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Annual Reports in Medicinal Chemistry
- 1st Edition, Volume 41 - December 8, 2006
- Editor: Anthony Wood
- Language: English
- Paperback ISBN:9 7 8 - 0 - 1 2 - 0 4 0 5 4 1 - 1
- eBook ISBN:9 7 8 - 0 - 0 8 - 0 4 6 7 4 1 - 2
Annual Reports in Medicinal Chemistry provides timely and critical reviews of important topics in medicinal chemistry together with an emphasis on emerging topics in the biolog… Read more
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Request a sales quoteAnnual Reports in Medicinal Chemistry provides timely and critical reviews of important topics in medicinal chemistry together with an emphasis on emerging topics in the biological sciences, which are expected to provide the basis for entirely new future therapies. Sections I-IV are disease orientated and generally report on specific medicinal agents. Sections V and VI continue to emphasize important topics in medicinal chemistry, biology, and drug design. Section VII looks at Trends and Perspectives in the pharmaceuticals market.
- Critical reviews of the previous year's literature in many topics of interest to medicinal chemists
- Highlights major developments in medicinal chemistry
- Includes a comprehensive set of cumulative indices to easily locate topics in all published volumes
medicinal, pharmaceutical and organic chemists
Contributors
Preface
Novel Approaches for the Treatment of Schizophrenia
1 Introduction
2 Approaches targeting altered NMDA receptor function
3 Approaches primarily targeting cognition
4 Approaches primarily targeting psychosis
5 Emerging mechanisms and conclusions
Recent Strategies for the Development of New Antidepressant Drugs
1 Introduction
2 Monoamine reuptake inhibitors
3 SSRIs with monoaminergic receptor modulation
4 Serotonergic receptor modulation
5 Neuropeptide receptor modulation
6 Conclusion
Neuroprotective Agents for the Treatment of Ischemic and Hemorrhagic Stroke
1 Introduction
2 Conclusion
Novel Sodium Channel Blockers for the Treatment of Neuropathic Pain
1 Introduction
2 Background
3 Biological target validation
4 Discovery of novel small molecule blockers
5 Conclusions
Centrally Acting Anti-Obesity Agents
1 Introduction
2 CB1R Antagonists
3 Neuropeptide receptor modulators
4 Aminergic receptor modulators
5 Monoamine re-uptake inhibitors
6 Conclusions
Nuclear Hormone Receptor Modulators for the Treatment of Diabetes and Dyslipidemia
1 Introduction
2 PPARs
3 RXR modulators
4 LXR
5 FXR
6 Conclusion
11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitors
1 Introduction
2 11β-HSD Isozymes
3 Potential therapeutic indications
4 11β-HSD1 Inhibitors
5 Conclusion
Glucokinase Activators for the Treatment of Type 2 Diabetes
1 Introduction
2 Biology of glucokinase
3 Small-molecule glucokinase activators
4 Conclusion and outlook
Renin Inhibitors
1 Introduction
2 Biology
3 Classical renin inhibitors
4 Aliskiren
5 Piperidines
6 Piperazines
7 Aminopyrimidines
8 Conclusion
Antiarrhythmic Agents
1 Introduction
2 Potassium channel modulators
3 Other antiarrhythmic approaches
4 Miscellaneous approaches
Progress in Anti-SARS Coronavirus Chemistry, Biology and Chemotherapy
1 Introduction
2 SARS coronavirus proteases
3 SARS-CoV 3CLpro inhibitors
4 PLpro inhibitors
5 Viral entry inhibitors
6 Miscellaneous inhibitors
7 Future outlook
Inhibitors of the Expression of Vascular Cell Adhesion Molecule-1
1 Introduction
2 Therapeutic potential
3 Antioxidants
4 Cyclic depsipeptides
5 Chalcones
6 Other compounds
7 Conclusion
Recent Advances in Gastrointestinal Prokinetic Agents
1 Introduction
2 Prokinetic agent target classes
3 Conclusions
PGD2 Antagonists
1 Introduction
2 DP Antagonists
3 CRTH2 Antagonists
4 Conclusion
Progress in the Development of Inhaled, Long-Acting β2-Adrenoceptor Agonists
1 Introduction
2 Quinolinones (8-hydroxycarbostyril)
3 Formamides
4 Saligenins
5 New head groups
6 Dual pharmacology
7 Conclusion
The Acyl Sulfonamide Antiproliferatives and Other Novel Antitumor Agents
1 Introduction
2 The acyl sulfonamide antiproliferatives
3 SNS-595
4 Other novel antiproliferative agents
5 Summary and outlook
Progress on Mitotic Kinesin Inhibitors as Anti-cancer Therapeutics
1 Introduction
2 Inhibitors of kinesin spindle protein
3 Conclusions
Developing Infectious Disease Strategies for the Developing World
1 Introduction
2 Avian influenza
3 MDR-TB
4 Conclusion
Influenza Neuraminidase Inhibitors as Antiviral Agents
1 Introduction
2 Inhibitors based upon six-membered heterocycles
3 Inhibitors based on five-membered ring structures
4 Drugs approved or under clinical trial
5 Conclusions
Recent Developments in Antifungal Drug Discovery
1 Introduction
2 Advances in antifungals with known mechanism of action
3 Emerging antigungal agents
4 Trends in antifungal drug discovery
Genomic Data Mining and Its Impact on Drug Discovery
1 Introduction
2 Gene expression profiling
3 Classification of human cancers using microRNA expression profiles
4 Pharmacogenetics and drug metabolism
5 Conclusion
HTS of cDNA and RNAi for Target Identification
1 Introduction
2 High-throughput reverse genetics screens in cell-based systems
3 Gain of function screens using mammalian cDNAs
Genomic Approaches to Identify Molecular Basis of Multi-Factorial Diseases
1 Introduction
2 The complexities of the human genome
3 Current status of our understanding of human diseases at the molecular level
4 New methods to identify genes and pathways activated in complex multi-factorial diseases
5 Future directions
Structure–Activity Relationships for In vitro and In vivo Toxicity
1 Introduction
2 Structure–toxicity relationships where outcomes may be associated with specific structural fragments
3 Toxicities linked to descriptors for the overall properties of the molecule
4 Predicting structure–toxicity relationships
5 Conclusion
Importance of Early Assessment of Bioactivation in Drug Discovery
1 Introduction
2 Assays to monitor formation of reactive metabolites
3 Strategic directions
The Application of Pulmonary Inhalation Technology to Drug Discovery
1 Introduction
2 The lungs
3 Absorption and bioavailability
4 Pharmacokinetics
5 Safety
6 Inhalation dosage form and delivery system considerations
7 Inhalation product development
8 Inhalation products
9 Conclusions
Recent Advances in Oral Prodrug Discovery
1 Introduction
2 Prodrugs of poorly soluble compounds
3 Prodrugs of polar compounds
4 Prodrugs targeting active transporters
5 Prodrugs for targeted tissue delivery
6 Prodrugs with other benefits
7 Conclusions
Oxytocin Antagonists and Agonists
1 Introduction
2 Oxytocin antagonists
3 Oxytocin agonists
4 Conclusions
Knowledge and Intelligence in Drug Design
1 Introduction
2 Possession of facts
3 Possession of skill
4 Artifical intelligence in drug design
5 Conclusion
To Market, To Market – 2005
1 Introduction
2 Ciclesonide (asthma, COPD)
3 Clofarabine (anticancer)
4 Darifenacin (urinary incontinence)
5 Deferasirox (chronic iron overload)
6 Doripenem (antibiotic)
7 Eberconazole (antifungal)
8 Entecavir (antiviral)
9 Eszopiclone (hypnotic)
10 Exenatide (anti-diabetic)
11 Galsulfase (mucopolysaccharidosis VI)
12 Luliconazole (antifungal)
13 Lumiracoxib (anti-inflammatory)
14 Nepafenac (anti-inflammatory)
15 Pegaptanib (age-related macular degeneration)
16 Pramlintide (anti-diabetic)
17 Palifermin (mucositis)
18 Ramelteon (insomnia)
19 Rasagiline (Parkinson's disease)
20 Sorafenib (anticancer)
21 Tamibarotene (anticancer)
22 Tigecycline (antibiotic)
23 Tipranavir (HIV)
24 Udenafil (erectile dysfunction)
25 Ziconotide (severe chronic pain)
Compound Name, Code Number and Subject Index. Vol. 41
Cumulative Chapter Titles Keyword Index, Vol. 1–41
Cumulative NCE Introduction Index, 1983–2005
Cumulative NCE Introduction Index, 1983–2005 (By Indication)
- No. of pages: 556
- Language: English
- Edition: 1
- Volume: 41
- Published: December 8, 2006
- Imprint: Academic Press
- Paperback ISBN: 9780120405411
- eBook ISBN: 9780080467412
AW
Anthony Wood
Affiliations and expertise
Pfizer Global Research and Development, Sandwich Laboratories, Sandwich, Kent, UKRead Annual Reports in Medicinal Chemistry on ScienceDirect