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Elsevier

Books in Life sciences

  • Baicalin

    Pharmacology, Clinical Applications, and Future Prospects
    • 1st Edition
    • Xiao Ma + 2 more
    • English
    Baicalin: Pharmacology, Clinical Applications, and Future Prospects is an essential reference for researchers and pharmaceutical professionals seeking to deepen their understanding of baicalin, a potent flavonoid with significant therapeutic potential. This comprehensive guide consolidates foundational knowledge and recent advancements in baicalin research, addressing critical aspects such as efficacy, toxicity, and pharmacokinetics. By systematically exploring baicalin’s drug development potential, this book serves as a vital resource for those aiming to make original contributions to the field.The book is organized into three main parts, beginning with the Foundations of Baicalin Research, which explores the historical and traditional uses of baicalin, extraction methods, and modern research advancements. The second part, Pharmacology of Baicalin, provides an in-depth analysis of its mechanisms of action, bioavailability, and pharmacokinetic parameters, while also presenting current applications for various diseases, including pulmonary, liver, cardiovascular, and nervous system disorders. Finally, the Prospects section addresses future directions in drug delivery and administration, focusing on innovative approaches to enhance baicalin’s bioavailability and therapeutic efficacy.By balancing scientific rigor with accessibility, this book is tailored for PhD students, postdoctoral researchers, and pharmaceutical professionals. It highlights cutting-edge research and practical applications, empowering readers to explore the full potential of baicalin in drug development and clinical practice. Whether you are new to the field or an experienced researcher, “Baicalin: Pharmacology, Clinical Applications, and Future Prospects” offers invaluable insights that will enhance your understanding and inspire future research endeavors.

  • AI-Driven Diagnostics for 6G-Enabled Smart Healthcare

    • 1st Edition
    • Sangeeta Kumari + 3 more
    • English
    AI-Driven Diagnostics for 6G-Enabled Smart Healthcare explores the transformative integration of artificial intelligence (AI) and next-generation 6G networks in the healthcare sector. The book begins by highlighting the evolution of healthcare technology and the critical role of AI-driven diagnostics, emphasizing how 6G facilitates real-time, ultra-reliable communication. Key features of 6G, such as ultra-low latency and massive connectivity are discussed, showcasing their impact on advanced healthcare applications like remote diagnostics and patient monitoring. In addition, the integration of AI in medical diagnostics is examined, focusing on machine learning and deep learning techniques that enhance disease detection through medical imaging and clinical data analysis.Users will also find content that explores the benefits of remote patient monitoring, particularly for underserved populations, and delves into edge AI for localized, low-latency diagnostic processing. Other sections cover real-time imaging diagnostics are highlighted and address predictive analytics, detailing AI models that forecast diseases and the role of IoT devices and wearables in healthcare diagnostics. Final sections cover ethical considerations and regulatory challenges.

  • The Analytical Chemistry of Cannabis

    Chemistry, Pharmacology, Manufacturing, Use, and Control of Medicinal Cannabis and Cannabinoid Dosage Formulations
    • 2nd Edition
    • Brian F. Thomas + 2 more
    • English
    The Analytical Chemistry of Cannabis: Chemistry, Pharmacology, Manufacturing, Use, and Control of Medicinal Cannabis and Cannabinoid Dosage Formulations: Second Edition presents advanced methods in analytical chemistry to address modern issues surrounding cannabis-based products. Since the first edition, the cannabis industry has rapidly expanded its array of recreational and medicinal products. This volume provides crucial methods to support the manufacturing, labeling, and distribution of safe, consistent products with known chemical content and performance. It offers updated information on the chemistry and pharmacology of cannabis and cannabinoids and aims to resolve industry challenges by fostering understanding among scientists, public health officials, and non-scientist stakeholders.The book is valuable for professionals in analytical chemistry, pharmacology, medicine, and law enforcement, as well as for advanced academic courses in related fields.

  • Kefir

    Properties, Functionality, and Health Benefits
    • 1st Edition
    • Carlos Adam Conte Junior + 1 more
    • English
    Kefir: Properties, Functionality, and Health Benefits covers the more practical side of kefir production, technology, and product development. It focuses on the scientifically demonstrated benefits of this beverage, especially antimicrobial and antioxidant effects, intestinal microbiota modulation, immune response modulation, and anticancer properties. Bioactive compounds responsible for these effects are also explored to provide a theoretical basis for developing new food and pharmaceutical formulations. In addition, the book covers kefir’s potential role in neurodegenerative disease prevention. Finally, the readers will find strategies for product diversification, quality control, and biotechnological applications.Kefir is a fermented milk beverage that is growing in popularity among both researchers and consumers for its proven and potential health benefits. Companies interested in developing new fermented beverage products will find this work of interest.

  • Nanotechnological Innovations for Dairy Products

    Applications from Farm to Fork
    • 1st Edition
    • Ravi Pandiselvam + 2 more
    • English
    Nanotechnological Innovations for Dairy Products: Application from Farm to Fork offers an overview of the prominent, cutting-edge nanotechnology applications throughout the entire dairy supply chain, from farm-level production to consumer consumption. It will explore how nanotechnology can improve milk quality, extend shelf life, enhance nutritional value, and enable controlled release of bioactive compounds. It will also highlight the importance of ethical considerations, consumer acceptance, and transparency in the adoption of nanotechnology in the dairy industry. Written and edited by a team of international experts, Nanotechnological Innovations for Dairy Products: Application from Farm to Fork will guide researchers and industry stakeholders in implementing nanotechnology solutions in their practices and inspire future research and discoveries.

  • Precision Oncology in Liver Cancer

    Genomics, Infection, and the Exposome in African and Global Contexts
    • 1st Edition
    • Zodwa Dlamini
    • English
    Precision Oncology in Liver Cancer: Genomics, Infection, and the Exposome in African and Global Contexts explores liver cancer through the lens of precision medicine, integrating molecular profiling, environmental exposures, and targeted therapies. The book presents a multidisciplinary approach, covering infectious drivers like HBV/HCV, environmental carcinogens such as aflatoxins, and emerging tools including genomics, AI, and liquid biopsies. It emphasizes African-specific challenges and innovations, with case studies and comparative global insights. This volume equips researchers, clinicians, and policymakers with evidence-based strategies to address liver cancer disparities, offering a forward-looking framework for equitable cancer care and research in Africa and globally.

  • The Vitamins

    Fundamental Aspects in Nutrition and Health
    • 7th Edition
    • Gerald F. Combs Jr. + 1 more
    • English
    The Vitamins: Fundamental Aspects in Nutrition and Health, Seventh Edition presents both overviews and in-depth discussions of the sources, chemistry, metabolism, and functions of these essential nutrients in physiology and health. Further building upon previous editions of this widely used reference text, readers will gain updated information on the inclusion and interpretation of recent clinical research findings relevant to all vitamins, particularly Vitamins A, D, E, K, C, thiamin, folate and Vitamin B12. The latest information on nutritional deficiencies and ecological approaches to dealing with them along with a section on vitamin-drug interactions is also included.Readers will also find a revised table of signs of vitamin deficiencies in humans and animals, updated information on the roles of the gut microbiome in vitamin synthesis and metabolism, increased focus on vitamins as nutritional supplements, increased focus on vitamin stabilities in foods, including processing and cooking losses and a decision tree addressing the question: “Could I benefit from a vitamin supplement?.” At the end of each chapter, case studies, a quiz, and recommended reading list are included.

  • Practice of Neurocritical Care in Resource Limited Countries

    • 1st Edition
    • Hemanshu Prabhakar + 2 more
    • English
    Practice of Neurocritical Care in Resource Limited Countries offers a comprehensive examination of the unique challenges and practical strategies for delivering neurocritical care in low- and middle-income countries (LMICs). As the prevalence of neurological emergencies continues to rise in these regions, this book addresses the critical need for effective management in resource constrained environments. It begins by exploring the landscape of neurocritical care, including common neurological emergencies and their epidemiology in LMICs. The content outlines foundational principles of patient assessment and monitoring, as well as advanced management strategies for conditions such as traumatic brain injury, stroke, and spinal cord injury. Special attention is given to the nuances of caring for diverse patient populations, including pediatric and geriatric patients. Additionally, this book highlights the essential role of pain management, and nutritional support, in neurocritical settings. With contributions from experts across various LMICs, this resource emphasizes innovative approaches to training and capacity building, empowering healthcare professionals to provide high-quality neurocritical care despite the challenges of limited resources. This book is an invaluable tool for clinicians and educators dedicated to improving outcomes for neurologically ill patients in lesser-resourced healthcare systems.

  • Advances in Applied Mechanics: Letters

    • 1st Edition
    • Volume 63
    • English
    Advances in Applied Mechanics, Volume 63 highlights new advances, with this volume presenting interesting chapters written by an international board of authors. Chapters in this release cover higher order discontinuous Galerkin finite element methods for the contact problems, Anisotropic Recovery-Based Error Estimators and Mesh Adaptation Tailored for Real-Life Engineering Innovation, Adaptive mesh refinement on Cartesian meshes applied to the mixed finite element discretization of the multigroup neutron diffusion equations, and more. Other sections cover a posteriori error analysis for Finite Element approximation of some groundwater models Part I: Linear models, a posteriori error estimates for low frequency electromagnetic computations, and more.

  • Modern Bioinformatics

    From Molecular Insights to Biomedical Innovation
    • 1st Edition
    • Kolla Bhanu Prakash + 2 more
    • English
    Modern Bioinformatics: From Molecular Insights to Biomedical Innovation explores the rapidly advancing field of bioinformatics, addressing a critical gap in current literature by integrating quantum biology and quantum biosensors with computational bioinformatics. The book offers a thorough exploration of bioinformatics from foundational concepts to translational applications. It begins with molecular structures of proteins, DNA, and RNA, advancing through nano-molecular visualization and structural domain analysis. Readers gain insights into deep learning techniques like AlphaFold for protein structure prediction, AI applications in genomics, and molecular interactions critical to function. The text further covers computational methods in drug discovery, forensic bioinformatics, and molecular evolution.A unique emphasis is placed on the convergence of nanotechnology and quantum innovations in molecular diagnostics and biosensing, including quantum biosensors and quantum computing applications. The final sections focus on computational strategies for drug target identification, biomarker discovery, and clinical trial analysis, providing a holistic view of modern bioinformatics workflows. This book is an indispensable reference for advanced researchers, graduate students, and professionals in bioinformatics, molecular biology, and biomedical engineering seeking to integrate quantum computing and nanotechnology into their work.

  • Wellbeing and Ethics of Animals in Shelters

    • 1st Edition
    • Mandy B.A. Paterson + 1 more
    • English
    Wellbeing and Ethics of Animals in Shelters provides an up-to-date, all-in-one resource for animal care and shelter professionals seeking the latest guidance on improving sheltered animals’ quality of life. Central chapters review health and behavioral assessments for shelter animals, offer guidance for the care of shelter cats and dogs, and discuss key steps to the successful adoption of sheltered animals. Latter chapters explore the human component of shelter animal care. The book is an accessible and important resource for animal care and shelter professionals, animal welfare researchers, and students of animal behavior, biology, and veterinary sciences.Thousands of unwanted dogs, cats, and other animals are brought under the care of shelters around the world each year. The transition can be a frightening and stressful experience with physiological and behavioral implications for the animals. Written by renowned animal welfare experts, this book not only covers guidance on improving the lives of sheltered animals, but also explores how animals come to be under the care of shelters and the ethical considerations of sheltering animals.

  • Disorders of Memory

    • 1st Edition
    • Andrew E. Budson + 1 more
    • English
    Disorders of Memory provides a new update on research pertaining to memory disorders, with a central focus on differing components of memory processes, as well as clinical conditions affecting memory. The book covers methods of assessment and clinical treatment, management, and rehabilitation of these disorders. With chapters written by leading international experts, it provides an overview of our current knowledge on memory disorders that will be of benefit to both researchers and practitioners interested in neurology.

  • Pediatric Pulmonology

    A Global Handbook for Clinical Care Providers
    • 1st Edition
    • Allen J. Dozor
    • English
    Pediatric Pulmonology: A Global Handbook for Clinical Care Providers provides an in-depth exploration of pediatric respiratory diseases, offering a detailed examination of various conditions, diagnostic techniques, and treatment protocols. The book covers a wide range of topics, from the assessment of children with respiratory diseases to specific conditions such as asthma, cystic fibrosis, and bronchopulmonary dysplasia. Each chapter is contributed to by leading experts in the field, ensuring that the content is both authoritative and up-to-date. These crucial, practical skills are essential when a pediatric patient's first point-of-care is not a respiratory specialist.This is especially true of medical treatment in resource-poor areas. The book includes "how to guides" on vital procedures such as spirometry, chest imaging, and the management of respiratory emergencies. It also addresses respiratory diseases in newborns, the impact of environmental factors on children's respiratory health, and the unique challenges faced by children with neurologic and neuromuscular diseases. This comprehensive approach ensures that non-specialists gain a holistic understanding of pediatric respiratory diseases and their management.

  • Bioactive Compounds in Leaves of Bulbs, Roots, and Tubers

    A Food Chemistry Approach to Nutritional, Biological, and Pharmaceutical Applications
    • 1st Edition
    • Neela Satheesh + 1 more
    • English
    Bioactive Compounds in Leaves of Bulbs, Roots, and Tubers: A Food Chemistry Approach to Nutritional, Biological, and Pharmaceutical Applications offers a crucial resource for researchers and industry professionals aiming to harness underutilized plant parts for health and sustainability. Despite their rich phytochemical profiles and potential health benefits, these leaves remain largely unexplored, representing a missed opportunity for functional food development, nutraceuticals, and pharmaceuticals. This book bridges that knowledge gap by providing detailed insights into their chemical composition, bioactive properties, and innovative extraction methods, promoting their integration into food and medicine. It covers an extensive range of topics, including phytochemical profiling, nutritional and anti-nutritional analysis, green extraction technologies, and applications of bioactive compounds from turmeric, sweet potato, carrot, cassava, radish, turnip, kohlrabi, sugar beet, yam, taro, ginger, onion, garlic, and potato leaves. Additionally, it discusses safety, regulatory frameworks, and the potential use of these leaves as nutraceuticals, functional foods, and even animal feed, highlighting their significance for health and environmental sustainability. Bioactive Compounds in Leaves of Bulbs, Roots, and Tubers serves as an essential reference for advancing research, innovation, and sustainable utilization of these bioresources to improve human health, reduce waste, and promote eco-friendly food and pharmaceutical solutions.

  • Pharmaceutical Hot Melt Extrusion

    From Materials Selection to Commercial Production
    • 1st Edition
    • Purnima D. Amin
    • English
    The Practical/User Manual for Making Pharmaceutical Products with Hot Melt Extrusion (HME) is a comprehensive resource addressing the evolving landscape of HME technology. This reference explores the core principles of formulation development, equipment design, process scaling, and regulatory considerations, providing essential knowledge for researchers and industry professionals. It emphasizes innovative, green manufacturing practices, solvent-free processes, and patient-centric delivery systems, making it a vital guide for advancing pharmaceutical and nutraceutical formulations.This reference enhances understanding of cutting-edge HME applications, supporting environmentally sustainable practices and innovative product development for both academia and industry. It equips formulation scientists, R&D professionals, and students with the knowledge to accelerate research, improve efficiency, and translate laboratory innovations into market-ready solutions.

  • Progress in Medicinal Chemistry

    • 1st Edition
    • Volume 65
    • English
    Progress in Medicinal Chemistry, Volume 65 brings together state-of-the-art reviews and critical insights from leading scientists in the field. Each volume surveys the latest advances in drug discovery and development, with a focus on practical strategies, novel modalities, and real-world case studies. From target identification and structure-based design to optimization of pharmacokinetic properties, safety assessment, and translational science, these volumes provide a comprehensive, up-to-date overview for researchers, graduate students, and professionals working in medicinal chemistry, pharmacology, and related life sciences.Chapters in this new release cover Molecular Glues and Tactics in Hit Finding through to Lead Generation in Drug Discovery – current position and future directions.

  • Annual Reports in Medicinal Chemistry

    New Approaches in Conjugate Drug Design: Part 1
    • 1st Edition
    • Volume 67
    • English
    New Approaches in Conjugate Drug Design: Part 1, published as Volume 67 of the serial Annual Reports in Medicinal Chemistry, provides a comprehensive overview of current strategies in the design and application of drug conjugates. Chapters cover small molecule drug conjugates, antibody-to-small molecule carrier approaches, antibiotic-derived and terpene-derived antimicrobial conjugates, aptamer-RNA conjugates, and phenolic and metal natural product conjugates. Applications span anticancer, antiviral, antifungal, and theranostic therapies, including photoactivatable therapy and emerging approaches in quantum oncology. The volume serves as a reference on design principles, therapeutic applications, and clinical progress in conjugate-based drug discovery.

  • Analytical Pharmacology

    • 1st Edition
    • Su Zeng + 1 more
    • English
    Analytical Pharmacology covers a wide range of analytical methods, including PCR, flow cytometry, molecular imaging, and gene editing, in the context of mechanistic studies, target discovery, biomarker development, drug metabolism, and clinical evaluation. The comprehensive scope and emphasis on emerging technologies make it a valuable resource for researchers seeking to understand how analytical tools are applied to solve key scientific problems in pharmacology and toxicology. Pharmaceutical industry specialists, including quality control analysts, regulatory affairs specialists and pharmaceutical technicians, will find value in understanding how modern analytical techniques can enhance drug quality assessment and compliance with regulatory requirements. For all readers interested in practical applications there are detailed descriptions of analytical techniques and validation methods. Case studies are used throughout to enrich theory and practical application.The book offers research and academic readers detailed information on the emerging technologies of spatial transcriptomics and spatial omics, supporting their application in research studies and teaching

  • Vegan Food Products

    Sources, Production Methods, Challenges and Improvement Strategies
    • 1st Edition
    • Tuba Esatbeyoglu + 1 more
    • English
    Vegan Food Products: Sources, Production Methods, Challenges and Improvement Strategies assembles the science related to different vegan foods in a comprehensive reference that discusses the benefits and challenges of vegan food products. Comprised of 11 chapters, the book covers the vegan alternatives of different food groups, including meat, fish, egg, and dairy. It also presents a variety of vegan protein sources, such as plant-based proteins, macro- and microalgae and single-cell proteins. Sections explore production methods and technologies, including extrusion, dry-fractionation methods for enriching proteins, 3D printing, and in vitro methods. In addition, the health aspects of vegan foods, with a specific chapter devoted to the fortification studies, are covered, as well as the vegan food market, the consumer perception, and the sensory and nutritional quality of vegan products. Edited by well-known global researchers in the field, this book provides readers with a broad review of the most recent research on the opportunities and challenges of vegan ingredients and foods.

  • Bioactives from Aquatic Side Streams

    Innovative Extraction Procedures and Applications
    • 1st Edition
    • Sakhi Ghelichi + 2 more
    • English
    Bioactives from Aquatic Side Streams: Innovative Extraction Procedures and Applications examines the untapped potential of aquatic resources and byproducts as a rich source of bioactive compounds, including proteins and peptides, omega-3 fatty acids, phenolic compounds, pigments, vitamins, and minerals. With a focus on sustainable practices, this book explores the identification, extraction, characterization, and application of these bioactive compounds across various industries. Early chapters characterize the bioactivity of key compounds, describe the aquatic side streams available for sourcing these compounds, and provide a high-level overview of their extraction techniques.Central chapters focus on these processes for specific bioactive compounds, including hydrolysates, peptides, omega-3 oil, phospholipids, collagen, gelatin, chitin, chitosan, minerals, pigments, and more. Concluding chapters explore emerging techniques, market hurdles and possible solutions, and regulatory considerations for the sustainable sourcing of bioactive compounds from aquatic side streams. By equipping readers with the knowledge to develop new products that enhance existing ones, this book promotes the innovative use of aquatic byproducts for a more sustainable future.

  • Encyclopedia of Pharmacy Practice and Clinical Pharmacy

    • 2nd Edition
    • Zaheer-Ud-Din Babar
    • English
    Encyclopedia of Pharmacy Practice and Clinical Pharmacy, Second Edition, Four-Volume Set is a comprehensive international reference examining the science, practice, policy, and impact of medicines use across healthcare systems. Featuring around 210 chapters written by experts from around the world, it provides authoritative coverage of clinical pharmacy, pharmacy practice research methods, medication safety, medicines optimization, pharmacoepidemiology... pharmacovigilance, health policy, social and administrative pharmacy, pharmacoeconomics, public health, digital health, implementation science, pharmacy education, and workforce development.Designed to support both teaching and research, the encyclopedia brings together foundational knowledge, research methodologies, professional practice, and emerging developments in healthcare delivery. The content is written and referenced with the latest published empirical research.It serves undergraduate and postgraduate students, doctoral researchers, educators, pharmacists, clinicians, healthcare leaders, and policymakers, while supporting programmes in pharmacy, pharmacology, public health, health services research, and healthcare management.By bringing together scientific evidence, practice, and policy, this updated edition provides a valuable resource for understanding the evolving role of medicines and pharmacy in improving patient and population health worldwide.

  • Microbial Biofilms and Cancer - Part B

    • 1st Edition
    • Volume 225
    • English
    Biofilms in Cancer: Molecular Mechanisms, Host Reprogramming and Tumor Progression presents a focused and multidisciplinary examination of the emerging role of microbial biofilms in cancer biology. The volume challenges the conventional view of biofilms as merely persistent microbial communities and highlights their potential contribution to chronic inflammation, host-cell reprogramming, tumor development, cancer progression, and invasion.The book begins by establishing biofilms as an underestimated threat in cancer, providing a foundation for understanding the complex interactions between microbial communities and malignant tissues. It subsequently explores the molecular mechanisms through which quorum sensing and biofilm-associated signals can influence host-cell behavior, together with the mechanisms underlying biofilm formation and microbial interaction with host cells.A major focus of the volume is the biofilm-mediated modulation of the tumor microenvironment. The chapters examine how biofilm components can dysregulate cytokines and chemokines, sustain chronic inflammatory responses, and create conditions that may favor tumorigenesis. Particular attention is given to the transition from persistent microbial colonization and inflammation to malignant transformation and tumor progression.The book also provides organism- and cancer-specific perspectives, with detailed discussions of the contribution of Porphyromonas gingivalis and Candida biofilms to oral squamous cell carcinoma, as well as the involvement of Helicobacter pylori, Fusobacterium nucleatum, P. gingivalis, Escherichia coli, and Candida across specific cancer contexts. These chapters highlight the diversity of microbial strategies and host responses associated with biofilm-linked malignancies.The concluding perspective addresses the emerging role of biofilms in cancer invasion, bringing together microbial persistence, host-cell interaction, inflammatory signaling, and tumor progression into an integrated framework. Collectively, the volume provides a comprehensive overview of the biofilm–host–inflamm... axis, emphasizing how microbial communities may influence different stages of cancer biology.This book will be valuable to microbiologists, cancer biologists, oncologists, molecular biologists, immunologists, oral health researchers, infectious-disease specialists, biotechnologists, clinicians, and postgraduate researchers seeking to understand the increasingly important intersection of microbial biofilms and cancer. It also provides a foundation for identifying new research questions, biomarkers, preventive strategies, and potential therapeutic targets at the interface of infection and malignancy.

  • Innovations for Sustainable Agriculture

    From Lab to Farm to Table
    • 1st Edition
    • Katarzyna Chojnacka + 1 more
    • English
    Mixed crop-livestock systems offer promising strategies for sustainable farming. Innovations for Sustainable Agriculture: From Lab to Farm to Table details solutions for mitigating agricultural waste, such as carbon emissions and chemical runoff, and creating a circular economy on mixed farms. In addition to covering potential solutions, the book will analyze the effectiveness of each strategy in protecting the environment from harm. Notable topics covered include manure management, agricultural waste valorization, wastewater and resource recovery, and even dairy cow feed for lowering methane production.While the book is based primarily on the climates and farming systems of Europe, the climactic diversity of the continent will make this a useful resource for many other parts of the world with similar climates, including North America and portions of South America, Asia, and Oceana. Innovations for Sustainable Agriculture: From Lab to Farm to Table offers practical strategies and solutions to readers and will benefit audience members ranging from students and researchers to farmers and agricultural stakeholders.

  • Advances in Virus Research

    • 1st Edition
    • Volume 126
    • English
    Advances in Virus Research series, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.

  • Biomedical Basis of Human Disease

    From Research to Clinic
    • 1st Edition
    • Ahmed El-Hashash + 3 more
    • English
    Biomedical Basis of Human Disease: From Research to Clinic provides information on pathophysiology/mech... of organ system disease and selected disorders and diseases that cause the most deaths worldwide, including but not limited to cardiovascular, respiratory, gastrointestinal and nervous systems. This information is placed within the structural context of tissue/organ, molecular and cellular biology, pathophysiology, diagnostic and treatment methods, and disease models in sections that also describe recent research examples, such as recently developed cutting-edge in vitro and in vivo biomedical science methods to bridge the bench and bedside. This text is suitable for students, researchers and practitioners in biomedicine and basic medicine.

  • The Renaissance in GPCR Research and Drug Discovery

    Receptor Function, Receptor Structure, New Techniques, and Characterization of Drug Activity
    • 1st Edition
    • Terry P. Kenakin
    • English
    The Renaissance in GPCR Research and Drug Discovery: Receptor Function, Receptor Structure, New Techniques, Characterization of Drug Activity, Drug Discovery is a comprehensive reference for pharmacology researchers. It focuses on utilizing novel aspects of GPCR function for therapeutic advantage and applying new chemical types to modify GPCR behavior. Recent advancements have revitalized GPCR discovery, opening unexplored avenues for new drug development. The book's content is meticulously divided into five distinct parts, covering evolutionary perspectives, novel functions, investigative technologies, therapeutic modalities, and a broad range of GPCR ligands.Beyond these key topics, the book delves into the evolution of GPCRs as drug targets, the mechanisms behind their novel functions, and the latest technologies driving research and discovery. It also highlights new and recently approved therapeutic modalities and provides a broad coverage of GPCR ligands. Edited and authored by leading researchers, this book serves as an essential reference for drug discovery researchers and medicinal chemists, as well as AI researchers exploring this drug discovery space.

  • Cultured Meat Production

    Advances, Challenges and Opportunities
    • 1st Edition
    • Zuhaib F. Bhat + 1 more
    • English
    Cultured Meat Production: Advances, Challenges and Opportunities discusses technologies in this exciting field, along with the feasibility of commercial production of fully structured cultured meat and seafood. In addition to covering the latest science, the book examines consumer perception, religious and cultural considerations, and regulatory aspects, such as quality assurance and food safety. The book's chapters are written by academic and industry experts from around the world at the forefront of this exciting field. Researchers, entrepreneurs, and advanced student audiences who are interested in getting up-to-speed on lab-grown meat won't want to miss this timely book.The ever-expanding human population calls for novel ways to produce protein of sufficient quality and quantity, however finite animal and land resources and increasing environmental concerns are already beginning to limit our capacity to produce an adequate protein supply. Novel technologies now allow for the production of cultured meat and seafood, offering a potentially lower carbon footprint and substantially eliminating animal suffering.

  • Novel Plant Proteins as Mainstream Ingredients for Future Foods

    • 1st Edition
    • Khetan Shevkani
    • English
    Novel Plant Proteins as Mainstream Ingredients for Future Foods addresses the techno-functionality... health benefits, and sustainability of alternative proteins from familiar plant sources such as quinoa and other pseudocereals, rice bran, and hempseeds, along with more novel sources such as nigella seeds, fenugreek, moringa leaves, and the aquatic plant duckweed. The book provides a concise overview of the techno-functional, nutritional, and nutraceutical properties of these proteins that are essential for their application in functional foods, dietary supplements, and in the creation of healthier foods. Sections discuss advanced processing technologies capable of overcoming the limitations of conventional protein extraction methods and highlight the composition and nutritional value of fruits and vegetable by-products, elaborating on the quality and techno-functionality of fruit and vegetable seed protein isolates to critically examine their adoption by the food industry. The book concludes by analyzing the challenges associated with plant proteins such as allergens, antinutrient presence, compositional inconsistencies, poor nutritional quality compared to animal proteins, and undesirable sensory effects, along with promising solutions to enhance future applications.

  • Plant-Induced Systemic Resistance

    Mechanisms and Applications Against Biotic and Abiotic Stressors
    • 1st Edition
    • Sengottayan Senthil-Nathan + 2 more
    • English
    Plant-Induced Systemic Resistance: Mechanisms and Applications Against Biotic and Abiotic Stressors examines how intrinsic defense signaling and state-of-the-art biotechnologies can fortify crops while reducing reliance on chemical inputs. This rigorous treatment unpacks the biochemical circuitry of induced immunity, the networks coordinating defense, and the innovative molecular biology tools that empower durable protection under a variety of stress triggers. Against the backdrop of rising pest pressures, evolving resistance patterns, and environmental concerns, it presents a forward-looking framework for integrating host defenses within comprehensive crop protection initiatives.This volume traces a clear trajectory from foundational concepts to precision management solutions, delivering data-driven methodologies, decision support tools, and scalable practices for sustainable agriculture, enriched by real-world case studies that illustrate adoption across research, extension, and industry contexts. Governance, regulatory considerations, and societal implications are woven throughout to ensure responsible innovation.Bridging lab-derived knowledge with field-ready interventions, this essential resource opens avenues for interdisciplinary collaboration to bolster plant resilience against various biotic and abiotic stressors, expanding the toolkit for integrated crop protection.

  • Immunotherapy for Autoimmune Disorders

    Innovations and Insights
    • 1st Edition
    • Arun Kumar Singh + 4 more
    • English
    Immunotherapy for Autoimmune Disorders: Innovations and Insights revolutionizes the therapeutic paradigm for autoimmune illnesses, offering new perspectives over traditional medication therapies. This complete and accessible resource examines how immunotherapy teaches the immune system to detect and fight targeted cells, enhancing the body's immune response by providing additional components to strengthen its defense mechanisms. The book covers a wide range of topics, including the pathophysiology, diagnosis, and classification of autoimmune diseases, the immunopathogenesis of these disorders, and the development and application of monoclonal antibodies. It explores immune checkpoint inhibitors, T-cell modulation therapies, cytokine targeting therapies, B-cell depletion strategies, and more.Additionally, it addresses immunomodulatory agents, small molecules, personalized immunotherapy approaches, and the application of immunotherapeutic strategies for specific autoimmune diseases. Future directions and emerging therapies, as well as regulatory and ethical considerations, are also discussed. This is essential reading for medical professionals, researchers, and students seeking to learn about immunotherapy as an alternative approach to treating autoimmune disorders.

  • Advances in Clinical Chemistry

    • 1st Edition
    • Volume 135
    • English
    Advances in Clinical Chemistry series, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.

  • Comparative Fish Immunology

    • 1st Edition
    • Volume 42
    • English
    Comparative Fish Immunology, Volume 42 in the Fish Physiology series, presents chapters written by leading experts. Covering a broad range of topics, this edition explores the evolution and function of immune systems in fish, with particular attention to both innate and adaptive immune mechanisms across diverse aquatic species. Chapters examine adaptive immunity in jawless vertebrates and the unique VLR system, the role of antimicrobial peptides in teleost infections, and the use of zebrafish as a model for studying innate immune responses. Additional contributions explore pharyngeal mucosal lymphoid structures, the evolutionary origins of germinal centers in fish, and mechanisms of antigen presentation in teleosts.Other chapters address microbiota–host immune interactions, emerging insights into teleost neuroimmunology, and the modulation of immune function through behavioral fever. Together, these contributions provide a comprehensive overview of current discoveries and evolving perspectives in fish immunology, offering valuable insights for researchers, immunologists, and aquatic biologists interested in the physiology and immune biology of fishes.

  • Respiratory Critical Illness During Pregnancy

    Critical Care in Obstetrics
    • 1st Edition
    • English
    Respiratory Critical Illness During Pregnancy: Critical Care in Obstetrics, a volume in the Critical Care Obstetrics series, provides a novel reference for healthcare personnel caring for pregnant women with various health compromises specific to respiratory complications. The book's chapters reflect the growing scope of critical care obstetrics and the increasing importance and recognition of the hospital structure's field, covering the most common respiratory complications that any patient can present during pregnancy, including Asthma, Pulmonary Hypertension and Infection, Cystic Fibrosis, Sleep Disorders, Respiratory failure and more.All intensivists, regardless of primary discipline, must possess a core set of critical care skills that allow them to manage critically ill patients. Here, the authors have gathered the best evidence-based material on respiratory scenarios.

  • Probiotics

    A Comprehensive Exploration of Health Benefits and Innovation
    • 1st Edition
    • Ranbir Chander Sobti
    • English
    Probiotics: A Comprehensive Exploration of Health Benefits and Innovation explores the potential of probiotics and their fundamental role in human health and disease prevention. The book offers a thorough understanding of how beneficial microorganisms can enhance overall well-being and potentially transform treatment approaches across multiple disciplines. The first section lays the groundwork by exploring the fundamentals of probiotics, prebiotics, and their interactions with the human microbiome, while the second section examines the role of probiotics in disease prevention and management, highlighting their impact on conditions such as diabetes, obesity, and mental health.The third section discusses specialized applications of probiotics in women's health, pediatrics, and geriatrics, as well as their innovative uses in skin care and nutrition. Finally, the fourth section investigates the future potential of probiotics in synthetic biology, in personalized health, and in combatting antibiotic resistance. With contributions from a diverse group of experts in the field, the book serves as an interdisciplinary resource for researchers, clinicians, and industry professionals eager to explore the therapeutic potential and benefits of probiotics.

  • Chia Seeds

    Applications in the Agri-food Industry
    • 1st Edition
    • Shivani Pathania + 2 more
    • English
    Chia Seeds: Applications in the Agri-food Industry is a comprehensive guide to the properties of chia biomass (seeds, leaves, and ingredients/products thereof) and their utilization in the agri-food industry and beyond. The book is based on the analysis of chia value chain and summarizes the scientific, technical, and health aspects of chia (Salvia hispanica L.). Divided into 3 sections, it fills a critical gap in the literature by providing a comprehensive overview of chia biomass available to address key global bioeconomy and United Nation Sustainable Development Goals (SDGs) challenges.User will find advanced information for the utilization of chia-based biomass based on their specific properties, application of eco-efficient technologies for their processing and conversion into a variety of products for different groups of consumers, including those with special needs (e.g. celiac patients, vegans and vegetarians). In addition, the book offers practical guidance on the development of new value chains and their integration within the existing agri-food systems.

  • Clinical Genomics

    A Guide to Clinical Next Generation Sequencing
    • 2nd Edition
    • Shashikant Kulkarni + 1 more
    • English
    Clinical Genomics, Second Edition is a comprehensive, practical reference [AN1] designed specifically for laboratory directors, clinical medical directors, and genomic medicine professionals. Edited by renowned genomic pathology leaders Kulkarni and Roy, this updated edition offers clear guidance on the current technical, bioinformatic, clinical, regulatory, and reimbursement considerations involved in implementing next-generation sequencing technologies within clinical molecular diagnostic laboratories.Structu... for ease of reference, this book covers targeted gene sequencing methods, whole exome/genome approaches, emerging technologies such as long-read sequencing, and critical considerations for assay validation. Detailed sections address bioinformatics workflows, variant detection and interpretation methodologies, integration with clinical informatics systems, and essential IT infrastructure, including cloud-based solutions.This book also thoroughly addresses practical topics essential to laboratory management, such as regulatory compliance, ethical frameworks, billing strategies, and reimbursement paradigms, helping directors navigate the evolving landscape of genomic diagnostics.

  • Marine Mercury Bioaccumulation

    • 1st Edition
    • Luiz Drude de Lacerda
    • English
    Marine Mercury Bioaccumulation presents state-of-the-art research on mercury bioaccumulation in marine life. Written by leading experts in marine toxicology, this book delivers the latest information on monitoring and modeling mercury biomagnification in key marine taxa. Early chapters introduce the basic biology and ecology of how mercury travels through marine organisms and accumulates within marine food webs. Central chapters discuss the current status and exposure risks of key taxa, including marine vegetation, invertebrates, fishes, mammals, and birds. The book concludes with an assessment of human exposure to mercury through seafood products and novel modeling tools to assess environmental exposure risks and bioaccumulation.User... will find this to be a great resource for a global assessment of mercury contamination in the ocean, including biological resources, monitoring and modeling, current tools, existing research gaps, and suggestions on how to improve our monitoring and policy tools for improved safety of marine life and human consumption. This is an indispensable tool for researchers, resource managers, fisheries stakeholders, and students alike.

  • Perianal Crohn’s Disease

    Diagnosis and Treatment
    • 1st Edition
    • Bolin Yang + 2 more
    • English
    Perianal Crohn’s Disease: Diagnosis and Treatment includes the latest knowledge, concepts, first-hand theoretical views, and clinical experience of clinical frontline experts in the field of inflammatory bowel disease. The book systematically describes disease phenotypes, clinical features, examination methods, diagnoses, and treatments. It takes a scientific, practical, and systematic account of both common and rare conditions associated with Perianal Crohn’s Disease, offering informative content, clinical case information, cutting-edge viewpoints, and current, authoritative research findings. The book contains a depth of current clinical experience, including the use of photographs to support examples of conditions, methods, and techniques. In addition, it provides clear ideas and a wealth of clinical information for the clinical diagnosis and management of perianal Crohn's disease.

  • Protein Kinase Inhibitors

    The Promise of Natural Products in Cancer Therapeutics
    • 1st Edition
    • Md. Imtaiyaz Hassan + 1 more
    • English
    Protein Kinase Inhibitors: The Promise of Natural Products in Cancer Therapeutics explores a novel therapeutic avenue for cancer treatment through nutraceutical-based kinase inhibitors. The book covers their historical background, outlook, mechanistic pathways, and clinical aspects, highlighting their relevance in cancer therapy. It also examines the potential of polyphenolic derivatives and other natural compounds in inhibiting key kinases involved in major cancer signaling pathways, focusing on their application in clinical trials and marketed drugs. Sections explore the implications of polyphenols in cancer management, novel sources of breast cancer inhibitors, the role of natural products in lymphoma therapy, and the multitarget potential of phytochemicals. Each chapter is designed to provide a thorough understanding of how natural products can be harnessed to develop innovative cancer therapeutics. It will serve as a valuable resource for academics, scientists, young researchers, students, and pharmacists working or interested in kinase biology and cancer therapeutics with its unique perspective on using nature's own arsenal to combat cancer.

  • Wood-Water Interactions

    • 1st Edition
    • Samuel L. Zelinka + 3 more
    • English
    Wood-Water Interactions examines the complex relationship between wood and water using an intuitive approach to what has historically been treated as an opaque and demanding field of study. Wood-moisture interactions dominate nearly every facet of wood technology and utilization, yet new findings continue to change our understanding of this topic. Authored by experts in the field, the chapters follow a logical structure and include case studies with vivid illustrations. Readers are motivated to understand updated information about the interaction of water with wood, the effect of changes in moisture content on the properties of wood and wood-based materials as well as the latest research methods used to study wood-water interactions.

  • Pediatric Deep Brain Stimulation

    • 1st Edition
    • George M. Ibrahim + 1 more
    • English
    Pediatric Deep Brain Stimulation offers the first comprehensive, multi-disciplinary exploration of this rapidly advancing field, providing clinicians with an authoritative guide to the science, practice, and future of pediatric neuromodulation.Orga... into four integrated sections, the book begins with the essentials of a pediatric DBS program—including state-of-the-art imaging, peri-operative management, complication avoidance, and ethical considerations unique to the developing brain. Subsequent chapters examine the use of DBS across the spectrum of childhood movement disorders, from monogenic and acquired dystonias to non-dystonic conditions. A dedicated section addresses neuromodulation for pediatric epilepsy, with a focus on emerging technologies. The book concludes with cutting-edge applications of DBS in neurodevelopmental and neuropsychiatric disorders and a view toward the integration of neuroengineering to expand the reach and future potential of circuit-based interventions in children.Edited by a pediatric movement disorders neurologist and a pediatric functional neurosurgeon who together direct an integrative, comprehensive pediatric DBS program, this volume brings a uniquely collaborative perspective and deep clinical expertise. It is an essential resource for neurosurgeons, neurologists, epileptologists, pediatric specialists, and researchers committed to advancing care for children with severe neurological disease.

  • Diagnostic Reasoning

    Laboratory-Based Case Studies in Clinical Chemistry
    • 1st Edition
    • Ibrahim A. Hashim
    • English
    Training in clinical chemistry is acquired via different avenues that include didactic lectures on pathophysiology of disease, methodologies and practical aspects of testing, and through attendance of operations meetings, sign-out sessions, seminars and tutorials. There is little instruction on how to apply the vast amount of knowledge gained in the process to practice. In other branches of medicine, cases are regularly presented with clinical information and therapeutic interventions which form the basis of training. Diagnostic Reasoning: Laboratory-Based Case Studies in Clinical Chemistry fills this gap for clinical chemistry. The concise and practical approach of the book, including real-life scenarios, is an excellent resource for pathology trainees, clinical laboratory science students, clinical chemistry fellows, clinical laboratory professionals, and clinicians. These cases help professionals remain competent in the field and be successful in their board exams. The cases are stated as they present, often with no or few clinical details accompanying the sample request with only barcoded samples arriving into the laboratory. In a busy laboratory, thousands of these cases are received daily and it is impossible to review the clinical information associated with the specimens.

  • Patient Treatment and Management Following an Osteoporotic Vertebral Compression Fracture

    • 1st Edition
    • Douglas P. Beall
    • English
    Worldwide, vertebral compression fractures (VCFs) continue to be the most common major fragility fracture, affecting patients over the age of 50, and osteoporosis is the most prevalent condition associated with VCFs. Patient Treatment and Management Following an Osteoporotic Vertebral Compression Fracture provides treatment and management guidance of the osteoporosis disease process in patients who have had a VCF. This book opens with a foundation of osteoporosis and VCF and then reviews clinical and radiological assessment approaches, evaluation, treatment, and ongoing management options. Subsequent chapters cover the efficacy of the different vertebral augmentation types on patient outcomes, optimization methods, decisions for osteoporosis treatment in these patients, and recommendations to improve patient outcomes. Special attention is paid to the treatment sequence and objectives following an osteoporotic VCF. This book concludes with coverage of insightful developments in clinical management and current research and features targeted case studies representing common patient characteristics that showcase varying aspects of different VCFs and the underlying osteoporosis that gives rise to these fractures. This title serves as an invaluable resource for any practitioner managing fragility fractures in older patients as well as treating their underlying osteoporosis.

  • Thin Film Photovoltaics

    Single-Junction and Tandem
    • 1st Edition
    • Jeyakumar Ramanujam + 1 more
    • English
    Thin Film Photovoltaics: Single-junction and Tandem provides a comprehensive introduction to thin film solar cells and the latest developments in this expanding field. The book includes detailed information on material properties required for solar cells, working principles, energy band structure, charge transport to the electrodes and approaches to improve efficiency. Front-end and back-end processes are discussed in detail. Current challenges to commercial translation and potential opportunities to overcome to those challenges are also covered, and factors limiting solar cells parameters are also considered. Emphasis is on new materials and state-of-the-art technologies used for fabrication and characterization.Thi... book is suitable for researchers in academia and R&D in the subject areas of materials science and engineering, energy, physics, and chemistry.

  • Politics, Practice, and Policy

    How to Get Things Done in Food and Nutrition, 10 Case Studies
    • 1st Edition
    • Eileen Kennedy
    • English
    Food and Nutrition Policy: 10 Case Studies for Developing Effective Policies and Programs explains how policy compromises are reached and then changed over time as new information becomes available. Derived from the authors’ experiences while serving as a political appointee in the federal government, participating in international committees and boards, and from materials from a graduate course which she teaches on global food and nutrition policy at Tufts University, the 10 case studies presented in this book provide real world learning examples on how contentious issues are resolved in the political process.While each of the ten chapters focuses on a specific topic, the book showcases an overriding theme of food and health justice, equity, and empowerment. Readers will deduce key factors to examine pivotal policy decisions while the author dissects polarizing topics such as examining the successes and failures of dietary guidelines, front label packaging approaches, implications of expanding personalized nutrition, the obesity epidemic and the role of GMO’s in agricultural production, and more.

  • Guide to Plant Transcription Factors

    • 1st Edition
    • Aryadeep Roychoudhury
    • English
    Guide to Plant Transcription Factors is the first comprehensive resource on the dynamics of transcription factor function in plants, covering their roles in process regulation, stress management, post-translational modification, and epigenetic control. The book explores how transcription factors can be manipulated or engineered for crop improvement, offering insights into their regulatory mechanisms and practical applications.Transcr... factors bind to upstream regions of target genes and recruit additional proteins, often facilitating chromatin remodeling to enable further binding. They play critical roles in diverse physiological processes, including seedling development, shoot and root growth, flowering, fruit ripening, seed maturation, nitrogen fixation, and photosynthesis. Plant transcription factors belong to numerous families, each with distinct mechanisms and functions. They also govern plant responses to pathogens and tolerance to abiotic stresses through complex gene regulatory networks.This volume provides a systematic overview of recent advances in transcription factor research, their relationship with stress tolerance, and the roles of individual transcription factors in plant systems. Featuring contributions from leading scientists worldwide, Guide to Plant Transcription Factors is an essential reference for researchers, academics, and advanced students in plant biology and biotechnology.

  • Digital Transformation in Healthcare

    Innovations in Hospital and Medical Services
    • 1st Edition
    • Patricia Ordonez de Pablos + 1 more
    • English
    Digital Transformation in Healthcare: Innovations in Hospital and Medical Services explores the digital revolution in healthcare, addressing the challenges and opportunities faced by hospitals, medical faculties, and research institutions. The book highlights the role of advanced information technologies in providing innovative solutions for an ageing population's well-being. It covers critical areas such as hospital management, adapting medical education to digital advancements, and emerging IT tools in healthcare. The book features contributions from leading academics and practitioners worldwide, discussing topics like 5G, AI, big data, blockchain, and digital tools for citizen empowerment, supported by real-world case studies. This resource is invaluable for academics, offering new insights to shape innovative policies in healthcare, education, and information technologies. It fosters dialogue among managers, students, policymakers, and healthcare professionals, contributing to the global advancement of digital healthcare practices.

  • Technological Applications of Fungal Enzymes in Biorefinery and Bioproducts Development

    Volume 2
    • 1st Edition
    • Manikant Tripathi + 1 more
    • English
    Technological Applications of Fungal Enzymes in Biorefinery and Bioproducts Development provides a thorough understanding of technological advances and utilization of fungal enzymes for the development of useful products through using advanced microbial biotechnological techniques. This is the second of two volumes that provide a comprehensive overview of the utilization of fungal enzymes for biorefinery and bioproduct development. Volume 2 discusses basic and technological interventions in fungal enzyme applications exploring biotechnological strategies and how they can address challenges and solutions in the processes involved in fungal enzyme applications. The book also offers practical examples and case studies of technology advances in fungal enzyme-mediated development of biofuels and bioproducts. In combination with Volume 1, this book offers a holistic view of the potential and challenges of engineered fungal enzymes for researchers, scientists, and industry professionals seeking to deepen their knowledge of fungal enzymes and their role in biochemical advances.

  • Neuroscience of Social Behavior

    Bridging the Mind and Society
    • 1st Edition
    • Mikhail Votinov
    • English
    Social behavior is fundamental to human experience, yet the neural mechanisms that govern how individuals perceive, interpret, and respond to one another are only beginning to be understood. Neuroscience of Social Behavior: Bridging the Mind and Society offers a rigorous and integrative examination of the biological foundations of social interaction, synthesizing current knowledge from neuroscience, psychology, sociology, and anthropology into a coherent framework.The book addresses the full scope of social neuroscience, from the evolutionary origins of the social brain to the challenges posed by digital communication and artificial intelligence. Core topics include social perception, language and communication, empathy, mentalizing, moral cognition, decision-making, and the neural basis of both prosocial and antisocial behavior. The text further explores how hormones and neurochemistry modulate social bonds, how social reward and pain systems shape motivation, and how clinical conditions disrupt social functioning. Computational and translational perspectives are integrated throughout, connecting laboratory findings to real-world implications.By bridging multiple levels of analysis, from neural circuits and neurochemistry to behavior and societal context, this volume equips readers with a comprehensive understanding of how the brain supports, and sometimes undermines, our capacity for social life.

  • Lifestyle Epigenomics

    • 1st Edition
    • Ana B Crujeiras
    • English
    Lifestyle Epigenomics, a new volume in the Translational Epigenetics series, comprehensively details the interplay between lifestyle factors and epigenetic modifications associated with the onset of noncommunicable diseases and aging, shedding light on potential preventive and therapeutic strategies for disease from an epigenomics perspective. Here, more than 35 international experts in the field consider how lifestyle choices or habits can condition or prevent disease, along with tools for new research, from bioinformatics methodology to non-invasive sampling.Early, foundational chapters are followed by all-inclusive sections on epigenetic machinery in health and disease; dietary factors and epigenetics; adiposity and physical activity and epigenetics; psychological stress, social environment, toxins and contaminants exposure effects on epigenetics; and transgenerational and childhood epigenetics. To support understanding, each chapter includes a summary and key points lists, terms and definition, as well as research case studies outlining core components of recent studies, detailing their conditions, research techniques involved, and outcomes.

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