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    • Advances in Parasitology

      • 1st Edition
      • Volume 83
      • December 2, 2012
      • English
      • eBook
        9 7 8 0 1 2 4 0 7 7 3 3 1
      First published in 1963, Advances in Parasitology contains comprehensive and up-to-date reviews in all areas of interest in contemporary parasitology. Advances in Parasitology includes medical studies on parasites of major influence, such as Plasmodium falciparum and trypanosomes. The series also contains reviews of more traditional areas, such as zoology, taxonomy, and life history, which shape current thinking and applications. Eclectic volumes are supplemented by thematic volumes on various topics, including control of human parasitic diseases and global mapping of infectious diseases. The 2011 impact factor is 4.39.

    • Designing Antibodies

      • 1st Edition
      • December 2, 2012
      • Ruth Mayforth
      • English
      • Paperback
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      • eBook
        9 7 8 0 3 2 3 1 6 0 0 2 5
      Designing Antibodies provides a compilation of research in the design of antibodies. It describes the techniques used in antibody design, the kinds of antibodies generated through modern techniques, and their applications in medicine and science. The book begins with an overview of the humoral immune system and of antibody structure, function, and biosynthesis, which sets the stage for the subsequent discussions of developments in antibody technology. The remaining chapters discuss the making of monoclonal antibodies; the design of antibodies for human therapy; the connection of antibodies (either chemically or genetically) to other potentially therapeutic effector molecules such as toxins, enzymes, or even an antibody of another specificity; idiotypes and anti-idiotypic antibodies; and the ability of antibodies to functionally mimic enzymes and mediate catalysis. It is hoped that, in addition to illustrating the progress of research in antibody design, the various creative and innovative approaches reviewed in this book will be modified or will stimulate new ideas that will spur the research and application of designer antibodies.

    • Cardiovascular Fluid Dynamics

      • 1st Edition
      • December 2, 2012
      • D.H. Bergel
      • English
      • Paperback
        9 7 8 0 1 2 4 3 1 4 6 7 2
      • eBook
        9 7 8 0 3 2 3 1 5 2 6 9 3
      Cardiovascular Fluid Dynamics, Volume 1 explores some problems and concepts of mammalian cardiovascular function, with emphasis on experimental studies and methods. It considers pressure measurement in experimental physiology, including the measurements of pulsatile flow, flow velocity, lengths, and dimensions; the use of control theory and systems analysis in cardiovascular dynamics; the application of computer models in cardiovascular research; the meaning and measurement of myocardial contractility; and the consequences of the steady-state analysis of arterial function. Organized into 10 chapters, this volume begins with an overview of the mammalian cardiovascular system and the essential features of cardiovascular function. It then discusses the practical problems associated with the use of pressure transducers in physiological and cardiac laboratories, the challenges involved in pulsatile flow measurement using flowmeters and thermal devices, and the mechanical analysis of the circulatory system. It explains some computer modeling techniques used in investigating the hemodynamics of the cardiovascular system, including the heart and heart muscle; basic concepts of muscle mechanics and the mechanical properties of cardiac muscle; the fluid mechanics of heart valves; and the pressure and flow in large arteries. The book concludes with a chapter on vascular resistance and vascular input impedance. This book is intended for biologists, physical scientists, and others interested in cardiovascular physiology.

    • Genetic Control of Insect Pests

      • 1st Edition
      • December 2, 2012
      • G Davidson
      • English
      • Paperback
        9 7 8 0 1 2 4 3 3 7 5 2 7
      • Hardback
        9 7 8 0 1 2 2 0 5 7 5 0 2
      • eBook
        9 7 8 0 3 2 3 1 6 0 8 0 3
      Genetic Control of Insect Pests focuses on laboratory and field trials of genetic control methods of insects, which entails the use of insects to control themselves. It particularly describes species-specific and non-polluting genetic methods that have the advantage over most other methods of being efficient when the target insect is in low density, as the released insects have the capacity to search out the wild populations. Composed of nine chapters, the core parts of the book cover the mass-rearing, sterilization, and release of populations in the hope that these will mate with wild populations, leading to fertility reduction and population elimination. The book also examines techniques that use naturally existing population incompatibilities and techniques, which can result in population replacement rather than eradication with the intention to render such replacement populations harmless beforehand by genetic manipulation. This book is a valuable source of information for those who are searching for biological alternatives of insect pests control.

    • Regulatory T Lymphocytes

      • 1st Edition
      • December 2, 2012
      • Benvenuto Pernis
      • English
      • Paperback
        9 7 8 0 1 2 4 1 4 5 9 0 0
      • Hardback
        9 7 8 0 1 2 5 5 1 8 6 0 4
      • eBook
        9 7 8 0 3 2 3 1 4 9 0 9 9
      Regulatory T Lymphocytes documents the proceedings of a symposium on ""Regulatory T Lymphocytes"" held at Arden House on the Harriman Campus of Columbia University from June 8-10, 1979. The meeting was the fourth of the P&S Biomedical Sciences Symposia. Starting with the opening address on regulatory T lymphocytes and their antigen receptors, the remainder of the book presents the contributions made by researchers at the symposium. These contributions are organized into seven parts. Part I contains studies T cell receptors. Part II presents studies on T cell subpopulations. Parts III and IV examine helper T cells. Parts V and VI deal with suppressor T cells. Part VII contains papers on regulatory T cell circuits.

    • Humoral Factors in Host Defense

      • 1st Edition
      • December 2, 2012
      • Yuichi Yamamura
      • English
      • Paperback
        9 7 8 0 1 2 4 3 1 5 0 9 9
      • Hardback
        9 7 8 0 1 2 7 6 8 2 2 0 4
      • eBook
        9 7 8 0 3 2 3 1 5 3 1 1 9
      Humoral Factors in Host Defense contains the proceedings of the First Takeda Science Foundation Symposium on Bioscience, held on October 28-30, 1982, in Kyoto, Japan. The symposium focused on the humoral factors regulating immune responses, with emphasis on T cell-derived immunoregulatory molecules; molecular mechanisms of interferons; factors involved in differentiation and activation of immunocytes; and the use of the molecular genetics approach to host defense factors. Organized into four parts encompassing 22 chapters, this volume begins with an overview of interleukin-2 and T cell-replacing factors, along with their immunological functions and biochemical features. It then discusses antigen-specific T cell factors; immunoregulatory molecules from human monoclonal T cells; physiological and pathological roles of lymphokines; regulation of the immune system by monoclonal T cell peptides; production of a glycosylated human protein by recombinant DNA technology; and molecular genetics of immunoglobulin genes and the major histocompatibility antigen. Geneticists and biologists will find this book extremely useful.

    • Cytoplasmic Genes and Organelles

      • 1st Edition
      • December 2, 2012
      • Ruth Sager
      • English
      • Paperback
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      • Hardback
        9 7 8 0 1 2 6 1 4 6 5 0 9
      • eBook
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      Cytoplasmic Genes and Organelles is about cytoplasmic genes: what they are and what they do. It applies the concepts and methods of cytoplasmic genetics to the problems of cell and molecular biology to which they can uniquely contribute. It shows geneticists the many attractive problems in this area awaiting their attention; cell biologists and biochemists the usefulness of cytoplasmic genetic analysis in their endeavors; and students the potential power of an integrated experimental approach using cytoplasmic genes together with the more conventional tools of biochemistry and electron microscopy in the investigation of organelle biogenesis. The book treats the following aspects of cytoplasmic genetic systems: (1) the properties of cytoplasmic DNA; (2) the genetic analysis of cytoplasmic systems; and (3) the functions of cytoplasmic genes in organelle biogenesis. The opening chapter summarizes the principal findings to provide readers with a bird's eye view of the subject. Subsequent chapters cover topics such as cytoplastmic DNAs; cytoplasmic genes in Chlamydomonas; mitochondrial genetics of yeast; cytoplasmic genes in higher plants; the role of mitochondrial genes in mitochondrial biogenesis; and cytoplasmic genes and cell heredity.

    • The Isolated hepatocyte

      • 1st Edition
      • December 2, 2012
      • E.J. Rauckman
      • English
      • Paperback
        9 7 8 0 1 2 4 3 3 3 6 7 3
      • eBook
        9 7 8 0 3 2 3 1 5 6 7 9 0
      The Isolated Hepatocyte: Use in Toxicology and Xenobiotic Biotransformations covers the link between research on the isolated hepatocyte and the disciplines of cell culture, toxicology, metabolism, and molecular biology. This book is composed of 11 chapters and begins with an overview of the regulation of liver growth, sulfation, glucuronidation of xenobiotics in specific liver sites. The next chapters deal with toxicology studies in cultured hepatocytes from various species and the in vitro control of hepatocyte proliferation. These topics are followed by discussions of choices and methods of cytotoxicity measures; hepatoxicity of metals; the metabolism and toxicity of xenobiotics in a primary culture; and the mechanism of carcinogen-induced pleiotropic drug resistance in hepatocytes. The concluding chapters describe the in vivo and in vitro measurement of chemically-induced DNA repair in hepatocytes, as well as the genotoxicity studies with human hepatocytes. This book is intended primarily to toxicologists and researchers.

    • T and B Lymphocytes: Recognition and Function

      • 1st Edition
      • December 2, 2012
      • Fritz Bach
      • English
      • Paperback
        9 7 8 0 1 2 4 1 2 3 6 9 4
      • Hardback
        9 7 8 0 1 2 0 6 9 8 5 0 9
      • eBook
        9 7 8 0 3 2 3 1 4 2 8 4 7
      T and B Lymphocytes: Recognition and Function is the 16th volume of the 1979 ICN-UCLA Symposia on Molecular and Cellular Biology. This book is organized into seven sections, encompassing 74 chapters that summarize molecular level progress in the field of immunobiology. It emphasizes cell membrane, techniques developed for its analysis, and varied products of the major histocompatibility complex, as well as other receptors on cells of the immune system. The book starts by describing two approaches for molecular association evaluation. First is the use of artificial membranes or lipid vesicles for the incorporation of antigens for recognition by T-lymphocytes both at the afferent and efferent levels. Second is the chemical crosslinking of cell surface components with a variety of different crosslinking reagents. This is followed by a discussion on the molecular nature of a T-cell receptor that provides insights of the target(s) recognized by T-lymphocytes. Several chapters discuss data dealing with the issue of the apparent differential recognition by T- and B-cells while both use the same VH genes. Antiidiotypic sera, together with the activity of ""regulator"" T-cells, are also discussed, with regard to their role in networks of regulation of the immune response. This book presents works demonstrating that human T-lymphocytes can also be cloned and both noncytotoxic proliferating T-lymphocytes and Tc can be so obtained. This is along with the continuing studies regarding heterogenity of B-lymphocytes as well as macrophages. Part V focuses on the interaction between lymphocyte and virus and molecular modifications of viral-infected cells. The subsequent section deals with recognition, reactivities, and function of T- and B-lymphocytes. Considerable chapters in this section discuss T-cell cytotoxicity, dichotomy of MHC control over anti H-Y cytotoxic T-cell responses, mouse alloantibodies, and mixed lymphocyte reactions. The concluding part describes immunological tools, such as synthetic membranes and cloned T-cells with biological function.

    • Cell Biology A Comprehensive Treatise V4

      • 1st Edition
      • December 2, 2012
      • David M. Prescott
      • English
      • Paperback
        9 7 8 0 1 2 4 1 4 4 4 4 6
      • eBook
        9 7 8 0 3 2 3 1 4 7 6 2 0
      Cell Biology, A Comprehensive Treatise, Volume 4: Gene Expression: Translation and the Behavior of Proteins discusses the translation of genetic information into proteins. It also explains the activities and behaviors of proteins, which is the final stage of gene expression. This book opens with a discussion of the components and mechanism of the translational machinery – their structures, biogenesis, and cellular levels. It then explains the protein synthesis, wherein each chapter focuses on one aspect of the detailed process. Other topics covered in this book are the structure and function of cytoplasmic ribonucleoprotein complexes and the proteolytic cleavage in the posttranslational processing of proteins. This text also covers the regulation of enzyme activity and the movement of material between nucleus and cytoplasm. The last three chapters are more in-depth discussions on protein synthesis, intracellular transport, regulation, and secretion. As with the other volumes of this book series, readers will definitely benefit from the vast information provided in this book regarding protein, its activities, behaviors, and synthesis.

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