Skip to main content
Elsevier

Books in Life sciences

  • Diagnosis and Analysis of Glaucoma using AI and ML for Medical Imaging

    • 1st Edition
    • Mohammad Sufian Badar
    • English
    Diagnosis and Analysis of Glaucoma Using AI and ML for Medical Imaging highlights the importance of early detection while also discussing and updating on current treatment options to slow disease progression, emphasizing the role of artificial intelligence (AI) and machine learning (ML) in improving diagnosis and management. Sections explore causes, symptoms, diagnostic challenges, and treatment strategies for glaucoma, integrating insights on how AI and ML models can enhance healthcare delivery. Practical case studies and discussions on how accessible AI tools can be utilized by healthcare workers, NGOs, students, and researchers to address diagnostic barriers prevalent in resource-limited settings are included.This targeted resource is aimed at increasing understanding of this often asymptomatic, progressive eye disease, particularly in developing countries. Healthcare professionals, students, and policymakers will find this resource valuable with its straightforward, easy-to-understand, curriculum-aligned content. Its emphasis on practical applications and awareness-building makes it a valuable tool for advancing glaucoma care and fostering interdisciplinary collaboration in eye health.

  • Brain Energy Metabolism in Alzheimers Disease - Part B

    • 1st Edition
    • Volume 187
    • English
    Brain Energy Metabolism in Alzheimer’s Disease – Part B, Volume 187 in the International Review of Neurobiology series, presents current advances and comprehensive reviews on metabolic dysfunction in neurodegenerative diseases. This volume brings together contributions from an international panel of experts, focusing on the molecular and cellular mechanisms underlying energy imbalance in Alzheimer’s disease and related disorders.Chapters in this release explore key processes such as autophagy and ESCRT pathways, tau modifications, insulin resistance, and mitochondrial dysfunction. Additional sections examine neurovascular–glial interactions, genetic and epigenetic factors in neurodegeneration, and the roles of metallospecies, noncoding RNAs, and phase separation in disease progression.Further contributions address neuroprotective signaling pathways, metabolic impairments in glucose and lipid homeostasis, and emerging diagnostic and therapeutic approaches, including liquid biopsy markers and targeted metabolic interventions. Together, these chapters provide an integrated overview of the mechanisms, biomarkers, and therapeutic opportunities associated with brain energy metabolism in neurodegenerative diseases, making this volume an essential reference for researchers and clinicians in neuroscience and neurobiology.

  • Gene and Cell Therapies

    Principles of Pharmaceutical Development
    • 1st Edition
    • Chris Van Der Walle
    • English
    Gene and Cell Therapies: Principles of Pharmaceutical Development explores increasing interest in gene and cell therapies following powerful demonstrations of their capability to treat rare genetic disorders, advanced cancers, and regenerate or repair tissues. Sections cover the design of viral vectors, oncolytic viruses, ribonucleic acid cancer vaccines, and autologous and allogeneic cell therapies, along with impacts on their pharmaceutical development. Advances in molecular and cell biology that have led to efficacious and safe gene and cell therapies are also covered, including their relationship to the process and analytical developments that ensure quality.Gene and Cell Therapies: Principles of Pharmaceutical Development scope and style, along with included case studies, learning points, and lecture slides will allow non-specialists to develop a foundational understanding, while new concepts urge further advancements. Although these new, advanced medicines are continually being improved upon, their complex manufacture remains a key obstacle to increasing patient access.

  • Cardiometabolic Dynamics

    A Deep Dive into Health and Disease
    • 1st Edition
    • Yihua Bei + 1 more
    • English
    Cardiometabolic Dynamics: A Deep Dive into Health and Disease explores the intricate relationship between metabolic health and cardiovascular diseases, illuminating how cellular and molecular mechanisms contribute to metabolic dysregulation. The book delves into the ways metabolic pathologies act as precursors to cardiovascular conditions, including hypertension, atherosclerosis, cardiomyopathy, and heart failure. With a focus on healthy cardiometabolic dynamics, it underscores the crucial role they play in sustaining cardiovascular wellness, offering a comprehensive perspective on the intersection of metabolism and heart health.The book further examines the influence of lifestyle factors, such as diet and exercise on cardiovascular metabolism and highlights emerging technologies like omics, genetic engineering, and wearable devices to advance research, diagnosis, and treatment.

  • How Plant-Based Fermented Foods are Shaping the Future of Health and Sustainability

    • 1st Edition
    • Volume 120
    • English
    How Plant-Based Fermented Foods are Shaping the Future of Health and Sustainability, Volume 120 in the Advances in Food and Nutrition Research series, presents interesting chapters on topics such as What is the role of fermented plant foods in sustainable and secure food systems?, Recent trends in plant-based fermented foods: fermentation technologies and their impacts on phytochemicals and health benefits, Beyond dairy: The science and sustainability of plant-based yogurt alternatives, Designing fermentation to enhance oat and faba bean properties, The role of fermentation in digestion of plant-based food, Fermented Plant-Based Diets and Gut Health: A Critical Evaluation, and much more.Additional chapters cover B vitamins bioavailability in plant-based fermented foods: Beyond content to nutritional impact and Legume Fermentation: Nutritional Benefits and Emerging Applications.

  • Ion Channels in Cellular Pathophysiology Part B

    • 1st Edition
    • Volume 98
    • English
    Ion Channels in Cellular Pathophysiology Part B, Volume 98 covers a variety of timely topics, including Nerve electrophysiological alterations in experimental diabetic neuropathy, Possible therapeutic effects of essential oils on Na channels in experimental diabetic neuropathy, Breast cancer and voltage gated ion channels, Cardioprotective effect of natural products on doxorubicin-induced acute cardiotoxicity and cardiac ischemia-reperfusion injury,and Modulation of ion channels by Group I metabotropic glutamate receptors.

  • Explainable AI in Clinical Practice

    Advanced Applications and Future Directions
    • 1st Edition
    • Saurav Mallik + 4 more
    • English
    Explainable AI in Clinical Practice: Advanced Applications and Future Directions builds on foundational concepts to explore the practical implementation and emerging trends of transparent AI in healthcare. Featuring contributions from leading experts, this volume presents advanced methodologies, real-world case studies across various medical specialties, and strategies for overcoming ethical, regulatory, and operational challenges. The book offers comprehensive frameworks for integrating explainable AI into clinical workflows, emphasizing trust, patient understanding, and regulatory compliance. In addition, it examines future technologies such as federated learning, multimodal systems, and human-AI collaboration, providing insights into the evolving landscape of AI in medicine.Essential for healthcare professionals, researchers, and policymakers, this volume aims to accelerate the responsible adoption of explainable AI, ultimately enhancing patient care, clinical decision-making, and healthcare system efficiency.

  • Hormones in Neuroscience

    The Pancreas and Pancreatic Hormones
    • 1st Edition
    • Victor R. Preedy + 3 more
    • English
    Hormones in Neuroscience: The Pancreas and Pancreatic Hormones explores the latest research in neuroendocrinology in relation to the pancreas and pancreatic hormones. This volume aims to cover the deficiencies in existing literature on the link between hormones and neurological tissues. This book offers a translational context and seeks to address the behavioral consequences of altered endocrine gland pathology while also addressing causative and modulating influences.

  • Cadmium Contamination in Soils and Plants

    Mechanisms and Mitigation
    • 1st Edition
    • Fang-Jie Zhao + 2 more
    • English
    Cadmium Contamination in Soils and Plants presents a rigorous, up-to-date account of how this toxic metal enters agricultural landscapes, persists in soils, interacts with living systems, and ultimately affects food safety and human health. The volume synthesizes cutting-edge findings on the processes that drive Cd movement from soil to crops and clarifies the biological pathways by which plants and microorganisms respond. It translates scientific insight into practical solutions for safer agricultural production systems, drawing on recent advances in measurement, modeling, and remediation.This book is intended for researchers, graduate students, and professionals across environmental science, agronomy, and public health who need an authoritative, research-grounded reference to inform decisions in cultivation-related settings.

  • Microbiome in Head and Neck Cancer: Pathogenesis, Diagnosis and Therapeutic Implications

    Part A
    • 1st Edition
    • Volume 169
    • English
    Microbiome in Head and Neck Cancer: Pathogenesis, Diagnosis and Therapeutic Implications, Volume 169 in the Advances in Immunology series, presents an authoritative exploration on how microbial communities contribute to the initiation, progression, and treatment of head and neck cancers. Chapters highlight The Microbiome of the Head and Neck Region, Overview Head and Neck Microbiota and the Factors Influencing the Head and Neck Microbiome, Mechanistic Pathways of Dysbiosis in Cancer Development, Oral Microbiota and OPMDs, Oral Potentially Malignant Disorders (OPMDs): An Overview, Oral Microbiota and Oral Cancer, Oral Squamous Cell Carcinoma (OSCC): An Overview, and much more.Additional chapters cover the Role of the Oral Microbiome in Oral Cancer (OSCC), Microbiome as a Prognostic Indicator in Oral Cancer, Diagnostic and Therapeutic Applications, Microbiome-Based Diagnostic Approaches, Modulating the Head and Neck Microbiome for Cancer Prevention, Microbiome-Targeted Therapeutics in Head and Neck Cancer, Artificial Intelligence in Microbiome Data Analysis: Applications in Head and Neck Cancer, and Challenges and Future Directions in Head & Neck Microbiome Research.

  • Native and Modified Starches for Food Applications

    • 1st Edition
    • Pothiyappan Karthik + 2 more
    • English
    Native and Modified Starches for Food Applications, a volume in the Applications of Starches in Food and Packaging series, provides an in-depth exploration of the diverse types and sources of starches, their functional properties, and their applications in various culinary contexts. Chapters cover the gelatinization process, texture modification, and sustainable utilization of starches in addition to exploring future directions in starch research and applications. As the food industry continues to seek natural, functional ingredients, this resource meets the demand for a comprehensive and up-to-date exploration of the use of starches in food applications.Users will find this to be a great resource for facilitating informed decision-making in recipe development, processing techniques, and the creation of innovative, sustainable, and gluten-free food products.

  • Deep Learning in Bioinformatics

    Techniques and Applications in Practice
    • 2nd Edition
    • Habib Izadkhah
    • English
    Deep Learning in Bioinformatics: Techniques and Applications in Practice, Second Edition explores how deep learning can be utilized for addressing important problems in bioinformatics, including drug discovery, de novo molecular design, sequence analysis, protein structure prediction, gene expression regulation, protein classification, biomedical image processing and diagnosis, biomolecule interaction prediction, and in systems biology. The book also presents theoretical and practical successes of deep learning in bioinformatics, pointing out problems and suggesting future research directions. This updated edition includes several new chapters, applications, and examples for new Deep Learning advances and techniques.Dr. Izadkhah provides valuable insights and will help researchers use deep learning techniques in their biological and bioinformatics studies.

  • Environmental Microbiology

    • 4th Edition
    • Ian Pepper + 3 more
    • English
    Environmental Microbiology, Fourth Edition is the revised edition of a key, foundational text for the field of environmental microbiology which hits all the pillars of the field and takes into account the tremendous advances in environmental microbiology over past decade. It provides comprehensive information on traditional methodologies utilized to study environmental microbes, as well as state-of-the-art technologies. Emphasis is placed on molecular and bio-informatic approaches to the study of environmental microbes, including nucleic acid and ‘omic methodologies. The book is divided into seven parts that stretch across microbiology concepts, microbial environments, microbial methods and technologies, microbial transport, biogeochemistry, and bioremediation, water and foodborne pathogens, wastewater treatment and distribution, and urban microbiology. Environmental Microbiology, Fourth Edition is the study of microbes within all habitats, and their beneficial and detrimental impacts on human health and welfare. This book illustrates the significance of environmental microbes in our daily lives in terms of not only the overall health of the planet, but also: what infects us; what heals us; what we drink; what we eat; and what we breathe.

  • Harnessing Plant-Stimulating Molecules

    Innovations in Stress Biology and Crop Resilience
    • 1st Edition
    • M. Iqbal R. Khan + 1 more
    • English
    Harnessing Plant-Stimulating Molecules serves as an authoritative reference on the multifaceted molecular regulators and biotechnological innovations underpinning plant resilience to environmental stressors. This volume delivers an exhaustive treatment of diverse classes of signaling entities—including phytohormones, secondary messengers, secondary messengers, reactive oxygen and nitrogen species, and heterotrimeric G proteins—elucidating their roles in complex stress adaptation pathways.In addition to molecular and biochemical foundations, this book explores advanced methodologies such as nanoparticle-facilit... metabolic modulation, RNA interference, and gene-editing strategies aimed at optimizing nutrient utilization. It also highlights the emerging significance of biostimulants in modulating plant–microbe interactions and interplant signaling networks. Detailed discussions on systemic signaling mediated by mobile molecules and photoreceptor-mediat... photomorphogenic responses further enrich the scope.By integrating cutting-edge approaches, particularly CRISPR–Cas systems, with computational modeling for simulating metabolic networks, the volume facilitates accelerated crop improvement strategies essential for addressing contemporary challenges in food security and agroecosystem sustainability.Desig... as an indispensable resource for researchers, advanced graduate students, and industry professionals, Harnessing Plant-Stimulating Molecules bridges fundamental plant molecular biology with translational biotechnology, fostering the development of resilient, high-performance crops adapted to the challenges of a changing climate.

  • Mastering Supraventricular Tachycardia Diagnostics in the Electrophysiology Lab

    • 1st Edition
    • Konstantinos P. Letsas + 1 more
    • English
    Mastering Supraventricular Tachycardia Diagnostics in the Electrophysiology Lab provides a comprehensive, practical, and systematically organized guide to diagnostic pacing maneuvers for the differential diagnosis of supraventricular tachycardias during electrophysiology studies.Emerging from the need to provide a complete collection of literature on diagnostic pacing maneuvers published over the last 40 years, this book includes more than 30 diagnostic pacing maneuvers, with detailed instructions on when and how to perform them, how to interpret the findings, and how to recognize their potential pitfalls.This book aspires to serve as a thorough and comprehensive guide, structured both as a benchside reference companion for the electrophysiology lab and as an educational resource for cardiac electrophysiology fellows newly introduced to the fascinating yet challenging world of invasive cardiac electrophysiology.

  • Imaging of Acute Encephalopathies, An Issue of Neuroimaging Clinics of North America

    • 1st Edition
    • Volume 36-3
    • Natalia Nagornaya + 1 more
    • English
    In this issue of Neuroimaging Clinics, guest editors Drs. Natalia Nagornaya and Gaurav Saigal bring their considerable expertise to the topic of Imaging of Acute Encephalopathies. Top experts discuss hypoxic ischemic encephalopathy; stroke-like syndromes in encephalopathy; metabolic derangement and vitamin deficiencies in encephalopathy; vascular and hematologic disorders; autoimmune, paraneoplastic, or idiopathic disorders in encephalopathy; and more.

  • Pharmacology of T-Cell Therapies

    • 1st Edition
    • Volume 106
    • English
    Pharmacology of T-Cell Therapies, Volume 106 in the Advances in Pharmacology series, highlights new advances in the field, with this new volume presenting interesting chapters written by an international board of authors. Topics in this new release include Enhancing persistence of therapeutic T cells, T cell manufacturing impacts on in vivo function, Transient T cell therapies, In vivo T cell therapies, T cell subsets for therapy, Engineering T cell metabolism to enhance therapeutic efficacy, and Tracking Therapeutic T cells In Vivo contacts.

  • The Organic Chemistry of Drug Design and Drug Action

    • 4th Edition
    • Richard B. Silverman + 2 more
    • English
    The Organic Chemistry of Drug Design and Drug Action, Fourth Edition presents a unique approach to medicinal chemistry based on physical organic chemical principles and reaction mechanisms that rationalize drug action. The book's coverage allows readers to extrapolate core principles and mechanisms to many related classes of drug molecules. It reflects the significant changes in the process of drug design over the last decade and preserves the successful approach of the previous editions while also including significant changes in format and coverage.It is designed for undergraduate and graduate students in chemistry who are studying medicinal chemistry or pharmaceutical chemistry. Users, including research chemists and biochemists working in pharmaceutical and biotechnology industries will find this update to be useful in their daily work.

  • ESKAPE Pathogens

    Virulence, Resistance, and Management
    • 1st Edition
    • Karthikeyan Ramalingam
    • English
    ESKAPE Pathogens: Virulence, Resistance, and Management provides comprehensive coverage on ESKAPE pathogens, including their virulence mechanisms, resistance patterns, and challenges in their management. The book offers the latest information on ESKAPE pathogens' pathogenicity, mechanisms of antibiotic resistance, and innovative approaches to manage these pathogens. It explores recent advancements in the field of genomics, proteomics, and transcriptomics that could potentially provide valuable insights into the mechanisms and genetic basis of antibiotic resistance in ESKAPE pathogens. Finally, the book highlights the need for alternative treatment options and innovative management strategies to combat the emergence of multidrug-resistant strains.This is a helpful resource to researchers, clinicians, educators, industry professionals, and advanced students interested in the latest research and strategies for combating multidrug-resistant pathogens.

  • Mucins

    • 1st Edition
    • Volume 732
    • English
    Mucins, Volume 732 serves as a valuable resource for researchers aiming to investigate mucin biology in greater depth, offering a wide range of experimental approaches and analytical strategies. Topics in this new release cover Enrichment/isolation... glycoproteomics, Mucinase cleavage characterization and usage in glycoproteomics, Fluorescent protein-based FRET substrates for activity screening of mucinases, Development of clinical lectin assays based on MS glycomic discovery, Enzymatic selective sulfation of synthetic mucins, cryoEM, Cell-based mucin arrays and glycoengineering, CRISPR screens to characterize and identify glycan-binding proteins, and much more.Additional sections cover MD Simulations, Interactions with pathogenic bacteria, Interactions with microbiota, Covalent crosslinking of mucins, Liquid Glycan and Liquid Lectin Array-based exploration of musin recognition, Quantification of mucins, Mucins in IBD, Investigations of mucins and innate immunity, Generating synthetic mucin glycopeptides, and Microscopy and imaging.

  • Protein Misfolding and Human Diseases

    Deciphering the Central Role of Pathological Aggregation
    • 1st Edition
    • Pranav Kumar Prabhakar + 2 more
    • English
    Protein Misfolding and Human Diseases: Deciphering the Central Role of Pathological Aggregation investigates the misfolding of proteins and implications for a variety of debilitating conditions. The book comprehensively overviews pathological protein aggregation, exploring its mechanisms in specific illnesses, including Alzheimer's disease, Parkinson’s disease, Huntington’s disease, prion diseases, ALS, and systemic amyloidosis. It addresses disrupted cellular pathways and failures in protein homeostasis during aging, delineating the unifying principles across protein conformational disorders. Sections feature structural insights into protein aggregates from amyloid fibrils to inclusion bodies and offer therapeutic strategies to disrupt aggregation pathways, enhance cellular protein quality control, and provide immunotherapy solutions.Finally, the book closes with a discussion of the latest advances in research and considerations for future directions to combat protein aggregation. It will serve as an invaluable reference on the intricacies of protein misfolding and its clinical implications. Researchers, academics and graduate students working across these fields will benefit from this comprehensive guide. Additionally, clinicians and healthcare professionals will find it invaluable for understanding the molecular basis of protein misfolding disorders.

  • Epidemic Modeling

    Principles, Algorithms, and Applications
    • 1st Edition
    • Teddy Lazebnik
    • English
    Epidemic Modeling: Principles, Algorithms, and Applications is a comprehensive introduction and practical guide to building, understanding, and applying epidemiological models in real-world contexts. Bridging theory and practice, the book walks readers through the full modelling pipeline from the biological, social, and political drivers of disease spread to classical compartmental models such as SIR, and onward to modern computational techniques including agent-based simulation, machine learning, and optimization under uncertainty. Each chapter builds progressively, pairing clear conceptual explanations with hands-on code, real data examples, and step-by-step methods that readers can adapt to new challenges. Drawing on extensive academic and industry experience, the text emphasizes how modelling decisions are made in practice addressing real-world complications such as incomplete data, reporting delays, and measurement error. Designed as both a learning resource and long-term reference, the book equips readers to move beyond running existing models to designing, evaluating, and communicating their own. It also fosters a shared language across disciplines, helping technical and non-technical audiences engage meaningfully with modelling insights. Timely and practical, this book empowers the next generation of modelers and decision-makers to respond effectively to an increasingly complex epidemic landscape.

  • Sports Neurology, An Issue of Neurologic Clinics

    • 1st Edition
    • Volume 44-3
    • Amaal J. Starling
    • English
    In this issue of Neurologic Clinics, guest editor Dr. Amaal J. Starling brings her considerable expertise to the topic of Sports Neurology. Top experts discuss brain health in the healthy athlete and management of sports-related neurologic injuries, including the assessment and management of sports-related concussion, spinal cord injuries, peripheral nerve injuries, and much more.

  • Protein-Based Nanoparticles in Drug Delivery

    • 1st Edition
    • Prashant Kesharwani
    • English
    Protein-based Nanoparticles in Drug Delivery is a comprehensive book aimed at pharmaceutical scientists and researchers both in academia and corporate environments focused on nanotechnology drug delivery and pharmaceutical-relat... disciplines. The book covers the design and characterization of various protein nanoparticles, sheds light on the power of an endogenous substance as a drug delivery system, and highlights the possible future trends in the use of protein-based drug delivery. It covers in-depth novel applications of protein-based drug delivery from fundamental to most current use cases. The book comprises three parts. Part one is devoted to the foundations of protein-based drug delivery, including nanocarriers development, drug encapsulation, targetability, and in vivo properties. Part two explores the applications of protein-based nanoparticles in drug delivery, covering topics such as protein nanoparticles in cancer therapy, genetic material delivery, and nanocarriers based on milk protein, silk, and gliadin. Part three addresses recent advances and regulatory aspects of protein-based nanoparticles in drug delivery, including clinical translation, challenges, biological toxicity, and environmental hazards associated with protein-based nanoparticles. Protein-based Nanoparticles in Drug Delivery provides a complete journey of protein-based drug delivery, offers an in-depth understanding of the design and characterization of various protein nanoparticles, and highlights possible future trends in this field. Pharmaceutical scientists will benefit from the novel applications of protein-based nanoparticles drug delivery approaches in the biological field. Nanotechnologists, biologists, chemists, physicists, engineers, and clinicians will also benefit from the foundational content provided as a basis to support communication and tackle the multidisciplinary challenges associated with research in this exciting field.

  • Smart Healthcare 2.0

    Integrating Digital Twins with AI-Driven Predictive Analytics
    • 1st Edition
    • Ramesh Chandra Poonia + 1 more
    • English
    Smart Healthcare 2.0: Integrating Digital Twins with AI-Driven Predictive Analytics offers a groundbreaking exploration of how digital twin technology, combined with real-time sensing and predictive analytics, is transforming healthcare delivery. As the global healthcare landscape shifts toward proactive, personalized care, this book addresses the urgent need for comprehensive resources that unify artificial intelligence, Internet of Things (IoT), and biomedical engineering within the digital twin framework. It provides an essential guide for researchers, engineers, and clinicians aiming to harness virtual patient models and data-driven insights to improve health outcomes and system efficiency in the era of ubiquitous healthcare.This volume covers a wide spectrum of topics, starting with foundational concepts of digital twins in precision health and advancing through smart sensing technologies, scalable system architectures, and AI-powered predictive analytics. Readers will explore detailed discussions on edge-cloud computing, secure communication protocols including blockchain, and simulation platforms that enable virtual patient modeling. The book also addresses critical themes such as chronic disease management, emergency response optimization, ethical AI deployment, interoperability standards, and workforce readiness. Real-world case studies and future-focused chapters on cognitive twins and quantum simulation provide a rich, multidisciplinary perspective.

  • Advances in Research on Pediatric Gender Affirming Healthcare

    • 1st Edition
    • Danielle Moyer + 2 more
    • English
    Advances in Research on Pediatric Gender Affirming Healthcare summarizes recent and ongoing research efforts across global regions in the field of pediatric gender affirming healthcare. The book begins with an overview of the current and historical context in which research and clinical practice of pediatric gender affirming care occurs. It goes on to cover gender development and developmental pathways, risk, and resilience among transgender and gender diverse youth, and provides an overview of healthcare and barriers to access before exploring specific care models for pediatric gender affirming healthcare.The final chapter summarizes the current state of research, highlights key gaps in scientific knowledge, and asserts a call to action to researchers in the field to answer principal questions with high-quality research methods. Contributors from diverse backgrounds and experience come together with informative scientific findings in an effort to reduce bias and better meet the needs of this marginalized group of young people.

  • Mucosal Barriers and Host-Microbiota Interplay

    Dysbiosis to Barrier Dysfunction
    • 1st Edition
    • Linda Chia-Hui Yu
    • English
    Mucosal Barriers and Host-Microbiota Interplay: Dysbiosis to Barrier Dysfunction, a volume in Elsevier's new series Hot Topics in Physiology, provides an in-depth exploration of mucosal barriers, including their structure, establishment, and consideration of different diseases and intervention strategies. Published in association with the International Union of Physiological Sciences (IUSP), this is an ideal reference for those researching or studying biology and medicine, particularly gastroenterology. Biotechnological companies working on metagenomics sequencing and analysis may also find this volume useful.As a massive load of commensal microbes, consisting of bacteria, viruses, and fungi resides in the gastrointestinal tract and other mucosal surfaces, collectively termed microbiota, this book provides an update on new and existing knowledge. Mucosal barriers, including the epithelial layers and immune cells act as the frontline to strategically confine these microorganisms and prevent the entry of microbes into the body proper.

  • Drug Targeting Complexity

    Tissue-Specific Regulation and Molecular Paradigms in Cancer Therapy
    • 1st Edition
    • Lalit Kumar + 2 more
    • English
    Drug Targeting Complexity: Tissue-Specific Regulation and Molecular Paradigms in Cancer Therapy presents a rigorous examination of advanced strategies for the selective targeting of neoplastic cells and their distinct microenvironments. This comprehensive volume elucidates both tissue-specific and tumor-specific molecular targets, clarifying how these methodologies can significantly enhance therapeutic precision while mitigating off-target effects. The initial section of the text provides an in-depth analysis of tissue-specific regulatory targets across various organs, including the liver, lungs, brain, skin, and bones. It delineates the critical mediators and mechanisms that govern tumor immunity, thereby identifying novel therapeutic avenues.Each chapter meticulously evaluates key regulatory molecules such as TGF-β, CTLA-4, and IL-10, exploring their roles in tumorigenesis and the potential for targeted interventions across a spectrum of malignancies. Subsequent sections focus on tumor tissue-specific molecular targets, encompassing immunological checkpoints, growth factors, and signaling pathways pertinent to cancers of the liver, stomach, ovary, prostate, and colon. The text provides insights into the application of monoclonal antibodies and molecular inhibitors as strategies to impede cancer progression and address therapeutic resistance. Concluding chapters address emerging therapeutic paradigms, including precision medicine and nanotechnology.

  • Antimicrobial Peptides

    From Science to Applications
    • 1st Edition
    • Anil Kumar Chhillar + 4 more
    • English
    Antimicrobial Peptides: From Science to Applications provides comprehensive coverage on the biology, diversity, and mechanisms of action associated with antimicrobial peptides (AMPs). The book aims to equip readers with the knowledge required to understand, harness, and optimize these molecules for development and application across various sectors. Sections overview the biology and diversity of antimicrobial peptides, cover their molecular structure and function, and delve into their unique mechanisms of action and evolutionary significance in nature. Subsequent chapters go on to explore the utilization of AMPs in medicine, agriculture, the environment, and biotechnology.Culmin... in discussions on future trends, regulatory considerations, and strategies to overcome challenges, this book is an informative reference for researchers, scientists, graduate students, and industry professionals engaged in the study and development of antimicrobial peptides as a potential solution to address pressing challenges such as antibiotic resistance, food security, and environmental sustainability.

  • Bioorthogonal Labeling

    • 1st Edition
    • Volume 731
    • English
    Biorthogonal Tagging, Volume 731 in the Methods in Enzymology series, highlights new advances in the field, with this new volume presenting interesting chapters such as Staudinger Ligations and Related Reactions: Scope and Applications in Chemical Biology, Strain-Promoted Bioorthogonal Cycloadditions to Investigate Sialyltransferases Promiscuity Towards Unnatural Sialic Acids, Practical Guidelines for the Bioorthogonal AMI–Isonitrile Ligation, Nitrones and Other Dipoles in Bioorthogonal Chemistry Applications, 1,2-Aminothiol-Speci... Conjugation for Dual-Color Fluorescent Labeling via Ultrafast TAMMs, Genetic Incorporation of Bicyclononyne for Cell-Surface Protein Labeling via Tetrazine Ligation, and much more.Additional chapters cover Genetic Code Expansion for Single Noncanonical Amino Acid Incorporation into SARS-CoV-2 Omicron Spike on Amber-Free Lentiviral Particles, Bioorthogonal Click-Chemistry Labeling and Visualization of Dual Noncanonical Amino Acid–Incorporated HIV-1 Env on Intact Virions, Studying Bacterial Glycans with Azidosugars and Bioorthogonal Chemistry, Bioorthogonal Tagging of DNA and RNA, Efficient Labeling of Pathogenic Fungal Chitin with Bioorthogonal Probes, and many more timely topics.

  • Next-Generation Onco-Therapeutics

    • 1st Edition
    • Awanish Kumar + 1 more
    • English
    Next-Generation Onco-Therapeutics explores the latest advancements in cancer treatment, focusing on personalized medicine and innovative therapeutic strategies. This book serves as a comprehensive resource for understanding how emerging technologies can reshape oncological care, providing insights into effective and compassionate patient management.The content explores the cutting-edge developments in cancer therapies, featuring clinical examples and case studies that illustrate the practical application of new treatment modalities. It emphasizes the importance of integrative approaches that address the diverse needs of cancer patients, ensuring that healthcare professionals are equipped with the most current information in this rapidly evolving field.

  • Nanophytomedicine

    Harnessing Phytochemicals for Advanced Therapeutics
    • 1st Edition
    • Ali Zarrabi + 2 more
    • English
    Nanophytomedicine: Harnessing Phytochemicals for Advanced Therapeutics explores the integration of phytochemicals and nanotechnology to develop advanced therapeutic solutions. The book offers an extensive overview of phytochemicals, explaining their sources, extraction methods, classifications, and applications in medicine. This emerging field aims to utilize the natural properties of phytochemicals to create innovative treatments for various diseases, with a particular focus on hard-to-treat conditions such as cancer. By combining plant-derived compounds with nanomaterials, researchers are unlocking new potential in precision medicine, seeking to enhance the efficacy of treatments while minimizing side effects and improving patient outcomes.In 18 comprehensive chapters, the book delves into the therapeutic properties of phytochemicals, such as their antioxidant, antifungal, and anti-inflammatory effects. It highlights the role of these compounds in combating diseases including cancer, neurological disorders, diabetes, and cardiovascular diseases. The use of nano drug delivery systems is emphasized, showcasing how these technologies can improve the delivery and effectiveness of phytochemicals.

  • Cutting-Edge Technology for Plant Metabolite Profiling in Drug Discovery and Quality Control

    • 1st Edition
    • Ramesh Kumar Ahirwar + 4 more
    • English
    Cutting-Edge Technology for Plant Metabolite Profiling in Drug Discovery and Quality Control offers a comprehensive exploration of advanced methods in plant metabolomics, along with their integration in industrial applications across various sectors. The book delves into a range of methodologies, including metabolic engineering strategies, metabolite imaging techniques, nuclear magnetic resonance (NMR) for plant metabolite analysis, microfluidics for metabolite profiling, computational methods, and bioinformatics tools. It also explores plant metabolomics for crop improvement, pharmaceutical development, archaeological examinations, cosmetic formulations, and food quality, with case studies featured throughout the book to showcase real-world applications and scenarios. As the demand for natural products and plant-derived therapeutics continues to rise, there is a need for reliable and effective methods to identify, quantify, and optimize the bioactive compounds present in plants. This book provides a comprehensive guide to the latest advances in this field while also delivering a multidisciplinary overview of the wide-ranging impact plant metabolites have across a variety of applications. Researchers working with plant metabolites across molecular and cellular biology, pharmaceutical science, biotechnology, biochemistry and plant science will benefit from this book. Additionally, it will be of interest to specialists working across relevant industries, such as pharmaceuticals, nutraceuticals, cosmetics and agriculture.

  • Smart Hospital Anatomy with Advanced Sensors

    Innovations in Patient Care
    • 1st Edition
    • Amit Kumar Tyagi + 1 more
    • English
    Smart Hospital Technology with Advanced Sensors: Innovations in Patient Care explores the transformative role of advanced sensor systems in modern healthcare environments. This book presents a comprehensive overview of smart hospital technologies, emphasizing the integration of AI, IoT, and automation to enhance patient care and hospital operations. Topics covered include wearable and implantable sensors, AI-driven diagnostics, robotic surgery, smart ICUs, and cybersecurity in healthcare. It also addresses emerging trends such as blockchain for medical data, ethical AI, and the convergence of smart hospitals with smart cities. Content is supported by global case studies and expert contributions.Design... for students, researchers, and academics in bioinformatics, this book offers foundational knowledge, current applications, and future directions in digital healthcare. It serves as a valuable resource for understanding the challenges and opportunities in building intelligent, data-driven hospital systems that improve outcomes and redefine patient experiences.

  • Polyphenols in Wound Healing

    • 1st Edition
    • Bushra Akhtar + 1 more
    • English
    Polyphenols in Wound Healing presents a comprehensive exploration of how naturally occurring compounds—polyphenol... a pivotal role in advancing wound care therapies. Divided into four thoughtfully curated sections, the book begins with an in-depth review of the science of wound healing, introducing readers to the fundamentals of skin physiology, the various types of wounds, and key therapeutic targets. Other sections delve into the world of polyphenols, offering detailed information on their natural sources, especially medicinal plants, and the techniques used for their extraction, isolation, and purification. A focus on how polyphenols act on biological pathways to support wound healing is also included.This includes mechanisms such as reducing inflammation, combating oxidative stress, modulating matrix metalloproteinases, enhancing collagen synthesis, and promoting tissue regeneration and angiogenesis. Each chapter is backed by current research, offering mechanistic insights that bridge traditional knowledge with modern biomedical science. This structured and progressive organization ensures that all key aspects of polyphenol-based wound healing are clearly presented and easy to follow, making the book highly accessible for researchers, clinicians, and students alike.

  • Recent Advances in Molecular Docking

    Methods, Tools, and Applications
    • 1st Edition
    • Khalid Raza
    • English
    Recent Advances in Molecular Docking: Methods, Tools, and Applications offers an authoritative guide to modern molecular docking techniques, emphasizing the integration of artificial intelligence and machine learning. The volume covers foundational principles, computational workflows, and advanced scoring functions, providing researchers and practitioners with practical tools to improve drug-target interaction predictions. It highlights applications across pharmaceuticals, including cancer, neurological disorders, and infectious diseases, which are all supported by real-world case studies. Challenges in docking accuracy, reproducibility, validation, and ethical and regulatory considerations are also covered.Authored by international experts, it bridges theoretical knowledge with practical applications, making it an essential resource for computational biologists, pharmacologists, and drug developers aiming to leverage AI-driven docking in precision medicine.

  • Agroforestry Solutions for Soil Restoration and Sustainable Land Management

    • 1st Edition
    • Ram Prakesh Yadav + 3 more
    • English
    Agroforestry Solutions for Soil Restoration and Sustainable Land Management, a volume in the Agricultural Soil Degradation and Restoration series, offers a rigorous, cross-disciplinary assessment of tree–crop integration as a driver of resilient landscapes and livelihoods around the world. Rooted in edaphic science, agroecology, and development studies, it analyzes contemporary pressures, evaluates viable interventions, and maps forward-looking research avenues. By blending empirical evidence with policy considerations, it demonstrates how diversified, multi-species systems enhance nutrient balance, water regulation, carbon dynamics, and biodiversity, while supporting stable incomes and high-quality food.This essential resource for researchers, educators, and practitioners covers design principles, deployment pathways, governance, extension strategies, and economic analysis, complemented by real-world case studies. Readers will find robust study designs, interoperable data assets, and reproducible workflows that enable scalable decision-making and monitoring. The narrative emphasizes UNCCD targets and climate-smart land use, with clear implications for sustainable intensification and ecosystem stewardship.

  • Revolutionizing Microbial Technology

    Unlocking the Potential of Artificial Intelligence
    • 1st Edition
    • Akanksha Srivastava + 1 more
    • English
    Revolutionizing Microbial Technology: Unlocking the Potential of Artificial Intelligence explores the potential integration of artificial intelligence (AI) and machine learning in the fields of microbiology and biotechnology. The book delves into various applications of AI in microbiology across different sectors. This includes coverage of basic microbiology, identification and characterization of microbes, how AI can be implemented in microbiology laboratory practices, and how bioinformatics can help analyze microbial data and help understand complex biological systems. It discusses implementation of AI in healthcare for the diagnosis of microbial diseases and AI-driven microbial therapies and examines potential AI solutions for the acceleration, cost-effectiveness, and efficiency of the drug discovery and drug development process. Additional coverage includes the AI integration in the food and agricultural industries. Revolutionizing Microbial Technology provides a comprehensive understanding to researchers, academics, industry professionals and students of the potential of AI as an advance tool for microbial research and application.

  • Nonclinical Evaluation Studies of Cellular and Gene Therapy Products

    Strategies, Models, and Regulatory Frameworks
    • 1st Edition
    • Wang Quanjun + 2 more
    • English
    Nonclinical Evaluation Studies of Cellular and Gene Therapy Products: Strategies, Models, and Regulatory Frameworks systematically explores the nonclinical evaluation of Cell and Gene Therapies (CGT) products, emphasizing risk mitigation and innovation. The book provides comprehensive coverage, including 20+ chapters spanning preclinical toxicology, pharmacokinetics, and novel evaluation models. It is the first book to integrate organ-on-chip models into CGT evaluation, reflecting FDA/NMPA modernization initiatives. It includes practical guidance on addressing CRISPR off-target effects, immunogenicity, and long-term carcinogenicity risks.

  • Advances in Biomedical Engineering - Part B

    • 1st Edition
    • Volume 405
    • English
    Advances in Biomedical Engineering – Part B, Volume 405 presents the latest developments, research trends, and methodologies in the evolving field of biomedical engineering. This volume covers a range of topics, including advanced medical devices, biomaterials, biomedical imaging, tissue engineering, biomechanics, and computational modeling. Specific chapters in this new release include Advances in biomedical engineering, Recent advances in nanomedicine as drug delivery system, Advances in Nano biomaterials for Biomedical Engineering, Neurodiagnostic: Advances in diagnostic tools, Advances in Ferroptosis Research and Application, Bioink-based 3D Bioprinting: Paving the Path for Regenerative Medicine, MRI Acute/Sub-Acute Ischemic Stroke Segmentation with Deep Learning: A Comprehensive Review, and more.Contributions from leading experts highlight both theoretical advancements and practical applications designed to improve healthcare diagnostics, treatment, and patient outcomes. This comprehensive resource is ideal for researchers, practitioners, and students seeking to stay informed about cutting-edge technologies and future directions in biomedical engineering.

  • Applied Microbiology

    Microbes, Pharmaceutical Techniques and Procedures
    • 1st Edition
    • Saurabh Bhatia + 1 more
    • English
    Recently, molecular technologies have positively affected the field of applied microbiology, providing rapid quantitative as well as qualitative information on microorganisms present in a given sample. The development of microbiology-based inventions suggests a worthwhile but challenging prospect to create pharmaceutical products and harvest the superior potential therein. Some of the challenges while patenting the microorganisms can be overcome by updating aspirants related with ethical and regulatory issues, especially guidelines established in microbiology to explore its more clinical applications. Applied Microbiology: Microbes, Pharmaceutical Techniques and Procedures includes diverse applications of microorganisms in 21st century like emerging infections and their futuristic impact over the society. Applied Microbiology: Microbes, Pharmaceutical Techniques and Procedures carries outcomes of present research to reach those whose aspiration allows using this information and know-how in both the basic as the applied settings.

  • NEURO BASIC: Brain and Spine Illustrated Compendium – Anatomical Notebook

    • 1st Edition
    • Helbert de Oliveira Manduca Palmiero
    • English
    NEURO BASIC: Brain and Spine Illustrated Compendium – Anatomical Notebook is a comprehensive, visually driven neuroanatomy reference for medical students, residents, and healthcare professionals specializing in neurology and neurosurgery. It addresses the need for an accessible resource that bridges foundational anatomy and clinical application. The book fills the gap left by traditional texts that are either overly detailed or insufficiently practical, offering an integrated approach that emphasizes surgical relevance and visual clarity. Its content helps learners understand complex neuroanatomical relationships essential for diagnosis, surgical planning, and clinical decision-making, thereby enhancing their ability to interpret neuroimaging and perform neuroanatomical localization.

  • The Cytokines of the Immune System

    The Role of Cytokines in Disease Related to Immune Response
    • 2nd Edition
    • Zlatko Dembic
    • English
    Cytokines of the Immune System: The Role of Cytokines in Disease Related to Immune Response, Second Edition is a comprehensive and essential resource for graduate and postgraduate training of physicians, dentists, biomedical specialists, and those interested in scientific research in biology and biochemistry. The book provides an up-to-date, textbook-like description of immunology, focusing on the critical role of cytokines in immune responses. With advancements in cytokine research and signal transduction, this new and improved edition offers a deeper understanding of cytokine-receptor interactions, supported by novel figures based on crystal-structure conformations from the protein database.These insights are invaluable for inspiring new drug designs and therapeutic strategies. The book delivers a thorough overview of immunology, detailing the development and regulation of the immune system, with a special focus on cytokines. It presents an upgraded description of interleukins, immune-modulatory cytokines, and chemokines, exploring their structure, sources, functions, receptors, disease associations, and therapeutic potentials. This edition also introduces the latest information on innate lymphoid cells and their cytokines, as well as their adaptive immunity counterparts. A dedicated chapter on the cytokine storm provides critical insights into this phenomenon.

  • Basic Microbiology

    History, Fundamentals and Insights
    • 1st Edition
    • Saurabh Bhatia + 2 more
    • English
    Basic Microbiology: History, Fundamentals and Insights offers an exploration of the microbiology, providing a foundation in the study of microorganisms and their impact on health and disease. Beginning with an introduction to microbiology, the book covers the metabolism of microorganisms, revealing the biochemical processes that sustain microbial life. It then examines microbial genetics, uncovering the mechanisms of genetic variation and inheritance in microbes. Detailed chapters on bacteria, fungi, viruses, and protozoa provide thorough insights into the structure, function, and classification of these diverse organisms. The book also covers the principles of immunity, explaining the body’s defense mechanisms against microbial invasion. Finally, it addresses infection and diseases, highlighting the relationship between pathogens and human health. Ideal for students, educators, and professionals in microbiology and related field, Basic Microbiology: History, Fundamentals and Insights serves as an essential resource for understanding the microscopic world and its relevance to medicine and biology.

  • Flavonoids Against Cancer Hallmarks

    • 1st Edition
    • Dharambir Kashyap + 1 more
    • English
    Flavonoids Against Cancer Hallmarks provides an in-depth exploration of the anti-cancer potential of flavonoids and their ability to target key cancer hallmarks. The book encompasses a thorough analysis of flavonoids' sources, bioavailability, metabolic disposition, long-term safety, and adverse effects. It highlights the mechanisms through which flavonoids inhibit cancer growth and proliferation, focusing on their immunomodulatory, anti-angiogenic, anti-metastatic, and cell cycle inhibitory effects. Designed for oncology specialists, pharmacology and pharmacy students, cancer research scholars, and pharmaceutical industry researchers, this comprehensive guide also reviews recent cancer epidemiology and updates on existing therapeutic strategies.By detailing how flavonoids counteract cancer stemness and influence immune responses, this book offers innovative insights into utilizing plant-derived compounds for cancer treatment. It stands out by providing a detailed overview of flavonoids' cellular and molecular mechanisms while also evaluating the pros and cons of current therapeutic options, making it essential reading for a global audience.

  • Advances in Clinical Chemistry

    • 1st Edition
    • Volume 134
    • English
    Advances in Clinical Chemistry, Volume 134 in this ongoing series, examines physiologic and pathophysiologic biochemistry and impacts on Clinical Chemistry testing and design. Sections cover Molecular mechanisms of disease and advances in the development of improved diagnostic and predictive biomarkers. Specific chapters in this new release include Biomarkers in Heart Failure, RNA biomarkers in antidoping, Cardiovascular disease and miRNA, Chronic low-grade inflammation in vegetarians and vegans: biomarker evidence and methodological considerations, Advances in microfluidic extracellular vesicle technology, and Biomarkers for Assessing Magnesium Status.As these evolving technologies and analytic strategies have become increasing relevant given the healthcare and socioeconomic impact worldwide, this book provides an essential reference.

  • Mesenchymal Stem Cells and Extracellular Vesicles as Next-Generation Therapeutics

    Basic Concepts, Clinical Applications, and Cross-Disciplinary Innovations
    • 1st Edition
    • Naresh Kasoju + 1 more
    • English
    Mesenchymal Stem Cells and Extracellular Vesicles as Next-Generation Therapeutics: Basic Concepts, Clinical Applications, and Cross-Disciplinary Innovations provides a comprehensive exploration of the groundbreaking roles stem cells and extracellular vesicles (EVs) play in regenerative medicine. The book examines the fundamental biology of stem cells and EVs, their therapeutic applications across tissues - including skin, neural, cardiac, ocular, and more and the innovative, interdisciplinary approaches shaping the future of healthcare. Sections cover Basic and Emerging Concepts, Therapeutic Applications and Disease Focus, and Cross-disciplinary Innovations and Future Directions the field will encounter in this rapidly growing branch of medicine.Written by experts in the field for researchers and academics engaged in regenerative medicine, stem cell biology, and biomedical engineering, this book will be of interest to healthcare professionals such as physicians, surgeons, and specialists interested in tissue repair and regeneration.

  • Apolipoprotein E in Health and Disease

    Unravelling its Intricate Roles
    • 1st Edition
    • Dileep Kumar + 2 more
    • English
    Apolipoprotein E in Health and Disease: Unravelling its Intricate Roles delves into the multifaceted functions of Apolipoprotein E (ApoE) across various health conditions and diseases. This comprehensive volume offers an in-depth exploration of ApoE, illuminating its structural insights, functional significance, and genetic variability. Each chapter examines the role of ApoE in different disease contexts, including cardiovascular diseases, Alzheimer's disease, neurological disorders, metabolic syndrome, liver health, cancer, and inflammatory disorders. Key chapters investigate ApoE's impact on lipid metabolism, atherosclerosis, and heart health while also probing its involvement in genetic predispositions and mechanistic implications in Alzheimer's disease. In addition, the book extends its exploration to the broader influence of ApoE on cognitive decline and other neurological conditions, metabolic health, liver function, cancer risk, and immune modulation. With a strong focus on the pharmacogenetics of ApoE, the book paves the way for precision medicine, offering insights into how ApoE genotypes influence medication responses and therapeutic strategies. Future prospects and challenges in harnessing ApoE for disease management are discussed, alongside its role in infectious diseases, genetic engineering innovations, and targeted drug delivery systems.

  • Advances in Diffusion Magnetic Resonance Imaging for Neurodegenerative Diseases Research

    • 1st Edition
    • Frederic Sampedro
    • English
    Advances in Diffusion Magnetic Resonance Imaging for Neurodegenerative Diseases Research covers how diffusion MRI has contributed to our understanding of a wide range of neurodegenerative diseases, unraveling early microstructural brain damage even at presymptomatic stages. Sections cover the technical basis of diffusion MRI, focusing on the interpretation of its imaging-derived metrics in terms of neuronal damage. Subsequent chapters are organized by disease, taking an in-depth look at how the use of diffusion MRI has contributed to our recent understanding of, and motivated potential new monitoring and therapeutic strategies for Alzheimer's disease, frontotemporal dementia, Parkinson's disease, multiple sclerosis, progressive supranuclear palsy, Huntington's disease, multiple system atrophy, motor neuron diseases, and more.The book concludes with implications for future research, making it a must-have reference for researchers and clinicians interested in the field of neuroimaging for neurodegenerative disorders.

  • AI in Breast Cancer Stem Cells and Proteomics

    Precision Oncology Perspectives
    • 1st Edition
    • Manzoor Ahmad Mir + 1 more
    • English
    AI in Breast Cancer Stem Cells and Proteomics: Precision Oncology Perspectives explores the intersection of artificial intelligence, cancer stem cell biology, and proteomics to address the persistent challenges of relapse, metastasis, and therapy resistance in breast cancer. This book provides a translational framework for precision oncology through advanced computational and molecular approaches. It gives insight into the biology of breast cancer stem cells (BCSCs), their heterogeneity, and the role of proteomics in identifying biomarkers and therapeutic targets. The integration of AI enables predictive modeling, drug resistance profiling, and multi-omics data analysis, offering novel insights into personalized treatment strategies. Academics benefit from a comprehensive, interdisciplinary resource that bridges cancer biology, bioinformatics, and clinical applications.The book equips researchers, clinicians, and students with case studies, algorithmic tools, and practical workflows to translate proteomic data into actionable medical interventions.

Related subjects