Books in Medicinal chemistry

Annual Reports in Medicinal Chemistry

1st Edition
Volume 43
October 20, 2008
John E. Macor
English
Paperback
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eBook
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Progress in Heterocyclic Chemistry

1st Edition
Volume 20
September 26, 2008
Gordon Gribble + 1 more
English
eBook
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This is the 20th annual volume of Progress in Heterocyclic Chemistry, which covers the literature published during 2007. As with previous volumes in the series, Volume 20 will enable the reader to keep abreast of developments in heterocyclic chemistry in an effortless way.

The Practice of Medicinal Chemistry

3rd Edition
July 24, 2008
Camille Georges Wermuth
English
eBook
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The Practice of Medicinal Chemistry fills a gap in the list of available medicinal chemistry literature. It is a single-volume source on the practical aspects of medicinal chemistry. Considered ""the Bible"" by medicinal chemists, the book emphasizes the methods that chemists use to conduct their research and design new drug entities. It serves as a practical handbook about the drug discovery process, from conception of the molecules to drug production. The first part of the book covers the background of the subject matter, which includes the definition and history of medicinal chemistry, the measurement of biological activities, and the main phases of drug activity. The second part of the book presents the road to discovering a new lead compound and creating a working hypothesis. The main parts of the book discuss the optimization of the lead compound in terms of potency, selectivity, and safety. The Practice of Medicinal Chemistry can be considered a ""first-read"" or ""bedside book"" for readers who are embarking on a career in medicinal chemistry.

Progress in Medicinal Chemistry

1st Edition
Volume 46
April 8, 2008
G. Lawton + 1 more
English
Hardback
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eBook
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Appropriate selection of biochemical targets is one of the most important drivers of cost effectiveness in the discovery of new medicines. Despite the many advances in genetics, genomics and systems biology, ‘validation’ of a target is not achieved until therapeutic efficacy is demonstrated by a drug candidate. Volume 46 of this series reviews the medicinal chemistry aimed at six diverse targets from which important new medicines are emerging: * HIV integrase (discovery of the first-in-class inhibitor drug raltegravir)* 11-beta-Hydroxystero... dehydrogenase (new approach to glucocorticoid regulation)* Nicotinic a7 choline receptor (agonists and positive allosteric modulators). * Bradykinin receptor (new approach to pain therapy)* Histone deacetylase (new drugs for cancer)* 5-HT2c receptor modulators (various CNS indications)

Annual Reports in Medicinal Chemistry

1st Edition
Volume 42
November 20, 2007
John E. Macor
English
Paperback
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eBook
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Cancer Drug Design and Discovery

1st Edition
November 14, 2007
Stephen Neidle
English
eBook
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The ultimate source of information on the design of new anticancer agents, emphasizing small molecules, this newest work covers recent notable successes resulting from the human genome and cancer genomics projects. These advances have provided information on targets involved in specific cancers that are leading to effective medicines for at least some of the common solid tumors. Unique sections explain the basic underlying principles of cancer drug development and provide a practical introduction to modern methods of drug design. Appealing to a broad audience, this is an excellent reference for translational researchers interested in cancer biology and medicine as well as students in pharmacy, pharmacology, or medicinal and biological chemistry and clinicians taking oncology options.

Progress in Medicinal Chemistry

1st Edition
Volume 45
February 19, 2007
F.D. King + 1 more
English
Hardback
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eBook
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The success of any drug discovery project relies upon the quality of the lead that initiates the lead optimization process. What defines a ‘quality lead’, where these ‘quality leads’ come from and how one discovers them has been the subject of intense debate within the pharmaceutical industry, relies upon defining those properties that historically have led to successful drug discovery. This volume addresses these questions and specifically discusses diabetes, obesity and tuberculosis.

Annual Reports in Medicinal Chemistry

1st Edition
Volume 41
December 8, 2006
Anthony Wood
English
Paperback
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eBook
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Annual Reports in Medicinal Chemistry provides timely and critical reviews of important topics in medicinal chemistry together with an emphasis on emerging topics in the biological sciences, which are expected to provide the basis for entirely new future therapies. Sections I-IV are disease orientated and generally report on specific medicinal agents. Sections V and VI continue to emphasize important topics in medicinal chemistry, biology, and drug design. Section VII looks at Trends and Perspectives in the pharmaceuticals market.

Progress in Medicinal Chemistry

1st Edition
Volume 44
April 25, 2006
F.D. King + 1 more
English
Hardback
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eBook
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The perceived lack of drug discovery productivity in recent times has led to much debate in the pharmaceutical/biote... industry as escalating R&D costs are not being matched by increased output. Few observers doubt that selecting the right targets, ie those which are critical to disease pathology and are ‘druggable’, is the best starting point for improved productivity.The seven chapters of this volume describe recent progress towards drugs acting at a range of ‘druggable’ targets. One chapter addresses kinases, one covers an ion channel, two proteases are featured and three of the chapters cover G-protein coupled receptors, which has historically perhaps been the most fruitful area for medicinal chemists.

Landmark Papers in Clinical Chemistry

1st Edition
November 15, 2005
Richard M. Rocco
English
Hardback
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eBook
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This is the first major review of the developments in clinical laboratory science in the 20th century presented in the words of the original inventors and discoverers. Introductory comments by the editor help place the works within the historical context.Landmark Papers addresses:*The origin of the home pregnancy test available today in every drugstore*The woman who invented a billion dollar technology, refused to patent it and went on to win a Nobel Prize*The scientists who worked on the US Government’s crash program at the start of WWII to find a substitute for the malaria drug quinine*The blood test used to monitor the effectiveness of cholesterol lowering drugs that today are taken by over 20 million patients*The graduate student who invented a technology for testing for infectious diseases, took it to Africa to screen people for malaria for the first time and which is now used to test for HIV infection world-wide*The invention of molecular diagnostics by Linus Pauling and the road to individualized medicine*The development of the glucose meter used by diabetics up to six times a day to monitor their metabolic control

Life Sciences

Physical Sciences & Engineering

Social Sciences & Humanities

Health

Books in Medicinal chemistry

Annual Reports in Medicinal Chemistry

Progress in Heterocyclic Chemistry

The Practice of Medicinal Chemistry

Progress in Medicinal Chemistry

Annual Reports in Medicinal Chemistry

Cancer Drug Design and Discovery

Progress in Medicinal Chemistry

Annual Reports in Medicinal Chemistry

Progress in Medicinal Chemistry

Landmark Papers in Clinical Chemistry