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    • Molecular Pharmacology V3

      • 1st Edition
      • December 2, 2012
      • E.J. Ariens
      • English
      • Paperback
        9 7 8 0 1 2 4 1 4 3 9 6 8
      • eBook
        9 7 8 0 3 2 3 1 4 7 1 4 9
      Molecular Pharmacology: The Model of Action of Biologically Active Compounds, Volume 1 discusses the mode of action of bioactive compounds on a molecular level. This book reviews the processes that control the uptake of drugs, their diffusion through tissues, as well as their metabolism and excretion. Comprised of three sections, this volume starts with an overview of the different aspects of drug distribution and metabolism. This text then examines the totality of intermolecular processes or reactions between drug and receptor molecules, which is known as drug-receptor interaction. Other chapters explore the actions of various pharmacodynamic agents, including hormones and substances with selective toxicity, auxins, and odorants. This book discusses as well the ways in which the actions of drugs combine with the tissues and act upon themselves. The final chapter deals with the complicated types of relations between stimulus and effect. Pharmacologists and researchers will find this book useful.

    • Metabolic Maps of Pesticides

      • 1st Edition
      • December 2, 2012
      • Hiroyasu Aizawa
      • English
      • Paperback
        9 7 8 0 1 2 4 1 2 1 6 7 6
      • eBook
        9 7 8 0 3 2 3 1 4 0 7 5 1
      Metabolic Maps of Pesticides provides a summary of investigations and drawings of the metabolic patterns on pesticides that were collected with the aid of Chemical Abstracts Service (CAS) for the years 1970-1979. Some maps were taken from the original reports, some were slightly modified for clarity, and some were tentatively drawn from descriptions in the original articles. The pesticides are classified based on their chemical structures as functional groups or based on common chemical nomenclature. The chemical classifications highlight the properties of the mother pesticides and the impact of their degenerative metabolites on the environment. Metabolic maps are provided for the following: acid amides, amidines and guanidines, anilines and nitrobenzenes, biphenyl ethers, DDT and its analogs, dithio- and thiolcarbamates, five- and six-membered heterocyclic compounds, imides, organochlorine compounds, oxime carbamates, phenoxyacetic acids, pheny ring fused five-membered heterocyclic compounds, phenyl(aryl) carbamates, phenylureas and related compounds, phosphonothiolates and phosphonothioates, phosphonates, phosphorothioamides, phosphates, phosphorothiolates, pyrethroids, pyridines, triazines, and substituted benzenes and miscellaneous compounds.

    • Handbook of Flexible Manufacturing Systems

      • 1st Edition
      • December 2, 2012
      • Nand K. Jha
      • English
      • Paperback
        9 7 8 0 1 2 3 9 6 0 7 8 8
      • eBook
        9 7 8 0 3 2 3 1 3 9 3 5 9
      This handbook is a compilation of the current practical knowledge of flexible manufacturing systems (FMS). FMS allow manufacturing plants of all sizes to reduce their inventory while increasing their ability to meet consumer demands. By controlling automatic guided vehicles, robots, and machine tools with one central computer, products can now be produced in a variety of styles and models all at the same time. FMS are designed to adapt quickly and economically to changes in requirements and to unpredictable events. This guide explains how to effectively employ these useful new systems.

    • Natural Product Biosynthesis by Microorganisms and Plants Part C

      • 1st Edition
      • Volume 517
      • November 1, 2012
      • English
      • Hardback
        9 7 8 0 1 2 4 0 4 6 3 4 4
      • eBook
        9 7 8 0 1 2 4 0 4 6 1 7 7
      This new volume of Methods in Enzymology continues the legacy of this premier serial by containing quality chapters authored by leaders in the field. The third of 3 volumes covering Natural product biosynthesis by microorganisms and plants.

    • Cellular Imaging Techniques for Neuroscience and Beyond

      • 1st Edition
      • August 8, 2012
      • Floris G. Wouterlood
      • English
      • Hardback
        9 7 8 0 1 2 3 8 5 8 7 2 6
      • eBook
        9 7 8 0 1 2 3 8 5 8 7 3 3
      The imaging of small cellular components requires powerful instruments, and an entire family of equipment and techniques based on the confocal principle has been developed over the past 30 years. Such methods are commonly used by neuroscience researchers, but the majority of these users do not have a microscopy or a cell biology backgrounds and do can encounter difficulties in obtaining and interpreting results. This volume brings experts in high-resolution optical microscopy applications in neuroscience and cell biology together to document the state of the art. Outlining what is currently possible, the volume also discusses promising developments for the future and aids readers in selecting the most scientifically meaningful approach to solve their questions. Each chapter discusses instrumentation and technology in relationship to application in research. All of the common and cutting edge trends are covered - fluorescence / laser electron / nonlinear microscopy, infrared fluorescence, multiphoton imaging, tomography, FRAP, live imaging, STED, PALM/STORM, etc.

    • Cardiac Muscle: The Regulation Of Excitation And Contraction

      • 1st Edition
      • December 2, 2012
      • Richard Nathan
      • English
      • Paperback
        9 7 8 0 1 2 4 3 1 7 1 2 3
      • eBook
        9 7 8 0 3 2 3 1 5 5 1 8 2
      Cardiac Muscle: The Regulation of Excitation and Contraction is a 12-chapter text that covers the research studies on characterizing the ionic and molecular mechanisms that regulate excitation and contraction of cardiac muscle. This book describes first the ionic currents underlying diastolic depolarization and pacing of the heart. The discussions then shift to the mechanisms of action of calcium-channel antagonists; the regulation of calcium influx by indigenous factors, such as voltage- or calcium-mediated inactivation; the identification of fixed negative charges on the surface of the sarcolemma; and the regulation of gating and permeability of ion channels by these charges. These topics are followed by examining the molecular and ionic mechanisms that underlie the electrophysiologic actions of adrenergic and cholinergic neurotransmitters and peptide hormones. This text further explores the theoretical and experimental studies of the sodium-calcium exchange process, its stoichiometry, and how the exchanger might contribute to current flow during or after the action potential. Other chapters consider the mechanism of twitch and tonic tension regulation by cardiac glycosides and intracellular sodium and how toxic concentrations induce cardiac arrhythmias. A chapter highlights the identification of sarcolemmal binding sites for calcium, the likelihood that such binding or the release of calcium from the sarcoplasmic reticulum plays a role in the regulation of contraction and the release of calcium from the sarcoplasmic reticulum. The remaining chapters deal with the structural similarities among calcium-binding proteins of the contractile apparatus and the calcium channel, and the regulation of contraction by calcium-binding proteins. Physiologists, pathophysiologists, clinicians, researchers, and students who are interested in heart’s function will find this book invaluable.

    • Comparative Endocrinology V2

      • 1st Edition
      • December 2, 2012
      • U.S. Von Euler
      • English
      • Paperback
        9 7 8 0 1 2 4 3 3 3 9 3 2
      • eBook
        9 7 8 0 3 2 3 1 5 7 0 5 6
      Comparative Endocrinology: A Treatise in Two Volumes, Volume II, Part One: Invertebrate Hormones, Part Two: Tissue Hormones focuses on animal physiology, morphology, and chemistry and systematic and comprehensive explanation of endocrine principles from the comparative point of view. The selection first offers information on hormones controlling reproduction and molting in invertebrates and the structure of neurosecretory systems in invertebrates. Discussions focus on protozoa, crustacea, insects, and neurosecretory systems of the head, thorax, and abdomen. The text then ponders on bradykinin, angiotensin, and substance P and heparin. The publication examines physiologically active lipid anions and 5-hydroxytryptamine. Topics include biologically active unsaturated fatty acids without alcoholic hydroxyl groups, prostaglandin, endometrial acids in menstrual fluid, turnover rate, and biosynthesis and fate. The manuscript also tackles cholinergic neurohormones and adrenergic neurohormones. The selection is a dependable source of data for readers interested in invertebrate and tissue hormones.

    • Methods of Enzymatic analysis V4

      • 2nd Edition
      • December 2, 2012
      • Hans-UIrich Bergmeyer
      • English
      • Paperback
        9 7 8 0 1 2 4 3 3 7 9 1 6
      • eBook
        9 7 8 0 3 2 3 1 6 1 3 2 9
      Methods of Enzymatic Analysis, Volume 4 reviews developments in the use of enzymes as tools in analytical biochemistry, including advances in assay techniques. It discusses the principles and methods for the elucidation of structures of enzymes, such as peptides, proteins, amino acids, fatty acid metabolites, lipids, steroids, nucleic acids, purines, pyrimidines, nucleosides, and coenzymes. It also considers the isolation and characterization of active centers in enzymes. This volume is divided into four parts, each discussing a group of enzymes and their determination. Part I focuses on proteins, peptides, and amino acids including amines and amides. Part II is concerned with fatty acid metabolites, lipids, and steroids ranging from polyunsaturated fatty acids and lecithin to choline, acetylcholine, triglycerides, glycerol, acetoacetate, triacetate, fumarylacetoacetate, 20-ketosteroids, prostaglandins, bile acids, and cholesterol. Part III discusses nucleic acids, purines, pyrimidines, nucleosides, coenzymes, and related compounds, whereas Part IV looks at other substrates and effectors such as inorganic phosphate. The book concludes with a chapter on metabolites and their concentrations in animal tissues. Biochemists as well as students and researchers working in the field of analytical biochemistry will find this book highly informative.

    • Plant Physiology 6C

      • 1st Edition
      • December 2, 2012
      • F.C. Steward
      • English
      • Paperback
        9 7 8 0 1 2 4 1 4 6 0 0 6
      • eBook
        9 7 8 0 3 2 3 1 4 9 1 9 8
      Plant Physiology: A Treatise, Volume VIC: Physiology of Development: From Seeds to Sexuality deals with the physiology of development in angiosperms, from seeds to sexuality. This book treats germination and cell division, growth, and development from a single point of view, emphasizing the problems of early development in flowering plants. This volume begins with an introduction to the process of germination, focusing on the dispersal unit that emerges at some stage in the life cycle of plants, seed viability and dormancy, and properties of seed components. The following chapters discuss cell division in higher plants, the importance of cell expansion for the growth of the whole plant, and the sexuality of angiosperms. Topics such as meiosis in the anther and the ovule, male spores and gametophytes, and the embryo sac are discussed in detail. This book concludes with problems that arise, and points of view that emerge, as development is considered in the light of genetics. This book is a valuable resource for researchers, students, and specialists in related fields who wish to gain insights on the concepts and research trends in the physiology of development in flowering plants.

    • Biological Basis of Detoxication

      • 1st Edition
      • December 2, 2012
      • John Caldwell
      • English
      • Paperback
        9 7 8 0 1 2 4 3 1 2 1 2 8
      • eBook
        9 7 8 0 3 2 3 1 5 0 1 0 1
      Biological Basis of Detoxication focuses on the biological processes involved in detoxication, with emphasis on the biochemistry of the removal of xenobiotics from an organism. Topics range from the formation of toxic metabolites and compounds that are not metabolized at all to the tissue distribution and nutritional considerations, the kinetics and mechanisms of the metabolic and excretory processes, and the integration of xenobiotic metabolism in the activation and detoxication of carcinogens. Organized into 14 chapters, this book begins with an overview of the enzymatic basis for the metabolic activation of foreign compounds in forming reactive chemical intermediates. The first few chapters discuss the identification of reactive electrophiles derived from xenobiotics, intratissue distribution of activating and detoxicating enzymes, enzymatic and non-enzymatic modes of xenobiotic metabolism, and unmetabolized compounds. The middle chapters explore the biological basis of detoxication of oxygen free radicals, physiologic and kinetic aspects of the fate of xenobiotics, excretion of xenobiotics, and effects of nutrition on detoxication. The remaining chapters look at the relationships between the enzymes of detoxication and host defense mechanisms, metabolic basis of target organ toxicity, the enzymatic factor in selective toxicity, and intraindividual and interindividual variations in rates of hepatic metabolism of exogenous chemicals. Pharmacologists, toxicologists, and biochemists will find this book highly informative.

Related subjects

Agricultural and biological sciences

Drug discovery

Immunology

Microbiology and virology

Neuroscience

Pharmaceutical sciences

Pharmacology

Toxicology