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Elsevier

Books in Life sciences

  • Systems Biology in Crop Improvement

    Emerging Tools and Technologies
    • 1st Edition
    • Tariq Aftab
    • English
    Systems Biology in Crop Improvement offers a detailed overview of how principles and methodologies from systems biology are transforming crop research and breeding. This volume, part of the Systems Biology in Agriculture and Plant Sciences series, explores the integration of omics technologies, computational modeling, and high-throughput phenotyping to deepen our understanding of plant responses and traits.Addressing the urgent challenge of feeding a growing global population, the book emphasizes how systems biology enables insights into molecular, genetic, and environmental interactions that influence a crop’s traits and performance. It discusses applications ranging from stress resilience—abiotic and biotic—to nutrient use efficiency, nutritional enhancement, and quality markers. The volume highlights innovative strategies such as genomic editing and synthetic biology, and how these advances can be translated into practical breeding programs.Bringing together contributions from leading researchers and practitioners, Systems Biology in Crop Improvement aims to inspire new collaborations, innovations, and discoveries, ultimately contributing to a more sustainable and robust food system for future generations.

  • Nanotechnology Applications for the Diagnosis and Therapeutic Treatment of Fungal Diseases

    • 1st Edition
    • Virendra Gajbhiye + 2 more
    • English
    Nanotechnology Applications for the Diagnosis and Therapeutic Treatment of Fungal Diseases offers comprehensive coverage of the fundamentals of fungal diseases and the applications of nanotechnology for their diagnosis and treatment.The book covers the basics of human fungal pathogens, the molecular mechanisms of infection, and current diagnostic strategies and treatment regimes. It then goes on to discuss nanotechnology-based approaches for the detection and identification of human fungal pathogens. It also discusses antifungal drugs, their modes of action, and how nanoparticles are utilized to deliver these agents, highlighting their significance in treating various fungal infections. Additionally, it provides a comprehensive overview of nanotechnology-based products, as well as the current and future applications of nano-methodologies and technologies in the field of fungal infectious diseases. With contributions from experts in the field, Nanotechnology Applications for the Diagnosis and Therapeutic Treatment of Fungal Diseases is an informative resource for scientists, researchers, and medical personnel to better understand fungal diseases in order to design and develop novel and accessible nano-based therapies for their treatment.

  • Antimicrobial Resistance in Humans, Animals, and the Environment

    One Health Approach
    • 1st Edition
    • Kunal Ranjan + 3 more
    • English
    Antimicrobial Resistance in Humans, Animals, and the Environment: One Health Approach examines the global impact of antimicrobial resistance (AMR) with a specific focus on the interconnectedness between animal, human, and environmental health. The book details the origin, evolution and ecology of AMR and its updated epidemiology. It discusses the transmission of antimicrobial resistance between humans, animals, and the environment. It delves into the molecular mechanisms of drug resistance development and epidemiology in human and animal health; the different challenges in treating antimicrobial-resist... infections including rapid diagnosis and the development of new antimicrobial agents; and alternative strategies treating drug-resistant infections. Antimicrobial Resistance in Humans, Animals, and the Environment: One Health Approach is a useful comprehensive resource for researchers, academics postgraduate students, PhD students, early career researchers, and medical scientists in microbiology, infectious diseases, and biotechnology, public health professionals, clinical personnel treating AMR, or policymakers interested in implementing antimicrobial stewardship program in hospitals.

  • Microbial Enzymes

    Classification, Biochemistry, Production and Applications
    • 1st Edition
    • Abdel Moneim Elhadi Sulieman
    • English
    Microbial Enzymes: Classification, Biochemistry, Production and Applications explores the multifaceted roles of microbial enzymes, emphasizing their stability, ease of handling, and manipulation, all of which make them invaluable in various industrial processes. With 25 in-depth chapters, the book delves into the biochemistry of enzymes, their various sources, and their importance in biotechnology. It covers modern techniques for microbial enzyme detection and determination, methods of enzyme immobilization, and the application of microbial enzymes in industries such as food, medicine, pharmaceuticals, and textiles. Special sections discuss the biosynthesis of metal nanoparticles by microbial enzymes and the role of microbial toxins in different sectors. The book's chapters are organized in a way that provides detailed insights into the classification of enzymes, the mechanisms of microbial enzymes, and their industrial importance. Topics include bacterial, fungal, and algal enzymes, their applications, and the latest advancements in enzyme technology. Other sections address the challenge of antibiotic resistance and explores innovative methods for enzyme production and molecular engineering.

  • Proteomics in Cell Communication

    • 1st Edition
    • Volume 200
    • English
    Proteomics in Cell Communication, offers a comprehensive exploration of the dynamic field of proteomics and its vital role in understanding cellular communication. This book includes interesting chapters on topics such as In vivo cell-type specific secretome profiling, Assays for surface antigens in extracellular vesicles using proximity labeling strategy, Cell type-specific proximity biotinylation using TurboID to identify secreted proteins from cardiomyocytes in vitro and in vivo, Native-state and cell type-specific proteomics using TurboID proximity labeling in mouse models, Adapted Luminex approach to assess phosphoproteins and cytokines released from specific cell types in the brain in vivo, and much more.Other sections covers In-depth cell-selective proteomics and secretomics in vivo based on azidonorleucine labelling, Visualizing and profiling de novo protein synthesis in Drosophila with cell-type specificity, A Split GFP Approach for Cell-Type-Specific Protein Localization Analysis in Drosophila, Quantitative deep profiling of the cell surface proteome using the "Cell Surface Capture" technique, Proteomic profiling of extracellular fluids to identify secreted proteins from muscle and fat tissues, and much more.

  • Methods for the Study of Microbial Biofilms

    Current Trends and Recent Advancements
    • 1st Edition
    • Abhishek Guldhe + 2 more
    • English
    Methods for the study of microbial biofilms: Current Trends and Recent Advancements provides a detailed overview of the latest techniques for the study of biofilms. The book explores a wide range of methods for the characterization and study of cells within biofilms, including microscopy techniques, genomic approaches, transcriptomics, proteomic and proteogenomic tools. Computational and mathematical modelling are also covered.Chapters investigate the physiology of biofilm cells, gene expression pathways related to the formation, maturation and dispersion of biofilms, and molecular factors governing the biofilm formation and development, providing an overview of techniques that can be used at the cellular and molecular level. This book provides a broad overview of the biofilm field, along with the range of techniques that can be used to study and better understand them.

  • Chemoresistance in Glioblastoma

    Understanding and Management
    • 1st Edition
    • Dileep Kumar + 1 more
    • English
    Chemoresistance in Glioblastoma: Understanding and Management gives clear insights into the detailed characteristic aspects of glioblastoma disease and the different therapeutic targets that are employed in reducing resistance to chemotherapeutic agents. The book delves deep into the root causes of multidrug resistance and the quest for novel molecular targets among growth factors, receptors, signal transduction proteins, microRNAs, transcription factors, proto-oncogenes, and tumor suppressor genes. In addition, it gives insights on the pathological and molecular features of glioblastoma and the role of cancer stem cells in the resistance to chemo and immunotherapy.While designed as a comprehensive guide, the book also serves as a valuable reference for professionals seeking to deepen their understanding, refine their skills, and explore new avenues within chemoresistance.

  • Plant-Based Proteins Processing

    Emerging Trends and Applications
    • 1st Edition
    • C.K. Sunil + 2 more
    • English
    Plant-Based Proteins Processing: Emerging Trends and Applications covers sources, extraction, properties, bioavailability, modification, applications, and marketing opportunities, in addition to the conventional and emerging technologies applied for obtaining plant-based proteins. This book consists of five sections, starting with Section A which includes chapters on overview, sources, digestibility and bioavailability, nutritional properties, and food byproducts as a source of protein. Section B covers the extraction of plant-based proteins, which has chapters on the chemical, enzyme, and novel techniques for extraction of plant proteins. Section C chapters focus on the modification of the plant protein, including all the modification methods (Thermal, Non-thermal, Biological, and Chemical methods) and their effects on the protein. Section D includes the applications of the proteins, and the last Section, E, covers the market, challenges, and future opportunities for plant-based proteins. Plant-Based Proteins Processing is a complete guide for students, researchers, professionals, consumers, food manufacturers, and others who are engaged in plant-based protein production.

  • Introduction to Contemporary Philosophy of Medicine

    • 1st Edition
    • James A. Marcum
    • English
    Introduction to Contemporary Philosophy of Medicine explores philosophical approaches to the nature of medicine, ranging from the Analytic Philosophy of Medicine to Feminist and Gender Medicine. Digital, Complementary, and Alternative Medicines are also discussed, with each diverse approach informed by different ontological and epistemological concepts, such as causation, disease, and health, which are introduced and discussed in detail. This is a key guide for students and other healthcare professionals interested in philosophical issues in contemporary medicine.Contemporar... philosophy of medicine is certainly a growing discipline in the 21st century, with substantial literature. But the discipline has no overarching paradigm that reflects consensus. Rather, contemporary philosophy of medicine is diverse, with various approaches not only to the problems facing contemporary medicine, but also how best to address and potentially resolve them. This book explores these concepts and their diverse approaches.

  • Neurobiology of Aging

    Exploring Cognitive Decline and Neurodegeneration
    • 1st Edition
    • Sachchida Nand Rai
    • English
    Neurobiology of Aging: Exploring Cognitive Decline and Neurodegeneration is a comprehensive reference exploring the complexities of the aging brain. This book examines the intricate processes driving cognitive decline and neurodegeneration. From the gradual loss of neurons and synapses to the formation of protein aggregates characteristic of Alzheimer's disease, each chapter reviews key aspects of brain aging. Chapters dissect the mechanisms driving neuronal loss, synaptic dysfunction, and protein misfolding, shedding light on the intricate interplay of oxidative stress, inflammation, and mitochondrial dysfunction. This book also navigates through strategies for healthy brain aging, from the impact of diet and exercise to the role of cognitive stimulation.

  • Precision Medicine in Neurodegenerative Diseases: From Research to Clinical Practice

    • 1st Edition
    • Volume 297
    • English
    Precision Medicine in Neurodegenerative Diseases: From Research to Clinical Practice, Volume 298 in the Progress in Brain Research series, highlights new advances in the field, with this new volume presenting interesting chapters on timely topics such as Introduction to Precision Medicine in Neurodegeneration, Genetic and Epigenetic Drivers of Neurodegenerative Disorders, Biomarkers: From Early Detection to Treatment Personalization, Multi-Omics Integration in Disease Research, AI and Emerging Technologies for Diagnosis, Advanced Neuroimaging in Precision Neurology, and much more.Additional chapters cover Precision Therapeutics for Alzheimer's Diseases, Personalized Management of Parkinson's Diseases, Pharmacogenomics and CRISPR-Based Therapies, Patient-Centric Care and Digital Health Tools, and Global Case Studies and Collaborative Frameworks, Future Horizons: Innovation, Aging, and Equity.

  • Protein Misfolding Diseases

    • 1st Edition
    • Volume 148
    • English
    Protein Misfolding Diseases, delves into the intricate molecular mechanisms behind a class of devastating disorders caused by abnormal protein folding. This comprehensive book explores interesting and updated topics, including Protein misfolding in hemophilia, Characterizing Protein Misfolding: Inside and Out, Heat Shock proteins (HSPs) as chaperones for Oncogenesis, Protein Misfolding and Cancer: Molecular Insights and Future Perspectives, Proteostasis and Pathogenesis: Unraveling the Complexity of Protein Misfolding Disorders, Small molecule inhibitors targeting α-synuclein aggregation: Progress and future outlook, and much more.Additional sections cover Chaperone Machinery in Neurodegeneration: A Spotlight on Protein Misfolding Diseases and Calpain- mediated proteolytic cleavage.

  • Encyclopedia of Reproduction

    • 3rd Edition
    • Michael K. Skinner
    • English
    The Encyclopedia of Reproduction, Third Edition, Six Volume Set comprehensively reviews biology and abnormalities, also covering the most common diseases in humans, such as prostate and breast cancer, as well as normal developmental biology, including embryogenesis, gestation, birth and puberty. Each of the 575 chapters provides a comprehensive overview by leaders in their respective fields that is ideal for advanced undergraduate students, research professionals, and clinicians. Chapters explore the latest advances in cloning, stem cells, endocrinology, clinical reproductive medicine, and genomics.As reproductive health is a fundamental component of an individual’s overall health status and a central determinant of quality of life, this 6-volume set provides the most extensive and authoritative reference within the field.

  • Nanomedicine and Nutrigenomics

    Pioneering the Future of Health
    • 1st Edition
    • Yugal Kishore Mohanta + 2 more
    • English
    Nanomedicine and Nutrigenomics: Pioneering the Future of Health offers a comprehensive introduction to nanomedicine and nutrigenomics, ensuring readers grasp the fundamental concepts, techniques, and applications. The book provides an overview of nanotechnology, nanomaterials, and gene-nutrient interactions, paving the way for understanding the potential healthcare applications of these groundbreaking methodologies. It emphasizes the synergy between nanomedicine and nutrigenomics, showcasing how they can optimize health outcomes and delving into nanotechnology's role in enhancing drug delivery systems, diagnostics, and therapeutics, while also highlighting personalized nutrition interventions based on genetic makeup. The book addresses future advancements, ethical implications, and challenges, presenting a holistic view.

  • Recent Trends in Enzyme Immobilization

    • 1st Edition
    • Shailendra Kumar Arya + 3 more
    • English
    Recent Trends in Enzyme Immobilization explores the forefront of enzyme technology, providing a comprehensive guide on the latest methodologies and advancements. This book begins by setting the stage with foundational insights into enzyme immobilization, then progresses to discuss innovative techniques and their applications across various industries, including biopharmaceuticals, environmental science, and food processing. Structured to cater to both newcomers and seasoned professionals in biotechnology and biochemical engineering, each chapter delivers in-depth analysis and up-to-date research findings. Readers will find valuable resources in the practical guidance offered for optimizing enzyme stabilization, activity, and reusability in industrial applications. Moreover, the text addresses the theoretical underpinnings that frame current practices and illuminates future directions for research and technological advancements. Designed as an indispensable resource, this book aims to bridge the gap between academic research and practical application. It equips researchers, practitioners, and advanced students with the necessary tools and knowledge to drive innovation in enzyme immobilization, fostering the development of sustainable solutions and novel approaches in their work. With contributions from leading global experts, Recent Trends in Enzyme Immobilization serves as a critical reference that promises to inspire and guide readers through the complexities and potentials of this dynamic field.

  • The Potential of Intermittent Fasting in Age-related Diseases and Precision Anti-aging Therapeutics

    • 1st Edition
    • Abhishek Kumar Singh + 2 more
    • English
    The Potential of Intermittent Fasting in Age-related Diseases and Precision Anti-aging Therapeutics takes an in-depth look at the beneficial and efficacious role of Intermittent Fasting (IF) in a wide array of aging-associated diseases. It provides a comprehensive resource that not only outlines the potential benefits and future research directions but also delves into the limitations and nuances of IF in managing these conditions. The book is divided sections and begins by covering the fundamentals of aging and the effects of IF. Subsequent sections examine the physiological impact IF has on aging; its potential influence on stress resistance, heart, gut, and overall health optimization; social and ethical considerations as a therapeutic strategy; bridging IF research findings and clinical practice; and the potential integration and application of IF into age-related diseases treatment. Offering a consolidated and scientifically grounded perspective aimed at equipping readers with a balanced understanding, this book serves as a go-to reference for researchers and clinicians alike seeking clear and accurate insights into how IF can positively influence the health and longevity of the aging population.

  • Future Fat Alternatives

    Concepts, Structuring and Food Applications
    • 1st Edition
    • Zong Meng
    • English
    Future Fat Alternatives: Concepts, Structuring and Food Applications provides a deep dive into the strategies for the development of fat alternatives for food applications, covering all structuring strategies including oleogels, emulsion gels, and foamed gels as well as cell-cultured fats. In addition, this book details other applications such as additive manufacturing and fat alternatives in different food applications and discusses their nutritional benefits. Divided into eight sections, this book begins with an overview of the structural-propertie... relationship in traditional fats, then segues into the benefits and challenges of fat alternatives, the prospects and challenges of cell-cultured fats, the additive manufacturing of fat analogs and how they pave the way toward novel food development. The applications of different fat alternatives and their nutritional benefits in bakery, meat, chocolate, and cheese products as well as nutraceutical delivery systems are also discussed.This book presents an excellent resource for researchers working across the food sciences in the fields of oil and fat production, research and development, sensory analysis, and technology and engineering.

  • Harnessing Genomic Tools for Crop Improvement

    A Software User Manual for Transforming Geneticists to Genomicists
    • 1st Edition
    • Lakshmi Narayana R. Vemireddy + 2 more
    • English
    In the rapidly evolving landscape of crop genetics, the book, Harnessing Genomic Tools for Crop Improvement is an essential resource designed for researchers, students, and professionals seeking to leverage bioinformatics tools for precision breeding. This comprehensive manual provides step-by-step guidance on utilizing molecular data derived from genetics and breeding experiments, offering hands-on instructions for key software applications in genetic diversity analysis, QTL mapping, genome-wide association mapping, haplotype analysis and genomic selection.Beyond technical tutorials, the book explores cutting-edge bioinformatics tools such as sequence databases, BLAST, primer designing, and sequence alignment, ensuring users gain a holistic understanding of genomics-driven crop improvement. Definitions, terminology clarifications, and interpretation of the results help bridge the gap between theory and application, simplifying complex analyses.Whether you are a novice or an experienced researcher, this book equips you with the skills to analyze and apply genomic data effectively, making it an invaluable asset for transforming geneticists into genomicists in both plant and animal sciences.

  • The Science and Culture of Latin American Foods

    Harnessing Ingredients for Health
    • 1st Edition
    • Sonia G. Sáyago-Ayerdi + 3 more
    • English
    The Science and Culture of Latin American Foods: Harnessing Ingredients for Health combines science and technology to demonstrate the importance of rescuing and preserving traditional and ancestral knowledge to exploit the functional benefits of the regions’ many roots, plants, seeds, insects, and more. Divided into four sections, Ingredients, Nutraceuticals, Functional Foods, and Cuisine, the book discusses the sustainable development of these ingredients while highlighting origin, production, classification, and medicinal properties. Readers will discover the potential of potent bioactive peptides derived from native foods like cacao, chipilín leaves, and Huauzontle, a pre-Hispanic ingredient thriving and surviving in Mexican cuisine.In addition, they will learn how Asia and Africa influence Latin American cuisine and about the importance these regional culinary dishes have in global gastronomy today.

  • Sustainable Urban Environments for Human Health

    • 1st Edition
    • Nidhi Singh + 3 more
    • English
    Sustainable Urban Environments for Human Health integrates concepts related to energy sustainability, urbanization, and human health into a single comprehensive resource. This book addresses the multifaceted global crises involving energy, economy, environment, and public health by exploring synergies and anticipating future perspectives, opportunities, and challenges to ensure resilience in a rapidly evolving human-driven world. Themes include ecological urban planning for health, renewable energy in urban environments, air quality and respiratory health, green infrastructure and health, active transportation and health, energy equity and social determinants of health, urban agriculture and food systems.

  • DSM-5-TR - Diagnostics différentiels
    • 3rd Edition
    • Michael B. First + 2 more
    • French
    Un aspect crucial de la démarche diagnostique est d’examiner, parmi la multitude de troubles répertoriés dans le DSM-5-TR, ceux qui pourraient éventuellement expliquer le tableau clinique. Après avoir établi cette liste de possibilités, l’étape suivante consiste à recueillir des informations cliniques supplémentaires (à partir des antécédents personnels, d’informations provenant de l’entourage, du dossier médical, de l’évaluation de l’état mental et des analyses de laboratoire) afin de réduire les options au diagnostic différentiel le plus probable, ce qui deviendra alors le diagnostic positif menant à un premier projet thérapeutique.DSM-5-... Diagnostics différentiels aide ainsi les cliniciens et les étudiants souhaitant s’exercer à la démarche diagnostique à améliorer leurs compétences dans la formulation d’un diagnostic différentiel complet grâce à une variété d’approches permettant d’aborder la présentation sémiologique. Il comporte notamment uncadre diagnostique en six étapes, 30 arbres décisionnels pour établir le diagnostic différentiel des symptômes clés et 67 tableaux de diagnostic différentiel à utiliser une fois établi un diagnostic provisoire. En collaboration avec les auteurs du DSM-5-TR, experts en diagnostics et en évaluations psychiatriques, ce manuel a été entièrement mis à jour afin d’illustrer les évolutions du DSM-5-TR. Il inclut deux nouveaux arbres décisionnels (pour les symptômes dissociatifs et les comportements pathologiques répétitifs). Le manuel comporte également la classification du DSM-5-TR, ce qui facilite le codage et fournit une vue générale de tous les diagnostics devant être pris en compte lors de la formulation d’un diagnostic différentiel. Les index alphabétiques des arbres décisionnels et des tableaux dediagnostics différentiels aideront les lecteurs à trouver facilement les informations recherchées. Ce manuel est ainsi extrêmement utile aux étudiants et aux praticiens, expérimentés ou débutants.Michael B. First, M.D., est professeur de psychiatrie clinique à l’Université Columbia de New York, New York, États-Unis.Cet ouvrage a été publié dans sa version originale par l’American Psychiatric Association.

  • Basics in Amino Acid Metabolism in Humans in Health and Disease

    • 1st Edition
    • Milan Holeček
    • English
    Basics in Amino Acid Metabolism in Humans in Health and Disease summarizes the significance of amino acids and their metabolism. This book provides a single source of information bringing together a wide variety of research on the subject, explaining the rationality and risks of using some amino acids as dietary supplements. The first chapters describe amino acids' structure, classification, and transport across cell membranes and their role in protein synthesis, gluconeogenesis, and ketogenesis. The central part of the book is focused on the role of individual amino acids in the synthesis of various biologically essential substances and their metabolism in acquired and hereditary diseases. The following chapters are dedicated to the role of particular organs, such as the small intestine, intestinal microbiota, liver, muscle, kidneys, brain, adipose tissue, and lungs. The next sections are focused on amino acid metabolism under various physiological (food intake, starvation, exercise, and elderly) and pathological (systemic inflammatory response, cirrhosis, diabetes, chronic renal insufficiency, and cancer) conditions. The last chapter summarizes the benefits and potential adverse effects of increased intake of individual amino acids. The author, Professor Milan Holeček, has been studying and researching in the area for over 40+ years. "Basics in Amino Acid Metabolism in Humans in Health and Disease" is written for healthcare professionals, primarily nutritionists, specialists in intensive metabolic care, clinical nutrition, diabetology, hepatology, gerontology, gastroenterology, nephrology, and oncology.

  • Updates on Pediatric Brain and Spine Tumors, An Issue of Neuroimaging Clinics of North America

    • 1st Edition
    • Volume 36-1
    • Christopher Filippi + 1 more
    • English
    In this issue of Neuroimaging Clinics, guest editors Drs. Christopher Filippi and Jane McEniery bring their considerable expertise to the topic of Updates on Pediatric Brain and Spine Tumors. Top experts discuss changes to the WHO classification for pediatric brain and spine tumors; circumscribed astrocytic tumors; glioneuronal tumors; congenital neonatal tumors; radiomics and AI for pediatric brain tumor; tumor predisposition syndromes; and more.

  • Genome Chaos

    Rethinking Genetics, Evolution, and Molecular Medicine
    • 2nd Edition
    • Henry H. Heng
    • English
    Genome Chaos: Rethinking Genetics, Evolution, and Molecular Medicine, Second Edition transports readers from Mendelian genetics to 4D genomics, building a case for genes and genomes as distinct biological entities where the genome, rather than individual genes, defines system-level inheritance and represents a clear unit of selection for macroevolution. In this thought-provoking text, Dr. Henry Heng invigorates fresh discussions in Genome Architecture Theory and helps readers reevaluate their current understanding of human genetics, evolution, and new pathways for advancing molecular and precision medicine.In this timely new edition, Dr. Heng fully embraces the integration of system information with genome-mediated evolutionary mechanisms, and supports this framework with recent findings and growing, interdisciplinary research. Ten evidence-based chapters discuss 4D genomics, genes and genomes as distinct biological entities, genome chaos and cellular macroevolution, karyotype coding and fuzzy inheritance, as well as an entirely novel model of evolution driven by information flow, and more. Brand-new chapters consider the creation and maintenance of system information for complexity and biodiversity, as well as modes of analyzing information-based and historically contingent evolutionary framework. This synthesis offers a revolutionary paradigm of evolutionary theory. It also hypothesizes about how information flow, matter arrangement, and energy interact.

  • Atlas of Microsurgery of the Lateral Skull Base

    • 1st Edition
    • Mario Sanna + 5 more
    • English
    Atlas of Microsurgery of the Lateral Skull Base is a practical resource for all clinicians interested in training for lateral skull base surgery. This new atlas of lateral skull base surgery allows readers to become familiar with the delicate lateral skull base, an important part of the body’s neurological system. Featuring step-by step dissection images, this resource is perfect for those studying anatomy of this region. Clinical surgical cases are also presented and discussed for each surgical approach, including relevant clinical and radiological background. Decision-making discussions provided for each clinical case ensure readers will fill any gaps in their neurosurgery training.

  • Endothelium and Cardiovascular Diseases

    Vascular Biology and Clinical Syndromes
    • 2nd Edition
    • Protasio L. Da Luz + 3 more
    • English
    Endothelium and Cardiovascular Diseases: Vascular Biology and Clinical Syndromes, Second Edition offers new discoveries in clinical settings, cellular, molecular, genetic, and epigenetic mechanisms which have led to novel understanding of the key role of endothelium in both cardiovascular and non-cardiovascular diseases. The innovations it presents have implications for both pathophysiological concepts and clinical decisions. Among other topics, cardiovascular and pulmonary medicine, immunity and inflammation, genetics and epigenetics, heart failure, renal disease, familial hypercholesterolemia... diabetes, and hypertension are discussed at length.With 20 new chapters covering everything from endothelium transition to connective tissue disorders, this second edition is sure to be indispensable to anyone wishing to learn the importance of endothelium to every facet of health.

  • Crop Physiology

    Applications for Genetic Improvement and Agronomy in Diverse Cropping Systems
    • 3rd Edition
    • Ignacio A. Ciampitti + 3 more
    • English
    Crop Physiology: Applications for Genetic Improvement and Agronomy in Diverse Cropping Systems, Third Edition, provides updated perspectives on crop science at the interface of plant breeding and agronomy. It builds on the premise that farmers rely on two key sets of tools: varieties (what to grow) and practices (how to grow). Within this context, crop physiology plays a central role in guiding both breeding strategies and agronomic decisions.This edition is designed for researchers and advanced students interested in the fundamentals of crop ecophysiology, including the use and efficiency of water, nitrogen, and carbon, as well as crop adaptation to environmental stresses such as heat, frost, drought, waterlogging, phosphorous, and biological nitrogen fixation. The volume brings together region-specific insights, with detailed chapters on physiological traits and processes that underpin crop performance and productivity in diverse systems.

  • Biology of Fatty Acids

    Biochemical, Nutritional and Pharmacological Functions
    • 1st Edition
    • E. P. Meran Keshawa + 1 more
    • English
    Biology of Fatty Acids: Biochemical, Nutritional, and Pharmacological Functions offers an in-depth exploration of the vital roles fatty acids play in human health. From their influence on metabolism and immune functions to their potential in disease prevention and treatment, this book covers a wide range of topics. With contributions from leading experts, it examines the latest research on fatty acids in nutrition, emerging plant-based sources, and their pharmacological potential in treating conditions like neurodegenerative diseases and cancer. A must-read for scientists, healthcare professionals, and anyone interested in the transformative impact of fatty acids on human health.

  • Flexible Constant-Force Robotic Manipulators

    Design and Applications
    • 1st Edition
    • Qingsong Xu
    • English
    Flexible Constant-Force Robotic Manipulators: Design and Applications offers a comprehensive survey of recent designs of flexible constant-force robotic manipulators, focusing on their applications in biomedical fields. The book presents innovative design approaches, including flexure mechanisms and bistable beams that enable compliant constant-force and constant-torque motion. Key topics include constant-force gripper designs for biological sample manipulation, polishing end-effectors for robotic manufacturing, and manipulators for ultrasound imaging that maintain consistent contact with the human body. This book defines the roles of these manipulators in biological cell manipulation, part polishing, ultrasound imaging, and healthcare, aiming to improve the quality of life. It is suitable for beginners, providing fundamental principles of compliant mechanism-based flexible robotics, and for advanced audiences, offering in-depth descriptions of state-of-the-art techniques. Readers will gain insights into the current limitations and future directions of robotic technology in precision medical treatment, making it a valuable resource for both newcomers and experienced professionals in the field.

  • Recent Advances in Hemodynamics and Blood Mimetics

    • 1st Edition
    • João Mário Rodrigues Miranda + 4 more
    • English
    Recent Advances in Hemodynamics and Blood Mimetics is a comprehensive compilation of recent developments in biofluid mechanics and biomimetics, covering topics such as numerical modeling, biomedical applications of microfluidics, biomimetic flows, biomedicine applications, and organ-on-chip technology. The book explores blood hemodynamics at different scales, including application to diseases, the relationship between blood biomechanics and rheology, the mimetization of blood properties at arterial and capillary level, including the study of blood mechanical and flow properties, flow and surface properties of blood cells, and mimetization of these same properties in fluid/particle systems.These concepts are applied to the development of organ-on-chip to improve the replication of biological processes in the human body. The book organizes recent knowledge on hemodynamics and blood mimetics and is representative of the different lines of research in the field, showing an integrated view of blood biomechanics encompassing all scales to create a valuable resource where different research lines can be found and their principles understood.

  • Imaging Blood-Brain Barrier Dysfunction in Brain Disorders

    • 1st Edition
    • Danny J.J. Wang + 1 more
    • English
    Imaging Blood-Brain Barrier Dysfunction in Brain Disorders delves into the intricate structure and function of the blood-brain barrier (BBB), examining its essential role in the pathogenesis of various brain disorders. The book offers a comprehensive overview of cutting-edge medical imaging technologies for visualizing BBB function, both in a healthy state and under diseased conditions. Readers will gain an in-depth understanding of how the BBB influences normal brain function, including aspects such as aging and sleep, and how its dysfunction is linked to serious neurological conditions.Furthermo... the book explores BBB anomalies in brain disorders like stroke, traumatic brain injury, cerebral small vessel disease, Alzheimer's disease, and sleep apnea. It highlights modern medical imaging technologies, such as MRI, for observing BBB function in vivo. It emphasizes the importance of BBB imaging for monitoring and potentially curing brain disorders, and discusses its potential in the early detection of neurological disorders, allowing for timely and effective treatment strategies.

  • Nanodiagnostics to Identify and Detect Microbial Infections and Antimicrobial Resistance

    Volume 1 - Nanotheranostics, Microbial Infections, and Antimicrobial Resistance
    • 1st Edition
    • Divakar Sharma + 1 more
    • English
    Nanodiagnostics to Identify and Detect Microbial Infections and Antimicrobial Resistance: Volume One, Nanotheranostics, Microbial Infections, and Antimicrobial Resistance offers a comprehensive understanding of the global problem of antimicrobial resistance (AMR) and provides insights into the various aspects of AMR and how nanodiagnostics can be utilized to combat it. This volume discusses the development of nanotechnologies for detecting and diagnosing microbial resistant pathogens and explores a range of nano-inspired diagnostics, including biosensors, microfluidic-assiste... devices, nanorobotics, and nanocapsules.This book encompasses contributions from experts in the field, making it a valuable resource for researchers, academics, graduate students, industry professionals, and clinicians in microbiology, nanotechnology, and infectious diseases. It aids in early detection and identification of antimicrobial resistance, offering innovative solutions to combat this global challenge.

  • Novel Bioproducts through Metabolic Engineering of Secondary Metabolites

    • 1st Edition
    • Yogesh K. Ahlawat + 3 more
    • English
    Novel Bioproducts through Metabolic Engineering of Secondary Metabolites provides comprehensive coverage of the latest developments in metabolic engineering and secondary metabolites, along with their roles in industrial product development. Sections cover the pivotal role secondary metabolites play in nature, their diverse classes, their significant applications in industry and medicine, and the fundamentals of metabolic engineering. Additional coverage includes biosynthetic pathways of secondary metabolites, strain development and optimization, rational design of pathway modifications, industrial enzymes and chemicals from metabolic engineering, and cutting-edge tools and technologies in metabolic engineering. The book concludes with a roadmap for the future of metabolic engineering, exploring emerging trends such as CRISPR and genome editing, artificial intelligence applications, and the evolving landscape of synthetic biology and bioeconomy.

  • Bacterial Efflux Systems

    • 1st Edition
    • Volume 724
    • English
    Bacterial Efflux Systems, Volume 722 covers experimental and computational approaches to study the function, structure, and mechanism of bacterial efflux pump systems. The methods covered include preparation of samples for structural and functional analyses and in vivo activity analysis. Specific chapters in this release cover Efflux pump functional assays, NMR and functional analysis efflux pumps, Methods for saturation mutagenesis and functional characterization, Cooperation and functional interplay between pumps, Mapping interactions, HDX-MS, and much more.Other sections cover Recombinant Expression and purification, Reconstitution of a RND efflux pump in different artificial membranes for a structural biology approach, Reconstitution of rnd and mfs efflux pumps for structural biology, CusCBA system, Expression and purification of efflux pumps of Gram positives, Expression and purification of efflux pumps of archaea, ABC transporters: BmrA preparation for NMR and PatA/PatB in peptidisc, In situ structural analysis of efflux assemblies by cryoET, Molecular dynamics simulations, and so much more.

  • Functionalized Drug Delivery Systems

    • 1st Edition
    • Umesh Gupta + 1 more
    • English
    Functionalized Drug Delivery Systems delves into the potential of various functionalized drug delivery systems, such as polymeric micelles, dendrimers, metallic nanoparticles, and SMEDDS. It offers a comprehensive guide from basic concepts to advanced surface engineering techniques. The book covers liposomes, dendrimers, metal nanoparticles, polymeric micelles, niosomes, and ethosomes, concluding with a chapter on the regulatory framework. This invaluable resource is perfect for pharmaceutical researchers and graduate students keen on advancing their understanding and application of these innovative drug delivery methods. The book also provides consolidated literature reviews, making it a foundational text for new researchers.Its chapters are dedicated to specific techniques, offering detailed insights into each method. Readers will gain knowledge on improving drug absorption and targeted delivery, supported by practical examples and case studies. The final chapter on regulatory frameworks ensures compliance and best practices in developing functionalized drug delivery systems. This book is an essential read for anyone in the field of pharmaceutical research.

  • Phytochemicals and Gut Health

    Evidence and Opportunities for Gastrointestinal Management
    • 1st Edition
    • Sachchida Nand Rai + 2 more
    • English
    Phytochemicals and Gut Health: Evidence and Opportunities for Gastrointestinal Management highlights specific plant phytochemicals, their bioactive compounds, and the influence they have on the gut-brain axis. By exploring sources, production, mechanisms of action, and clinical applications, the book uncovers how certain bioactives can optimize health and improve gastrointestinal diseases while reducing the side effects and limited efficacy of current medical treatments. The book's authors identify different classes of plant-based phytochemicals such as phenolic metabolites, alkaloids, terpenoids, and glucosinolates while demonstrating a better understanding of the gut-nutraceutical axis that can improve microbiota for GI disorders, and more. Readers will also gain important perspectives on mechanisms of action and the synergistic effects phytochemicals have on cardiovascular and neurological health.

  • An Introduction to Applied Clinical Ethics in Pathology and Laboratory Medicine

    A Case-Based Approach
    • 1st Edition
    • Ifeoma U. Perkins
    • English
    An Introduction to Applied Clinical Ethics in Pathology and Laboratory Medicine: A Case-Based Approach offers an organized pragmatic approach to processing ethical dilemmas that frequently occur in pathology and laboratory medicine in a systematic way. This is a novel resource strategically crafted in a case-based format to help readers confidently reach potential solutions with strong ethical reasoning that not only further quality patient care but honor the good intentions of pathologists and laboratorians. Readers will gain confidence in their ability to think critically about complex problems in pathology that create ethical conflict. This book is for healthcare providers, practicing anatomic and clinical pathologists, pathology residents and fellows, pathology educators and graduate medical education program directors, students of allied health sciences, researchers, laboratory technologists, and any members of the clinical care team who utilize laboratory services.

  • Biophysics of Life

    Origin and Evolution
    • 1st Edition
    • Mohammad Ashrafuzzaman
    • English
    Biophysics of Life: Origin and Evolution explores the biophysical mechanisms involved in the formation and evolution of life. The book considers a range of topics, including the history of life’s physical evolution, physics laws governing the origins of life, biophysical and biochemical principles in the building blocks of life, biomolecular mutations, and physics and quantum mechanical interpretations of evolution. Biophysical and biochemical techniques for sequencing life’s origins are also explored, as well as bioinformatics and AI algorithms tracking the origins of life. Additionally, biophysics of life in extreme conditions is considered, as well as biophysics of artificial life.As physics laws govern most of the molecular processes associated with biological life, this book seeks to investigate the origin and development of life through that lens, considering how life’s maturation happened as a result of the coordinated actions of physics, chemistry, and biology. This is an important reference for researchers working across biophysics, biochemistry, molecular biology, cell biology, and in related fields.

  • Medications for Older Persons

    Recommendations, Harms, Evidence
    • 1st Edition
    • Roger Thomas
    • English
    Medications for Older Persons: Recommendations, Harms, Evidence provides a comprehensive resource detailing the benefits of medications for older individuals. It also addresses the potential harms associated with the prescription of potentially inappropriate medications or omissions in prescribing and examines how many adverse events, rehospitalizations, and deaths can be attributed to these medications. The book opens with a summary of medications that most benefit older patients, followed by the impact of older persons’ alcohol consumption, self-medication, and medication list accuracy and how these factors correlate to health outcomes.The remainder of the book is devoted to the assessment of medication groups focusing on Numbers Needed to Treat, Numbers Needed to Harm, and characteristics and numbers of adverse events. Medication groups covered include cardiovascular, central nervous system, renal, gastrointestinal, musculoskeletal, respiratory, endocrine, pain, and fall prevention.

  • Liquid biopsy in Cancer Management

    Integrating Diagnostics and Clinical Applications
    • 1st Edition
    • Shvetank Bhatt + 3 more
    • English
    Liquid biopsy in Cancer Management: Integrating Diagnostics and Clinical Applications provides a comprehensive overview of liquid biopsy, covering its fundamental principles, technological advancements, clinical applications, and future prospects. In 16 chapters, the book focuses both on the practical implications of liquid biopsy in cancer management, and on its role in early detection, treatment monitoring, and personalized therapy. It emphasizes the integration of liquid biopsy into both diagnostic practices and therapeutic strategies, highlighting its potential to transform cancer care. The book discusses the latest research findings and explores future directions in liquid biopsy research, providing readers with a forward-looking view of the field.It includes case studies and examples to illustrate the clinical utility of liquid biopsy and enhance understanding of its applications. Overall, the book aims to be a comprehensive and authoritative resource on the subject, providing readers with a thorough understanding of the current state and future directions of liquid biopsy in cancer management.

  • Therapeutic Potential of Medicinal Plants

    The Science Behind Natural Remedies
    • 1st Edition
    • Vera Popović + 1 more
    • English
    When synthetic drugs produce adverse side effects, practitioners may look to natural alternatives to alleviate symptoms or complement existing treatment. Therapeutic Potential of Medicinal Plants: The Science Behind Natural Remedies, investigates the bioactive compounds and functionality of medicinal plants and herbs which are recommended to help certain health conditions and overall well-being while highlighting cultivation that can be done sustainably to promote biodiversity conservation. Written by over 50 experts in the fields of nutrition, organic food, fertility, phytopharmacology, biotechnology, nanotechnology, plant botanicals, and herbal medicine, “Therapeutic Potential of Medicinal Plants: The Science Behind Natural Remedies,” introduces readers to the the chemical composition of over 75 plants, herbs, grains and seeds while highlighting their anti-inflammatory, antimicrobial, antioxidant, and immunomodulatory effects to improve overall well being and manage certain conditions such as diabetes, osteoarthritis, cardiovascular and neurodegenerative diseases. Bioactive compounds, essential oils and phytochemicals in certain plants and marine compounds are reviewed for their efficacy to help improve gynecological health, alleviate menopausal symptoms and lower blood pressure. The book also discusses the toxicity and safety implications associated with the use of medicinal herbs during pregnancy and other life stages.

  • Artificial Intelligence and Machine Learning in Healthcare

    • 1st Edition
    • Arman Kilic
    • English
    Artificial Intelligence and Machine Learning in Healthcare discusses the potential of groundbreaking technologies on the delivery of care. A lot have been said about how artificial intelligence and machine learning can improve healthcare, however there are still many doubts and concerns among health professionals, all of which are addressed in this book. Sections cover History and Basic Overview of AI and ML, with differentiation of supervised, unsupervised and deep learning, Applications of AI and ML in Healthcare, The Future of Healthcare with AI, Challenges to Adopting AI in Healthcare, and ethics and legal processes for implementation.This book is a valuable resource for bioinformaticians, clinicians, graduate students and several members of biomedical field who needs to get up to speed on the revolutionary role of AI and Machine Learning in healthcare.

  • Preventable Medical Errors

    The Role of Different Sciences in Medical Education and Practice
    • 1st Edition
    • Erwin B. Montgomery Jr.
    • English
    Preventable Medical Errors: The Role of Different Sciences in Medical Education and Practice addresses the issues of staying up to date with evolving medical practices, by providing practical examples linked to real-world patient safety concerns and illustrating theoretical discussions with clear clinical practice scenarios. The book is divided into two sections, Part 1 - How Did It Come To This? and Part 2 - Where Does It Go From Here?; which guide the reader through how we got here historically and how we can navigate our way out using the tools the author presents. Thus paving the way, bridging a gap between theory and practice, while emphasizing the importance of patient safety. Written for all medical professionals, at the forefront of postmodern and scientific medical advancements, to ultimately improve clinical outcomes and reduce preventable medical errors.

  • Cyclic Peptides

    • 1st Edition
    • Volume 723
    • English
    Cyclic Peptides, Volume 721 covers peptide structures and their enhancement, stability, specificity, and overall functionality. As a growing suite of computational and experimental tools support the discovery and optimization of these molecules, ranging from well-established modeling platforms to emerging deep-learning algorithms that expand design possibilities, this book aims to provide a comprehensive overview of cyclic peptide research, covering fundamental principles, production strategies, and the latest technological advances in both synthetic and computational realms.Cyclic peptides are a powerful approach to constraining peptide structures, enhancing their stability, specificity, and overall functionality. They can be generated through diverse techniques—including chemical synthesis, mRNA display, and DNA display—that enable the creation of tailored peptide libraries.

  • Pathology of Wildlife and Zoo Animals

    • 2nd Edition
    • Karen A. Terio + 2 more
    • English
    Pathology of Wildlife and Zoo Animals, Second Edition is the much-anticipated update to the leading resource on the study of diseases in non-domestic species. The book offers comprehensive coverage of the pathology of wildlife and zoo species, including a wide scope of animals, disease types and geographic regions. Chapters include information on performing necropsies, proper techniques to meet the specialized needs of forensic cases, laboratory diagnostics, and an introduction to basic principles of comparative clinical pathology. The taxon-based chapters provide information about diseases in related groups of animals and include descriptions of gross and histologic lesions, pathogenesis and diagnostics.For each group of animals, notable, unique, gross and microscopic anatomical features are provided to further assist the reader in deciding whether differences from the domestic animal paradigm are "normal." Additional online content, which includes text, images and whole scanned glass slides of selected conditions expand the published material thus resulting in a comprehensive approach to the topic.

  • Edible Oils Analysis

    Trends In Infrared Spectroscopy And Other Analytical Methods
    • 1st Edition
    • Andrei A. Bunaciu + 2 more
    • English
    Edible Oils Analysis: Trends In Infrared Spectroscopy and Other Analytical Methods provides the fundamentals of infrared spectroscopy and the latest research on its applications in edible oils and honey analysis.The book is organized into two distinct sections, Infrared Spectroscopy in Edible Oils and Honey Analysis. The introductory part encourages readers with basic knowledge by bringing a theoretical background. Then the book introduces the most important sampling methodology used for infrared spectroscopy, such as chemometrics methods, and machine learning in infrared spectroscopy analysis. And finally, this title provides descriptions of analytical studies of the presented applications.Food adulteration and consequently the determination of authenticity represent subjects of high importance in food industry, generating major concerns among food manufacturers. Thus, this is an excellent resource for food scientists, analytical chemists, quality control laboratories dealing with food and drug administration, besides governmental agencies responsible for food quality and safety

  • Fundamentals of Redox Biology

    • 1st Edition
    • Shyamal K Goswami
    • English
    Fundamentals of Redox Biology is a comprehensive guide to understanding the complex roles of cellular redox systems in biological processes and human health. Exploring the regulation, physiological functions, and pathological implications of reactive oxygen species (ROS) and free radicals, this book serves as an essential resource for students and professionals in biochemistry and related fields. It delves into the fundamentals of redox signaling, the impact of antioxidants on homeostasis, and the intricate balance between oxidative stress and disease development, including conditions like cancer and neurological disorders. This foundational text is invaluable for advancing knowledge in redox biology.In addition to providing a historical perspective on redox biology, the book examines how ROS influence epigenetic regulation and mitochondrial function, particularly in immune responses to infections. It also integrates discussions on the role of redox systems across multiple disciplines, making it relevant to cell biology, molecular biology, immunology, and beyond. With its detailed exploration of both theoretical and applied aspects, the book positions itself as a pivotal resource for understanding the mechanisms underlying redox balance and its broad applications in life sciences.

  • Pediatric Neurology

    Clinical and Imaging Case Studies
    • 1st Edition
    • Hugo A. Arroyo + 4 more
    • English
    Pediatric Neurology: Clinical and Imaging Case Studies is a richly illustrated, case-based resource that explores the complementary roles of neurology and radiology for patient diagnosis and treatment. This unique volume is authored by world-class child neurologists and pediatric neuroradiologists who demonstrate the essential role of interdisciplinary collaboration in clinical care. Expert-selected cases comprise this valuable educational tool and reference text for diverse audiences including primary care physicians, neurologists, neurosurgeons, and neuroradiologists.

  • Translational Neurosurgery

    • 1st Edition
    • Adam E.M. Eltorai + 2 more
    • English
    Translational Neurosurgery provides a comprehensive overview reflecting the depth and breadth of the field of translational research focused on neurosurgery, with input from a distinguished team of basic and clinical investigators. It covers the principles of evidence-based medicine and applies these principles to the design of translational investigations, helping researchers navigate challenging considerations in study design and implementation. This book is a valuable resource for neurosurgeons and neurosurgery investigators who want to understand more about translational research, and also for basic scientists interested in translating their research into clinical practice.

  • Pathology of the Laboratory Rabbit

    • 1st Edition
    • Alys Bradley
    • English
    Pathology of the Laboratory Rabbit serves as a “go to” text for all pathologists working on laboratory rabbits in safety assessment studies. The book helps diagnostic veterinary pathologists rule out spontaneous non-clinical disease pathology when assigning cause of death to these animals which are also kept as domestic pets. The book provides a comprehensive text on the spontaneous pathology seen in common laboratory rabbit strains. This is the first book collating information on all organ systems in these strains.

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