Atlas of Endoscopy Imaging in Inflammatory Bowel Disease, Second Edition, serves as a comprehensive guide to the latest advancements in IBD. This new edition keeps readers updated with cutting-edge medical treatments, state-of-the-art endoscopy, and imaging technologies, as well as the evolution of interventional IBD. It explores the latest advancements in IBD diagnosis and management, including the most recent endoscopy instruments for measuring disease activity and the transformative world of image-enhanced endoscopy. Additionally, it delves into the groundbreaking application of Artificial Intelligence (AI) in IBD, revolutionizing diagnosis, disease monitoring, and dysplasia surveillance. New content introduces a range of topics to stay at the forefront of Inflammatory Bowel Disease (IBD) knowledge. These include Intestinal Ultrasound, Device-Associated Enteroscopy in Crohn’s Disease, insights into IBD-Like Conditions (Autoinflammatory Disorders), and the value of Intraoperative Endoscopy in IBD procedures. The book also integrates New Consensus Guidelines for Endoscopy Imaging in IBD, explores the Applications of Artificial Intelligence (AI) in IBD diagnosis and monitoring, addresses the intersection of COVID, COVID Vaccines, and IBD, and presents New Applications of Interventional IBD techniques. This second edition serves as a dynamic repository of state-of-the-art information, providing invaluable insights on differential diagnosis, advanced endoscopy, and imaging technologies, with a pronounced focus on AI. It also offers updated guidelines for disease activity assessment and the latest advancements in endoscopic therapy modalities. Designed to cater to a diverse range of medical professionals, it stands as an indispensable reference, fostering a comprehensive and up-to-date understanding of Inflammatory Bowel Disease (IBD). Within these pages,Gastroenterologists and IBD specialists will discover a wealth of resources to aid their pursuit of cutting-edge treatments and AI-driven insights. Primary care clinicians will find an expanded list of differential diagnoses that enables more accurate early-stage identification. Surgeons can elevate their expertise by delving into the intricacies of interventional IBD techniques, while pathologists and radiologists can enhance their diagnostic skills through AI and image-enhanced endoscopy. This comprehensive resource ensures that medical professionals across various disciplines are well-equipped to navigate the evolving landscape of IBD diagnosis, treatment, and management.
Curcumin Bioavailability and Sustainability as Therapeutic Agent: Strategies for Sustained Release Curcumin is a comprehensive reference on techniques to enhance the bioavailability of curcumin, while also covering sustainability aspects across its production cycle. This book focuses on the information needs of pharmaceutical scientists aiming at developing drug delivery systems and formulations that can maximize the therapeutic impact of curcumin drugs. After an introduction to curcumin therapeutic properties, the authors delve into the bioavailability challenges confronted by curcumin, discussing influencing factors, pharmacokinetic pathways, and formulations to augment its bioaccessibility. Chapter 3 explores innovative formulation paradigms, encompassing nanoparticle-based delivery systems and lipidic matrices, tailored to overcome solubility limitations and increase absorptive efficacy. Chapter 4 covers delivery systems, encompassing prodrug strategies, encapsulation modalities, and nanocarrier technologies. Chapter 5 investigates sustainable sourcing and production, raising awareness to ethical cultivation practices, eco-friendly extraction methodologies, and proficient waste management techniques within curcumin production processes. In Chapter 6 discusses balancing bioavailability augmentation with sustainability principles including case studies. Chapter 7 navigates the domain of pharmacokinetic studies and clinical trials, providing an overview of bioaccessibility and bioavailable formulations. Chapter 8 explores safety profiles, regulatory requirements, and quality benchmarks, encompassing product labeling and claims concerning curcumin's bioavailability and sustainability. Chapter 9 casts a future view contemplating nascent technologies for bioavailability and sustainability optimization. The final chapter concludes the book with the author's observations on its central themes. Curcumin Bioavailability and Sustainability as Therapeutic Agent: Strategies for Sustained Release Curcumin provides practical strategies to be explored by pharmaceutical scientists in increasing bioavailability of curcumin formulations. Research physicians and nutritionists may also benefit from the evidence-based information on curcumin's therapeutic activities provided across the book.
Age-Related Hearing Loss, Brain Health, and Dementia reviews the effects of hearing loss on the brain and examines the most up-to-date perspectives on the possible causal relation between hearing loss and cognitive impairment. Through this synthesis, the book will explore the links between hearing loss and the brain to improve understanding and promote better hearing for better brain health.
Extracellular Mitochondria in Health and Disease covers this new and significant area of research, shedding light on their roles in intercellular communication and disease pathology. These tiny powerhouses, traditionally known for their intracellular functions, are now recognized for their extracellular activities that impact various physiological and pathological processes. The book delves into a range of topics, including cellular mechanisms of mitochondrial transfer, metabolic signaling, and the crosstalk between extracellular vesicles and mitochondria. It serves as a comprehensive guide for scientists, researchers, and students eager to explore these novel findings and their potential implications.Other sections examine the roles of extracellular mitochondria in immune regulation and inflammation, neurodegeneration and neuroprotection, and their therapeutic potential. By bridging gaps in existing literature, this resource offers up-to-date research and discoveries, providing valuable insights into how extracellular mitochondria could revolutionize medical advancements and improve patient outcomes.
Drug Metabolism in Diseases: Leveraging Drug Metabolism and Disposition in Precision Medicine and Therapeutic Development, now in second edition, provides pharmaceutical scientists and biologists with the needed foundational knowledge required to understand the interplay between diseases and physiological conditions, how they impact drug metabolism and disposition, and its implications in personalized treatment. The book has been expanded with six new chapters, and completely updated with the scientific findings since the first edition published in 2016. The new chapters in the book cover drug metabolism in metabolic syndrome , transplant patients, geriatric patients, the developmental regulation of drug metabolism and disposition, the effect of gut microbiota on xenobiotic and endobiotic metabolism, the regulation of expression of drug-metabolizing enzymes by oncogenic signaling pathways, and drug metabolism in HIV patients. All other chapters in the first edition like drug metabolism in pregnancy, pediatric patients, patients of cardiovascular disease, and kidney diseases were completely updated to include the latest research results and references. Drug Metabolism in Diseases: Leveraging Drug Metabolism and Disposition in Precision Medicine and Therapeutic Development is a comprehensive reference on the mutual effect between drug metabolism and diseases, which has great implications in precision medicine and therapeutic development. Pharmaceutical scientists and drug metabolism researchers in academia and corporate R&D departments will benefit from the expanded coverage provided by expert authors. Research physicians interested in better understand the impact of diseases in drug metabolism will also benefit from the comprehensive overview of the area.
Myasthenia Gravis, Part B, Volume 183 of the series International Review of Neurobiology highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.
Bioactive Components for Functional Foods defines each chemical family of bioactives and collects many of the functional components described in foods and their implications on nutrition and health. It also discusses non-phytochemical components, such as probiotics, bioactive peptides, and fatty acids and their relationship to health. Readers will learn about the metabolism and bioavailability of bioactives, interactions with gut microbiota, interactions of probiotics as food ingredients with other food components, and more.Readers will also find the latest marketing and regulatory issues for functional foods while learning about future trends of micro and nanoencapsulation, delivery systems, and nutraceuticals.
Drug Discovery Approaches for the Treatment of Neurodegenerative Disorders: Alzheimer’s Disease, Second Edition examines the drug discovery process for neurodegenerative diseases by focusing specifically on Alzheimer’s Disease and illustrating the paradigm necessary to ensure future research and treatment success. The new edition of this book is updated with the most recent developments around the therapeutic strategies for drug discovery like amyloid hypothesis, tau, apo E, insulin, and others. It also includes a new chapter on drug delivery to the brain. The content covers diagnosis, epidemiology, drug discovery strategies, current therapeutics, and much more to provide a holistic approach to the discovery, development, and treatment of Alzheimer’s Disease. Through its coverage of the latest research in targeted drug design, preclinical studies, and mouse and rat models, the book is a must-have resource for all pharmaceutical scientists, pharmacologists, neuroscientists, and clinical researchers working in this area. Pharmaceutical researchers will benefit from the updated coverage on therapeutic approaches to neurodegenerative diseases like Alzheimer’s disease, Parkinson’s disease, Amyotrophic lateral sclerosis, multiple sclerosis, frontotemporal disorder, Huntington’s diseases and many more. Patients and advocacy groups can also benefit from the overview of current treatment options and the scientific progress in the field.
Biophysics of Tissue Self-Organization in Morphogenesis: The Role of Dynamics Along the Biointerface delves into the interactions between tissue and the extracellular matrix. It explores the fundamentals of cell self-rearrangement and the interrelation between biological mechanisms and physical principles responsible for tissue self-organization. The book examines modeling approaches to tissue self-organization and the application of engineering principles to solve medical problems. It also discusses tools, applications, and medical implications, particularly in embryo development, wound healing, and cancerous diseases, concluding with future developments.Covering subcellular to supracellular levels, this book is an interdisciplinary guide for researchers in cell biology, biophysics, developmental biology, and more.
Comprehensive Integrative Oncology is a vital resource for clinicians who seek to blend integrative therapies with conventional oncology care to enhance patient outcomes. This book, authored by experts in both conventional and integrative medicine, emphasizes a holistic approach to cancer treatment. It provides practical guidance on incorporating scientifically-backed therapies like botanicals, supplements, mind-body practices, lifestyle changes, nutrition, and exercise into standard cancer care, all while prioritizing patient safety, prevention, and overall wellness. The book delves into the philosophy of integrative oncology, offers tools for practical application, and presents integrative strategies for cancer prevention and symptom management.Additionally, it explores the needs of special populations within oncology. It serves as an indispensable textbook for oncology researchers and practitioners who aim to provide holistic and patient-centered care.