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    • The Immunology of the Domestic Ruminants

      • 1st Edition
      • March 12, 2025
      • Ian R. Tizard
      • English
      • Paperback
        9 7 8 0 4 4 3 3 3 5 7 2 3
      • eBook
        9 7 8 0 4 4 3 3 3 5 7 3 0
      The Immunology of Domestic Ruminants: Cattle, Sheep, and Goats provides a thorough examination of the immune systems of these animals. It explores their normal immune functions and their roles in combating infectious and parasitic diseases, chronic inflammatory conditions, and immunodeficiency disorders. The book incorporates new data from the bovine genome project and highlights significant breed differences. Both innate and adaptive immunity are systematically covered, offering insights into basic and applied aspects of bovine immunology. In addition to detailing the immunology of major bacterial, viral, and parasitic diseases in cattle, the book reviews bovine vaccines and emphasizes the importance nutrition.This essential resource caters to professionals in large animal research and practice, providing comprehensive information on the immunology of domestic cattle, sheep, and goats.

    • Natural Biopolymers for Drug Delivery

      • 1st Edition
      • March 11, 2025
      • Amit Kumar Nayak + 2 more
      • English
      • Paperback
        9 7 8 0 3 2 3 9 5 3 6 7 2
      • eBook
        9 7 8 0 3 2 3 9 5 8 5 8 5
      Natural Biopolymers for Drug Delivery thoroughly details the properties, benefits and challenges of using these biomaterials in drug delivery, with a strong focus on biocompatibility and reduction of unwanted interactions. An extensive range of natural biopolymers are explored, such as cellulose, chitosan, casein, gelatin, cashew gum, and many more. Biocompatibility, toxicity and regulatory considerations are also thoroughly discussed, ensuring the reader is fully equipped for efficient biomaterials selection and utilization in drug delivery applications. This is a must-have reference for those working in the fields of materials science, biomedical engineering, pharmaceutical science and pharmacology, chemical engineering and clinical science.

    • Cholecystokinin

      • 1st Edition
      • March 10, 2025
      • Christine Feinle-Bisset + 1 more
      • English
      • Paperback
        9 7 8 0 4 4 3 2 3 7 2 0 1
      • eBook
        9 7 8 0 4 4 3 2 3 7 2 1 8
      Cholecystokinin: From Gallbladder to Cognition and Beyond covers the biology, physiology, and pathophysiological roles of cholecystokinin (CCK) peptides. The book begins with a historical overview before providing in-depth chapters on the biology of CCK, from biogenesis to cell expression, including intestinal and extraintestinal endocrine cells, the central and peripheral nervous system, and receptor function. CCK phylogenesis is explored across various species, including fish, birds, insects and amphibians. The physiology of CCK covers intestinal CCK secretion, the gallbladder and pancreas, and the role of CCK in the gut-brain axis, gastrointestinal motor function, appetite regulation, and cardiovascular function.Methods used for CCK research are also discussed. A number of chapters then covers the roles of CCK in various diseases, including metabolic diseases, tumors, psychiatric illness, the immune system and nociception, as well as potential therapeutic approaches targeting CCK receptors.

    • Methods for Monitoring Mitochondrial Functions During Pathogen Infection

      • 1st Edition
      • Volume 194
      • March 10, 2025
      • English
      • Hardback
        9 7 8 0 3 2 3 9 9 2 1 9 0
      • eBook
        9 7 8 0 3 2 3 9 9 2 2 0 6
      Methods for Monitoring Mitochondrial Functions During Pathogen Infection, Volume 194 in the Methods in Cell Biology series highlights advances in the field, with this new volume presenting interesting chapters on timely topics, including Mitochondrial Labeling with Fluorescent Proteins for Enhanced Morphological Characterization and Visualization of Intercellular Mitochondrial Transfer, Visualizing mitochondrial electron transport chain complexes and super-complexes during infection of human macrophages with Legionella pneumophila, Quantitative assessment of mitochondrial membrane potential in macrophages in sepsis, Quantification of mitochondrial reactive oxygen species in macrophages during sepsis, and much more.Additional chapters cover Quantification of intracellular and mitochondrial ATP content in macrophages during lipopolysaccharide-i... inflammatory response, Analysis of cytosolic mtDNA release during Staphylococcus Aureus infection, Monitoring mitochondria dynamics upon infection using a tomographic approach, A screening system to determine bacterial effects on MADCAM1 expression by high endothelial venule cells, Isolation of mitochondria from Mycobacteria infected cells, Monitoring mitochondrial localization of Mycobacterial proteins, and more.

    • Challenges in Delivery of Therapeutic Genomics and Proteomics

      • 2nd Edition
      • March 6, 2025
      • Aliasgar Shahiwala + 1 more
      • English
      • Paperback
        9 7 8 0 4 4 3 2 7 4 1 6 9
      • eBook
        9 7 8 0 4 4 3 2 7 4 1 7 6
      Challenges in Delivery of Therapeutic Genomics and Proteomics, Second Edition is a complete reference on the biological principles involved in gene and protein delivery to cells and tissues. Highlighting the various chemical, physical, and biological approaches to protein and gene delivery, the book provides guidelines for pharmaceutical researchers in academia and corporate R&D. This new edition brings updates on the delivery of therapeutic proteomics and genomics in each chapter, and newly developed chapters on the regulatory aspects of related products, CRISPR/Cas9 gene editing, and computational tools in genomics and proteomics.After an overview of the barriers to genomics and proteomics delivery, the book dives into physical, chemical, and biological methods of gene delivery. Further chapters extensively discuss the delivery of proteins and therapeutic peptides through the respiratory, oral, parenteral, transdermal, topical, uterine, and rectal pathways. This book is the ideal reference for pharmaceutical scientists dealing with gene and protein/peptide delivery. Regulators and corporate researchers can also benefit from the wide coverage of delivery methods presented.

    • La maladie de Parkinson

      • 5th Edition
      • March 6, 2025
      • Luc Defebvre + 2 more
      • French
      • Paperback
        9 7 8 2 2 9 4 7 8 9 8 2 3
      • Paperback
        9 7 8 2 2 9 4 7 8 7 1 2 6
      • eBook
        9 7 8 2 2 9 4 7 8 7 3 3 1
      La collection « Elsevier Monographies » permet aux praticiens d’approfondir et d’actualiser leurs connaissances, en exposant les données fondamentales actuelles et leurs applications dans la pratique clinique.La maladie de Parkinson est, après la maladie d’Alzheimer, l’affection neurologique la plus répandue au sein de la population après 50 ans. Sa prévalence augmentant avec l’âge, surtout au-delà de 60 ans, on peut prévoir dès aujourd’hui qu’avec le vieillissement de la population, le nombre de patients ne cessera d’augmenter dans les années à venir.Modèle d’affection neurodégénérative, la maladie de Parkinson se manifeste de façon variable selon les patients et les stades d’évolution, bien au-delà des seuls troubles moteurs qui la caractérisent. Ces dernières années, la recherche a connu des avancées significatives, tant sur le plan de la compréhension des mécanismes physiopathologiques et génétiques que sur celui des stratégies diagnostiques et thérapeutiques.Cette cinquième édition, réalisée en collaboration avec les meilleurs spécialistes cliniciens et chercheurs francophones, propose une actualisation complète des connaissances, enrichie de neuf nouveaux chapitres. Cette nouvelle édition aborde ainsi des thématiques essentielles comme l’histoire et l’épidémiologie de la maladie, les innovations en électrophysiologie, la santé bucco-dentaire, les indications des injections de toxine botulique ou encore le rôle du pharmacien d’officine. De plus, une attention particulière a été portée à la démarche neuropalliative, aux dispositifs de soins à domicile et aux questions pratiques telles que le permis de conduire.Ce livre s’adresse aux praticiens et à tous les professionnels de santé, médicaux et paramédicaux, exerçant dans un service de neurologie ou concernés par la pathologie parkinsonienne : neurologues, internes préparant le diplôme d’études spécialisées de neurologie, neuropsychologues, psychiatres, rééducateurs, orthophonistes et kinésithérapeutes.PO... CLÉSL’histoire et l’épidémiologie de la maladie.Les causes, la physiopathologie et les signes cliniques.La prise en charge thérapeutique des patients. Luc Defebvre est chef du service de neurologie et pathologie du mouvement, responsable du Centre Expert Parkinson, unité Inserm 1172, CHU et université de Lille.Marc Vérin est neurologue au service de neurologie, CHU d’Orléans, laboratoire interdisciplinaire pour l’innovation et la recherche en santé d’Orléans (LI2RSO), équipe « Brain Clinical and Experimental Neuroplasticity » (B-CLINE), université d’Orléans.

    • The Nervous System

      • 1st Edition
      • Volume 5
      • March 4, 2025
      • Mayeen Uddin Khandaker + 1 more
      • English
      • Paperback
        9 7 8 0 4 4 3 2 7 4 1 4 5
      • eBook
        9 7 8 0 4 4 3 2 7 4 1 5 2
      The series Stem Cell Innovation in Health and Disease is a timely and fascinating collection of information and new discoveries and provides a contemporary snapshot album from the fast-moving field of regenerative medicine and stem cell therapeutics. The Nervous System, Volume 5 addresses the recent data accumulated on the potential applications of stem cells to treat diseases and disorders of the nervous system. This volume will highlight the recent development of cutting edge in vitro and in vivo research tools and approaches, including human and murine organoid cultures, genetic editing in vitro and in vivo, human iPSC models of disease, haploid cells for genetic as well as compound screening paradigms, genetically engineered mice, and stem cell transplantation to treat nervous system disorders and diseases. The volume is written for researchers and scientists in stem cell therapy, cell biology, regenerative medicine and organ transplantation; and is contributed by world-renowned authors in the field.

    • Innovations in Biomedical Engineering

      • 1st Edition
      • March 3, 2025
      • Shubham Mahajan + 1 more
      • English
      • Paperback
        9 7 8 0 4 4 3 3 0 1 4 6 9
      • eBook
        9 7 8 0 4 4 3 3 0 1 4 7 6
      Innovations in Biomedical Engineering: Trends in Scientific Advances and Application addresses the burgeoning demand for a comprehensive resource that not only showcases the latest advancements in this dynamic field but also shows how these innovations can be effectively translated into real-world applications. In essence, the book acts as a bridge, connecting discoveries, research, and innovations in biomedical engineering to tangible, real-world applications.

    • African Plant-Based Products as a Source of Potent Drugs to Overcome Cancers and their Chemoresistance

      • 1st Edition
      • Volume 115
      • March 3, 2025
      • English
      • Hardback
        9 7 8 0 4 4 3 2 9 3 3 4 4
      • eBook
        9 7 8 0 4 4 3 2 9 3 3 5 1
      African Plant-Based Products as a Source of Potent Drugs to Overcome Cancers and their Chemoresistance: Part 3. Potential Pharmaceuticals to Overcome Cancers and their Chemoresistance offers detailed information on the best cytotoxic phytoconstituents of African medicinal plants that could be useful for the development of efficient pharmaceuticals that could be further explored to efficiently overcome cancers and their drug resistance. The book identifies and comments on the various classes of cytotoxic African secondary metabolites. The book also clearly identifies and comments on the best cytotoxic molecules identified in African medicinal plants. The book appears an amazing tool for Scientists to have state-of-the-art of the best cytotoxic phytoconstituents from the African flora, and to boost their clinical investigations.

    • Salmonella Biofilms, Infection, and Therapeutic Management

      • 1st Edition
      • March 1, 2025
      • Awanish Kumar + 1 more
      • English
      • Paperback
        9 7 8 0 4 4 3 2 2 0 5 5 5
      • eBook
        9 7 8 0 4 4 3 2 2 0 5 6 2
      Salmonella Biofilms, Infection, and Therapeutic Management provides an overview of salmonella biofilms, their detection and identification, associated salmonellosis infection, prevention and treatment.The book discusses salmonella, the formation of biofilm, and biofilm associated bacterial infection. It aims to provide insight on how salmonellosis and biofilm relate to one another as well as how they relate to other diseases in the host. It also discusses the therapeutic strategy for reducing salmonella infection and current treatment options. Salmonella Biofilms, Infection, and Therapeutic Management is a useful reference for those engaged in the study of the study of salmonella biofilm, its formation, disease manifestation, and management.

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