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Elsevier

Books in Life sciences

  • Sustainable Thermal Processing in Food Manufacturing

    Ohmic, Microwave and Induction Technologies
    • 1st Edition
    • Ravi Pandiselvam + 2 more
    • English
    Sustainable Thermal Technologies in Food Processing: Ohmic, Microwave, and Induction Technologies offers an authoritative resource on advanced thermal processing technologies critical for modern food preservation and extraction. Addressing the limitations of conventional thermal methods, this reference explores energy-efficient, high-quality, and environmentally responsible heating techniques. The chapters cover fundamental engineering principles, food safety mechanisms, system design, process control, and digital innovations including AI and IoT integration. Specialized topics include drying, pasteurization, cooking, bioactive compound extraction, thawing, fermentation, and nutritional impacts. The text also presents industrial-scale applications, regulatory frameworks, and future research directions, providing a holistic understanding of these emerging technologies. This book equips industry professionals, academic researchers, and students with critical insights to select, model, and implement sustainable thermal processes. It supports innovation in food manufacturing by delivering comparative evaluations, scale-up challenges, and sustainability assessments, fostering adoption of green technologies for improved food safety, quality, and environmental performance.

  • Research Methods

    Principles in Practice
    • 1st Edition
    • Samy A. Azer
    • English
    Research Methods: Principles in Practice provides undergraduate research students, novice researchers, and instructors with engaging approaches to understanding research and how to apply and use different research methods. The book helps students develop skills in conducting literature searches, reading literature, designing research projects, selecting research methods, collecting data, interpreting findings, and writing research reports. Topics covered include research philosophy; study design; developing research questions; the use of theories in research; research ethics; qualitative, quantitative, and mixed-methods research; social media research; and writing a research report. The book provides practical activities, model answers at the end of each chapter, and further reading, enabling students to gain a deeper understanding of research methods and to master their application.

  • Artificial Intelligence in Point-of-Care Nanobiosensors Technology

    Enhancing Disease Diagnostics and Improved Healthcare Outcomes
    • 1st Edition
    • Tharmaraj Vairaperumal + 2 more
    • English
    Artificial Intelligence in Point-of-Care Nanobiosensors Technology: Enhancing Disease Diagnostics and Improved Healthcare Outcomes delves into the revolutionary integration of artificial intelligence (AI) with nanobiosensors to elevate point-of-care (POC) diagnostics for both communicable and non-communicable diseases. Readers will find insightful chapters covering topics ranging from foundational AI and machine learning techniques to specific applications in cardiovascular disease, diabetes, cancer, chronic respiratory ailments, and infectious diseases. Each chapter not only highlights recent breakthroughs in nanobiosensors but also emphasizes the pivotal role of AI in enhancing diagnostic accuracy and facilitating personalized health interventions. Additional discussions around regulatory considerations and the future landscape of AI in biomedical research make this an essential read for those navigating this rapidly evolving field. This book primarily targets researchers and professionals engaged in the interdisciplinary realms of AI, nanomaterials, and biomedical sciences. By providing a critical understanding of emerging AI-based diagnostic technologies and their applications in POC settings, this book fosters collaboration across diverse scientific domains.

  • Electrochemical Sensors and Biosensors for Food Safety

    Fundamentals, Nanomaterials, and Real-World Applications
    • 1st Edition
    • J. Tharini + 1 more
    • English
    Electrochemical Sensors and Biosensors for Food Safety: Fundamentals, Nanomaterials, and Real-World Applications is a vital resource addressing the urgent need for highly sensitive detection of organic, inorganic, and biological pollutants in food and water. Detecting hazardous molecules at nanomolar levels is crucial for ensuring public health and food safety, yet current methods often lack the sensitivity and specificity required for early detection. This book explores how advanced nanomaterials and flexible substrate matrices enhance the performance of electrochemical sensors, providing accurate, rapid, and cost-effective solutions for detecting contaminants in complex samples. The book covers essential topics, including the fundamentals of electrochemical sensing, nanocomposite synthesis, computational modeling, fabrication of flexible electrodes, and integration with artificial intelligence and IoT technologies. It discusses applications in detecting pesticides, heavy metals, veterinary drugs, food additives, and microbial pathogens, as well as the regulatory frameworks governing their use. Case studies and future directions highlight the potential for developing smart, reusable sensors that can be implemented in real-world food safety monitoring systems.Electrochemi... Sensors and Biosensors for Food Safety: Fundamentals, Nanomaterials, and Real-World Applications serves as an indispensable guide for researchers, industry professionals, and policymakers committed to advancing food safety technologies, protecting public health, and promoting innovative solutions for sustainable food systems.

  • Brain Point-of-Care Ultrasound

    Practical Guide and Protocols
    • 1st Edition
    • Camilo N. Rodríguez + 6 more
    • English
    Brain Point-of-Care Ultrasound: Practical Guide and Protocols explores brain hemodynamics and parenchyma examination, providing an orderly and protocolized approach that facilitates individualized clinical decisions with ease. Covering ultrasound configuration, in-depth anatomical knowledge, and advanced parameters, this guide aims to integrate brain ultrasound seamlessly into the Point-of-Care Ultrasound (POCUS) modality, addressing the critical need for comprehensive patient assessment. From basic principles to specialized clinical situations, each section of this guide is meticulously crafted to empower practitioners with practical insights. Chapters explore Doppler spectral wave interpretation, angle correction nuances, autoregulation dynamics, and non-invasive pressure estimations, among others, thus enabling precise monitoring and targeted decision-making. With a focus on integration across disciplines and specialties, this book bridges the gap between classical pathology and contemporary practice, positioning brain ultrasound as a pivotal tool in the armamentarium of modern critical care.

  • PFAS Contamination

    Global Prevalence, Toxicological and Ecotoxicological Impacts, and Mitigation Strategies
    • 1st Edition
    • Saranya Narayanasamy + 1 more
    • English
    PFAS Contamination: Global Prevalence, Toxicological and Ecotoxicological Impacts, and Mitigation Strategies offers a comprehensive overview of per- and polyfluoroalkyl substances (PFAS), highlighting their global environmental prevalence, toxicological effects and health risks, and state-of-the-art remediation approaches. The book taps into the increasing recognition of PFAS as “forever chemicals” and explores the widespread contamination of these compounds in water, soil, and air along with their toxicological effects on human health and the ecosystem. It highlights advancements in detection methods as well as physicochemical, biological, and emerging remediation technologies, including plasma-based technologies, bioremediation, and advanced nanotechnology-based methods, such as plasma technology, bioremediation, and adsorption methods.Case studies illustrate successful applications, and the book examines policy frameworks, regulatory measures, and the public health impact of PFAS. This resource serves as a vital source of information for environmental toxicologists, environmental scientists, environmental consultants, engineers, and regulators studying PFAS prevalence, toxicity mechanisms, remediation, and practical strategies for mitigating PFAS contamination and fostering a deeper understanding of the global efforts to address this critical issue.

  • Epigenetic Mechanisms at the Crossroads of Development, Immune Response, and Neuropathology

    • 1st Edition
    • Varun Sasidharan Nair + 1 more
    • English
    Epigenetic Mechanisms at the Crossroads of Development, Immune Response, and Neuropathology offers an in-depth exploration of how epigenetic mechanisms shape neural development, immune interactions, and disease progression in the central nervous system. This interdisciplinary volume synthesizes current knowledge across neuroscience, immunology, and pathology, addressing the critical need for integrated frameworks that connect molecular regulation with clinical outcomes. The book covers foundational epigenetic processes such as DNA methylation, histone modifications, and non-coding RNAs, illustrating their roles in neural differentiation, circuit formation, and brain plasticity.It further examines how environmental factors influence epigenetic landscapes, impacting resilience and vulnerability to neuropsychiatric and neurodegenerative disorders. The volume also delves into the epigenetic drivers of neuropathologies including glioblastoma, neuroinflammation, and neurodegeneration, highlighting emerging therapeutic strategies. With contributions from leading international experts, this resource bridges basic science and translational research, providing valuable insights for researchers, clinicians, and advanced students seeking to understand and target complex CNS disorders.

  • Molecular Mechanisms of Cancer Resistance

    Emerging Technologies and Therapeutic Strategies
    • 1st Edition
    • Ahmet Acar
    • English
    Molecular Mechanisms of Cancer Resistance: Emerging Technologies and Therapeutic Strategies explores innovative tools and strategies designed to address the critical issue of drug resistance in cancer treatment. This comprehensive volume is tailored for researchers, clinicians, and students, offering insights into the latest advancements and methodologies in the field. The book covers essential topics such as molecular mechanisms of drug resistance, the tumor microenvironment, and emerging technologies like single-cell analysis and computational modeling. Each chapter features contributions from leading experts, providing a multi-dimensional perspective on both foundational concepts and cutting-edge research.By engaging with this book, the academic audience gains access to groundbreaking research and therapeutic strategies that enhance understanding and practice. The knowledge acquired will inspire collaboration and innovation, ultimately contributing to more effective and personalized cancer treatment approaches.

  • Shared Research Resources

    Best Practices in Management and Administration
    • 1st Edition
    • Joshua Z. Rappoport + 1 more
    • English
    Shared Research Resources: Best Practices in Management and Administration brings together best practices and case studies from research institutions around the world. Covering all areas of management, with examples and applications specific to the research environment, this is the perfect reference to build managerial skills. The first part is dedicated to introducing Shared Research Resources (SRR) management. The second part covers all aspects of staffing. Part three contains complete coverage of operations, including service development, instrument procurement, marketing, management software, customer support, safety, maintenance and repair. Part four is dedicated to fiscal management, budgeting, and reporting.Part five covers strategic management. Part six is devoted to the sustainability of the core facility. The final part covers assessment, including annual reports, program reviews, and audits. This book is a complete reference targeted at SRR managers and staff who need to keep updated with current best practices and case studies. It is also important reading for research institution managers and function leaders.

  • Bioactive Compounds

    Mechanisms, Challenges and Strategies for Bioaccessibility and Bioavailability
    • 1st Edition
    • Cristobal Noe Aguilar + 3 more
    • English
    Bioactive Compounds: Mechanisms, Challenges and Strategies for Bioaccessibility and Bioavailability covers nutrition, food science, and pharmacology, elucidating the intricate dynamics of bioactive compounds and their impacts on human health. This comprehensive volume delineates the crucial differences between bioaccessibility and bioavailability, providing insights into their implications for health outcomes. Readers will explore the behavior of key classes of bioactive compounds, including polyphenols, carotenoids, and peptides, as well as their sources and interactions within the food matrix. The book further examines the essential role of gut microbiota in absorption processes, highlighting how these interactions can influence bioactive compound efficacy in the human body.Sections not only discuss the mechanisms of absorption, distribution, metabolism, and excretion (ADME) of bioactive compounds but also introduce cutting-edge tools and strategies designed to enhance their bioaccessibility and bioavailability.

  • Autophagy and Neurodegeneration

    • 1st Edition
    • Volume 409
    • English

  • Dietary Fiber

    Extraction, Properties and Modifications for Food Applications
    • 1st Edition
    • Tabli Ghosh + 1 more
    • English
    Dietary Fiber: Extraction, Properties and Modifications for Food Applications is an essential resource for food scientists and researchers seeking to understand the full potential of dietary fiber in the food industry. The book highlights fiber's various sources and critical health benefits, including detailed discussions on extraction techniques, characterization, and functional properties, equipping readers with the knowledge needed to innovate and enhance food formulations. Sections explore advanced topics such as nano and microencapsulation techniques that enhance fiber stability and bioavailability and the role of dietary fiber in gut health, microbiome modulation, and broader health implications.As the demand for healthier, functional foods grow, this book addresses the challenges of modifying dietary fiber to improve its solubility, viscosity, and stability through an array of physical, biological, chemical, and alternative methods. Readers will walk away with the knowledge needed to tailor dietary fiber for specific applications in functional food products and precision nutrition for better health outcomes.

  • Genome Editing and Human Health

    • 1st Edition
    • Volume 157
    • English

  • Emerging and Established Therapeutic Targets in Cancer Immunotherapy

    From Bench to Bedside
    • 1st Edition
    • Eyad Elkord + 1 more
    • English
    Emerging and Established Therapeutic Targets in Cancer Immunotherapy: From Bench to Bedside provides a comprehensive overview of emerging and established therapeutic targets and strategies in cancer immunotherapy. As cancer immunotherapy continues to evolve, this volume connects fundamental scientific insights with therapeutic development and clinical translation, providing a valuable resource for researchers, clinicians, and students. Chapters examine immune checkpoints, including LAG-3, TIM-3, TIGIT, and VISTA; modulation of the tumor microenvironment through targeting myeloid-derived suppressor cells, regulatory T cells, and stromal components; and emerging approaches such as neoantigen-based vaccines, multispecific antibodies, and next-generation CAR-T cell therapies. Additional chapters address tumor mutational burden, metabolic reprogramming, epigenetic regulation, and the microbiome, alongside strategies to overcome therapeutic resistance and the application of multi-omics and artificial intelligence to target discovery. Regulatory and manufacturing considerations for clinical translation are also discussed. The volume provides current scientific insights, identifies promising research directions, and offers practical guidance for developing effective immunotherapies, helping researchers design innovative experiments and accelerate drug development, and clinicians understand emerging therapies and optimize patient care. It is a vital resource for advancing the next generation of cancer immunotherapy and improving outcomes for patients worldwide.

  • Traumatic Brain Injury Rehabilitation

    • 1st Edition
    • Vishal K. Chavda + 4 more
    • English
    Traumatic Brain Injury Rehabilitation addresses the critical need for an integrated resource spanning traumatic and vascular brain injury models. This reference consolidates diverse experimental platforms from classical rodent systems to advanced human brain organoids and AI-driven simulations, targeting researchers and clinicians navigating the complexities of neurotrauma and stroke. The book responds to the growing demand for translational approaches that link bench-side discoveries with bedside applications to improve therapeutic development. The content is systematically organized into sections covering foundational principles, preclinical models of traumatic brain injury and stroke, pediatric brain injury models, in vitro and ex vivo platforms, clinical biomarkers and neuroimaging, and emerging future directions including personalized medicine and AI modeling. Each chapter offers detailed methodologies, comparative evaluations, and clinical translation insights, supported by extensive visuals such as flowcharts, neuroimaging figures, and infographics to enhance comprehension.

  • Systems Biology of Addiction Medicine

    Gut–Brain Axis, OMICS, and Molecular Technologies
    • 1st Edition
    • Mohammad Shabani + 3 more
    • English
    Systems Biology of Addiction Medicine: Gut–Brain Axis, OMICS, and Molecular Technologies is a cutting-edge reference that explores the complex neurobiological mechanisms underlying substance use disorders (SUD). This volume emphasizes the importance of the microbiome-gut-brain axis (MGBA), multi-OMICS approaches, and molecular tools such as CRISPR-Cas9 in advancing addiction research. It addresses the urgent need for integrated frameworks to understand the bidirectional communication between the gut and brain in disorders like nicotine, opioid, alcohol, neurostimulant, and cannabis use. The book synthesizes foundational knowledge with recent developments, offering detailed methodologies, case studies, and translational strategies that bridge basic science and clinical application. Its comprehensive scope makes it invaluable for researchers and clinicians seeking to develop personalized, evidence-based therapies for SUDs. The contents include dedicated sections on the MGBA's role across various substances, detailed chapters on multi-OMICS, SNP, and immunotherapy techniques, and discussions on emerging molecular technologies like CRISPR. Each chapter combines literature reviews, recent advances, and practical applications, supported by schematic figures designed for clarity. The volume aims to empower neuroscientists, psychiatrists, pharmacologists, and biotech professionals with the latest scientific insights and tools to address the global challenge of addiction. By fostering interdisciplinary understanding, this resource supports hypothesis generation, research innovation, and the development of targeted interventions to improve patient outcomes.

  • The Biomechanics of Osseointegration

    • 1st Edition
    • Adriano Piattelli + 1 more
    • English
    The Biomechanics of Osseointegration offers a comprehensive, evidence-based exploration of the biomechanical, anatomical, and biological principles essential to safe and effective use of dental implants. By integrating core sciences with clinical applications, it equips both current and future practitioners with the tools to deliver long-term success in implant therapy. From fundamental concepts such as bone biology and stress-strain relationships to advanced topics like finite element modeling, fatigue testing, and real-world clinical implications, this work bridges the divide between theory and practice. Readers gain deep insight into the biomechanics of standard, short, pterygoid, and zygomatic implants across varying bone types, loading conditions, and anatomical challenges. Examined are long-term histological findings from retrieved human implants, unpacking the reasons behind the success of design elements such as the Cone Morse connection. Grounded in both research and practical examples—including case studies and data spanning three decades—the importance of connecting basic science with clinical expertise is highlighted. Designed primarily for dentists considering the integration of implantology into their practice, as well as postgraduate students in Periodontology, Prosthodontics, Oral Surgery, and Biomedical Engineering, The Biomechanics of Osseointegration also serves as a valuable resource for undergraduate dental and biomechanical engineering students who are entering the field with limited formal education in implant science. With an interdisciplinary approach and emphasis on biomechanics and biology, it provides a critical foundation for anyone committed to advancing in the field of dental implants—ensuring their work is not only innovative but also grounded in safe and effective treatment principles.

  • Substance Use Disorders and Behavioral Addictions

    Neurochemical Mechanisms and Clinical Implications
    • 1st Edition
    • Mohammad Shabani + 2 more
    • English
    Substance Use Disorders and Behavioral Addictions: Neurochemical Mechanisms and Clinical Implications offers an in-depth exploration of the neurochemical foundations of addiction, addressing both substance-related and behavioral disorders. This volume is essential for neuroscientists, psychiatrists, and pharmacologists seeking to understand the complex neurobiological pathways involved in addiction. It covers key neurochemical systems such as dopamine, glutamate, serotonin, and endocannabinoids, and examines their roles across a spectrum of disorders including nicotine, opioids, alcohol, stimulants, cannabis, psychedelics, sedatives, caffeine, antihistamines, and behavioral addictions like gambling, gaming, pornography, and binge eating. This content synthesizes cutting-edge preclinical techniques—such as optogenetics and neuroimaging—with clinical models like cue-reactivity and pharmacogenomics, providing a translational perspective that bridges research and practice. The purpose of this book is to fill existing gaps where neurochemical insights are often isolated from clinical application, especially in the context of rising addiction rates globally and emerging treatments like psilocybin and neuromodulation. It aims to equip researchers and clinicians with current, practical knowledge to develop innovative interventions, improve diagnostics, and personalize treatment strategies. Whether used as a reference for research, clinical decision-making, or advanced coursework, this volume offers a vital resource for advancing understanding and management of addiction in diverse settings.

  • Smart Microscopy, AI, and Robotics

    Automated Future Disease Detection
    • 1st Edition
    • Priyadarshini Pattanaik + 2 more
    • English
    Smart Microscopy, AI, and Robotics: Automated Future Disease Detection addresses the need to combine automated microscopy with artificial intelligence and robotics to improve accuracy, throughput, and safety in disease detection. It surveys methods for image acquisition, processing, segmentation, and interpretation across sample types, including blood smears, tissue biopsies, cytology, and cytopathology, equipping researchers, clinicians, and technologists with actionable knowledge for deploying AI-powered diagnostic pipelines.The book covers foundational principles and advanced applications, beginning with microscopy and contrast-enhanced imaging, followed by automated microscope–robotics integration, image acquisition and analysis pipelines, and AI methods for disease detection. It then explores applications such as blood disorders, infectious diseases, and cancer diagnostics, including AI-based analysis of neurological and cellular imaging, advanced deep-learning architectures, and foundation models for smart microscopy. System-level considerations address performance metrics, explainability, bias mitigation, ethics, clinical governance, regulation, safety, and human–AI interaction and interoperability. The book also examines AI-enabled drug discovery, therapeutic target identification, smart laboratories, automated diagnostics, and global health impact.Readers will gain practical guidance on building high-throughput, AI-assisted diagnostic systems that are robust, interpretable, and scalable, with insights into data annotation, model validation, and integrating AI with robotic microscopy in clinical and research settings. The work anticipates developments such as self-calibrating instruments, autonomous laboratory workflows, and digital pathology ecosystems.

  • Redefining the MicroRNA Functionality in Cancer Diagnostics and Therapeutics

    • 1st Edition
    • Vivek Kumar + 2 more
    • English
    Redefining the MicroRNA Functionality in Cancer Diagnostics and Therapeutics is an authoritative volume that explores the pivotal role of microRNAs (miRNAs) in precision oncology. The book integrates fundamental biology, cutting-edge bioinformatics, and translational research, providing a comprehensive overview of miRNA mechanisms, regulation, and clinical applications. It emphasizes technological advances such as single-cell profiling, CRISPR engineering, and AI-driven diagnostics. The content covers miRNA biology, multi-omics integration, innovative therapeutic strategies, and clinical translation, including liquid biopsies and biosensors.In addition, it also addresses industry and regulatory aspects, offering practical insights for translating research into clinical and commercial settings. Rich with case studies and visual aids, the book bridges the gap between bench research and bedside implementation. For the academic audience, this book offers a multidisciplinary resource that enhances understanding of miRNA-based diagnostics and therapeutics, fostering innovation and accelerating clinical adoption in cancer care.

  • Advances in Immunology

    • 1st Edition
    • Volume 172
    • English
    Advances in Immunology, Volume 172, provides current research contributions in immunology, including a detailed examination of gasdermin activation mechanisms and their role in initiating membrane pore formation to execute pyroptosis. Further chapters from an international group of contributors extend the volume's coverage of immune mechanisms and disease relevance.

  • Epigenetics of Alzheimer's and Parkinson's Disease Part A

    • 1st Edition
    • Volume 118
    • English
    Epigenetics of Alzheimer's and Parkinson's Disease Part A, published as Volume 118 of the serial Advances in Genetics, provides a focused survey of the epigenetic mechanisms underlying two of the most prevalent neurodegenerative disorders. Contributions from international researchers examine microRNA-based therapeutic strategies, exosome-mediated pathways, noncoding RNA regulation, DNA and histone modifications, and gene-environment-epi... interactions in Alzheimer's and Parkinson's disease. The volume offers researchers a current reference point for understanding how epigenetic regulation contributes to disease onset and progression, and how these mechanisms might be targeted therapeutically.

  • Microbiome-Drug Interactions in Neurological Disorders: Pharmacological Mechanisms, Targets, and Therapeutic Advances

    • 1st Edition
    • Volume 109
    • English
    Advances in Pharmacology series, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.

  • Advances in Applied Microbiology

    • 1st Edition
    • Volume 138
    • English

  • Viticulture and Climate Change

    Challenges and Opportunities
    • 1st Edition
    • Stefano Poni
    • English
    Accelerating atmospheric shifts are redefining grape production worldwide in complex and often unpredictable ways, disrupting long-established practices while opening the door to new possibilities. Viticulture and Climate Change examines how rising temperatures, irregular rainfall patterns, and increasingly frequent extreme events influence cultivation outcomes, including vine seasonal development, berry composition, and overall vineyard performance. It presents a forward-looking panorama that translates scientific insight into applied guidance, enabling the effective implementation of adaptive and sustainable grape-growing practices.Rather than treating individual factors in isolation, the text adopts a whole-system view. The volume is organized to follow the vineyard lifecycle, from establishment through routine operations to long-term planning, with case studies aptly embedded throughout. It addresses variety and rootstock selection, spacing, training systems, soil care, canopy handling, water use, and innovative inputs. Dedicated sections explore frost, heatwaves, drought, flooding, and hail scenarios, alongside appropriate responses such as pruning adjustments, shading solutions, and protective materials. Emerging topics—such as manipulation of ripening dynamics for low- and no-alcohol wines, carbon cycling, and renewable energy integration—are also considered.Advances in sensing, mapping, automation, and modeling are presented within interconnected digital platforms, offering new ways to monitor conditions and guide interventions. Biotic threats from pathogens and insects are discussed in the context of variable climatic pressures, with emphasis on tolerance and robustness-enhancing measures.Drawing on a broad body of research and experience by a leading expert in the field, Viticulture and Climate Change interprets findings with clarity and purpose, transforming technical information into accessible knowledge with practical relevance across diverse regions in support of improved real-world, cost-effective decision-making.

  • Human-AI Interaction for Digital Healthcare Systems

    • 1st Edition
    • Jinwoo Kim
    • English
    Human-AI Interaction for Digital Healthcare Systems defines Human‑AI Interaction (HAII) as the next evolutionary phase of Human‑Computer Interaction, addressing the shift from reactive systems to proactive AI agents. Using digital healthcare as its primary application domain, it introduces a rigorous, evidence‑based methodology for designing AI systems that are effective, safe, and trusted in real‑world clinical contexts. The text integrates the Sensing–Reasoning–Ac... (SRA) loop into human‑centered design, balancing system efficacy with environmental conformance. It provides structured guidance across the full lifecycle, analysis, planning, design, and evaluation,ensuring AI systems deliver measurable clinical and user value. Beyond theory, the book emphasizes empirical validation, detailing controlled experiments (e.g., RCTs) and real‑world performance analysis using Real‑World Data (RWD) and Real‑World Evidence (RWE), with explicit consideration of regulatory requirements for Software as a Medical Device (SaMD).

  • Mitochondria Part A

    • 1st Edition
    • Volume 216
    • English

  • The AI Biotech Breakthrough

    Innovating Life with Intelligent Machines
    • 1st Edition
    • Dibyajit Lahiri + 4 more
    • English
    The AI Biotech Breakthrough: Innovating Life with Intelligent Machines explores how artificial intelligence is revolutionizing the fields of genomics, biochemistry, and biotechnology. With an emphasis on practical implementation and cross-disciplinary integration, this book provides researchers with a forward-looking roadmap for applying AI tools in biological research and life science innovation. Chapters cover foundational AI concepts tailored for biologists and explore their applications across key biotechnology domains. Readers will find detailed analysis of how machine learning and computational methods accelerate drug discovery, optimize genomic and proteomic data interpretation, and enable novel approaches in metabolic engineering and synthetic biology. Additional topics include AI-driven diagnostics, personalized medicine, bioprocess optimization, and the use of AI in agricultural biotechnology and microbial systems. Each chapter includes real-world case studies, method summaries, and discussions of emerging trends, providing a high-value guide for researchers at the interface of biology and data science. This book is a valuable resource for geneticists, biotechnologists, computational biologists, systems biologists, bioinformaticians, and graduate students seeking to harness the power of AI for transformative impact across the life sciences.

  • Microbiome Profiling, Techniques, and Therapeutic Management

    • 1st Edition
    • Sanjana Mehrotra + 1 more
    • English
    Microbiome and Tumorigenesis: Microbiome Profiling, Techniques, and Therapeutic Management, vol. 2 offers a comprehensive exploration of cutting-edge methodologies and clinical applications in microbiome research. This book focuses on the intersection of microbiome science with cancer therapy, bioinformatics, and environmental influences, making it a valuable resource for researchers, clinicians, and graduate students in biomedical and life sciences. The book is structured into three parts: tools and techniques for microbiome analysis, the role of the microbiome in cancer therapy, and the impact of diet, environment, and epigenetics on microbiome–tumor interactions. Topics include sampling strategies, AI-driven data analysis, microbiome-based biomarkers, and therapeutic interventions, with contributions from experts across academia and industry. This book equips the academic audience with both foundational and advanced insights into microbiome research. It supports interdisciplinary learning, fosters translational thinking, and provides practical knowledge for designing experiments, interpreting data, and developing novel therapeutic strategies.

  • Wearable Sensors for Healthcare Monitoring

    Smart Tools for Real-time Applications
    • 1st Edition
    • Pushpesh Ranjan + 1 more
    • English
    Wearable Sensors for Healthcare Monitoring: Smart Tools for Real-time Applications addresses the growing need for advanced diagnostic tools amid increasing global health challenges. The reference explores state-of-the-art wearable biosensors that enable non-invasive, continuous, and real-time monitoring of disease biomarkers in biofluids such as sweat, saliva, and tears. This technology offers promising solutions to overcome limitations of conventional diagnostics, providing sensitive, portable, and user-friendly healthcare management tools. The contents cover fundamental to advanced topics including nanoengineered materials, design and fabrication methods, classifications of biosensors, and detection techniques for various biomarkers. Additional chapters focus on applications in diabetic care, inflammatory biomarker monitoring, wound healing, infectious disease detection, personalized nutrition, and integration with intelligent wireless technologies.The book also addresses self-powered wearable devices and market commercialization prospects, offering a holistic view of the wearable biosensor landscape. This books benefits researchers, academicians, clinicians, diagnostic laboratories, and industry professionals by delivering comprehensive insights into the design, development, and application of wearable biosensors. It serves as a valuable platform for innovation, enabling the creation of high-performance, affordable, and smart diagnostic tools that can transform personalized healthcare and point-of-care monitoring.

  • Cancer Progression and the Immune System

    Mechanisms, Microenvironment, and Immunotherapy
    • 1st Edition
    • Pranav Kumar Prabhakar + 3 more
    • English
    Cancer Progression and the Immune System: Mechanisms, Microenvironment, and Immunotherapy examines the dynamic interplay between cancer and immunity, highlighting how immune responses shape tumor growth and therapeutic outcomes. The book explores immune surveillance, tumor immunoediting, and evasion strategies, alongside the role of the tumor microenvironment, chronic inflammation, and immunosuppressive factors. It provides detailed coverage of cutting-edge immunotherapies, including checkpoint inhibitors, CAR-T cell therapy, cancer vaccines, and NK cell-based approaches, as well as molecular and cellular insights into immune regulation. Designed for oncologists, immunologists, and researchers, this resource bridges foundational immunology with translational applications. It equips readers with knowledge of emerging therapies, biomarkers, and systems-level approaches, offering a roadmap for innovative cancer treatment strategies.

  • Structure, Function, and Regulation of G Protein-Coupled Receptors Part A

    • 1st Edition
    • Volume 748
    • English
    G protein-coupled receptors constitute one of the largest classes of cell surface receptors in the human genome and drug targets for approximately one third of the currently prescribed medicines. The has been a tremendous advance in understanding the activation, signaling, and regulation of these receptors over the past couple of years using cellular, biochemical, structural, and pharmacological approaches. These two volumes of Methods in Enzymology cover these recent advances in the form of short overview of the key topics as well as step-by-step protocols developed to probe the functional attributes of these versatile receptors.

  • Artificial Intelligence and Clinical Cognition in Pediatric and Neonatal Medicine

    • 1st Edition
    • Anthony Chang + 1 more
    • English
    Artificial Intelligence and Clinical Cognition in Pediatric and Neonatal Medicine is an essential guide with an introduction to data science and artificial intelligence to provide the reader with a quick orientation and education on AI in healthcare. This book vastly improves the speed of adoption of AI in pediatric and neonatal healthcare by providing a framework of AI deployment in children and healthcare. In addition to a large section on the principles and theories of artificial intelligence as well as its application in a number of pediatric subspecialties, the book will have about 50 commentaries that all have the same structure The book is presented in a systematic manner for all clinicians to understand the in-depth thinking of the leaders in the pediatric AI domain from an international perspective. Artificial Intelligence and Clinical Cognition in Pediatric and Neonatal Medicine is an essential guide with an introduction to data science and artificial intelligence to provide the reader with a quick orientation and education on AI in healthcare. It also offers a framework for success in planning, deployment, implementation, and evaluation of AI models in healthcare. In addition, current state of the art of pediatric subspecialties will be presented with future directions to guide the pediatric and neonatal clinicians. Finally, a colorful collection of commentaries by leaders of AI use in children’s health is inserted throughout the book.

  • Clinical Management of Pancreatic Cancer

    From Diagnosis to Palliative Care
    • 1st Edition
    • Takuji Okusaka + 1 more
    • English
    Clinical Management of Pancreatic Cancer: From Diagnosis to Palliative Care provides comprehensive guidance and support at every step of the pancreatic cancer journey, covering all aspects from initial diagnosis to compassionate and holistic care, ensuring healthcare professionals have the knowledge and resources they need for effective management and improved quality of life. The book not only presents the latest advancements in pancreatic cancer management, including innovative surgical techniques, targeted therapies, radiotherapy approaches, and palliative care interventions but also focuses on maintaining and improving patients' quality of life throughout their journey, incorporating palliative medicine and supportive care to alleviate symptoms and enhance overall well-being. IN 4 sections and 29 chapters Clinical Management of Pancreatic Cancer: From Diagnosis to Palliative Care Advocates for patient-centered care by emphasizing communication, shared decision-making, and tailoring treatment approaches to individual needs and preferences. It raises awareness about pancreatic cancer, its challenges, and the importance of early detection, while also dispelling misconceptions and offering hope through informed management strategies. The book also highlights the significance of palliative medicine and comprehensive supportive care to manage symptoms, alleviate pain, and address psychosocial and emotional needs of both patients and their families.Clinical Management of Pancreatic Cancer: From Diagnosis to Palliative Care serves as a bridge between research and clinical practice, offering researchers a broader perspective and equipping clinicians with a valuable resource that enhances their knowledge, decision-making, and patient care skills in the realm of pancreatic cancer management.

  • Advancements in Digital Cytopathology and Artificial Intelligence

    • 1st Edition
    • Keluo Yao + 2 more
    • English
    Advancements in Digital Cytopathology and Artificial Intelligence offers an extensive and reliable resource for those intrigued by the opportunities for employing artificial intelligence in cytopathology, within both clinical and research settings. The book provides advances in research and commercial technologies, regulatory and business environment updates and special considerations in cytopathology that impacts AI applications in the medical field. It describes the current state of cytopathology digitization and AI technologies, the current cytopathology practice environment, including laws and compliance issues in the context of digitization and AI technologies. This an essential reference for cytologists and trainees who are interested in AI and digital pathology and AI researchers and industry partners who are interested in developing applications for cytopathology.

  • Clinical Brain Stimulation Part A

    • 1st Edition
    • Volume 308
    • English
    Progress in Brain Research series, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.

  • Advances in Pancreatic Cancer Immunotherapy

    • 1st Edition
    • Vivek P. Chavda + 2 more
    • English
    Advances in Pancreatic Cancer Immunotherapy explores cutting-edge strategies to combat one of the most lethal malignancies. This book provides a focused, comprehensive resource on immunotherapy innovations for pancreatic cancer. It examines the tumor microenvironment, mechanisms of immune evasion, and the latest therapeutic modalities, including immune checkpoint inhibitors, cancer vaccines, and adoptive cell therapies. Chapters cover clinical and preclinical studies, combination strategies, biomarker-driven personalization, and regulatory considerations, offering a deep dive into both foundational science and translational applications. For researchers, clinicians, and graduate students, this book delivers actionable insights into overcoming treatment resistance, integrating immunotherapy into clinical practice, and shaping future research directions. It serves as an essential reference for understanding and applying immunotherapeutic advances to improve patient outcomes.

  • Decoding Cancer

    Precision Oncology through AI, Machine Learning, and Multi-Omics Analytics
    • 1st Edition
    • Pawan Kumar Maurya + 1 more
    • English
    Decoding Cancer: Precision Oncology through AI, Machine Learning, and Multi-Omics Analytics offers an integrated perspective on how computational technologies are transforming cancer research and care. It bridges cancer biology with advanced data-driven approaches to enable precision oncology. The book covers fundamentals of cancer biology alongside applications of artificial intelligence, machine learning, and big data analytics in biomarker discovery, early detection, and personalized treatment. Chapters explore multi-omics integration, predictive modeling, radiomics, surgical robotics, and ethical considerations, supported by diagrams, case studies, and annotated workflows. For academics and professionals, this resource provides actionable insights into cutting-edge tools and methodologies, helping readers understand how computational oncology accelerates translational research and clinical decision-making. It serves as a comprehensive guide for students, researchers, and clinicians navigating the future of data-driven cancer care.

  • Understanding PCR

    A Practical Bench-Top Guide
    • 2nd Edition
    • Rowena Jenkins + 1 more
    • English
    Understanding PCR: A Practical Bench-Top Guide delivers a comprehensive resource offering researchers the information they need to plan their polymerase chain reactions, from reagents and conditions to analysis and beyond. This updated edition covers a broad spectrum of topics including laboratory preparation, primer design, DNA analysis, quantitative PCR, cloning, protein expression, and the latest applications. The book equips researchers with the knowledge to confidently design and execute PCR experiments, enhancing reproducibility and efficiency. By integrating updated techniques and practical insights, this revised reference supports researchers, laboratory professionals, and students working across molecular biology and related fields.

  • Vagus Nerve

    From Homeostatic Regulations to Disease Etiopathogenesis, Treatment, and Prevention
    • 1st Edition
    • Boris Mravec
    • English
    Vagus Nerve: From Homeostatic Regulations to Disease Etiopathogenesis, Treatment, and Prevention is a comprehensive reference that encapsulates every critical aspect of the vagus nerve, tracing its anatomy, phylogeny, and physiology while exploring its pivotal role in both maintaining homeostasis and the development of various diseases. This groundbreaking work details the potential of vagus nerve stimulation as a therapeutic and preventive measure for a wide range of conditions, including neurological, psychiatric, inflammatory, cardiovascular, and gastrointestinal disorders. This book demystifies the mechanisms of vagus nerve function and its implications for health and disease. Each section delves into the historical context of vagus nerve research, its anatomical and functional characteristics, and its regulatory roles across multiple organ systems. Additionally, the book investigates the etiopathogenesis of diseases linked to vagus nerve dysfunction and outlines experimental methods for investigating its functions. With a focus on prognosis and therapy, this book highlights the prognostic value of vagus nerve activity and explores various therapeutic modalities that influence it. Concluding with directions for future research, this essential resource aims to foster a deeper understanding of the vagus nerve's significance in health and disease, opening new avenues for therapeutic innovation and clinical application.

  • Statistics in Medicine

    • 5th Edition
    • Robert H. Riffenburgh + 1 more
    • English
    Statistics in Medicine, 5th Edition serves as an essential resource for health care students, professionals and researchers seeking to understand the application of statistical methods in medical research. This comprehensive text encompasses a wide range of topics, from foundational concepts to advanced techniques, ensuring that readers are well-equipped to design, analyse, and interpret health-related studies. The book includes updated chapters on critical subjects such as missing data, regression models for discrete outcomes, polytomous response regression, classification and regression trees, and the integration of machine learning and AI with statistical methodologies. Each chapter provides practical examples and step-by-step methods, helping readers understand complex concepts while reinforcing learning through exercises and real-world applications. For the academic audience, this book offers a user-friendly approach to medical statistics, making it accessible even to those with limited statistical training. By bridging the gap between theory and practice, it empowers health care professionals to conduct rigorous research, interpret findings accurately, and contribute meaningfully to advancements in medical science.

  • Antimicrobial Resistance in the 21st Century

    Equity, Technology, and One Health Approaches
    • 1st Edition
    • Ajmer Singh Grewal + 4 more
    • English
    Antimicrobial Resistance in the 21st Century: Equity, Technology, and One Health Approaches offers a timely, interdisciplinary exploration of one of the most pressing global health challenges. Moving beyond traditional clinical and microbiological perspectives, this volume integrates equity, digital innovation, and One Health principles into a cohesive framework for understanding and addressing antimicrobial resistance (AMR). It examines how social determinants, economic pressures, and policy environments intersect with biological drivers to shape resistance patterns and outcomes worldwide. Drawing on expertise across pharmacy, medicine, public health, veterinary science, and data science, the book combines foundational knowledge with advanced insights. Real-world case studies and applied examples highlight antimicrobial use in human and animal health, stewardship strategies, infection prevention, and surveillance of both common and neglected diseases. Special attention is given to vulnerable populations, including neonates, children, and marginalized communities, alongside critical discussions of ethics, gender, and global inequities. The integration of artificial intelligence, data analytics, and digital surveillance tools demonstrates how emerging technologies can enhance prediction, monitoring, and decision-making in AMR. By bridging theory, practice, and policy, this book equips readers with the tools to design sustainable, evidence-based interventions. It is an essential resource for researchers, students, and professionals seeking to navigate and address the complex, interconnected dimensions of AMR in a rapidly evolving global landscape.

  • Advances in Agronomy

    • 1st Edition
    • Volume 203
    • English
    Advances in Agronomy, Volume 203, the latest release in this leading reference on agronomy, contains a variety of updates and highlights new advances in the field, each written by an international board of authors.

  • Flow Cytometry-Based Diagnosis for Inborn Errors of Immunity

    • 1st Edition
    • Reza Yazdani
    • English
    Flow Cytometry-based Diagnosis for Inborn Errors of Immunity addresses the need for a practical, comprehensive reference on applying flow cytometry to the diagnosis, classification, characterization, and prognostic evaluation of inborn errors of immunity (IEI). As flow cytometry becomes central to identifying and characterizing IEI, clinical immunologists and basic immunology researchers require an accessible resource that bridges fundamental principles with disease-specific diagnostic applications, alongside guidance valuable to laboratory professionals, students, and early-career practitioners.The reference covers flow cytometry principles, emerging technologies, technical considerations, and quality standards, alongside a framework for classifying IEI, before turning to practical diagnostic approaches for major disease categories. Protocols, diagnostic algorithms, immunophenotyping strategies, and functional assays demonstrate how flow cytometry rapidly identifies cellular and functional abnormalities to support diagnosis, while addressing its complementary role alongside molecular testing, narrowing candidate diagnoses, guiding genetic testing, and confirming genetic findings. Discussion of predictive and prognostic markers and international clinical experience extends its relevance across high-resource and resource-limited settings.Flow Cytometry-based Diagnosis for Inborn Errors of Immunity equips clinicians, laboratory professionals, and researchers with the knowledge and tools to translate flow cytometric findings into accurate diagnosis and informed patient care, strengthening the diagnostic pathway for IEI.

  • Asiatic-Pacific Ticks

    Species of Medical and Veterinary Importance
    • 1st Edition
    • Ze Chen + 1 more
    • English
    Asiatic-Pacific Ticks: Species of Medical and Veterinary Importance provides the most comprehensive and updated research on the taxonomy, biology, and bionomics of tick species native to the Palearctic and Oriental zoogeographic regions. It synthesizes all current research on each species using global perspectives, as these species begin to spread beyond their native habitats.Written and edited by international experts on the ticks of eastern Asia, this book covers the 12 primary species, including the Asian longhorned tick and those under the Hyalomma genus. Each chapter begins by discussing the species’ classification history, followed by identification descriptions for all active life stages, and a detailed discussion of biology and bionomics. The chapters end with a discussion of pathogenic agents associated with each species and their context for human and animal ecology.Asiatic-Paci... Ticks: Species of Medical and Veterinary Importance is a vital resource for entomologists, both in human-medical and veterinary focuses. Public health personnel and parasitologists tracking diseases in tick species will also find this useful.

  • The Autism Spectrum

    Identification, Understanding, and Treatment in Global Context
    • 1st Edition
    • Matthew K. Belmonte + 1 more
    • English
    The Autism Spectrum: Identification, Understanding, and Treatment in Global Context provides an update to the basic and clinical sciences of autism with an understanding of how research and clinical treatments are affected by recent shifts of focus: from diagnostic categories to symptomatic dimensions, from provider-centered to patient-centered treatment approaches, from high-resource, individualistic country insights to those contributed from global cultures.This volume discusses the field’s current state, whence it has come, where it is going, and how to get there. The volume weds basic and clinical understandings, state-of-the-art multivariate analyses, historical and cross-cultural information and relevance, and a patient-centered focus.

  • Nutritional and Health Aspects of Food in Oceania

    • 1st Edition
    • Diana Bogueva + 1 more
    • English
    Nutritional and Health Aspects of Food in Oceania provides an analysis of traditional and ethnic foods from Australia, New Zealand, Fiji, Papua New Guinea, Tonga, Hawaii, Samoa, Tuvalu, Solomon Islands, and New Caledonia. The book addresses the history of use, origin, composition, preparation, ingredient origin, nutritional aspects, and effects on health for various foods and food products in each of these countries. In addition, it presents both local and international regulations while also providing suggestions on how to harmonize these regulations to promote global availability of these foods.

  • Healthcare 4.0

    Pharmaceutical Advancement in the Digital Age
    • 1st Edition
    • Atheer Awad + 1 more
    • English
    Healthcare 4.0: Pharmaceutical Advancement in the Digital Age is a well-structured and easy to understand book that discusses digital health technologies in context of their pharmaceutical applications and the future they hold for this sector. The contents of the book are structured in four parts, covering digital health, software technologies, hardware technologies and the outlook and impact of these innovations to pharmaceutical care. Topics covered include artificial intelligence (AI) and machine learning, blockchain, computational modelling, Telemedicine and Telepharmacy, and virtual/augmented/mi... reality and associated hardware (such as sensors, robotics, smartphones and 3D printing).This book is the perfect resources for academics and corporate researchers in pharmacy, pharmacists, physicians and pharmacy technicians to better understand and position themselves to benefit from the technological developments impacting pharma

  • Decision Neuroscience

    • 2nd Edition
    • Jean-Claude Dreher
    • English
    Decision Neuroscience: An Integrative Perspective, Second Edition, Volume Two presents the most recent and compelling lesional, neuroimaging, electrophysiological... and computational studies in combination with hormonal and genetic studies that have led to a clearer understanding of the neural mechanisms behind reward and decision-making. The neural bases of reward and decision-making processes are of critical interest to scientists because of the fundamental role that reward plays in a number of behavioral processes (such as motivation learning, and cognition), and because the neural bases have theoretical and clinical implications for understanding dysfunctions of the dopaminergic system in several neurological and psychiatric disorders.This book provides a comprehensive update on groundbreaking work that addresses fundamental questions about the nature of behavior, including how does the brain process reward and how does it make decisions when facing multiple options? It features entirely new content, as well as expanded coverage on drug and behavioral addiction and the role of subthalamus stimulation in neurological disorders and neuroeconomics.

  • Virtual Possibilities

    Extended Reality as Assistive Technology for Inclusive Care
    • 1st Edition
    • Samiya Khan
    • English
    Virtual Possibilities: Extended Reality as Assistive Technology for Inclusive Care provides invaluable insights for researchers and related medical professionals into the transformative potential of virtual reality as a technological aid. The book navigates through the diverse applications of virtual reality in healthcare, transcending traditional uses such as medical training and therapeutic interventions. It is a dedicated examination of virtual reality's role in social care, addressing the unique needs of individuals across the spectrum, from differently abled individuals and children with learning disabilities to those grappling with disorders, trauma, and the elderly. It presents the state-of-the-art in this field, acting as a bridge, facilitating the translation of theory into practice and fostering ongoing research. Users will find this to be a valuable resource for researchers, professionals, and policymakers interested in the future applications of virtual reality in healthcare and social care.

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