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    • Modelling Methodology for Physiology and Medicine

      • 2nd Edition
      • December 5, 2013
      • Ewart Carson + 1 more
      • English
      • Paperback
        9 7 8 0 1 2 8 1 0 2 9 3 0
      • Hardback
        9 7 8 0 1 2 4 1 1 5 5 7 6
      • eBook
        9 7 8 0 1 2 4 0 9 5 2 5 0
      Modelling Methodology for Physiology and Medicine, Second Edition, offers a unique approach and an unprecedented range of coverage of the state-of-the-art, advanced modeling methodology that is widely applicable to physiology and medicine. The second edition, which is completely updated and expanded, opens with a clear and integrated treatment of advanced methodology for developing mathematical models of physiology and medical systems. Readers are then shown how to apply this methodology beneficially to real-world problems in physiology and medicine, such as circulation and respiration. The focus of Modelling Methodology for Physiology and Medicine, Second Edition, is the methodology that underpins good modeling practice. It builds upon the idea of an integrated methodology for the development and testing of mathematical models. It covers many specific areas of methodology in which important advances have taken place over recent years and illustrates the application of good methodological practice in key areas of physiology and medicine. It builds on work that the editors have carried out over the past 30 years, working in cooperation with leading practitioners in the field.

    • Neuropeptide Analogs, Conjugates, and Fragments

      • 1st Edition
      • October 22, 2013
      • P. Michael Conn
      • English
      • Paperback
        9 7 8 1 4 8 3 2 0 4 1 0 9
      • eBook
        9 7 8 1 4 8 3 2 1 7 5 3 6
      Methods in Neurosciences, Volume 13: Neuropeptide Analogs, Conjugates, and Fragments covers the synthesis and characterization of peptide analogs, conjugates, and fragments, their use as ligands for receptors, and their role in the development and use of antisera. The book discusses techniques such as novel synthetic approaches; biotinylation; purification and characterization; radioligand techniques and assay development; use of agonists and antagonists; distinguishing receptor subtypes; conjugation to carrier proteins; antiidiotypic antibody development; and radiolabeling. Neuroscientists, biochemists, neurochemists, and pharmacologists will find the book useful.

    • Molecular Endocrinology

      • 2nd Edition
      • October 22, 2013
      • Franklyn F. Bolander
      • English
      • eBook
        9 7 8 1 4 8 3 2 8 8 2 1 5
      Aimed at graduate level courses, this textbook provides students with a solid background in the basics of molecular endocrinology. Molecular Endocrinology, Second Edition, summarizes the area and provides an in-depth discussion of the molecular aspects of hormone action, including hormone-receptor interactions, second messenger generation, gene induction, and post-transcriptional control. Thoroughly revised and updated, the Second Edition includes new information on growth factors, hematopoietic-immune factors, nonclassical hormones, receptors, transduction, transcriptional regulation, as well as other relevant topics.Incorporating an abundance of new information, this text retains the self-contained, focused, and easily readable style of the First Edition. Professionals in related fields will also find this book to be a helpful summary and general reference source.

    • Biological Response Mediators and Modulators

      • 1st Edition
      • October 22, 2013
      • J. Thomas August
      • English
      • Paperback
        9 7 8 1 4 8 3 2 0 2 8 2 2
      • eBook
        9 7 8 1 4 8 3 2 1 6 2 5 6
      Biological Response Mediators and Modulators explains that the behavior of a cell depends upon the absorption of the ligand, the quantity of functional receptors existing for ligand recognition and binding, and the transduction of the signal through successive intercellular events. The book presents such model systems as the low-density lipoprotein (LDL) receptor, the epidermal growth factor receptor, and the insulin receptor. The LDL receptor is a model for a class of surface receptors that facilitate the cellular application of macromolecules through the process of receptor-mediated endocytosis. The book discusses the general characteristics of receptor-mediated endocytosis. Another topic of interest is the property of growth-related cell surface receptors. The section that follows describes the function of these receptors as tyrosine-specific protein kinases, which is related to the protein yields of some viral oncogenes. The amount of receptors in a cell depends upon the rates of synthesis and inactivation. The book will provide valuable insights for scientists, cytologists, students, and researchers in the field of chemistry.

    • Laboratory Methods in Enzymology: RNA

      • 1st Edition
      • Volume 530
      • September 11, 2013
      • Jon Lorsch
      • English
      • eBook
        9 7 8 0 1 2 4 2 0 0 5 1 7
      Methods in Enzymology volumes provide an indispensable tool for the researcher. Each volume is carefully written and edited by experts to contain state-of-the-art reviews and step-by-step protocols. In this volume, we have brought together a number of core protocols concentrating on RNA, complementing the traditional content that is found in past, present and future Methods in Enzymology volumes.

    • Routes of Drug Administration

      • 1st Edition
      • October 22, 2013
      • A. T. Florence + 1 more
      • English
      • Paperback
        9 7 8 0 7 2 3 6 0 9 2 2 3
      • eBook
        9 7 8 1 4 8 3 1 8 3 6 1 9
      Routes of Drug Administration covers topics about parenteral and enteral routes of drug administration. The book discusses the anatomy and physiology of administration sites; the formulation and design of delivery systems; and other relevant aspects of biopharmaceutics. The text describes pulmonary delivery, nasal, buccal, and transdermal routes of administration for systemic delivery, as well as a number of systems for more localized therapy with antibiotics. Innovative methods of antibiotic administration, such as continuous and intermittent infusion, endotracheal installation, aerosol delivery, antibiotic-impregnat... catheters, antibiotic-containin... bone cement, and beads, are also considered. Senior undergraduate and postgraduate students in pharmacy, medicine, nursing and allied health sciences and practitioners in these fields, as well as other professionals concerned with the preparation and administration of medicines and the monitoring of drug therapy will find the book useful.

    • Joining and Assembly of Medical Materials and Devices

      • 1st Edition
      • May 31, 2013
      • Y N Zhou + 1 more
      • English
      • Hardback
        9 7 8 1 8 4 5 6 9 5 7 7 4
      • eBook
        9 7 8 0 8 5 7 0 9 6 4 2 5
      As medical devices become more intricate, with an increasing number of components made from a wide range of materials, it is important that they meet stringent requirements to ensure that they are safe to be implanted and will not be rejected by the human body. Joining and assembly of medical materials and devices provides a comprehensive overview of joining techniques for a range of medical materials and applications.Part one provides an introduction to medical devices and joining methods with further specific chapters on microwelding methods in medical components and the effects of sterilization on medical materials and welded devices. Part two focuses on medical metals and includes chapters on the joining of shape memory alloys, platinum (Pt) alloys and stainless steel wires for implantable medical devices and evaluating the corrosion performance of metal medical device welds. Part three moves on to highlight the joining and assembly of medical plastics and discusses techniques including ultrasonic welding, transmission laser welding and radio frequency (RF)/dielectric welding. Finally, part four discusses the joining and assembly of biomaterial and tissue implants including metal-ceramic joining techniques for orthopaedic applications and tissue adhesives and sealants for surgical applications.Joining and assembly of medical materials and devices is a technical guide for engineers and researchers within the medical industry, professionals requiring an understanding of joining and assembly techniques in a medical setting, and academics interested in this field.

    • Mechanisms of Drug Toxicity

      • 1st Edition
      • October 22, 2013
      • H. RaÅ¡ková
      • English
      • Paperback
        9 7 8 1 4 8 3 1 2 4 7 8 0
      • eBook
        9 7 8 1 4 8 3 1 5 7 2 0 7
      Mechanisms of Drug Toxicity, Volume 4 presents the proceedings of the 3rd International Pharmacological Meeting held in Sao Paulo, Brazil in 1966. The book discusses the drug-induced pathobiotic effects; the mechanisms of adverse reactions; and enzyme induction in the mechanism of chronic toxicity. The text also describes the influence of inducing substances on the growth of liver and microsomal electron transport systems; the quantitative aspects of chronic toxicity; and the facts and fallacies in predicting drug effects in human.

    • Cilia, Part A

      • 1st Edition
      • Volume 524
      • March 12, 2013
      • English
      • Hardback
        9 7 8 0 1 2 3 9 7 9 4 5 2
      • eBook
        9 7 8 0 1 2 3 9 8 4 8 6 9
      This new volume of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers cilia and includes chapters on such topics as electron microscopy of IFT in cilia and flagella, radial spoke isolation and assays, and biomechanical measurements of kinocilium.

    • Membrane Electrodes in Drug-Substances Analysis

      • 1st Edition
      • October 22, 2013
      • Vasile V. Cosofret
      • J. D. R. Thomas
      • English
      • Hardback
        9 7 8 0 0 8 0 2 6 2 6 4 2
      • Paperback
        9 7 8 1 4 8 3 1 2 1 6 8 0
      • eBook
        9 7 8 1 4 8 3 1 5 4 1 0 7
      Membrane Electrodes in Drug-Substances Analysis discusses the analytical control of drugs using ion-selective membrane electrodes. This book is divided into three parts, comprised of 18 chapters organized according to the topics they cover. The first part covers the general aspects of membrane electrodes, which includes topics such as theoretical considerations and the basic characteristics of membrane electrodes. Part II deals with the general methods of analysis using membrane electrodes, and Part III tackles the determination of drug-substances. This book will be of great use to researchers and professionals engaged in drug research.

Related subjects

Agricultural and biological sciences

Drug discovery

Immunology

Microbiology and virology

Neuroscience

Pharmaceutical sciences

Pharmacology

Toxicology