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Books in Life sciences

  • Nanotherapeutics for Treating Neurodegenerative Disorders

    • 1st Edition
    • Manish K. Chourasia + 3 more
    • English
    Nanotherapeutics for Treating Neurodegenerative Disorders reviews the complex landscape of neurodegenerative disorders, outlining the nuances of treatment strategies and the imperative role of nanotechnology in revolutionizing therapeutic interventions. From explaining the transport mechanisms of the Blood-Brain Barrier to unveiling the therapeutic potential of stem cell-derived nanocarriers, each chapter offers invaluable insights into the diverse array of nanotherapeutic approaches helping to reshape the landscape of neurological healthcare. By consolidating current updates on advanced targets-based nanotherapeutics, this book provides a comprehensive resource for neurodegenerative diseases converge.Whether seeking to unravel the complexities of mitochondrial dysfunction or to harness the potential of nanocarriers for targeted genetic material delivery, readers will find themselves equipped with the tools to navigate the forefront of neurotherapeutic innovation.

  • Fundamentals of Translational Tissue Engineering

    • 1st Edition
    • Yogesh Kumar Verma + 3 more
    • English
    Fundamentals of Translational Tissue Engineering explores the practical dimensions of tissue engineering (TE), outlining the intricate path of development of tissue engineered products. The book navigates the reader through the fundamental aspects and challenges in TE, equipping the reader with insights crucial to comprehending the journey a tissue engineered product traverses on its way to clinical translation. The first section, Material Sciences, provides the reader with a general overview covering the basics of scaffolds, biomaterials and techniques, while the larger, second section, Biological and Clinical Aspects, discussing the biological perspectives relating to tissue engineering.This is a multi-disciplinary work that will be ideal for audiences of varying levels of expertise, from the novice exploring fundamental concepts or the seasoned professionals seeking comprehensive information, readers of all backgrounds will be able to access and benefit from this tailored approach.

  • Advances in Biomembranes and Lipid Self-Assembly

    • 1st Edition
    • Volume 43
    • English
    Advances in Biomembranes and Lipid Self-Assembly, Volume 43 highlights new advances in the field, with this new volume presenting interesting chapters written by an international board of authors.

  • Advances in Noncoding RNA Diagnostics and Therapeutics in Immunity and Cancer

    • 1st Edition
    • Afsar Naqvi + 1 more
    • English
    Advances in Noncoding RNA Diagnostics and Therapeutics in Immunity and Cancer explores the critical role of noncoding RNAs in immune-mediated diseases and cancers, providing an essential resource on their diagnostic and therapeutic potential. The book contributes valuable insights into the pathobiology of noncoding RNAs and their application in various diseases, delving into the latest research on noncoding RNAs, including their mechanisms, interactions, and roles in disease. In addition, it examines how noncoding RNAs influence immune responses, inflammation, and cancer progression. With a focus on both diagnostic and therapeutic applications, this book highlights the potential of noncoding RNAs as biomarkers and therapeutic targets. Across comprehensive chapters, the book covers a wide range of topics, including the role of virus-encoded microRNAs in immune evasion, the therapeutic aspects of non-coding RNA in hepatocellular carcinoma, the impact of microRNAs in periodontal inflammation, and the involvement of miRNAs and lncRNAs in regulating the tumor microenvironment in HCC. Other chapters explore the functions and clinical value of tumor-derived exosomes and miRNAs in cancer immune response, the interaction of noncoding RNA in cancer metastasis, and a panorama of non‐coding RNA in prostate cancer. This book is an invaluable resource for basic science researchers in the noncoding RNA field, cancer biologists, immunologists and RNA biologists interested in the latest advancements in noncoding RNA research.

  • MRI of Brain Physiology

    Novel Methods and Clinical Applications
    • 1st Edition
    • Audrey P. Fan + 1 more
    • English
    MRI of Brain Physiology: Novel MRI Methods and Clinical Applications delves into the intricate world of brain physiology, focusing on the latest magnetic resonance imaging (MRI) methods and their clinical applications. Designed for biomedical engineers, technologists, radiologists, neurologists, neurosurgeons, and clinical researchers, this resource bridges the gap between advanced imaging techniques and practical clinical use. It covers a wide spectrum of cerebral physiology, from microvascular and macrovascular dynamics to cerebrovascular reserve, neurovascular coupling, and cerebrospinal fluid pathways. Each of the core chapters has a tripartite structure: physiology (concepts of the physiological processes), imaging techniques, and clinical applications. Readers will find detailed discussions on emerging MRI methods, including dynamic contrast, arterial spin labeling, and quantitative BOLD models. The book also addresses the functional impact of physiological changes on tissue microstructure and integrity, offering insights into multiparametric relaxation mapping and quantitative susceptibility mapping. Uniquely, this book gives a comparative approach to different brain physiological MRI methods, highlighting their strengths, limitations, and reliability.

  • Moving Toward Nonanimal Approaches in Medical Research and Testing

    • 1st Edition
    • Gail A. Van Norman + 1 more
    • English
    Moving Toward Nonanimal Approaches in Medical Research and Testing pioneers a single-source guide for researchers regarding nonanimal research tools and methodologies and their many advantages and applications in place of animals. This book is presented in three parts: historical, ethical, legislative, and scientific contexts on the need to shift away from animal-based research and testing; the latest advances in nonanimal tools and methods for biomedical research and testing of human therapeutics and other compounds, including microphysiological systems, bioprinting, biobanks, and artificial intelligence; and achieving a practical shift toward these powerful approaches, including advocacy for legal, regulatory, and policy change, securing funding for nonanimal studies, and how to overcome bias against nonanimal methods. This book, primarily directed to researchers in biomedicine, human medical therapeutics, and toxicology, will also appeal to researchers in industry, providing overview and insights about the latest applications of nonanimal research tools and methods for product development and testing. Clinicians who wish to understand the reliability of testing therapeutics with nonanimal versus animal methods, as well as advocacy groups seeking an up-to-date understanding of ethical, economic, political, and scientific considerations in moving toward nonanimal approaches, will also find significant value in this text. Finally, legislators and those involved in regulatory review and oversight will benefit from this single comprehensive source for developing a basic understanding of nonanimal research and human safety.

  • Neuromorphic Computing for Brain Computer Interfaces

    Enhanced Synergies in Mind and Machine
    • 1st Edition
    • Seifedine Kadry + 3 more
    • English
    Neuromorphic Computing for Brain Computer Interfaces: Enhanced Synergies in Mind and Machine examines practical situations where interpretability is crucial, going beyond theoretical considerations and providing case studies and examples to illustrate how Brain Computer Interfaces could be implemented in the real world. The book encompasses novel concepts, cutting-edge research, frameworks, and tools that facilitate comprehension of neuromorphic computing models. It is an ideal, comprehensive reference for professionals, researchers, and students who want to grasp the fundamental concepts and most recent developments in brain-computer interfaces (BCIs) and neuromorphic computing.

  • A Modern Atlas for Implantable Devices of the Spine, Brain, and Nerve

    For Pain, Movement Disorders, and Nerve Dysfunction
    • 1st Edition
    • Timothy R. Deer + 1 more
    • English
    A Modern Atlas for Implantable Devices of the Spine, Brain, and Nerve: For Pain, Movement Disorders, and Nerve Dysfunction is an essential resource for healthcare professionals and researchers working in neuromodulation. This groundbreaking text focuses on the latest advancements in implantable technologies, exploring innovative techniques, frequencies, and neural targets that have revolutionized patient care. Covering a diverse range of conditions related to pain, movement disorders, and nerve dysfunction, the atlas provides a detailed overview of spinal, brain, and peripheral nerve procedures. It combines anatomical insights with clinical best practices to help professionals achieve enhanced outcomes in complex medical scenarios.In addition to introducing cutting-edge devices, the book delves into procedures like spinal cord stimulation and dorsal root ganglion modulation, offering a roadmap for navigating intricate anatomical and procedural landscapes. The atlas includes valuable sections on sacral nerve modulation and peripheral nerve stimulation, ensuring comprehensive coverage of neuromodulation's expanding possibilities. By bridging theoretical knowledge with practical application, this resource equips practitioners with the tools needed to address diverse patient challenges effectively.

  • Glial Mechanisms in Sleep and Circadian Biology

    • 1st Edition
    • Marcos G. Frank
    • English
    Glial Mechanisms in Sleep and Circadian Biology presents a comprehensive and up-to-date discussion of the role of glial cells in numerous, often unexpected, aspects of sleep. It seamlessly links glial cell activity to the multi-system processes that affect sleep. Experts in the field discuss how glial cells influence the sleep-wake cycle, the accumulation and discharge of sleep drive, the timing of sleep and wake across the 24-hour day, and how glial cells may govern important sleep functions (e.g., brain plasticity and metabolism). This is a book that could well change scientists’ and practitioners’ traditional beliefs about the factors underlying sleep.Users will find the book's content at the forefront of one of the hottest topics in basic sleep research. Over the last decade, scientists have made breakthrough discoveries revealing that sleep is not only a product of neurons, but of neuronal-glial interactions.

  • Cryo-EM Methods and Management

    • 1st Edition
    • Edward T. Eng + 2 more
    • English
    Cryo-EM Methods and Management provides a detailed introduction to the latest advances of cryo-EM, from technical innovations to the logistical challenges of maintaining a modern cryo-EM facility. The book consists of four parts, beginning with an overview of cryo-EM. It then moves on to discuss Cryo-EM workflows, with chapters focusing on sample handling and preparation, data collection and hardware, and data procession and visualization. The third part centers on aspects of cryo-EM infrastructure and community building, considering facility set-up and management, monitoring facility performance, instrumentation monitoring , data sharing and standards, and training and development standards. The book then closes with a section looking towards future prospects for cryo-EM. This is an ideal reference for cryo-EM facility and lab managers, providing guidance to the often-overlooked aspect of facility building and management. Additionally researchers working with cryo-EM across molecular biology, structural biology, cell biology and biochemistry will benefit from this book.

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