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Books in Toxicology general

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121-130 of 300 results in All results

Toxicology and Experimental Models

  • 1st Edition
  • October 22, 2013
  • H. Yoshida + 2 more
  • English
  • eBook
    9 7 8 - 1 - 4 8 3 1 - 4 8 4 8 - 9
Advances in Pharmacology and Therapeutics II, Volume 5: Toxicology and Experimental Models is the fifth of a six-volume compilation of the scientific papers of invited speakers of the Eighth International Congress of Pharmacology. Organized into six parts, this book begins by elucidating the rational interpretation of species and strain differences in toxicity for the prediction of risk to man. Subsequent parts discuss the chemical interactions resulting in liver and kidney injury; the role of heme synthesis and degradation in predicting drug toxicity; and delayed toxic effects of pre- and perinatal drug exposure. Other chapters describe models of experimental peptic ulcers and therapeutic agents and models and quality control of laboratory animals.

Bioreduction in the Activation of Drugs

  • 1st Edition
  • October 22, 2013
  • P. Alexander + 2 more
  • English
  • eBook
    9 7 8 - 1 - 4 8 3 1 - 9 0 8 3 - 9
Bioreduction in the Activation of Drugs covers the proceedings of the Second Biochemical Pharmacology Symposium. The book presents papers that cover the applications of bioreduction in drug activation, along with its concerns. The text first presents materials about enzymology, such as overview of enzyme systems involved in bioreduction of drugs and in redox cycling, and reductive role of glutathione in the redox cycling of oxidizable drugs. Next, the book covers papers on bacterial and parasites infection, which include reduction by the gut microflora of animals and human and reduction of nitroimidazoles in vitro and DNA damage. The remaining articles deal with cancer treatment, such as hypoxia-mediated nitro-heterocyclic drugs in the radio- and chemotherapy of cancer, and the biological properties of reduced nitroheterocyclics and possible underlying biochemical mechanisms. The text will be of great use to researchers and practitioners of medicine, pharmacology, and biochemistry.

Annual Review of Chronopharmacology

  • 1st Edition
  • October 22, 2013
  • A. Reinberg + 2 more
  • English
  • eBook
    9 7 8 - 1 - 4 8 3 1 - 9 1 0 2 - 7
Annual Review of Chronopharmacology, Volume 2 presents a scholarly means of rapidly communicating findings and developments in chronopharmacology, which is considered a quickly emerging field. This text first discusses aspects and statistical procedures in chronobiology and chronopharmacology. This book then explains circadian and circannual changes in nephrotoxic effects of heavy metals and antibiotics; chronotoxicology and chronopharmacology with emphasis on carcinostatic agents; and chronopharmacology of cardiovascular medications. The chronopharmacology and chronotherapy of asthma are also tackled. This book concludes by explaining the chronopharmacology of antidepressant drugs and of the inflammatory process. This publication will be invaluable to those interested in the field of chronopharmacology.

Advances in Pharmacological Research and Practice

  • 1st Edition
  • October 22, 2013
  • J. Knoll + 1 more
  • English
  • eBook
    9 7 8 - 1 - 4 8 3 1 - 4 8 0 1 - 4
Advances in Pharmacological Research and Practice, Volume 1: Pharmacological Protection of the Myocardium presents the proceedings of the 4th Congress of the Hungarian Pharmacological Society, held in Budapest, Hungary in 1985. This book presents a comprehensive view of the development in the fields of pharmacological protection of the myocardium and the pharmacology of the vascular system. Organized into two sections encompassing 70 chapters, this volume begins with an overview of the ischemic biochemical changes with emphasis on the role of cAMP and the protein kinase system. This text then explores the cellular electrophysiological disorders seen in acute myocardial ischemia as well as their pharmacological modification. Other chapters consider the prevention of primary ventricular fibrillation that includes measures aimed at maintaining electrical stability. The final chapter deals with drugs affecting beneficially the pathological lipoprotein levels. This book is a valuable resource for cardiologists and pharmacologists.

Receptors and Centrally Acting Drugs Pharmacokinetics and Drug Metabolism

  • 1st Edition
  • October 22, 2013
  • E. S. Vizi + 2 more
  • English
  • eBook
    9 7 8 - 1 - 4 8 3 1 - 5 1 4 1 - 0
Advances in Pharmacological Research and Practice, Volume 2: Receptors and Centrally Acting Drugs presents the proceeding of the 4th Congress of the Hungarian Pharmacological Society, held in Budapest, Hungary in 1985. This book presents a comprehensive view of the developments in the fields of receptors and centrally acting drugs as well as in pharmacokinetics and drug metabolism. Organized into two sections encompassing 25 chapters, this volume begins with an overview of prejunctional regulation of neuromuscular transmission. This text then explores the whole-body autoradiography that is used extensively in toxicological research and screening. Other chapters consider the three major classes of models used in pharmacokinetics. This book discusses as well the various aspects of melanin–drug interactions. The final chapter deals with the investigation on the melanin affinity of amphetamine derivatives. This book is a valuable resource for pharmacologists, pharmacokineticists, and researchers.

Natural Toxins

  • 1st Edition
  • October 22, 2013
  • C.L. Ownby + 1 more
  • English
  • eBook
    9 7 8 - 1 - 4 8 3 2 - 8 6 8 1 - 5
The 9th World Congress on Animal, Plant and Microbial Toxins was sponsored by the International Society on Toxinology which recently celebrated its 25th anniversary. The Society was organized to promote research into all aspects of natural toxins, and to help with the dissemination of knowledge. This book presents the most recent information on natural toxins from animal, plant and microbial origins and describes the state of research and clinical studies in the field. The material included is illustrated, referenced and fully indexed.

Advances in Drug Research

  • 1st Edition
  • October 22, 2013
  • N. J. Harper + 1 more
  • English
  • eBook
    9 7 8 - 1 - 4 8 3 2 - 1 5 1 3 - 6
Advances in Drug Research, Volume 12 covers articles on advances in drug research. The book presents articles on cyclic nucleotides as targets for drug design; the opposing regulatory roles of cyclic nucleotides in the heart; and the integrated control of trematode diseases. The text also includes articles about the chemical and biological studies on indomethacin, sulindac and their analogs; as well as the pharmacokinetics, pharmacodynamics, toxicity, and the effects of bromocriptine. Toxicologists, pharmacologists, physicians, and drug researchers will find the book invaluable.

Bacterial Endotoxins

  • 1st Edition
  • October 22, 2013
  • George Weinbaum + 2 more
  • English
  • eBook
    9 7 8 - 1 - 4 8 3 2 - 1 5 8 8 - 4
Microbial Toxins, Volume IV: Bacterial Endotoxins covers a general introduction of bacterial endotoxins, as well as research concerning structure (both morphological and physical), chemistry, immunology, biosynthesis, and genetics of bacterial endotoxins. The book describes the general characteristics of bacterial endotoxins; the anatomy and chemistry of Gram-negative cell envelopes; and the physical structure of bacterial lipopolysaccharides. The text also discusses the isolation and chemical and immunological characterization of bacterial lipopolysaccharides; the chemistry of the unique carbohydrates of bacterial lipopolysaccharides; and the relation of bacteriophage attachment to lipopolysaccharide structure. The chemical and biological heterogeneity of endotoxins, as well as the biosynthesis of the core region of lipopolysaccharide are also considered. The book further tackles the biosynthesis of O-antigens and the genetic aspects of biosynthesis and structure of Salmonella lipopolysaccharide. Microbiologists, biochemists, bacteriologists, immunologists, and people involved in biochemical research will find the book useful.

Drug Design

  • 1st Edition
  • October 22, 2013
  • E. J. Ariëns
  • English
  • eBook
    9 7 8 - 1 - 4 8 3 2 - 1 6 0 4 - 1
Drug Design, Volume II covers the design of bioactive compounds interacting with enzymes and playing a role in enzyme synthesis. The book discusses the modulation of pharmacokinetics by molecular manipulation; the factors in the design of reversible and irreversible enzyme inhibitors; and the design of organophosphate and carbamate inhibitors of cholinesterases. The text also describes the design of reactivators for irreversibly blocked acetylcholinesterase; drug design based on the inhibition of protein synthesis in the context of susceptible enzymic reactions; as well as the role of enzymes and their synthesis as a target for antibiotic action. The rational design of antiviral agents; the design of penicillin; the design of peptide hormone analogs; as well as the advances in the design of diuretics are also considered. The book further tackles the design of biologically active steroids; the rational elements in the development of superior neuromuscular blocking agents; and the design of tumor-inhibitory alkylating drugs. Pharmacologists, chemists, and people involved in drug design will find the book invaluable.

Drug Design

  • 1st Edition
  • October 22, 2013
  • E. J. Ariëns
  • English
  • eBook
    9 7 8 - 1 - 4 8 3 2 - 1 6 0 7 - 2
Drug Design, Volume V covers the fundamental approaches to the development of bioactive compounds. The book discusses the utilization of operational schemes for analog synthesis in drug design; the design of enzyme inhibitors (transition state analogs); and the significance of structure-absorption-distribution relationships for drug design. The text describes the role of charge-transfer processes in the action of bioactive materials, as well as the approaches to the rational combination of antimetabolites for cancer chemotherapy. The physicochemical, quantum chemical, and other theoretical techniques for the understanding of the mechanism of action of central nervous system (CNS) agents, such as psychoactive drugs, narcotics, and narcotic antagonists and anesthetics, are also encompassed. Chemists, biochemists, pharmacologists, and people involved in drug design will find the book invaluable.

Related subjects

Toxicology