, characteristics, functions, and their integral relationship with tissue regeneration. This first section offers readers a solid foundation and understanding of the book’s scope and significance in contemporary research and clinical applications. Subsequent chapters explore each major organ, including skeletal muscle regeneration and vascular organoids.Additional... the book presents innovative strategies and methods for research, culminating in a forward-looking perspective on the future of tissue regeneration. Authored by experts, it serves as a vital resource for researchers, clinicians, and surgeons involved in tissue repair.

  • Synthesis of Best-Seller Drugs

    • 2nd Edition
    • Ruben Vardanyan + 1 more
    • English
    Synthesis of Best-Seller Drugs, Second Edition provides detailed information on the most popular drugs, using a practical layout arranged according to drug type. Each chapter reviews the main drugs in each of nearly 40 key therapeutic areas, also examining their classification, novel structural features, models of action, and synthesis. Of high interest to all those who work in the captivating areas of biologically active compounds and medicinal drug synthesis, in particular medicinal chemists, biochemists, and pharmacologists, the book aims to support current research efforts, while also encouraging future developments in this important field.

  • Viral Hemorrhagic Fevers

    Epidemiology, Pathogenesis, Management, and Preparedness
    • 1st Edition
    • Agiesh Kumar Balakrishna Pillai + 2 more
    • English
    Viral Hemorrhagic Fevers: Epidemiology, Pathogenesis, Management, and Preparedness covers the causative agents, outbreaks, and clinical management of emerging and re-emerging viral hemorrhagic fevers. Coverage includes a range of topics from basic virology, epidemiology, and disease pathogenesis of emerging and re-emerging hemorrhagic fever viruses. The book examines host-virus interactions, immune pathogenesis, and recent trends in disease diagnostics. It also covers current state-of-the-art in understanding molecular mechanisms of disease pathogenesis, the potential of molecular markers for disease prognostics, early prediction of disease outcome, advancements in diagnosis and drug development, and strategies in pandemic preparation, mitigation, and responses in public health security.With chapters written and compiled by a team of well-known virologists, clinicians as well as regulatory and public health experts. This book is a comprehensive guide that will help users understand the transmission, pathogenesis, and clinical management of emerging and re-emerging viruses causing hemorrhagic diseases.

  • Diabetes and Neurodegeneration

    • 1st Edition
    • Debasis Bagchi + 2 more
    • English
    Diabetes and Neurodegeneration unlocks the complex interplay between diabetes and Neurodegeneration, reviewing the relationship between these two prevalent health challenges. This book begins with a simple guide to understanding high blood sugar, tracing the historical milestones of hyperglycemia, and unveiling the primary factors that contribute to diabetes development, from genetic predisposition to lifestyle hazards. The second section aims to bridge the gap between diabetes and dementia, presenting early clinical evidence, case studies, and susceptibility assessments that underscore the strong link between hyperglycemia and neurodegeneration. Biomarkers and pathways connecting these conditions are explored, including the role of Advanced Glycated End (AGE) products and their implications in protein misfolding and aggregation. The narrative extends to therapeutic strategies, evaluating the efficacy of antidiabetic drugs, targeting insulin resistance, and introducing novel interventions to arrest amyloid-associated pathogenesis. This comprehensive guide provides both clinicians and researchers with a thorough understanding of the intricate link between diabetes and neurodegeneration.

  • One Planet, One Health, One Future

    Charting a Course for Global Wellness, Environmental Resilience, and Sustainable Food Systems
    • 1st Edition
    • Ranbir Chander Sobti + 4 more
    • English
    One Planet, One Health, One Future: Charting a Course for Global Wellness, Environmental Resilience, and Sustainable Food Systems provides a comprehensive synthesis of research findings, best practices, and emerging trends across the interconnected fields of health, environment, and agriculture, serving as a valuable reference for those seeking to deepen their understanding of interdisciplinary issues. Chapters explore topics such as precision public health, artificial intelligence in environmental monitoring, and regenerative agriculture practices. The book presents cutting-edge insights and innovative solutions that can inform and inspire the readers and contribute to advancing knowledge in their respective fields. Written by experts in diverse fields such as epidemiology, ecology, agronomy, and public health, the book offers multidimensional insights and perspectives for researchers, policymakers, and practitioners working at the intersection of public health, environmental science, and agricultural studies.

  • Smart and Intelligent Food Packaging

    Innovations and Insights
    • 1st Edition
    • Swarna Jaiswal + 2 more
    • English
    Smart and Intelligent Food Packaging: Innovations and Insights, a new volume in the Sustainable Food Packaging series, is a comprehensive guide to the latest developments in the field of packaging technology, with a focus on the integration of smart and intelligent features to enhance product quality, safety, and sustainability. Organized into three sections, the book covers fundamental concepts and technologies as well as real-world applications and case studies, providing readers with a complete understanding of the latest trends and best practices in this rapidly evolving field.With the growing importance of sustainability and increasing demand for sustainable and efficient packaging solutions, this series of books represents a comprehensive guide to navigating this rapidly evolving landscape.

  • Video Health Monitoring in Hospitals

    • 1st Edition
    • Wenjin Wang + 3 more
    • English
    Video Health Monitoring in Hospitals discusses the emergence of camera-based, contactless physiological measurement as a groundbreaking solution in healthcare monitoring. The book highlights the technology's non-invasiveness, capacity for continuous and long-term monitoring, and its ability to capture not only vital signs but also contextual information and behaviors. A unique aspect of this book is its rich set of compelling healthcare applications that will attract broader audiences (including researchers, engineers, clinicians, and students) from multidisciplinary fields.Finally, the book discusses the role of artificial intelligence in enhancing healthcare applications and aims to engage the healthcare industry in adopting this innovative approach to improve patient care and outcomes.

  • Myasthenia Gravis

    Disease, Diagnosis and Management
    • 1st Edition
    • Bhupendra G. Prajapati + 2 more
    • English
    Myasthenia Gravis: Disease, Diagnosis and Management is a comprehensive resource that explores recent advancements in diagnosing and treating Myasthenia Gravis, a rare autoimmune disease affecting the neuromuscular junction. With contributions from global experts, this book addresses the increasing prevalence of Myasthenia Gravis, reflecting the latest in diagnostic techniques and novel therapies such as complement inhibitors and FcRn antagonists. It aims to support healthcare professionals in delivering optimal care through evidence-based insights and patient-centered approaches. The book is divided into several chapters, beginning with an overview of the pathogenesis and immunoregulatory defects in Myasthenia Gravis. Subsequent chapters cover diagnostic methods, non-immunosuppressiv... treatments, and biological therapies targeting the immune system. Key topics include the role of intravenous immunoglobulin (IVIg) and plasma exchange (PLEX) in severe exacerbations, thymectomy, molecular mechanisms, and the potential of hematopoietic stem cell transplants. The book also delves into precision medicine, AI applications, clinical trial considerations, and novel therapeutics like anti-FcRn antibodies. Management strategies for ocular Myasthenia Gravis, and a holistic view of living with the disease are also discussed. Myasthenia Gravis: Disease, Diagnosis and Management is invaluable for healthcare providers, physicians, immunologists, ophthalmologists, rheumatologists, physical therapists, pharmacists, and translators. It offers a modern guide to understanding and managing Myasthenia Gravis, integrating clinical expertise with the latest research to improve patient outcomes.

  • Handbook of Spinal Anesthesia

    • 1st Edition
    • Craig D. Mcclain + 3 more
    • English
    Handbook of Spinal Anesthesia introduces the theoretical and practical aspects of administering spinal anesthesia. The book's chapters explore the anatomy of the spine and the mechanism of action of a neuraxial block, as well as the pharmacology of local anesthetics in this area. Sections also include guidance for assessing risks on a patient-by-patient basis and feature a range of administration techniques. Information on pre-operative patient care, patient monitoring and post-operative care is also included. The book considers complications and challenges in performing spinal anesthesia and closes with a chapter on recent advances in the field. This book acts as a comprehensive foundation to spinal anesthesia. It is an ideal reference for junior doctors, medical officers, and non-specialist physicians seeking a practical guide to performing spinal anesthesia.

  • A History of Angiogenesis

    Discoveries, Research and the Therapeutic Potential
    • 1st Edition
    • Gianfranco Natale + 2 more
    • English
    A History of Angiogenesis: Discoveries, Research and the Therapeutic Potential presents a recent history of discoveries in the angiogenic field that contribute to the development of the anatomical knowledge of the process, experimental models, and new pharmacological approaches in different angiogenesis-related diseases. This multifaceted book is enriched with deep scientific contents, and each chapter clearly defines historical steps, the emerging role during the years of new morphological findings, molecular pathways, and targets. Focus is also directed on key challenges associated and future directions.The history of angiogenesis research is an intriguing tool for discovering answers to a wide array of queries arising in the biological and medical world. This comprehensive resource skillfully integrates all the key aspects related to angiogenesis, and will be of immense help to students, researchers, and industry experts who want to explore the last two decades of angiogenesis discoveries and research.

  • Carbon Dots in Food Packaging and Preservation

    • 1st Edition
    • Jong Whan Rhim
    • English
    Carbon Dots in Food Packaging and Preservation provides an introduction to carbon dots (CDs) and explores their practical application in food packaging, addressing common challenges such as the need for safer food storage, longer shelf life, and eco-friendly packaging solutions. The book begins with a comprehensive overview of the basic principles of CDs and their unique properties relevant to this industry, such as their ability to fight germs, prevent food spoilage, and shield against harmful UV rays, which are crucial for improving food quality and safety. It then discusses their various applications and practical uses in creating innovative packaging materials, smart packaging systems, and sensors that respond to changes in food quality and counterfeiting, showcasing the potential of CDs in addressing key issues in food packaging technology. This book provides practical insights into the use of CDs for active and intelligent packaging, serving as a valuable resource for scientists, industry professionals, and policymakers seeking sustainable and effective solutions in food packaging practices.

  • Emerging Trends in Medical Robotics

    Technologies, Innovations and Applications
    • 1st Edition
    • Parveen Kumar + 2 more
    • English
    Emerging Trends in Medical Robotics: Technologies, Innovations and Applications, provides an overview of medical robotics, including fundamentals, a bibliometrics review, and essential elements. Other sections delve into emerging technologies such as the Internet of Medical Robots Things (IoMRT), artificial intelligence-driven medical robots, robotic cyber-physical systems, cybersecurity considerations, and the integration of digital twin technology.This book explore various applications of medical robots in surgery, healthcare management, diagnostics imaging, pharmacy and medication dispensing, hospital logistics, ethical considerations, future prospects, and challenges in the field.

  • Flavonoids for Plant Development and Stress Tolerance

    • 1st Edition
    • Praveen Guleria + 2 more
    • English
    Flavonoids for Plant Development and Stress Tolerance presents the latest information on the genetic and molecular networks induced by flavonoids that regulate plant and microbe interactions. Covering recent studies, innovations, and future perspectives on flavonoid metabolism, this book explores their role in modulating plant responses to environmental changes, providing valuable insights for current applications and future research directions.Flavonoid... are important secondary metabolites synthesized in plants, known for their antioxidant properties and their role in scavenging oxidative stress markers. While extensively studied in model plants, research on flavonoids in other species remains limited. To fully understand the mechanisms involved in various plant growth phases, it is essential to identify and characterize different flavonoids and their types.This volume offers a comprehensive overview of the diversity of flavonoids, their significance for food security, and the underlying molecular and biochemical mechanisms. It includes detailed descriptions of flavonoid biosynthesis, their functional diversity, and their involvement in plant responses to global climate change. Additionally, the book discusses flavonoid engineering, its status, and its potential to support agricultural sustainability.Focus... on the molecular and biochemical pathways responsible for flavonoid-mediated stress responses, this valuable reference resource aims to deepen understanding of both foundational concepts and recent advancements in flavonoid engineering—ultimate... contributing to the survival, productivity, and sustainability of plants under changing environmental conditions.

  • RNA Enzymology and Technology

    • 1st Edition
    • Volume 725
    • English
    RNA Enzymology and Technology, Volume 725 in the Methods in Enzymology series, highlights new advances in the field, with this new volume presenting interesting chapters on topics such as RNA enzymes in transcription, RNA processing, translation regulation, RNA transcriptase in gene expression regulation, Enzymes Involved in Ribosome Biogenesis and Translation Regulation, In Vitro Transcriptase: Methods for Studying RNA Synthesis, RNA Enzymes in RNA Silencing and Regulation, RNA Silencing Machinery: Mechanisms of RISC and MicroRNA Regulation, Enzymes in RNA-Based Therapeutics, and much more.Other chapters cover Antisense Oligonucleotides (ASOs) and RNase H: Mechanisms and Applications, RNA Enzymes in Targeted Therapeutics: From Bench to Bedside, Enzymes in RNA Sequencing and Analysis, Enzymes in High-Throughput RNA Sequencing: Applications and Challenges, Advanced Techniques and Future Directions, and much more.

  • Systems Biology in Crop Improvement

    Emerging Tools and Technologies
    • 1st Edition
    • Tariq Aftab
    • English
    Systems Biology in Crop Improvement offers a detailed overview of how principles and methodologies from systems biology are transforming crop research and breeding. This volume, part of the Systems Biology in Agriculture and Plant Sciences series, explores the integration of omics technologies, computational modeling, and high-throughput phenotyping to deepen our understanding of plant responses and traits.Addressing the urgent challenge of feeding a growing global population, the book emphasizes how systems biology enables insights into molecular, genetic, and environmental interactions that influence a crop’s traits and performance. It discusses applications ranging from stress resilience—abiotic and biotic—to nutrient use efficiency, nutritional enhancement, and quality markers. The volume highlights innovative strategies such as genomic editing and synthetic biology, and how these advances can be translated into practical breeding programs.Bringing together contributions from leading researchers and practitioners, Systems Biology in Crop Improvement aims to inspire new collaborations, innovations, and discoveries, ultimately contributing to a more sustainable and robust food system for future generations.

  • Fundamentals and Applications of Nanobiotechnology

    • 1st Edition
    • Basanta Kumara Behera
    • English
    Fundamentals and Applications of Nanobiotechnology offers a discussion on the integration of nanotechnology and biotechnology research and the industrial potential of nanobiotechnology across diverse sectors, such as the medical sciences, agriculture, cosmetics, and food sciences. Topics include the significance of biological nanoparticles, the different types of bionanoparticles, their structural interactions with biological systems, mechanisms of nanoparticle entry, and their applications in drug development, food sciences, agriculture, and cosmetics. Additionally, the book addresses the challenges, perspectives, and ethical considerations surrounding nanobiotechnology, offering a holistic view of the field's potential impact on society and the environment.Through detailed discussions and practical insights, this book serves as a resource for researchers, industry professionals, and students seeking to navigate the complexities of designing, commercializing, and utilizing nanobiotechnology-ba... products across various industries.

  • Handbook of Pharmaceutical Wet Granulation

    Theory and Practice in a Quality by Design Paradigm
    • 2nd Edition
    • Ajit S. Narang + 1 more
    • English
    Handbook of Pharmaceutical Wet Granulation: Theory and Practice in a Quality by Design Paradigm, Second Edition offers a single and comprehensive reference dedicated to all aspects of pharmaceutical wet granulation, taking a holistic approach by combining introductory principles with practical solutions. Chapters are written by international experts across industry, academic and regulatory settings, and cover a wide spectrum of relevant and contemporary wet granulation topics, techniques and processes. This completely revised and updated edition features five new chapters covering new AI tools applied to scaling up granulation processes, model drive design, machine learning models for granule property prediction, design and scale up of fluid bed granulation, and process analytical methods. This book is the prefect reference for pharmaceutical manufacturing professionals. Academic researchers will benefit from the practical advice provided by the editors and chapter authors.

  • DNA in Health, Identity, and Ancestry

    • 1st Edition
    • Hisham Atan Edinur + 2 more
    • English
    DNA in Health, Identity and Ancestry examines the human genome and advances in molecular techniques in relation to their value in health, genetic ancestry, and forensic DNA. This book systematically presents these three areas, providing new insights into recent developments in these fields, including gene editing, ancestral fraction determination, and DNA profiling. It covers the latest advances in molecular biology to understand the pertinent issues in these areas. DNA in Health, Identity and Ancestry provides an introduction to human genomes, and then delves into health, forensics and ancestry across 36 chapters. Each section is concluded with practical case studies to demonstrate the application of the principles discussed in each respective section. This book is a valuable resource for researchers, practitioners, and postgraduate students in biochemistry, molecular biology and genetics. It not only provides them with fundamental knowledge on genetics, diseases, population genetics and forensic DNA, but also presents advances, technical operational standards, analytical tools and recent developments in these respective areas.

  • Side Effects of Drugs Annual

    • 1st Edition
    • Volume 47
    • English
    Side Effects of Drugs Annual: A Worldwide Yearly Survey of New Data in Adverse Drug Reactions, Volume 47, first published in 1977, presents clinicians and medical investigators with a critical survey of new data and trends in adverse drug reactions and interactions. Topics covered include ADRs, ADEs and SEDs: A Bird’s Eye View, Lithium, Drugs of abuse, Side effects of drugs used in the treatment of Alzheimer's disease, Sedatives and hypnotics, Antipsychotic agents, Anti-epileptic Medications, Side effects of opioid analgesics and narcotic antagonists, Anti-inflammatory and antipyretic analgesics and drugs used in gout, Side effects of local anesthetics and therapeutic gases, and more.Other sections covered include Antihistamines (H1 receptor antagonists), Drugs that act on the respiratory tract, Positive inotropic drugs and drugs used in dysrhythmias, Beta adrenergic antagonists and antianginal drugs, Drugs acting on the cerebral and peripheral circulations, Antihypertensive drugs, and much much more.

  • Frontiers of Cancer Biology

    Current Trends in Cancer Research
    • 1st Edition
    • Devavarapu Kasi Viswa Prasad + 1 more
    • English
    Frontiers of Cancer Biology: Current Trends in Cancer Research presents the latest research in cancer, which is advancing day by day. This book provides an introduction to cancer genetics, as well as the roles of genomic instability, oncogenes, proto-oncogenes, tumor suppressor genes, and DNA damage and repair in relation to cancer. It then goes on to discuss viral genomics and cancer, epigenetics and cancer, cancer genetics, gene therapy in precision medicine. Finally, this book reviews the future direction of cancer genetics. Frontiers of Cancer Biology: Current Trends in Cancer Research is a valuable resource for researchers and professionals working in cancer biology, as well as academics that want to keep up to date with the field.

  • Non-pharmacological Interventions for Age-Related Neuropsychiatric Disorders

    • 1st Edition
    • Volume 298
    • English
    Non-pharmacological Interventions for Age-Related Neuropsychiatric Disorders, Volume 297 in the Progress in Brain Research series, highlights new advances in the field, with this new volume presenting interesting chapters on topics such as Introduction to Age-Related Cognitive Behavioral Changes, The Science Behind Non-Pharmacological Interventions, Cognitive Stimulation Therapy: Enhancing Memory and Mental Function, Mindfulness and Meditation: Promoting Emotional and Cognitive Health, Music and Art Therapy: Creative Approaches to Healing, and much more.Other sections cover Physical Activity: The Brain-Body Connection, The Science Behind Reminiscence Therapy: The Healing Power of Memory, The Role of Caregivers: Providing Compassionate and Effective Care, Ethical Considerations in Non-pharmacological Interventions, and Technology-Assisted Interventions for Neuropsychiatric Disorders.

  • Antimicrobial Resistance in Humans, Animals, and the Environment

    One Health Approach
    • 1st Edition
    • Kunal Ranjan + 3 more
    • English
    Antimicrobial Resistance in Humans, Animals, and the Environment: One Health Approach examines the global impact of antimicrobial resistance (AMR) with a specific focus on the interconnectedness between animal, human, and environmental health. The book details the origin, evolution and ecology of AMR and its updated epidemiology. It discusses the transmission of antimicrobial resistance between humans, animals, and the environment. It delves into the molecular mechanisms of drug resistance development and epidemiology in human and animal health; the different challenges in treating antimicrobial-resist... infections including rapid diagnosis and the development of new antimicrobial agents; and alternative strategies treating drug-resistant infections. Antimicrobial Resistance in Humans, Animals, and the Environment: One Health Approach is a useful comprehensive resource for researchers, academics postgraduate students, PhD students, early career researchers, and medical scientists in microbiology, infectious diseases, and biotechnology, public health professionals, clinical personnel treating AMR, or policymakers interested in implementing antimicrobial stewardship program in hospitals.

  • Pathophysiological Consequences of Alcohol

    • 1st Edition
    • Patricia E. Molina + 2 more
    • English
    Pathophysiological Consequences of Alcohol examines the impact of alcohol on physiological processes within various organ systems. The book starts with an introduction to relevant organ system physiology, then presents current, evidence-based findings on how alcohol use, whether acute or chronic, affects these processes. Each chapter, aside from the Introduction and Cellular and Molecular Physiology, begins with a system overview, explores alcohol's effects, and concludes with integrated cases or clinical vignettes. This volume is intended for those studying or working in physiology, biology, or neuroscience and is written by experts from a renowned Physiology Department.It includes comprehensive teaching material and offers insights into alcohol-related comorbidities. The book's authors are engaged in both research and education in the field.

  • Nanotechnology Applications for the Diagnosis and Therapeutic Treatment of Fungal Diseases

    • 1st Edition
    • Virendra Gajbhiye + 2 more
    • English
    Nanotechnology Applications for the Diagnosis and Therapeutic Treatment of Fungal Diseases offers comprehensive coverage of the fundamentals of fungal diseases and the applications of nanotechnology for their diagnosis and treatment.The book covers the basics of human fungal pathogens, the molecular mechanisms of infection, and current diagnostic strategies and treatment regimes. It then goes on to discuss nanotechnology-based approaches for the detection and identification of human fungal pathogens. It also discusses antifungal drugs, their modes of action, and how nanoparticles are utilized to deliver these agents, highlighting their significance in treating various fungal infections. Additionally, it provides a comprehensive overview of nanotechnology-based products, as well as the current and future applications of nano-methodologies and technologies in the field of fungal infectious diseases. With contributions from experts in the field, Nanotechnology Applications for the Diagnosis and Therapeutic Treatment of Fungal Diseases is an informative resource for scientists, researchers, and medical personnel to better understand fungal diseases in order to design and develop novel and accessible nano-based therapies for their treatment.

  • Proteomics in Cell Communication

    • 1st Edition
    • Volume 200
    • English
    Proteomics in Cell Communication, offers a comprehensive exploration of the dynamic field of proteomics and its vital role in understanding cellular communication. This book includes interesting chapters on topics such as In vivo cell-type specific secretome profiling, Assays for surface antigens in extracellular vesicles using proximity labeling strategy, Cell type-specific proximity biotinylation using TurboID to identify secreted proteins from cardiomyocytes in vitro and in vivo, Native-state and cell type-specific proteomics using TurboID proximity labeling in mouse models, Adapted Luminex approach to assess phosphoproteins and cytokines released from specific cell types in the brain in vivo, and much more.Other sections covers In-depth cell-selective proteomics and secretomics in vivo based on azidonorleucine labelling, Visualizing and profiling de novo protein synthesis in Drosophila with cell-type specificity, A Split GFP Approach for Cell-Type-Specific Protein Localization Analysis in Drosophila, Quantitative deep profiling of the cell surface proteome using the "Cell Surface Capture" technique, Proteomic profiling of extracellular fluids to identify secreted proteins from muscle and fat tissues, and much more.

  • Microbial Enzymes

    Classification, Biochemistry, Production and Applications
    • 1st Edition
    • Abdel Moneim Elhadi Sulieman
    • English
    Microbial Enzymes: Classification, Biochemistry, Production and Applications explores the multifaceted roles of microbial enzymes, emphasizing their stability, ease of handling, and manipulation, all of which make them invaluable in various industrial processes. With 25 in-depth chapters, the book delves into the biochemistry of enzymes, their various sources, and their importance in biotechnology. It covers modern techniques for microbial enzyme detection and determination, methods of enzyme immobilization, and the application of microbial enzymes in industries such as food, medicine, pharmaceuticals, and textiles. Special sections discuss the biosynthesis of metal nanoparticles by microbial enzymes and the role of microbial toxins in different sectors. The book's chapters are organized in a way that provides detailed insights into the classification of enzymes, the mechanisms of microbial enzymes, and their industrial importance. Topics include bacterial, fungal, and algal enzymes, their applications, and the latest advancements in enzyme technology. Other sections address the challenge of antibiotic resistance and explores innovative methods for enzyme production and molecular engineering.

  • Plant-Based Proteins Processing

    Emerging Trends and Applications
    • 1st Edition
    • C.K. Sunil + 2 more
    • English
    Plant-Based Proteins Processing: Emerging Trends and Applications covers sources, extraction, properties, bioavailability, modification, applications, and marketing opportunities, in addition to the conventional and emerging technologies applied for obtaining plant-based proteins. This book consists of five sections, starting with Section A which includes chapters on overview, sources, digestibility and bioavailability, nutritional properties, and food byproducts as a source of protein. Section B covers the extraction of plant-based proteins, which has chapters on the chemical, enzyme, and novel techniques for extraction of plant proteins. Section C chapters focus on the modification of the plant protein, including all the modification methods (Thermal, Non-thermal, Biological, and Chemical methods) and their effects on the protein. Section D includes the applications of the proteins, and the last Section, E, covers the market, challenges, and future opportunities for plant-based proteins. Plant-Based Proteins Processing is a complete guide for students, researchers, professionals, consumers, food manufacturers, and others who are engaged in plant-based protein production.

  • Protein Misfolding Diseases

    • 1st Edition
    • Volume 148
    • English
    Protein Misfolding Diseases, delves into the intricate molecular mechanisms behind a class of devastating disorders caused by abnormal protein folding. This comprehensive book explores interesting and updated topics, including Protein misfolding in hemophilia, Characterizing Protein Misfolding: Inside and Out, Heat Shock proteins (HSPs) as chaperones for Oncogenesis, Protein Misfolding and Cancer: Molecular Insights and Future Perspectives, Proteostasis and Pathogenesis: Unraveling the Complexity of Protein Misfolding Disorders, Small molecule inhibitors targeting α-synuclein aggregation: Progress and future outlook, and much more.Additional sections cover Chaperone Machinery in Neurodegeneration: A Spotlight on Protein Misfolding Diseases and Calpain- mediated proteolytic cleavage.

  • Methods for the Study of Microbial Biofilms

    Current Trends and Recent Advancements
    • 1st Edition
    • Abhishek Guldhe + 2 more
    • English
    Methods for the study of microbial biofilms: Current Trends and Recent Advancements provides a detailed overview of the latest techniques for the study of biofilms. The book explores a wide range of methods for the characterization and study of cells within biofilms, including microscopy techniques, genomic approaches, transcriptomics, proteomic and proteogenomic tools. Computational and mathematical modelling are also covered.Chapters investigate the physiology of biofilm cells, gene expression pathways related to the formation, maturation and dispersion of biofilms, and molecular factors governing the biofilm formation and development, providing an overview of techniques that can be used at the cellular and molecular level. This book provides a broad overview of the biofilm field, along with the range of techniques that can be used to study and better understand them.

  • Precision Medicine in Neurodegenerative Diseases: From Research to Clinical Practice

    • 1st Edition
    • Volume 297
    • English
    Precision Medicine in Neurodegenerative Diseases: From Research to Clinical Practice, Volume 298 in the Progress in Brain Research series, highlights new advances in the field, with this new volume presenting interesting chapters on timely topics such as Introduction to Precision Medicine in Neurodegeneration, Genetic and Epigenetic Drivers of Neurodegenerative Disorders, Biomarkers: From Early Detection to Treatment Personalization, Multi-Omics Integration in Disease Research, AI and Emerging Technologies for Diagnosis, Advanced Neuroimaging in Precision Neurology, and much more.Additional chapters cover Precision Therapeutics for Alzheimer's Diseases, Personalized Management of Parkinson's Diseases, Pharmacogenomics and CRISPR-Based Therapies, Patient-Centric Care and Digital Health Tools, and Global Case Studies and Collaborative Frameworks, Future Horizons: Innovation, Aging, and Equity.

  • Encyclopedia of Reproduction

    • 3rd Edition
    • Michael K. Skinner
    • English
    The Encyclopedia of Reproduction, Third Edition, Six Volume Set comprehensively reviews biology and abnormalities, also covering the most common diseases in humans, such as prostate and breast cancer, as well as normal developmental biology, including embryogenesis, gestation, birth and puberty. Each of the 575 chapters provides a comprehensive overview by leaders in their respective fields that is ideal for advanced undergraduate students, research professionals, and clinicians. Chapters explore the latest advances in cloning, stem cells, endocrinology, clinical reproductive medicine, and genomics.As reproductive health is a fundamental component of an individual’s overall health status and a central determinant of quality of life, this 6-volume set provides the most extensive and authoritative reference within the field.

  • Introduction to Contemporary Philosophy of Medicine

    • 1st Edition
    • James A. Marcum
    • English
    Introduction to Contemporary Philosophy of Medicine explores philosophical approaches to the nature of medicine, ranging from the Analytic Philosophy of Medicine to Feminist and Gender Medicine. Digital, Complementary, and Alternative Medicines are also discussed, with each diverse approach informed by different ontological and epistemological concepts, such as causation, disease, and health, which are introduced and discussed in detail. This is a key guide for students and other healthcare professionals interested in philosophical issues in contemporary medicine.Contemporar... philosophy of medicine is certainly a growing discipline in the 21st century, with substantial literature. But the discipline has no overarching paradigm that reflects consensus. Rather, contemporary philosophy of medicine is diverse, with various approaches not only to the problems facing contemporary medicine, but also how best to address and potentially resolve them. This book explores these concepts and their diverse approaches.

  • Neurobiology of Aging

    Exploring Cognitive Decline and Neurodegeneration
    • 1st Edition
    • Sachchida Nand Rai
    • English
    Neurobiology of Aging: Exploring Cognitive Decline and Neurodegeneration is a comprehensive reference exploring the complexities of the aging brain. This book examines the intricate processes driving cognitive decline and neurodegeneration. From the gradual loss of neurons and synapses to the formation of protein aggregates characteristic of Alzheimer's disease, each chapter reviews key aspects of brain aging. Chapters dissect the mechanisms driving neuronal loss, synaptic dysfunction, and protein misfolding, shedding light on the intricate interplay of oxidative stress, inflammation, and mitochondrial dysfunction. This book also navigates through strategies for healthy brain aging, from the impact of diet and exercise to the role of cognitive stimulation.

  • Chemoresistance in Glioblastoma

    Understanding and Management
    • 1st Edition
    • Dileep Kumar + 1 more
    • English
    Chemoresistance in Glioblastoma: Understanding and Management gives clear insights into the detailed characteristic aspects of glioblastoma disease and the different therapeutic targets that are employed in reducing resistance to chemotherapeutic agents. The book delves deep into the root causes of multidrug resistance and the quest for novel molecular targets among growth factors, receptors, signal transduction proteins, microRNAs, transcription factors, proto-oncogenes, and tumor suppressor genes. In addition, it gives insights on the pathological and molecular features of glioblastoma and the role of cancer stem cells in the resistance to chemo and immunotherapy.While designed as a comprehensive guide, the book also serves as a valuable reference for professionals seeking to deepen their understanding, refine their skills, and explore new avenues within chemoresistance.

  • Future Fat Alternatives

    Concepts, Structuring and Food Applications
    • 1st Edition
    • Zong Meng
    • English
    Future Fat Alternatives: Concepts, Structuring and Food Applications provides a deep dive into the strategies for the development of fat alternatives for food applications, covering all structuring strategies including oleogels, emulsion gels, and foamed gels as well as cell-cultured fats. In addition, this book details other applications such as additive manufacturing and fat alternatives in different food applications and discusses their nutritional benefits. Divided into eight sections, this book begins with an overview of the structural-propertie... relationship in traditional fats, then segues into the benefits and challenges of fat alternatives, the prospects and challenges of cell-cultured fats, the additive manufacturing of fat analogs and how they pave the way toward novel food development. The applications of different fat alternatives and their nutritional benefits in bakery, meat, chocolate, and cheese products as well as nutraceutical delivery systems are also discussed.This book presents an excellent resource for researchers working across the food sciences in the fields of oil and fat production, research and development, sensory analysis, and technology and engineering.

  • Sustainable Urban Environments for Human Health

    • 1st Edition
    • Nidhi Singh + 3 more
    • English
    Sustainable Urban Environments for Human Health integrates concepts related to energy sustainability, urbanization, and human health into a single comprehensive resource. This book addresses the multifaceted global crises involving energy, economy, environment, and public health by exploring synergies and anticipating future perspectives, opportunities, and challenges to ensure resilience in a rapidly evolving human-driven world. Themes include ecological urban planning for health, renewable energy in urban environments, air quality and respiratory health, green infrastructure and health, active transportation and health, energy equity and social determinants of health, urban agriculture and food systems.

  • Harnessing Genomic Tools for Crop Improvement

    A Software User Manual for Transforming Geneticists to Genomicists
    • 1st Edition
    • Lakshmi Narayana R. Vemireddy + 2 more
    • English
    In the rapidly evolving landscape of crop genetics, the book, Harnessing Genomic Tools for Crop Improvement is an essential resource designed for researchers, students, and professionals seeking to leverage bioinformatics tools for precision breeding. This comprehensive manual provides step-by-step guidance on utilizing molecular data derived from genetics and breeding experiments, offering hands-on instructions for key software applications in genetic diversity analysis, QTL mapping, genome-wide association mapping, haplotype analysis and genomic selection.Beyond technical tutorials, the book explores cutting-edge bioinformatics tools such as sequence databases, BLAST, primer designing, and sequence alignment, ensuring users gain a holistic understanding of genomics-driven crop improvement. Definitions, terminology clarifications, and interpretation of the results help bridge the gap between theory and application, simplifying complex analyses.Whether you are a novice or an experienced researcher, this book equips you with the skills to analyze and apply genomic data effectively, making it an invaluable asset for transforming geneticists into genomicists in both plant and animal sciences.

  • Recent Trends in Enzyme Immobilization

    • 1st Edition
    • Shailendra Kumar Arya + 3 more
    • English
    Recent Trends in Enzyme Immobilization explores the forefront of enzyme technology, providing a comprehensive guide on the latest methodologies and advancements. This book begins by setting the stage with foundational insights into enzyme immobilization, then progresses to discuss innovative techniques and their applications across various industries, including biopharmaceuticals, environmental science, and food processing. Structured to cater to both newcomers and seasoned professionals in biotechnology and biochemical engineering, each chapter delivers in-depth analysis and up-to-date research findings. Readers will find valuable resources in the practical guidance offered for optimizing enzyme stabilization, activity, and reusability in industrial applications. Moreover, the text addresses the theoretical underpinnings that frame current practices and illuminates future directions for research and technological advancements. Designed as an indispensable resource, this book aims to bridge the gap between academic research and practical application. It equips researchers, practitioners, and advanced students with the necessary tools and knowledge to drive innovation in enzyme immobilization, fostering the development of sustainable solutions and novel approaches in their work. With contributions from leading global experts, Recent Trends in Enzyme Immobilization serves as a critical reference that promises to inspire and guide readers through the complexities and potentials of this dynamic field.

  • The Potential of Intermittent Fasting in Age-related Diseases and Precision Anti-aging Therapeutics

    • 1st Edition
    • Abhishek Kumar Singh + 2 more
    • English
    The Potential of Intermittent Fasting in Age-related Diseases and Precision Anti-aging Therapeutics takes an in-depth look at the beneficial and efficacious role of Intermittent Fasting (IF) in a wide array of aging-associated diseases. It provides a comprehensive resource that not only outlines the potential benefits and future research directions but also delves into the limitations and nuances of IF in managing these conditions. The book is divided sections and begins by covering the fundamentals of aging and the effects of IF. Subsequent sections examine the physiological impact IF has on aging; its potential influence on stress resistance, heart, gut, and overall health optimization; social and ethical considerations as a therapeutic strategy; bridging IF research findings and clinical practice; and the potential integration and application of IF into age-related diseases treatment. Offering a consolidated and scientifically grounded perspective aimed at equipping readers with a balanced understanding, this book serves as a go-to reference for researchers and clinicians alike seeking clear and accurate insights into how IF can positively influence the health and longevity of the aging population.

  • Updates on Pediatric Brain and Spine Tumors, An Issue of Neuroimaging Clinics of North America

    • 1st Edition
    • Volume 36-1
    • Christopher Filippi + 1 more
    • English
    In this issue of Neuroimaging Clinics, guest editors Drs. Christopher Filippi and Jane McEniery bring their considerable expertise to the topic of Updates on Pediatric Brain and Spine Tumors. Top experts discuss changes to the WHO classification for pediatric brain and spine tumors; circumscribed astrocytic tumors; glioneuronal tumors; congenital neonatal tumors; radiomics and AI for pediatric brain tumor; tumor predisposition syndromes; and more.

  • The Science and Culture of Latin American Foods

    Harnessing Ingredients for Health
    • 1st Edition
    • Sonia G. Sáyago-Ayerdi + 3 more
    • English
    The Science and Culture of Latin American Foods: Harnessing Ingredients for Health combines science and technology to demonstrate the importance of rescuing and preserving traditional and ancestral knowledge to exploit the functional benefits of the regions’ many roots, plants, seeds, insects, and more. Divided into four sections, Ingredients, Nutraceuticals, Functional Foods, and Cuisine, the book discusses the sustainable development of these ingredients while highlighting origin, production, classification, and medicinal properties. Readers will discover the potential of potent bioactive peptides derived from native foods like cacao, chipilín leaves, and Huauzontle, a pre-Hispanic ingredient thriving and surviving in Mexican cuisine.In addition, they will learn how Asia and Africa influence Latin American cuisine and about the importance these regional culinary dishes have in global gastronomy today.

  • Nanomedicine and Nutrigenomics

    Pioneering the Future of Health
    • 1st Edition
    • Yugal Kishore Mohanta + 2 more
    • English
    Nanomedicine and Nutrigenomics: Pioneering the Future of Health offers a comprehensive introduction to nanomedicine and nutrigenomics, ensuring readers grasp the fundamental concepts, techniques, and applications. The book provides an overview of nanotechnology, nanomaterials, and gene-nutrient interactions, paving the way for understanding the potential healthcare applications of these groundbreaking methodologies. It emphasizes the synergy between nanomedicine and nutrigenomics, showcasing how they can optimize health outcomes and delving into nanotechnology's role in enhancing drug delivery systems, diagnostics, and therapeutics, while also highlighting personalized nutrition interventions based on genetic makeup. The book addresses future advancements, ethical implications, and challenges, presenting a holistic view.

  • DSM-5-TR - Diagnostics différentiels
    • 3rd Edition
    • Michael B. First + 2 more
    • French
    Un aspect crucial de la démarche diagnostique est d’examiner, parmi la multitude de troubles répertoriés dans le DSM-5-TR, ceux qui pourraient éventuellement expliquer le tableau clinique. Après avoir établi cette liste de possibilités, l’étape suivante consiste à recueillir des informations cliniques supplémentaires (à partir des antécédents personnels, d’informations provenant de l’entourage, du dossier médical, de l’évaluation de l’état mental et des analyses de laboratoire) afin de réduire les options au diagnostic différentiel le plus probable, ce qui deviendra alors le diagnostic positif menant à un premier projet thérapeutique.DSM-5-... Diagnostics différentiels aide ainsi les cliniciens et les étudiants souhaitant s’exercer à la démarche diagnostique à améliorer leurs compétences dans la formulation d’un diagnostic différentiel complet grâce à une variété d’approches permettant d’aborder la présentation sémiologique. Il comporte notamment uncadre diagnostique en six étapes, 30 arbres décisionnels pour établir le diagnostic différentiel des symptômes clés et 67 tableaux de diagnostic différentiel à utiliser une fois établi un diagnostic provisoire. En collaboration avec les auteurs du DSM-5-TR, experts en diagnostics et en évaluations psychiatriques, ce manuel a été entièrement mis à jour afin d’illustrer les évolutions du DSM-5-TR. Il inclut deux nouveaux arbres décisionnels (pour les symptômes dissociatifs et les comportements pathologiques répétitifs). Le manuel comporte également la classification du DSM-5-TR, ce qui facilite le codage et fournit une vue générale de tous les diagnostics devant être pris en compte lors de la formulation d’un diagnostic différentiel. Les index alphabétiques des arbres décisionnels et des tableaux dediagnostics différentiels aideront les lecteurs à trouver facilement les informations recherchées. Ce manuel est ainsi extrêmement utile aux étudiants et aux praticiens, expérimentés ou débutants.Michael B. First, M.D., est professeur de psychiatrie clinique à l’Université Columbia de New York, New York, États-Unis.Cet ouvrage a été publié dans sa version originale par l’American Psychiatric Association.

  • Basics in Amino Acid Metabolism in Humans in Health and Disease

    • 1st Edition
    • Milan Holeček
    • English
    Basics in Amino Acid Metabolism in Humans in Health and Disease summarizes the significance of amino acids and their metabolism. This book provides a single source of information bringing together a wide variety of research on the subject, explaining the rationality and risks of using some amino acids as dietary supplements. The first chapters describe amino acids' structure, classification, and transport across cell membranes and their role in protein synthesis, gluconeogenesis, and ketogenesis. The central part of the book is focused on the role of individual amino acids in the synthesis of various biologically essential substances and their metabolism in acquired and hereditary diseases. The following chapters are dedicated to the role of particular organs, such as the small intestine, intestinal microbiota, liver, muscle, kidneys, brain, adipose tissue, and lungs. The next sections are focused on amino acid metabolism under various physiological (food intake, starvation, exercise, and elderly) and pathological (systemic inflammatory response, cirrhosis, diabetes, chronic renal insufficiency, and cancer) conditions. The last chapter summarizes the benefits and potential adverse effects of increased intake of individual amino acids. The author, Professor Milan Holeček, has been studying and researching in the area for over 40+ years. "Basics in Amino Acid Metabolism in Humans in Health and Disease" is written for healthcare professionals, primarily nutritionists, specialists in intensive metabolic care, clinical nutrition, diabetology, hepatology, gerontology, gastroenterology, nephrology, and oncology.

  • Atlas of Microsurgery of the Lateral Skull Base

    • 1st Edition
    • Mario Sanna + 5 more
    • English
    Atlas of Microsurgery of the Lateral Skull Base is a practical resource for all clinicians interested in training for lateral skull base surgery. This new atlas of lateral skull base surgery allows readers to become familiar with the delicate lateral skull base, an important part of the body’s neurological system. Featuring step-by step dissection images, this resource is perfect for those studying anatomy of this region. Clinical surgical cases are also presented and discussed for each surgical approach, including relevant clinical and radiological background. Decision-making discussions provided for each clinical case ensure readers will fill any gaps in their neurosurgery training.

  • Genome Chaos

    Rethinking Genetics, Evolution, and Molecular Medicine
    • 2nd Edition
    • Henry H. Heng
    • English
    Genome Chaos: Rethinking Genetics, Evolution, and Molecular Medicine, Second Edition transports readers from Mendelian genetics to 4D genomics, building a case for genes and genomes as distinct biological entities where the genome, rather than individual genes, defines system-level inheritance and represents a clear unit of selection for macroevolution. In this thought-provoking text, Dr. Henry Heng invigorates fresh discussions in Genome Architecture Theory and helps readers reevaluate their current understanding of human genetics, evolution, and new pathways for advancing molecular and precision medicine.In this timely new edition, Dr. Heng fully embraces the integration of system information with genome-mediated evolutionary mechanisms, and supports this framework with recent findings and growing, interdisciplinary research. Ten evidence-based chapters discuss 4D genomics, genes and genomes as distinct biological entities, genome chaos and cellular macroevolution, karyotype coding and fuzzy inheritance, as well as an entirely novel model of evolution driven by information flow, and more. Brand-new chapters consider the creation and maintenance of system information for complexity and biodiversity, as well as modes of analyzing information-based and historically contingent evolutionary framework. This synthesis offers a revolutionary paradigm of evolutionary theory. It also hypothesizes about how information flow, matter arrangement, and energy interact.

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