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Elsevier

Books in Chemistry

Chemistry topic areas include: physical and theoretical, computational, organic, organometallic and inorganic, pharmaceutical and medicinal, analytical and bioanalytical, nuclear, general, nanochemistry, geochemistry, materials and polymer, as well as environmental, green and sustainable chemistry.

  • Comprehensive Medicinal Chemistry II

    • 2nd Edition
    • David J Triggle + 1 more
    • English
    The first edition of Comprehensive Medicinal Chemistry was published in 1990 and was very well received. Comprehensive Medicinal Chemistry II is much more than a simple updating of the contents of the first edition. Completely revised and expanded, this new edition has been refocused to reflect the significant developments and changes over the past decade in genomics, proteomics, bioinformatics, combinatorial chemistry, high-throughput screening and pharmacology, and more. The content comprises the most up-to-date, authoritative and comprehensive reference text on contemporary medicinal chemistry and drug research, covering major therapeutic classes and targets, research strategy and organisation, high-throughput technologies, computer-assisted design, ADME and selected case histories. It is this coverage of the strategy, technologies, principles and applications of medicinal chemistry in a single work that will make Comprehensive Medicinal Chemistry II a unique work of reference and a single point of entry to the literature for pharmaceutical and biotechnology scientists of all disciplines and for many industry executives as well.Also available online via ScienceDirect (2006) – featuring extensive browsing, searching, and internal cross-referencing between articles in the work, plus dynamic linking to journal articles and abstract databases, making navigation flexible and easy. For more information, pricing options and availability visit www.info.sciencedire...

  • Palladium in Heterocyclic Chemistry

    A Guide for the Synthetic Chemist
    • 2nd Edition
    • Jie Jack Li + 1 more
    • English
    Palladium chemistry, despite its immaturity, has rapidly become an indispensable tool for synthetic organic chemists. Heterocycles are of paramount importance in the pharmaceutical industry and palladium chemistry is one of the most novel and efficient ways of making heterocycles. Today, palladium-catalyzed coupling is the method of choice for the synthesis of a wide range of biaryls and heterobiaryls. The number of applications of palladium chemistry to the syntheses of heterocycles has grown exponentially. These developments highlight the need for a monograph dedicated solely to the palladium chemistry in heterocycles and this book provides a comprehensive explanation of the subject. The principal aim of Palladium in Heterocyclic Chemistry is to highlight important palladium-mediated reactions of heterocycles with emphasis on the unique characteristics of individual heterocycles. 1. Palladium chemistry of heterocycles has its "idiosyncrasies" stemming from their different structural properties from the corresponding carbocyclic aryl compounds. Even activated chloroheterocycles are sufficiently reactive to undergo Pd-catalyzed reactions. As a consequence of &agr and &bgr activation of heteroaryl halides, Pd-catalyzed chemistry may take place regioselectively at the activated positions, a phenomenon rarely seen in carbocyclic aryl halides. In addition, another salient peculiarity in palladium chemistry of heterocycles is the so-called "heteroaryl Heck reaction". For instance, while intermolecular palladium-catalyzed arylations of carbocyclic arenes are rare, palladium-catalyzed arylations of azoles and many other heterocycles readily take place. Therefore, the principal aim of this book is to highlight important palladium-mediated reactions of heterocycles with emphasis on the unique characteristics of individual heterocycles. 2. A myriad of heterocycles are biologically active and therefore of paramount importance to medicinal and agricultural chemists. Many heterocycle-containi... natural products (they are highlighted in boxes throughout the text) have elicited great interest from both academic and industrial research groups. Recognizing the similarities between the palladium chemistry of arenes and heteroarenes, a critical survey of the accomplishments in heterocyclic chemistry will keep readers abreast of such a fast-growing field. We also hope this book will spur more interest and inspire ideas in such an extremely useful area. This book comprises a compilation of important preparations of heteroaryl halides, boranes and stannanes for each heterocycle. The large body of data regarding palladium-mediated polymerization of heterocycles in material chemistry is not focused here; neither is coordination chemistry involving palladium and heterocycles. Many heterocycle-containi... natural products (highlighted throughout the text) have elicited great interest from both academic and industrial research groups. Recognizing the similarities between the palladium chemistry of arenes and heteroarenes, a critical survey of the accomplishments in heterocyclic chemistry keeps readers abreast of this fast-growing field. It is also hoped that this book will stimulate more interest and inspire new ideas in this exciting field.

  • Elsevier's Dictionary of Chemoetymology

    The Whys and Whences of Chemical Nomenclature and Terminology
    • 1st Edition
    • Alexander Senning
    • English
    Noting a marked lack of comprehensiveness and/or contemporaneity among typical reference works on chemical etymology, as well as a somewhat spotty coverage of chemical terms and their etymology in comprehensive dictionaries and textbooks the author decided to write an up-to-date desk reference on chemical etymology which would satisfy the needs of casual readers as well as those of more demanding users of etymological lore. Characteristic user-friendly features of the present work include avoidance of cumbersome abbreviations, avoidance of entries in foreign alphabets, and a broad coverage of all chemical disciplines including mineralogy. Biological, medical, geological, physical and mathematical terms are only considered where they appear of interest to mainstream chemists.This book does not provide definitions of terms (unless required in the etymological context) nor guidance as to the timeliness of different nomenclature systems. The typical user will from the outset be well aware of the exact meaning of the terms he or she focuses on and only require the etymological background to be used. Examples of sources which have been drawn upon in the preparation of this book, apart from the extremely useful Internet resource Google, are listed, but an exhausting enumeration would be tiresome and impractical..

  • Advances in Physical Organic Chemistry

    • 1st Edition
    • Volume 41
    • John P. Richard
    • English
    Advances in Physical Organic Chemistry provides the chemical community with authoritative and critical assessments of the many aspects of physical organic chemistry. The field is a rapidly developing one, with results and methodologies finding application from biology to solid state physics.

  • Advances in Physical Organic Chemistry

    • 1st Edition
    • Volume 41
    • John P. Richard
    • English
    Advances in Physical Organic Chemistry provides the chemical community with authoritative and critical assessments of the many aspects of physical organic chemistry. The field is a rapidly developing one, with results and methodologies finding application from biology to solid state physics.

  • Molecular and Nano Electronics: Analysis, Design and Simulation

    • 1st Edition
    • Volume 17
    • Jorge M. Seminario
    • English
    The aim of Molecular and Nano Electronics: Analysis, Design and Simulation is to draw together contributions from some of the most active researchers in this new field in order to illustrate a theory guided-approach to the design of molecular and nano-electronics. The field of molecular and nano-electronics has driven solutions for a post microelectronics era, where microelectronics dominate through the use of silicon as the preferred material and photo-lithography as the fabrication technique to build binary devices (transistors). The construction of such devices yields gates that are able to perform Boolean operations and can be combined with computational systems, capable of storing, processing, and transmitting digital signals encoded as electron currents and charges. Since the invention of the integrated circuits, microelectronics has reached increasing performances by decreasing strategically the size of its devices and systems, an approach known as scaling-down, which simultaneously allow the devices to operate at higher speeds.

  • Palladium in Heterocyclic Chemistry

    A Guide for the Synthetic Chemist
    • 2nd Edition
    • Volume 26
    • Jie Jack Li + 1 more
    • English
    Palladium chemistry, despite its immaturity, has rapidly become an indispensable tool for synthetic organic chemists. Heterocycles are of paramount importance in the pharmaceutical industry and palladium chemistry is one of the most novel and efficient ways of making heterocycles. Today, palladium-catalyzed coupling is the method of choice for the synthesis of a wide range of biaryls and heterobiaryls. The number of applications of palladium chemistry to the syntheses of heterocycles has grown exponentially. These developments highlight the need for a monograph dedicated solely to the palladium chemistry in heterocycles and this book provides a comprehensive explanation of the subject. The principal aim of the book is to highlight important palladium-mediated reactions of heterocycles with emphasis on the unique characteristics of individual heterocycles. 1. Palladium chemistry of heterocycles has its “idiosyncrasies” stemming from their different structural properties from the corresponding carbocyclic aryl compounds. Even activated chloroheterocycles are sufficiently reactive to undergo Pd-catalyzed reactions. As a consequence of &agr and &bgr activation of heteroaryl halides, Pd-catalyzed chemistry may take place regioselectively at the activated positions, a phenomenon rarely seen in carbocyclic aryl halides. In addition, another salient peculiarity in palladium chemistry of heterocycles is the so-called "heteroaryl Heck reaction". For instance, while intermolecular palladium-catalyzed arylations of carbocyclic arenes are rare, palladium-catalyzed arylations of azoles and many other heterocycles readily take place. Therefore, the principal aim of this book is to highlight important palladium-mediated reactions of heterocycles with emphasis on the unique characteristics of individual heterocycles. 2. A myriad of heterocycles are biologically active and therefore of paramount importance to medicinal and agricultural chemists. Many heterocycle-containi... natural products (they are highlighted in boxes throughout the text) have elicited great interest from both academic and industrial research groups. Recognizing the similarities between the palladium chemistry of arenes and heteroarenes, a critical survey of the accomplishments in heterocyclic chemistry will keep readers abreast of such a fast-growing field. We also hope this book will spur more interest and inspire ideas in such an extremely useful area. This book comprises a compilation of important preparations of heteroaryl halides, boranes and stannanes for each heterocycle. The large body of data regarding palladium-mediated polymerization of heterocycles in material chemistry is not focused here; neither is coordination chemistry involving palladium and heterocycles. Many heterocycle-containi... natural products (highlighted throughout the text) have elicited great interest from both academic and industrial research groups. Recognizing the similarities between the palladium chemistry of arenes and heteroarenes, a critical survey of the accomplishments in heterocyclic chemistry keeps readers abreast of this fast-growing field. It is also hoped that this book will stimulate more interest and inspire new ideas in this exciting area.

  • Liquid Chromatography of Natural Pigments and Synthetic Dyes

    • 1st Edition
    • Volume 71
    • Tibor Cserháti
    • English
    This latest volume in the series entitled Liquid Chromatography of Natural Pigments and Synthetic Dyes presents an overview of the latest developments in the field while critically evaluating this method of analysis and providing comparisons of the various liquid chromatographic separation techniques that are currently available. Natural pigments and synthetic dyes are extensively used in various fields of everyday life including food production, textile industry, paper production, agricultural practice and research and water science and technology. Besides their capacity for increasing the marketability of products, natural pigments have shown advantageous biological activity as antioxidants and anticancer agents. On the negative side, synthetic pigments have a significant impact on the environment and can cause adverse toxicological side effects. Both pigment classes exhibit considerable structural diversity. As the stability of the pigments against hydrolysis, oxidation and other environmental and technological conditions is markedly different, the exact determination of the pigment composition may help for the prediction of the shelf-life of products and the assessment of the influence of technological steps on the pigment fractions resulting in more consumer friend processing methods. Furthermore, the qualitative determination and identification of the pigments may contribute to the establishment of the provenance of the product. The unique separation capacity of liquid chromatographic (LC) techniques makes it a method of preference for the analysis of pigments in any complicated accompanying matrices.

  • Modern Instrumental Analysis

    • 1st Edition
    • Volume 47
    • Satinder Ahuja + 1 more
    • English
    Modern Instrumental Analysis covers the fundamentals of instrumentation and provides a thorough review of the applications of this technique in the laboratory. It will serve as an educational tool as well as a first reference book for the practicing instrumental analyst. The text covers five major sections:1. Overview, Sampling, Evaluation of Physical Properties, and Thermal Analysis2. Spectroscopic Methods 3. Chromatographic Methods 4. Electrophoretic and Electrochemical Methods 5. Combination Methods, Unique Detectors, and Problem Solving Each section has a group of chapters covering important aspects of the titled subject, and each chapter includes applications that illustrate the use of the methods. The chapters also include an appropriate set of review questions.

  • Chiral Analysis

    • 1st Edition
    • Kenneth W. Busch + 1 more
    • English
    Chiral Analysis covers an important area of analytical chemistry of relevance to a wide variety of scientific professionals. The target audience is scientific professionals with an undergraduate background in chemistry or a related discipline, specifically organic chemists, researchers in drug discovery, pharmaceutical researchers involved with process analysis or combinatorial libraries, and graduate students in chemistry. Chapters have been written with the nonspecialist in mind so as to be self-contained.

  • Annual Reports on NMR Spectroscopy

    • 1st Edition
    • Volume 59
    • Graham A. Webb
    • English
    Volume 59 of Annual Reports on NMR Spectroscopy contains current accounts of the many active, and exciting, areas of research which have a crucial dependence on NMR measurements. Nuclear magnetic resonance (NMR) is an analytical tool used by chemists and physicists to study the structure and dynamics of molecules. In recent years, no other technique has grown to such importance as NMR spectroscopy. It is used in all branches of science where precise structural determination is required and where the nature of interactions and reactions in solution is being studied. Annual Reports on NMR has established itself as a premier means for the specialist and nonspecialist alike to become familiar with new techniques and applications of NMR spectroscopy.

  • Annual Reports in Computational Chemistry

    • 1st Edition
    • Volume 2
    • David Spellmeyer
    • English
    Annual Reports in Computational Chemistry is a new periodical providing timely and critical reviews of important topics in computational chemistry as applied to all chemical disciplines. Topics covered include quantum chemistry, molecular mechanics, force fields, chemical education, and applications in academic and industrial settings. Each volume is organized into (thematic) sections with contributions written by experts. Focusing on the most recent literature and advances in the field, each article covers a specific topic of importance to computational chemists. Annual Reports in Computational Chemistry is a 'must' for researchers and students wishing to stay up-to-date on current developments in computational chemistry.

  • Single Crystal Growth of Semiconductors from Metallic Solutions

    • 1st Edition
    • Sadik Dost + 1 more
    • English
    Single Crystal Growth of Semiconductors from Metallic Solutions covers the four principal growth techniques currently in use for the growth of semiconductor single crystals from metallic solutions. Providing an in-depth review of the state-of-the-art of each, both experimentally and by numerical simulations. The importance of a close interaction between the numerical and experimental aspects of the processes is also emphasized. Advances in the fields of electronics and opto-electronics are hampered by the limited number of substrate materials which can be readily produced by melt-growth techniques such as the Czochralski and Bridgman methods. This can be alleviated by the use of alternative growth techniques, and in particular, growth from metallic solutions. The principal techniques currently in use are: Liquid Phase Epitaxy; Liquid Phase Electroepitaxy; the Travelling Heater Method, and; Liquid Phase Diffusion. Single Crystal Growth of Semiconductors from Metallic Solutions will serve as a valuable reference tool for researchers, and graduate and senior undergraduate students in the field of crystal growth. It covers most of the models developed in recent years. The detailed development of basic and constitutive equations and the associated interface and boundary conditions given for each technique will be very valuable to researchers for the development of their new models.

  • Sediment Quality and Impact Assessment of Pollutants

    • 1st Edition
    • Damià Barceló + 1 more
    • English
    Volume 1 of the Sustainable Management of Sediment Resources mini-series is the first attempt to fill many of these gaps in knowledge and also in practice. The volume includes sections on: Sampling Characterization of contaminants in sediments being bioavailability the main issue Chemical analysis Biological analysis Effect directed analysis and toxicity Identification evaluation Benthos sediment quality assessment Modelling of pollutant fate and behaviour Sediment quality guidelines This first volume is applicable to a wide audience, from students at the graduate level, to experienced researchers and laboratory personnel in academia, industry and government.This volume also available as part of a 4-volume set, ISBN 0444519599. Discount price for set purchase.

  • Solution Chemistry

    Minerals and Reagents
    • 1st Edition
    • Volume 17
    • P. Somasundaran + 1 more
    • English
    Surfactants have been used for many industrial processes such as flotation, enhanced oil recovery, soil remediation and cleansing. Flotation technology itself has been used in industry since the end of the 19th century, and even today it is an important method for mineral processing and its application range is expanding to other areas. This technology has been used in the treatment of wastewater, industrial waste materials, separation and recycling of municipal waste, and some unit processes of chemical engineering. The efficiency of all these operations depends primarily on the interactions among surfactants, solids and media. In this book, the fundamentals of solution chemistry of mineral/surfactant systems are discussed, as well as the important calculations involved. The influence of relevant physico-chemical conditions are also presented in detail.

  • Sorbent Deformation

    • 1st Edition
    • Volume 13
    • Andrei V. Tvardovskiy
    • English
    Sorbent Deformation discusses the theoretical and experimental study of the deformation of solid bodies during their ad- or absorptive interaction with gases or vapours. The book is the first monograph which deals with the problem of ad- and absorbent non-inertness, compiled from a 15-year study by the author on swelling or deformed ad- and absorptive systems. The results from the study are of practical and scientific value to engineers and scientists in the areas of physical chemistry, chemical engineering and environmental control. They could also be of interest to those looking to solve problems in such areas as forecasting, technological processing and fuel drying stimulation.

  • The Encyclopedia of Mass Spectrometry

    Volume 8: Hyphenated Methods
    • 1st Edition
    • English
    Volume 8: Hyphenated Methods Starting with gas chromatography–mass spectrometry (GC–MS) and continuing through GCxGC–MS, LC–MSn, and LC–NMR–MS, hyphenated methods have revolutionized chemical analysis. This volume covers that revolution in two parts. The first (Chapters 1–4) describes principles, instrumentation, and technology, and the second (Chapters 5–10) organizes major application areas in GC–MS and LC–MS. After a general introduction (Chapter 1), attention is paid to principles and instrumentation of GC–MS (Chapter 2) and LC–MS (Chapter 3). Other hyphenated methods, including online combinations of capillary electromigration methods and supercritical fluid chromatography with mass spectrometry, are in Chapter 4. Applications are then covered in the remaining chapters. The application-oriented chapters are focused on the role of mainly LC–MS in the pharmaceutical field (Chapter 5) and biochemical and biotechnological applications (Chapter 10), and the application of both GC–MS and LC–MS in relation to environmental analysis (Chapter 6), food safety and food analysis (Chapter 7), characterization of natural products (Chapter 8), and clinical, toxicological, and forensic analysis (Chapter 9).

  • Interface Science in Drinking Water Treatment

    Theory and Applications
    • 1st Edition
    • Volume 10
    • Gayle Newcombe + 1 more
    • English
    It is difficult to imagine anything more important to the human population than safe drinking water. Lack of clean drinking water is still the major cause of illness and death in young children in developing countries. In more fortunate communities, where water treatment is practiced, the primary aim of water authorities is to provide water that is free from pathogens and toxins. Most countries now have water quality regulations, or guidelines, which are driving water authorities to produce purer water, with the minimum of contamination from natural or man-made origin. At the same time, consumers are demanding that chemicals added during the treatment of drinking water be kept to a minimum. As a consequence, conventional clarification methods are being challenged to comply with the new regulations and restrictions and our understanding of the mechanisms involved is being tested as never before. Interface Science in Drinking Water Treatment contains a rigorous review of water treatment practices from a fundamental viewpoint. The book includes material from leading experts in the field of water treatment, reviewing their specific fields of expertise against a background of colloid and surface chemistry, and examines each step of the journey from source to consumer tap. It therefore permits the reader to develop a deep understanding of the complex processes taking place and of the necessary treatments which are vital for the provision of safe and palatable drinking water. The book is aimed at researchers, educators and practitioners in science and engineering, particularly those involved in water treatment and colloidal chemistry.

  • Advances in Heterocyclic Chemistry

    • 1st Edition
    • Volume 92
    • Alan R. Katritzky
    • English
    Established in 1960, Advances in Heterocyclic Chemistry is the definitive serial in the area-one of great importance to organic chemists, polymer chemists, and many biological scientists. Written by established authorities in the field, the comprehensive reviews combine descriptive chemistry and mechanistic insight and yield an understanding of how the chemistry drives the properties.

  • Surface Complexation Modelling

    • 1st Edition
    • Volume 11
    • Johannes Lutzenkirchen
    • English
    Surface Complexation Modelling deals with various aspects associate to the modelling of solutes adsorption from of solutes from aqueous solutions to minerals. The individual contributions cover fundamental aspects and applications. Applications cover case studies and present consistent surface complexation parameter sets. The model approaches range from simplistic to mechanistic. More fundamental contributions address underlying phenomena or stress the opportunities of modern computational methods. Several mineral systems are covered, including goethite, gibbsite, clay minerals etc.Surface Complexation Modelling presents the state-of-the-art of surface complexation modelling and suggests ideas for further model development. A number of chapters are authored by scientists working on nuclear waste storage, where the retention of radionuclides contributes to preventing radionuclide migration from the repository to the biosphere. Other contributions come from soil and environmental chemists with an interest in reactive transport of pollutants in soils or aquifers.

  • Cyclodextrin Materials Photochemistry, Photophysics and Photobiology

    • 1st Edition
    • Volume 1
    • Abderrazzak Douhal
    • English
    Cyclodextrin Materials Photochemistry, Photophysics and Photobiology provides to the scientific community the state-of-the art on photochemistry, photophysics and photobiology of cyclodextrin complexes in one book, and the chapters material will trigger further research in applied science connected to these small nanocapsules.The chapters contain a large number of information of value not only to readers working in the field of cyclodextrins, but also to researchers working on related areas like those of supramolecular chemistry, nanochemistry, and in general in nano- and biotechnology.

  • Handbook of Adhesives and Sealants

    General Knowledge, Application of Adhesives, New Curing Techniques
    • 1st Edition
    • Volume 2
    • Philippe Cognard
    • English
    Contributions from more than 60 authors, each a well-known specialist in their field, have been co-ordinated to produce the most comprehensive Handbook of Adhesives and Sealants ever published. The handbook will be published as 8 volumes, over a period of 4 years and will contain over 2800 pages, rich with case studies, industrial applications and the latest research. It is a work in progress, enabling the latest new and important applications to be included as they happen. Volume 2 of Elsevier’s Handbook of Adhesives & Sealants Series, General knowledge, application of adhesives & new curing techniques, covers the mechanisms of adhesion, its application, and drying and curing techniques. The volume is divided in to the following sections: • Theory of adhesion • Metering and dispensing • Design and calculation of bonded joints• Heat stable adhesives• UV curing • Flexible bonding and sealants Each contributing author is a scientist, practitioner, engineer, or chemist with an abundance of practical experience in their respective field, making this text an authoritative reference source for any materials scientist or engineer, whether in academia or industry.

  • Mathematical Problems for Chemistry Students

    • 1st Edition
    • Gyorgy Pota
    • English
    Mathematical Problems for Chemistry Students has been compiled and written (a) to help chemistrystudents in their mathematical studies by providing them with mathematical problems really occurring in chemistry (b) to help practising chemists to activate their applied mathematical skills and (c) to introduce students and specialistsof the chemistry-related fields (physicists, mathematicians, biologists, etc.) intothe world of the chemical applications.Some problems of the collection are mathematical reformulations of those in the standard textbooks of chemistry, others were taken from theoretical chemistry journals. All major fields of chemistry are covered, and each problem is given a solution.This problem collection is intended for beginners and users at an intermediate level. It can be used as a companion to virtually all textbooks dealing with scientific and engineering mathematics or specifically mathematics for chemists.

  • Mathematical Problems for Chemistry Students

    • 1st Edition
    • Gyorgy Pota
    • English
    Mathematical Problems for Chemistry Students has been compiled and written (a) to help chemistry students in their mathematical studies by providing them with mathematical problems really occurring in chemistry (b) to help practising chemists to activate their applied mathematical skills and (c) to introduce students and specialists of the chemistry-related fields (physicists, mathematicians, biologists, etc.) into the world of the chemical applications. Some problems of the collection are mathematical reformulations of those in the standard textbooks of chemistry, others were taken from theoretical chemistry journals. All major fields of chemistry are covered, and each problem is given a solution. This problem collection is intended for beginners and users at an intermediate level. It can be used as a companion to virtually all textbooks dealing with scientific and engineering mathematics or specifically mathematics for chemists.

  • Surface Area and Porosity Determinations by Physisorption

    Measurement, Classical Theories and Quantum Theory’
    • 1st Edition
    • James B. Condon
    • English
    Surface Area and Porosity Determinations by Physisorption is a practical guide for industry or academics to the measurement of surface area and pore size using the tool of physical adsorption. Starting with a brief description of what physical adsorption is and the raw data that is obtained. The instrumentation for measuring this isotherm is described in some details. Recommendations are presented as to what instrumentation would be most appropriate for a particular application. An appendix of current commercial instruments is included. The mathematics required for the simple analysis of the obtained isotherm is presented with step-wise instructions for the analysis of the more useful analysis methods. Subsequent chapters describe the analyses and the theories behind the analyses in more detail.

  • Chemistry and Application of H-Phosphonates

    • 1st Edition
    • Kolio D. Troev
    • English
    Chemistry and Application of H-Phosphonates is an excellent source for those planning the synthesis of new phosphorus-containin... compounds and in particular derivatives containing a phosphonate, phosphoramide or phosphonic acid diester group. The rich chemistry, low cost and easy availability of diesters of H-phosphonic acid makes them an excellent choice as synthone in a number of practically important reactions. Phosphonic acid esters are intermediates in the synthesis of important classes of compounds such as alpha-aminophosphoni... acids, bisphosphonates, epoxyalkylphosphonat... alpha-hydroxyalkylph... phosphoramides, poly(alkylene H-phosphonate)s, poly(alkylene phosphate)s, nucleoside H-phosphonates. The synthesis of each of these compound classes is reviewed in detail.Alpha-Aminoph... acids are an important class of biologically active compounds, which have received an increasing amount of attention because they are considered to be structural analogues of the corresponding Alpha-amino acids. The utilities of alpha-aminophosphona... as peptide mimics, haptens of catalytic antibodies, enzyme inhibitors, inhibitors of cancers, tumours, viruses, antibiotics and pharmacologic agents are well documented. Alpha-Hydroxyalkanep... are compounds of significant biological and medicinal applications. Dialkyl epoxyalkylphosphonat... are of interest because of their use as intermediates in the synthesis of bioactive substances, and as modifiers of natural and synthetic polymers. Bisphosphonates are drugs that have been widely used in different bone diseases, and have recently been used successfully against many parasites. Poly(alkylene H-phosphonate)s and poly(alkylene phosphate)s are promising, biodegradable, water soluble, new polymer-carriers of drugs. Nucleoside H-phosphonates seem to be the most attractive candidates as starting materials in the chemical synthesis of DNA and RNA fragments. The 5’-hydrogen phosphonate-3’-azido... is one of the most significant anti-HIV prodrug, which is currently in clinical trials.Chapters review the synthesis; physical and spectral properties (1H, 13C, 31P and 17O NMR data); characteristic reactions; important classes of compounds based on these esters of H-phosphonic acid; their application as physiologically active substances, flame retardants, catalysts, heat and light stabilizers, lubricants, scale inhibitors, polymer-carriers of drugs; preparation of H-phosphonate diesters and general procedures for conducting the most important reactions.

  • Turbulence in Porous Media

    Modeling and Applications
    • 1st Edition
    • Marcelo J.S. de Lemos
    • English
    ‘Turbulence in Porous Media’ introduces the reader to the characterisation of turbulent flow, heat and mass transfer in permeable media, including analytical data and a review of available experimental data. Such transport processes occurring a relatively high velocity in permeable media, are present in a number of engineering and natural flows. De Lemos has managed to compile, detail, compare and evaluate available methodologies for modelling simulating purposes, providing an essential tour for engineering students working within the field.- The hotly debated topic of heterogeneity and flow turbulence has never before been addressed in book format. - Offers an experimental approach to turbulence in porous media as it discusses disciplines that have been traditionally developed apart from each other.

  • Physico-Chemical Analysis of Molten Electrolytes

    • 1st Edition
    • Vladimir Danek †
    • English
    Physico-Chemical Analysis of Molten Electrolytes includes selected topics on the measurement and evaluation of physico-chemical properties of molten electrolytes. It describes the features, properties, and experimental measurement of different physico-chemical properties of molten salt systems used as electrolytes for different metal production, metallic layer deposition, as a medium for reactions in molten salts.The physico-chemical properties such as phase equilibria, density (molar volume), enthalpy (calorimetry), surface tension, vapor pressure, electrical conductivity, viscosity, etc. are the most important parameters of electrolytes needed for technological use. For each property the theoretical background, experimental techniques, as well as examples of the latest knowledge and the processing of most important salt systems will be given.The aim of Physico-Chemical Analysis of Molten Electrolytes is not only to present the state of the art on different properties of molten salts systems and their measurement, but also to present the possibilities of modeling molten salt systems, to be able to forecast the properties of an electrolyte mixture from the properties of the pure components in order to avoid experimentally demanding, and in most cases also expensive measurements.This book fills a substantial gap in this field of science. Also documententing the latest research in molten salts chemistry and brings new results and new insights into the study of molten salts systems using the results of X-ray diffraction and XAFS methods, Raman spectroscopy, and NMR measurements.

  • Lead Molecules from Natural Products

    Discovery and New Trends
    • 1st Edition
    • Volume 2
    • English
    Lead Molecules from Natural Products: Discovery and New Trends provides the reader with a thorough overview of current discoveries and trends in Natural Products research. This book consists of 22 chapters from well known scientists all over the world, with topics ranging from Natural Product Chemistry and Phytochemistry in their most basic form, to Molecular Biology and in silico drug design. Contributors describe their own laboratory experiences, revealing their findings, the legal issues encountered.The chapters, all of equally high quality, summarize years of extensive research in each area, and provide insight in the new themes of natural product research. The information will help to predict promising leads, useful for physicians in the treatment of different diseases and disease manifestations.

  • Advances in Heterocyclic Chemistry

    • 1st Edition
    • Volume 91
    • Alan R. Katritzky
    • English
    Established in 1960, Advances in Heterocyclic Chemistry is the definitive serial in the area - one of great importance to organic chemists, polymer chemists, and many biological scientists. Written by established authorities in the field, the comprehensive reviews combine descriptive chemistry and mechanistic insight and yield an understanding of how the chemistry drives the properties.

  • Modern Methods for Theoretical Physical Chemistry of Biopolymers

    • 1st Edition
    • Evgeni Starikov + 2 more
    • English
    Modern Methods for Theoretical Physical Chemistry of Biopolymers provides an interesting selection of contributions from an international team of researchers in theoretical chemistry. This book is extremely useful for tackling the complicated scientific problems connected with biopolymers' physics and chemistry. The applications of both the classical molecular-mechanical and molecular-dynamical methods and the quantum chemical methods needed for bridging the gap to structural and dynamical properties dependent on electron dynamics are explained. Also included are ways to deal with complex problems when all three approaches need to be considered at the same time. The book gives a rich spectrum of applications: from theoretical considerations of how ATP is produced and used as ‘energy currency’ in the living cell, to the effects of subtle solvent influence on properties of biopolymers and how structural changes in DNA during single-molecule manipulation may be interpreted.

  • Advances in Carbohydrate Chemistry and Biochemistry

    • 1st Edition
    • Volume 60
    • English
    Since its inception in 1945, this serial has provided critical and integrating articles written by research specialists that integrate industrial, analytical, and technological aspects of biochemistry, organic chemistry, and instrumentation methodology in the study of carbohydrates. The articles provide a definitive interpretation of the current status and future trends in carbohydrate chemistry and biochemistry.

  • Advances in Heterocyclic Chemistry

    • 1st Edition
    • Volume 90
    • Alan R. Katritzky
    • English
    Established in 1960, Advances in Heterocyclic Chemistry is the definitive serial in the area-one of great importance to organic chemists, polymer chemists, and many biological scientists. Written by established authorities in the field, the comprehensive reviews combine descriptive chemistry and mechanistic insight and yield an understanding of how the chemistry drives the properties.

  • Advances in Organometallic Chemistry

    • 1st Edition
    • Volume 54
    • Robert C. West + 2 more
    • English
    Almost all branches of chemistry and material science now interface with organometallic chemistry - the study of compounds containing carbon-metal bonds. The widely acclaimed serial Advances in Organometallic Chemistry contains authoritative reviews that address all aspects of organometallic chemistry, a field which has expanded enormously since the publication of Volume 1 in 1964.

  • Annual Reports on NMR Spectroscopy

    • 1st Edition
    • Volume 58
    • Graham A. Webb
    • English
    Nuclear magnetic resonance (NMR) is an analytical tool used by chemists and physicists to study the structure and dynamics of molecules. In recent years, no other technique has grown to such importance as NMR spectroscopy. It is used in all branches of science where precise structural determination is required and where the nature of interactions and reactions in solution is being studied. Annual Reports on NMR Spectroscopy has established itself as a premier means for the specialist and nonspecialist alike to become familiar with new techniques and applications of NMR spectroscopy.

  • Advances in Planar Lipid Bilayers and Liposomes

    • 1st Edition
    • Volume 3
    • A. Leitmannova Liu
    • English
    The lipid bilayer is central to life, as all living organisms possess a lipid bilayer structure, thereby underlying the lipid bilayer principle of biomembranes. The lipid bilayer principle and its applications are the main theme of this new book series.This new series on bilayer lipid membranes (BLMs and liposomes) include invited chapters on a broad range of topics, from theoretical investigations, specific studies, experimental methods, to practical applications. Written for newcomers, experienced scientists, and those who are not familiar with these specific research areas, the Series covers all aspects of lipid bilayer investigations, both fundamental and applied.

  • Progress in Medicinal Chemistry

    • 1st Edition
    • Volume 44
    • F.D. King + 1 more
    • English
    The perceived lack of drug discovery productivity in recent times has led to much debate in the pharmaceutical/biote... industry as escalating R&D costs are not being matched by increased output. Few observers doubt that selecting the right targets, ie those which are critical to disease pathology and are ‘druggable’, is the best starting point for improved productivity.The seven chapters of this volume describe recent progress towards drugs acting at a range of ‘druggable’ targets. One chapter addresses kinases, one covers an ion channel, two proteases are featured and three of the chapters cover G-protein coupled receptors, which has historically perhaps been the most fruitful area for medicinal chemists.

  • Advances in Synthetic Organic Chemistry and Methods Reported in US Patents

    • 1st Edition
    • Thomas F. DeRosa
    • English
    Advances in Synthetic Organic Chemistry and Methods Reported in US Patents provides synthetic guidelines for preparing current and commercially significant organic compounds, derivatives, and intermediates as reported in issued US Patents. Industries surveyed include agrochemical, cosmetics and personal care products. Each entry contains extensive information such as explicit laboratory directions for preparing all chemical intermediates and characterization data. Furthermore, product optimization studies, industrial preparation, and new synthetic methods have been included for selected entries, as well as projected research directions for future product development. In Advances in Synthetic Organic Chemistry and Methods Reported in US Patents the author's practical approach enables readers to identify research and market trends, and stay up-to-date on current developments in the field.

  • Pharmaceutical Manufacturing Encyclopedia, 3rd Edition Database

    • 3rd Edition
    • William Andrew William Andrew Publishing
    • English
    This industry standard database on pharmaceutical manufacturing processes has been completely updated to include FDA drugs approved up to the summer of 2004. The database gives details for the manufacture of 2226 pharmaceuticals that are being marketed as a trade-named product somewhere in the world. Each entry includes:ò Therapeutic function ò Chemical and common nameò Structural Formulaò Chemical Abstracts Registry no.ò Trade name, manufacturer, country, and year introducedò Raw Materialsò Manufacturing ProcessIn addition, references are also cited under each drug's entry to major pharmaceutical works where additional information can be obtained on synthesis and the pharmacology of the individual products. The database is for the Windows OS.

  • Annual Reports on NMR Spectroscopy

    • 1st Edition
    • Volume 57
    • Graham A. Webb
    • English
    Nuclear magnetic resonance (NMR) is an analytical tool used by chemists and physicists to study the structure and dynamics of molecules. In recent years, no other technique has grown to such importance as NMR spectroscopy. It is used in all branches of science where precise structural determination is required and where the nature of interactions and reactions in solution is being studied. Annual Reports on NMR has established itself as a premier means for the specialist and nonspecialist alike to become familiar with new techniques and applications of NMR spectroscopy.

  • Information Theory of Molecular Systems

    • 1st Edition
    • Roman F Nalewajski
    • English
    As well as providing a unified outlook on physics, Information Theory (IT) has numerous applications in chemistry and biology owing to its ability to provide a measure of the entropy/information contained within probability distributions and criteria of their information "distance" (similarity) and independence. Information Theory of Molecular Systems applies standard IT to classical problems in the theory of electronic structure and chemical reactivity. The book starts by introducing the basic concepts of modern electronic structure/reactivity theory based upon the Density Functional Theory (DFT), followed by an outline of the main ideas and techniques of IT, including several illustrative applications to molecular systems. Coverage includes information origins of the chemical bond, unbiased definition of molecular fragments, adequate entropic measures of their internal (intra-fragment) and external (inter-fragment) bond-orders and valence-numbers, descriptors of their chemical reactivity, and information criteria of their similarity and independence. Information Theory of Molecular Systems is recommended to graduate students and researchers interested in fresh ideas in the theory of electronic structure and chemical reactivity.

  • Studies in Natural Products Chemistry

    Bioactive Natural Products (Part M)
    • 1st Edition
    • Volume 33
    • Atta-ur Rahman
    • English
    Natural products present in the plant and animal kingdom offer a huge diversity of chemical structures which are the result of biosynthetic processes that have been modulated over the millennia through genetic effects. With the rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, it has become possible to isolate, determine the structures and biological activity of natural products rapidly, thus opening up exciting new opportunities in the field of new drug development to the pharmaceutical industry.The present volume contains 22 articles written by leading experts in natural product chemistry on biologically active natural products. It includes research on a variety of different classes of natural products including sesquiterpenes, quassinoids, diterpenoids, lignans, oligostilbenes, phenylethanoids, phenylpropanoid glycosides, curcumin analogues, glycosphingolipids etc. Many of these have been found to be active in a number of different disease conditions.

  • Crystallography Made Crystal Clear

    A Guide for Users of Macromolecular Models
    • 3rd Edition
    • Gale Rhodes
    • English
    Crystallography Made Crystal Clear makes crystallography accessible to readers who have no prior knowledge of the field or its mathematical basis. This is the most comprehensive and concise reference for beginning Macromolecular crystallographers, written by a leading expert in the field. Rhodes' uses visual and geometric models to help readers understand the mathematics that form the basis of x-ray crystallography. He has invested a great deal of time and effort on World Wide Web tools for users of models, including beginning-level tutorials in molecular modeling on personal computers. Rhodes' personal CMCC Home Page also provides access to tools and links to resources discussed in the text. Most significantly, the final chapter introduces the reader to macromolecular modeling on personal computers-featuring SwissPdbViewer, a free, powerful modeling program now available for PC, Power Macintosh, and Unix computers. This updated and expanded new edition uses attractive four-color art, web tool access for further study, and concise language to explain the basis of X-ray crystallography, increasingly vital in today's research labs.

  • Fundamentals of Preparative and Nonlinear Chromatography

    • 2nd Edition
    • Georges Guiochon + 2 more
    • English
    Fundamentals of Preparative and Nonlinear Chromatography, Second Edition is devoted to the fundamentals of a new process of purification or extraction of chemicals or proteins widely used in the pharmaceutical industry and in preparative chromatography. This process permits the preparation of extremely pure compounds satisfying the requests of the US Food and Drug Administration. The book describes the fundamentals of thermodynamics, mass transfer kinetics, and flow through porous media that are relevant to chromatography. It presents the models used in chromatography and their solutions, discusses the applications made, describes the different processes used, their numerous applications, and the methods of optimization of the experimental conditions of this process.

  • Nanochemistry

    • 1st Edition
    • Kenneth J. Klabunde + 1 more
    • English
    This book is devoted to nanochemistry: a branch of the actively developing interdisciplinary field of nanoscience. This branch of science studies the processes to production and reactions of nanoparticles and their compounds. It has been shown that such particles are of high activity and can undergo new and unusual chemical transformations. These transformations play an active role in our daily lives to provide reagents for self-cleaning glass surfaces and fabrics, different antiseptic coverings, sensors for monitoring the environment and catalysts preventing pollution. Nanochemistry covers the main studies of these reactions and reviews the work of leading scientists from different countries around the world. This book is the first monograph on nanochemistry, combining the elements of review and text book which allows for information on current and prospective directions in nanochemistry.

  • Theory of Simple Liquids

    • 3rd Edition
    • Jean-Pierre Hansen + 1 more
    • English
    The third edition of Theory of Simple Liquids is an updated, advanced, but self-contained introduction to the principles of liquid-state theory. It presents the modern, molecular theory of the structural, thermodynamic interfacial and dynamical properties of the liquid phase of materials constituted of atoms, small molecules or ions. This book leans on concepts and methods form classical Statistical Mechanics in which theoretical predictions are systematically compared with experimental data and results from numerical simulations. The overall layout of the book is similar to that of the previous two editions however, there are considerable changes in emphasis and several key additions including:•up-to-dat... presentation of modern theories of liquid-vapour coexistence and criticality•areas of considerable present and future interest such as super-cooled liquids and the glass transition•the area of liquid metals, which has grown into a mature subject area, now presented as part of the chapter ionic liquids

  • Statistical Design - Chemometrics

    • 1st Edition
    • Volume 25
    • Roy E Bruns + 2 more
    • English
    Statistical Design-Chemometrics is applicable to researchers and professionals who wish to perform experiments in chemometrics and carry out analysis of the data in the most efficient way possible. The language is clear, direct and oriented towards real applications. The book provides 106 exercises with answers to accompany the study of theoretical principles. Forty two cases studies with real data are presented showing designs and the complete statistical analyses for problems in the areas chromatography, electroanalytical and electrochemistry, calibration, polymers, gas adsorption, semiconductors, food technology, biotechnology, photochemistry, catalysis, detergents and ceramics. These studies serve as a guide that the reader can use to perform correct data analyses.

  • Advances in Inorganic Chemistry

    Homogeneous Biomimetic Oxidation Catalysis
    • 1st Edition
    • Volume 58
    • Rudi van Eldik + 1 more
    • English
    Advances in Inorganic Chemistry Volume 58 focuses on homogeneous biomimetic oxidation catalysis. Contributions by leading experts in the field cover important advances in inorganic and bioinorganic chemistry. Contributions include diversity-based approaches to selective biomimetic oxidation catalysis; the selective conversion of hydrocarbons with H2O2 using biomimetic non-heme iron and manganese oxidation catalysis; DNA oxidation by copper and manganese complexes; influences of the ligand in copper-dioxygen complex-formation and substrate oxidations; biomimetic oxidations by dinuclear and trinuclear copper complexes. In the final contribution the authors focus on green oxidation of alcohols using biomimetic copper complexes and enzymes as catalysts. Volume 58 provides another welcomed addition to the widely acclaimed series, Advances in Inorganic Chemistry.

  • Profiles of Drug Substances, Excipients and Related Methodology

    • 1st Edition
    • Volume 32
    • Harry G. Brittain
    • English
    Whilst following in the footsteps of previous volumes by presenting comprehensive reviews of drug substances and additional materials, this title also heralds a significant expansion of the scope of the series. Traditional contributions are now augmented by publication of critical review chapters that summarize information related to the characterization of drug substances and excipients. This change meets the needs of the pharmaceutical community and allows the development of a timely vehicle for publishing review materials on this topic. While offering comprehensive and specialised chapters, Profiles of Drug Substances, Excipients and Related Methodology, Volume 32 also presents a methodology review article on the validation of chromatographic methods of analysis, as well as a summary of the publications in 2004 that dealt with polymorphism and solvatomorphism.

  • Advances in Quantum Chemistry

    • 1st Edition
    • Volume 49
    • John R. Sabin + 1 more
    • English
    Advances in Quantum Chemistry presents surveys of current developments in this rapidly developing field that falls between the historically established areas of mathematics, physics, chemistry, and biology. With invited reviews written by leading international researchers, each presenting new results, it provides a single vehicle for following progress in this interdisciplinary area. This volume continues the tradition with high quality and thorough reviews of various aspects of quantum chemistry. It contains a variety of topics that include an extended and in depth discussion on the calculation of analytical first derivatives of the energy in a similarity transformed equation of motion couples cluster method.

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