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Books in Gene therapy

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    • Adenoviral Vectors for Gene Therapy

      • 3rd Edition
      • April 9, 2025
      • David T. Curiel + 1 more
      • English
      • Hardback
        9 7 8 0 3 2 3 8 9 8 2 1 8
      • eBook
        9 7 8 0 3 2 3 9 5 8 1 4 1
      Adenoviral Vectors for Gene Therapy, Third Edition, provides detailed, comprehensive coverage of gene delivery vehicles based on the adenovirus that is emerging as an important tool in gene therapy. These exciting new therapeutic agents have great potential for the treatment of disease, as platforms for gene therapy and gene editing, as well as for oncology approaches, making them class leading agents in the gene-advanced therapies arena.The fully updated and expanded third edition covers the basic biology of adenoviruses and highlights the potential use of adenoviral vectors for the treatment of disease, including their construction, propagation, and purification, cutting-edge vectorology, and the use of adenoviral vectors in preclinical animal models. The book also considers the regulatory issues surrounding human clinical gene therapy trials. New chapters include adenoviral vaccines for veterinary applications, adenoviruses for gene editing, nonhuman primate adenoviruses, COVID-19 vaccines, vaccine applications, and oncolytic adenoviruses for antitumor immunization. This broad scope of information provides a solid overview of the field, allowing the reader to gain a complete understanding of the development and use of adenoviral vectors.

    • Adenoviral Vectors for Gene Therapy

      • 2nd Edition
      • March 10, 2016
      • David T. Curiel
      • English
      • Hardback
        9 7 8 0 1 2 8 0 0 2 7 6 6
      • eBook
        9 7 8 0 1 2 8 0 0 5 1 0 1
      Adenoviral Vectors for Gene Therapy, Second Edition provides detailed, comprehensive coverage of the gene delivery vehicles that are based on the adenovirus that is emerging as an important tool in gene therapy. These exciting new therapeutic agents have great potential for the treatment of disease, making gene therapy a fast-growing field for research. This book presents topics ranging from the basic biology of adenoviruses, through the construction and purification of adenoviral vectors, cutting-edge vectorology, and the use of adenoviral vectors in preclinical animal models, with final consideration of the regulatory issues surrounding human clinical gene therapy trials. This broad scope of information provides a solid overview of the field, allowing the reader to gain a complete understanding of the development and use of adenoviral vectors.

    • Translating Gene Therapy to the Clinic

      • 1st Edition
      • November 14, 2014
      • Jeffrey Laurence + 1 more
      • English
      • Hardback
        9 7 8 0 1 2 8 0 0 5 6 3 7
      • eBook
        9 7 8 0 1 2 8 0 0 5 6 4 4
      Translating Gene Therapy to the Clinic, edited by Dr. Jeffrey Laurence and Michael Franklin, follows the recent, much-lauded special issue of Translational Research in emphasizing clinical milestones and critical barriers to further progress in the clinic. This comprehensive text provides a background for understanding the techniques involved in human gene therapy trials, and expands upon the disease-specific situations in which these new approaches currently have the greatest therapeutic application or potential, and those areas most in need of future research. It emphasizes methods, tools, and experimental approaches used by leaders in the field of translational gene therapy. The book promotes cross-disciplinary communication between the sub-specialties of medicine, and remains unified in theme.

    • Nonviral Vectors for Gene Therapy

      • 1st Edition
      • Volume 88
      • November 12, 2014
      • English
      • Hardback
        9 7 8 0 1 2 8 0 0 1 4 8 6
      • eBook
        9 7 8 0 1 2 8 0 0 3 6 7 1
      The field of genetics is rapidly evolving, and new medical breakthroughs are occurring as a result of advances in our knowledge of genetics. Advances in Genetics continually publishes important reviews of the broadest interest to geneticists and their colleagues in affiliated disciplines.

    • Gene Therapy of Cancer

      • 3rd Edition
      • August 28, 2013
      • Edmund C. Lattime + 1 more
      • English
      • Hardback
        9 7 8 0 1 2 3 9 4 2 9 5 1
      • eBook
        9 7 8 0 1 2 3 9 4 6 3 2 4
      Gene therapy as a treatment for cancer is at a critical point in its evolution. Exciting new developments in gene targeting and vector technology, coupled with results from the first generation of preclinical and clinical studies have led to the design and testing of new therapeutic approaches. The Third Edition of Gene Therapy of Cancer provides crucial updates on the basic and applied sciences of gene therapy. It offers a comprehensive assessment of the field including the areas of suicide gene therapy, oncogene and suppressor gene targeting, immunotherapy, drug resistance gene therapy, and the genetic modification of stem cells. Researchers at all levels of development, from basic laboratory investigators to clinical practitioners, will find this book to be instructive. Cancer gene therapy, like cancer therapy in general, is evolving rapidly, testing new concepts, targets and pathways, evoking new technologies, and passing new regulatory hurdles. Its essence, however, has not changed: the hope and challenges of returning altered genes to normal, using targeted gene expression to alter the function of both tumor and microenvironment, and in some cases normal cells, and delivering functionally important genes to specific cell types to increase sensitivity to killing or to protect normal cells from cancer therapies. In some instances, gene therapy for cancer forms a continuum from gene repair through the use of molecularly modified cells; the use of viral and non-viral vector based gene delivery to both tumor and tumor microenvironment; the use of viral and gene based vaccines; and development of new gene-based therapeutics. The unique mechanistically chosen vector platforms are at the heart of this technology because they allow for direct and selective cell death and transient to sustained delivery of vaccine molecules or molecules that affect the microenvironment, vasculature, or the immune response.

    • Gene Transfer Vectors for Clinical Application

      • 1st Edition
      • Volume 507
      • March 6, 2012
      • English
      • Hardback
        9 7 8 0 1 2 3 8 6 5 0 9 0
      • eBook
        9 7 8 0 1 2 3 8 6 5 1 0 6
      This volume of Methods in Enzymology looks at Gene Transfer Vectors for Clinical Application. The chapters provide an invaluable resource for academics, researchers and students alike. With an international board of authors, this volume covers such topics as General principles of retrovirus vector design, Chronic granulomatous disease (CGD), Gene therapy for blindness, and Retrovirus genetic strategy and vector design.

    • Gene Therapy: Prospective Technology assessment in its societal context

      • 1st Edition
      • July 21, 2006
      • Jörg Niewöhner + 1 more
      • English
      • Hardback
        9 7 8 0 4 4 4 5 2 8 0 6 3
      • Paperback
        9 7 8 0 4 4 4 5 6 0 9 2 6
      • eBook
        9 7 8 0 0 8 0 4 7 0 9 3 1
      This book presents work that has been conducted as part of the research project "Discourse on ethical questions of biomedicine" of the interdisciplinary Working Group Bioethics and Science Communication at the Max-Delbrueck-Center for Molecular Medicine (MDC)in Berlin-Buch, Germany. This book offers ground-breaking ideas on how the daily interworking of cutting-edge biomedical research assess the broader social context and its communication to stakeholders and the public. Editors cover three aspects: Scientific, Ethical and Legal, and Perception and Communication. This work establishes an international and interdisciplinary network of excellent researchers at the beginning of their careers, who brilliantly integrate their work into the different perspectives on gene therapy from the natural and social sciences, as well as the humanities and law.

    • Gene Therapy of the Central Nervous System: From Bench to Bedside

      • 1st Edition
      • November 11, 2005
      • Michael G. Kaplitt + 1 more
      • English
      • Paperback
        9 7 8 0 1 2 4 1 5 6 9 6 8
      • eBook
        9 7 8 0 0 8 0 4 5 4 3 7 5
      Few areas of biomedical research provide greater opportunities for radically new therapies for devastating diseases that have evaded treatment so far than gene therapy. This is particularly true for the brain and nervous system, where gene transfer has become a key technology for basic research and has recently been translated to human therapy in several landmark clinical trials. Gene Therapy of the Central Nervous System: From Bench to Bedside represents the first definitive volume on this subject. Edited by two pioneers of neurological gene therapy, this volume contains contributions by leaders who helped create this field and are expanding the promise of gene therapy for the future of basic and clinical neuroscience. Drawing upon this extensive collective experience, this book provides clear and informative reviews on a variety of subjects of interest to anyone exploring or using gene therapy for neurobiological applications in research and clinical praxis.

    • Nonviral Vectors for Gene Therapy, Part 2

      • 2nd Edition
      • Volume 54
      • July 7, 2005
      • Leaf Huang + 2 more
      • English
      • Hardback
        9 7 8 0 1 2 0 1 7 6 5 4 0
      • eBook
        9 7 8 0 0 8 0 4 5 6 1 3 3
      The field of non-viral vector research has rapidly progressed since the publication of the first edition. This new edition is expanded to two separate volumes that contain in-depth discussions of different non-viral approaches, including cationic liposomes and polymers, naked DNA and various physical methods of delivery, as well as a comprehensive coverage of the molecular biological designs of the plasmid DNA for reduced toxicity, prolonged expression and tissue or disease specific genes. New developments such as the toxicity of the non-viral vectors and recent advances in nucleic acid therapeutics are fully covered in these volumes.

    • Gene Therapy Methods

      • 1st Edition
      • Volume 346
      • February 22, 2002
      • English
      • Hardback
        9 7 8 0 1 2 1 8 2 2 4 7 7
      • eBook
        9 7 8 0 0 8 0 4 9 6 9 4 8
      This volume in the prestigious Methods in Enzymology series discusses methods currently used in preclinical and clinical gene therapy. Subjects covered in this book, such as the use of adeno-associated virus delivery for treatment of Parkinson's disease, are topical and are presented in the methods-oriented style popularized by this series.