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Elsevier

Books in Psychoneuropharmacology

This collection explores the neural mechanisms of psychoactive drugs, mental health, and neurobehavioral disorders. Supporting neuroscientists, psychiatrists, and clinicians, it features advances in psychotropic medications, brain signaling, and behavioral therapies that improve mental health outcomes.

  • Advances in Drug Research

    • 1st Edition
    • Volume 17
    • Bernard Testa
    • English
    This volume comprises five authoritative reviews on timely topics in drug research. The first two chapters deal with chemotherapeutic agents (selective antiviral agents and cepham antibiotics) and subsequent chapters deal with the cardiovascular system and topics in neuropharmacology.

  • Antipsychotic Drugs and Their Side-Effects

    • 1st Edition
    • Thomas R.E. Barnes
    • English
    In line with other volumes in the Neuroscience Perspectives Series, this volume covers the background, pharmacology, molecular biology, and biochemistry of antipsychotic drugs, together with an overview assessment of the therapeutic considerations. Over the past 40 years, the effectiveness of conventional neuroleptic agents for psychotic illness has been offset by a wide range of adverse side-effects, including motor side-effects like parkinsonism. Studies show that lowering doses may still produce the antipsychotic effect while lessening the risk of side-effects. As all available antispychotic drugs are able to block dopamine, specifically D2 receptors, doses below the threshold level for producing acute motor disorder can still be therapeutically effective. With the identification and characterization of multiple dopamine receptors, the possibility of more selective drugs with better side-effect potential has arisen. Other novel antipsychotic agents include D1 receptor blockers, partial dopamine agonists and non-dopamine drugs such as 5-HT receptor blockers, sigma receptor antagonists and NMDA receptor agonists. This volume reviews both the basic science of the conventional and atypical neuroleptics and their present and potential therapeutic use.

  • Metal Toxicology

    Approaches and Methods
    • 1st Edition
    • Robert A. Goyer
    • English
    Metal Toxicology addresses the effects of metals on human health, as well as their mechanisms of toxicity. Unlike most books on metal toxicity which are organized by individual metals, this book is arranged inan organ-by-organ basis. It deals with unifying mechanisms of metal toxicity within a given tissue, and with exposure of a tissue to more than one metal at a time.

  • T-Lymphocyte and Inflammatory Cell Research in Asthma

    • 1st Edition
    • G. Jolles + 2 more
    • English
    It is well established that asthma is an inflammatory disease of the airway mucosa and drugs like inhaled glucocorticoids are now commonly introduced early in therapy. A characteristic feature of this disease is the vast number of eosinophils in airway tissue, although many other migratory and resident inflammatory cells with the capacity to synthesize and release cytokines and putative asthma mediators are present in the inflamed mucosa. The cross-talk between lymphocytes and these cells and the role of cytokines in complex biological networks are currently areas of intense research.This volume gathers together chapters and discussions on the biology of immunocompetent and inflammatory cells, cellular interplay and communication, and on the relative importance of cells and mediators in disease.It should help contribute to further insights into the pathology of asthma and to the development of novel efficacious drugs for the treatment of asthma and related respiratory disorders.

  • Lithium and the Cell

    Pharmacology and Biochemistry
    • 1st Edition
    • Nicholas J. Birch
    • English
    This up-to-date compilation addresses the scientific problems of determining a mode of action of lithium and provides a cross-disciplinary perspective. In addition to psychiatrists interested in the therapeutic uses of lithium, it will also be of interest to biochemists using lithium as an inhibitor of phosphoinositide signaling, immunologists studying lymphocytes, and dermatologists studying viral replication in the skin.

  • Meyler's Side Effects of Psychiatric Drugs

    • 1st Edition
    • Jeffrey K. Aronson
    • English
    Elsevier now offers a series of derivative works based on the acclaimed Meylers Side Effect of Drugs, 15th Edition. These individual volumes are grouped by specialty to benefit the practicing physician or health care clinician. The unwarranted effects of medications used in psychiatry can adversely affect a treatment plan. This book is critical in helping psychiatrists and mental health professionals assess the adverse effects of drugs such as antidepressants, mood stabilizers, hypnosedatives, and antipsychotic drugs.The material is drawn from the 15th edition of the internationally renowned encyclopedia, Meyler’s Side Effects of Drugs, and the latest volumes in the companion series, Side Effects of Drugs Annuals. Drug names have usually been designated by their recommended or proposed International Non-proprietary Names (rINN or pINN); when those are not available, clinical names have been used. In some cases, brand names have been used.This volume is critical for any health professional involved in the administration of psychiatric mediations.

  • Animal and Translational Models for CNS Drug Discovery: Psychiatric Disorders

    • 1st Edition
    • Robert A. McArthur + 1 more
    • English
    Psychiatric Disorders is written for researchers in both academia and the pharmaceutical industry who use animal models in research and development of drugs for psychiatric disorders such as anxiety, obsessive-compulsive disorder, depression, schizophrenia, bipolar disorder, ADHD, and autistic spectrum disorder. Psychiatric Disorders has introductory chapters expressing the view of the role and relevance of animal models for drug discovery and development for the treatment of psychiatric disorders from the perspective of (a) academic basic neuroscientific research, (b) applied pharmaceutical drug discovery and development, and (c) issues of clinical trial design and regulatory agencies limitations. Each volume examines the rationale, use, robustness and limitations of animal models in each therapeutic area covered and discuss the use of animal models for target identification and validation. The clinical relevance of animal models is discussed in terms of major limitations in cross-species comparisons, clinical trial design of drug candidates, and how clinical trial endpoints could be improved. The aim of this series of volumes on Animal and Translational Models for CNS Drug Discovery is to identify and provide common endpoints between species that can serve to inform both the clinic and the bench with the information needed to accelerate clinically-effective CNS drug discovery. This is the first volume in the three volume-set, Animal and Translational Models for CNS Drug Discovery 978-0-12-373861-5, and is also available for purchase individually.

  • Encyclopedia of Violence, Peace, and Conflict

    • 1st Edition
    • Lester R. Kurtz
    • English
    The Encyclopedia of Violence, Peace, and Conflict, a three-volume set written by more than 200 eminent contributors from around the world, takes advantage of increasing, worldwide awareness in the public, private, commercial, and academic sectors about manifestations of violence in all segments of society. While the contributors do not use these volumes to make specific arguments, they do describe and clarify the developments in thought that have led to current theories about and positions on violence and peace. Our reviewers consistently note that while many in-depth studies of war, peace, and aggression exist, the attendant specialization keeps scholars from learning about related fields. No publication competing with the Encyclopedia of Violence, Peace, and Conflict can satisfy their need for a vast introductory work to such a diverse and socially-important field. This major work includes more than 190 multidisciplinary articles with over 1,000 cross-references and more than 2,000 bibliography entries for further reading which are arranged alphabetically for easy access.

  • Cytokines

    • 1st Edition
    • Anthony R. Mire-Sluis + 1 more
    • English
    This book provides comprehensive coverage of the cytokines from a pharmacological approach. The chapters are presented in a consistent format allowing easy cross-reference, with sample diagrams and a summary table of essential facts for each chapter at the end of the book.Cytokines is unique in stressing cytokine biology and the application of research data to provide disease therapy. With 33 detailed and up-to-date chapters about individual cytokines, this comprehensive reference will provide both clinicians and researchers in immunology and pharmacology with invaluable information.

  • Encyclopedia of Mental Health, Three-Volume Set

    • 1st Edition
    • Howard S. Friedman + 8 more
    • English
    Mental health is arguably one of the biggest issues facing modern society. The Encyclopedia of Mental Health presents a comprehensive overview of the many genetic, neurological, social, and psychological factors that affect mental health. It describes the impact of mental health on the individual and society, and illustrates the factors that aid positive mental health. 196 peer-reviewed articles written by more than 250 expert authors include essential material on assessment, theories of personality, specific disorders, therapies, forensic issues, ethics, cross-cultural and sociological aspects. Professionals and libraries find this timely work indispensable.