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Books in Life sciences

1-10 of 20305 results in All results

Misfolding of Amyloid-beta and tau in Alzheimer’s and Other Neurodegenerative Diseases

  • 1st Edition
  • January 1, 2099
  • Louise Serpell
  • English
  • eBook
    9 7 8 - 0 - 3 2 3 - 9 5 8 5 1 - 6
Misfolding of Amyloid-beta and tau in Alzheimer’s and Other Neurodegenerative Diseases describes historical discoveries of these two major proteins in Alzheimer’s disease and other neurodegenerative conditions. The book navigates through the importance of protein self-assembly, protein conformational change, and structural studies in understanding the positioning in the disease pathway. How these proteins are involved in the pathway to neuronal dysfunction, and the importance of understanding protein conformation and deposition for diagnosis are also highlighted. Although Alzheimer’s disease was discovered over 100 years ago, the role of protein misfolding in the pathology and cause of Alzheimer’s disease remains unclear. Amyloid-beta and Tau are both proteins well known for their involvement in Alzheimer’s disease. Both proteins misfolding and aggregate are deposited as cross-beta amyloid fibrils in the tissues.

Cancer Drug Design and Discovery

  • 3rd Edition
  • October 1, 2029
  • Stephen Neidle + 1 more
  • English
  • eBook
    9 7 8 - 0 - 3 2 3 - 9 9 4 8 8 - 0
Cancer Drug Design and Discovery, 3rd edition continues the tradition of bringing a complete and authoritative reference that features the identification of cellular and molecular targets and their involvement in human cancer initiation and progression. This book aims at helping lead drug discovery researchers to the development of more effective anticancer therapies. Organized in three major parts, the first five chapters deal with an introduction to cancer drug discovery, pharmacogenomics and precision medicine, natural products, structural biology and pre-clinical, models. The second part focusses on therapies, covering nucleic acid-based therapies, Proteolysis-targeting chimera (protac), inhibition of DNA repair, cell signaling agents, immunotherapies, antibody-drug conjugates, and epigenetics for cancer treatment. The final part deals with the practice of cancer drugs in the clinic setting, including IP, failure modes, regulation, and registration of anti-cancer drugs. Multi-authored by leading researchers and clinicians in the field, this book is a valuable for pharma researchers both in academia and corporate settings. The foundational content provided by the authors can also be of interest to oncologists and research physicians specialized in the covered types of cancer.

Aquaculture with Artificial Intelligence

  • 1st Edition
  • February 1, 2026
  • Baskaralingam Vaseeharan + 3 more
  • English
  • Paperback
    9 7 8 - 0 - 4 4 3 - 3 3 7 0 4 - 8
  • eBook
    9 7 8 - 0 - 4 4 3 - 3 3 7 0 5 - 5
Aquaculture with Artificial Intelligence: Smart Aquaculture acknowledges the crucial role that Artificial Intelligence (AI) will play in aquaculture and aquaculture-adjacent sectors in the coming years. The aquaculture industry faces various challenges, including environmental concerns, disease management, and resource optimization, and integrating AI into aquaculture practices can improve industry efficiency, sustainability, and overall productivity. This book explores how AI technologies such as machine learning for predictive analytics, computer vision for monitoring aquatic environments, and robotics for automated tasks can streamline various aspects of aquaculture requiring monitoring, management, and decision-making. Aquaculture with Artificial Intelligence: Smart Aquaculture is co-authored by a diverse team of experts bridging disciplines in aquaculture, aquatic immunology, biotechnology, and artificial intelligence. Early chapters provide a thorough introduction to the aquaculture industry to provide critical context for all audiences. Central chapters explore machine learning, bioimaging, drone technology, bioengineering, OMICs technologies, big data, and other AI technologies emerging in aquaculture. Global case studies highlight the practical applications of AI to various aspects of aquaculture operations, including automated feeding, water quality monitoring, disease protection, and precision aquaculture. The book concludes with a look to the future of the industry, research gaps, and opportunities for continued research. This is an essential read for aquaculturists, environmental scientists, data scientists, and roboticists interested in the intersection of aquaculture and AI.

Immunotherapies for Neurologic Diseases

  • 1st Edition
  • Volume TBD
  • December 1, 2025
  • Marinos C. Dalakas
  • English
  • Hardback
    9 7 8 - 0 - 3 2 3 - 9 0 8 8 7 - 0
  • eBook
    9 7 8 - 0 - 3 2 3 - 9 0 8 8 8 - 7
The evolution of neuroimmunotherapies with the concurrent progress in autoimmune neurology will introduce the book, followed by an update on “non-targeted” therapies highlighting the value of immunosuppressants, plasmapheresis, IVIg or hematopoietic bone marrow transplantation and their mode of action in autoimmune neurology. The new agents in each of these categories, along with biomarkers for therapeutic monitoring and the application of reliable scales in assessing response, will be covered. Chapters will discuss how neuroimmunotherapies work when key molecules and pathways associated with CNS or PNS tissue damage are targeted or inhibited. The volume will describe the approved agents targeting: 1) T-cell intracellular signaling pathways and molecules associated with antigen presentation; 2) B cells, B-cell trophic factors, and autoantibodies; 3) Fc receptor modulation; 4) complement; and 5) cytokines, cell adhesion and transmigration molecules. Didactic schemes and illustrations on how these drugs work in autoimmune neurological diseases will be provided in each chapter. The second part of the book will discuss the latest therapeutics for each major autoimmune neurological disease, aimed to provide a reliable, comprehensive and up-to-date source of information useful for clinical practice and education. Didactic and practical algorithms, a step-by step approach on how best to apply the most suitable therapies for a given state of the disease or proceed to escalation therapies will be provided.Treatment controversies and uncertainties will be authoritatively emphasized by scholars in each field. A chapter addressing potential immunotherapeutic approaches, now on the pipeline or on early trials, as future means of treating some neurodegenerative diseases will be included. Another chapter will cover the new and popular-although controversial -concept of treating autoimmune pain.The book discusses practical therapies with traditional immunosuppressants, steroids and IVIg. It describes targeted therapies with monoclonal antibodies or fusion proteins against B cells , T cells, complement, and FcRn, discussing what happens when key factors related to neurological autoimmunity are inhibited. The book provides a “how- to- do” approach for each of the major autoimmune diseases with algorithms and escalation therapies. Dedicated chapters will cover current therapies on encephalitis, NMOSD, Multiple sclerosis , autoimmune neuropathies, myopathies, neuromuscular junction disorders and neuroexcitability disorders like stiff person syndrome. The book is aimed for practitioners and academicians as a reliable and comprehensive source for applying neuroimmunotherapies and understanding their mechanisms.

Comprehensive Molecular Insect Science

  • 2nd Edition
  • November 1, 2025
  • Peter W. Atkinson + 1 more
  • English
  • Hardback
    9 7 8 - 0 - 3 2 3 - 9 5 4 2 4 - 2
  • eBook
    9 7 8 - 0 - 3 2 3 - 9 5 8 1 8 - 9
Updated and expanded, this new edition of Comprehensive Molecular Insect Science is a unique resource, providing comprehensive review articles on contemporary topics in insect science and entomology. Important new topics include genetic control, pollinators, the impact of climate change, and changing environmental impacts on insect physiology and molecular biology. Each section includes extensive discussion on the impact of genomics, proteomics, metabolomics and bioinformatics in the field, which has seen a revolution since publication of the previous edition.This work bridges gaps between disciplines, allows readers to easily learn the fundamentals of insect science and understand its applications e.g. in environmental control. Structured chapters guide the readers, providing links to references and practical resources such as methods.In the decades ahead, the fate of our civilization is intertwined with those of the insects and flora on our planet; a single authoritative reference work on molecular insect science provides an important part of the knowledge needed to act as responsible stewards of the planet.

Comprehensive Cancer, Inflammation and Immunity

  • 1st Edition
  • November 1, 2025
  • Blerina Osmanaj + 2 more
  • English
  • Hardback
    9 7 8 - 0 - 4 4 3 - 1 4 0 6 4 - 8
  • eBook
    9 7 8 - 0 - 4 4 3 - 1 4 0 6 5 - 5
Cancer, Inflammation and Immunity examines cancer development as a multi-step process involving malignancy, failing immunosurveillance and elevated immunosuppression. Capturing the complexity of the disease, it discusses contributing lifestyle and environmental factors, as well as the effectiveness of various treatments that aim to reinstate immunosurveillance. Featuring approximately 150 articles from world leading scholars, this interdisciplinary resource discusses cancer within an immunology context. Beginning with how tumors develop and metastasis occurs, it goes on to explain metabolic re-programming and other immuno-oncological events. It focusses on treatment strategies including the induction of tumor immunogenicity, the reprogramming of immune effectors and antigen presenting cells as well as the modulation of the tumor microenvironment. Successful combinatorial therapeutic approaches that address the malignancy at the level of the tumor and at the immune system are also discussed. This state-of-the art resource combines the fields of cancer, immunology and clinical immuno-oncology, and provides an extensive understanding of the disease to students, practicing clinicians and oncology researchers.

Transforming Global Healthcare Delivery

  • 1st Edition
  • November 1, 2025
  • Sandeep Reddy
  • English
  • Paperback
    9 7 8 - 0 - 4 4 3 - 3 3 0 2 0 - 9
  • eBook
    9 7 8 - 0 - 4 4 3 - 3 3 0 2 1 - 6
"Transforming Global Healthcare Delivery: Leveraging Technology to Increase Accessibility and Affordability" guides readers through the ongoing digital transformation of healthcare. The author makes the case for how tools like AI, telehealth, and data analytics can empower patients, connect underserved communities, and help health systems achieve the Quadruple Aim. Real-world examples along with the author's evaluations of digital health interventions showcase promising directions. The author argues realizing the full potential of new technologies requires corresponding advancement of care delivery models towards team-based, coordinated practice and spotlights innovative programs trailing shared appointments, community health workers, remote monitoring and more that can expand access and better meet individual needs. With authoritative analysis grounded in both research and practice, this book serves as a practical roadmap for digitally enabled, patient-centred care capable of delivering improved outcomes to all. Dr. Reddy has over 25 years of international experience as a clinician, researcher, and health system leader; offering an unmatched perspective on leveraging technology to enable patient-centred, value-based care. "Transforming Global Healthcare Delivery" draws on extensive qualifications across medicine, public health, management, and informatics.

Pathophysiological Consequences of Alcohol

  • 1st Edition
  • November 1, 2025
  • Patricia E. Molina + 2 more
  • English
  • Hardback
    9 7 8 - 0 - 4 4 3 - 3 4 2 5 8 - 5
  • eBook
    9 7 8 - 0 - 4 4 3 - 3 4 2 5 9 - 2
"Pathophysiological Consequences of Alcohol" presents how alcohol impacts physiological processes in organ systems. Relevant organ system physiology will first be presented as an overview, followed by up to date, evidenced-based findings related to how alcohol use either acutely or chronically impacts these processes. Each chapter, with the exception of the Introduction and Cellular and Molecular Physiology, begins with an overview of the physiology of the system, followed by the salient findings on alcohol's impact on that system, and ends with with an integrative case or clinical vignette. Written for those working and studying physiology, biology or neuroscience, by a team of experts involved in the study of how alcohol use contributes to risk for comorbidities, based in a leading Physiology Department, and heavily engaged in teaching of the discipline.

Hypinosis

  • 1st Edition
  • Volume 184
  • November 1, 2025
  • Devin Terhune + 2 more
  • English
  • Hardback
    9 7 8 - 0 - 4 4 3 - 3 4 4 2 1 - 3
  • eBook
    9 7 8 - 0 - 4 4 3 - 3 4 4 2 2 - 0