Medicinal Chemistry Approaches to Tuberculosis and Trypanosomiasis
- 1st Edition, Volume 52 - September 6, 2019
- Editor: Kelly Chibale
- Language: English
- Hardback ISBN:9 7 8 - 0 - 1 2 - 8 1 7 5 5 6 - 9
- eBook ISBN:9 7 8 - 0 - 1 2 - 8 1 7 5 5 7 - 6
Some of the more recent efforts in tuberculosis (TB) and trypanosomiasis drug discovery from both Product Development Partnerships (PDPs) and academia are highlighted in this th… Read more
Purchase options
Institutional subscription on ScienceDirect
Request a sales quoteSome of the more recent efforts in tuberculosis (TB) and trypanosomiasis drug discovery from both Product Development Partnerships (PDPs) and academia are highlighted in this this volume. Drug discovery approaches include both target- and phenotypic whole cell screening- approaches. Regarding the latter, mechanism of action studies through target identification are also illustrated.
- Provides an overview of the status of some of the current novel compounds in development as well as new emerging treatment options targeting novel mechanisms of action
- Identification of hits from phenotypic whole cell screening, followed by target identification
- Strategies aimed at improving the efficacy of existing clinically used anti-TB drugs by taking advantage inhibitors of mycobacterial transcriptional regulators to boost the anti-tubercular activity, and circumvent acquired-resistance
Medicinal chemists, synthetic chemists, biologists, pharmacologists and clinicians
1. Tuberculosis
Steven J. Berthel, Christopher B. Cooper and Nader P. Fotouhi
2. Antituberculosis agents: Beyond medicinal chemistry rules
Marco Pieroni
3. Development of MmpL3 inhibitors for tuberculosis treatment
Giovanna Poce, Sara Consalvi, Giulia Venditti, Cristina Scarpecci and Mariangela Biava
4. Inhibitors of enzymes in the electron transport chain of Mycobacterium tuberculosis
Andrew M. Thompson and William A. Denny
5. Recent advances in the design of inhibitors of mycobacterial transcriptional regulators to boost thioamides anti-tubercular activity and circumvent acquired-resistance
Nicolas Willand, Marion Flipo, Baptiste Villemagne, Alain Baulard and Benoit Deprez
6. Sustainable anti-trypanosomatid drugs: An aspirational goal for medicinal chemistry
Maria Laura Bolognesi
- No. of pages: 188
- Language: English
- Edition: 1
- Volume: 52
- Published: September 6, 2019
- Imprint: Academic Press
- Hardback ISBN: 9780128175569
- eBook ISBN: 9780128175576
KC