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Elsevier

Books in Life sciences

  • Cerebrovascular Diseases: Controversies and Challenges, An Issue of Neurologic Clinics

    • 1st Edition
    • Volume 33-2
    • William J. Powers
    • English
    Cerebrovascular disease results in huge health expenditures, multiple recurring physician visits, and a great number of surgical and non-surgical treatments along with research into causes and prevention. This issue addresses therapies, early therapies, diagnoses, and prevention. Topics include: Endovascular Treatment of Acute Ischemic Stroke; Acute Treatment of Blood Pressure after Ischemic Stroke and Intracerebral Hemorrhage; Diagnostic Evaluation for Non-traumatic Intracerebral Hemorrhage; Prevention of Recurrent Stroke in Patients with Patent Foramen Ovale; Management of Asymptomatic Carotid Stenosis; Stenting or Endarterectomy for Patients with Symptomatic Carotid Stenosis; The Therapeutic Value of Laboratory Testing for Hypercoagulable States in Secondary Stroke Prevention; Diagnosis and Treatment of Carotid and Vertebral Artery Dissection; Recurrent Stroke while on Anti-platelet Therapy; Anti-platelet and Anti-coagulant Therapy after Intracerebral Hemorrhage; Diagnosis and Treatment of Isolated Central Nervous System Angiitis/Vasculitis; Statins for Aneurysmal Subarachnoid Hemorrhage; Expansion of IV-tPA eligibility beyond NINDS and ECASS III criteria; and Treatment of Unruptured Arteriovenous Malformations. William J Powers MD, renowned for his clinical work with Stroke and Research in Cerebral blood flow and metabolism, and stroke treatment and prevention, leads this issue of Neurologic Clinics, with authors renown in the field.

  • Anti-Angiogenesis Drug Discovery and Development

    Volume 2
    • 1st Edition
    • Atta-ur Rahman + 1 more
    • English
    The inhibition of angiogenesis is an effective mechanism of slowing down tumor growth and malignancies. The process of induction or pro-angiogenesis is highly desirable for the treatment of cardiovascular diseases, wound healing disorders, and more. Efforts to understand the molecular basis, both for inhibition and induction, have yielded fascinating results. Originally published by Bentham and now distributed by Elsevier, Anti-Angiogenesis Drug Discovery and Development, Volume 2 is an compilation of well-written reviews on various aspects of the anti-angiogenesis process. These reviews have been contributed by leading practitioners in drug discovery science and highlight the major developments in this exciting field in the last two decades. These reader-friendly chapters cover topics of great scientific importance, many of which are considered significant medical breakthroughs, making this book excellent reading both for the novice as well as for expert medicinal chemists and clinicians.

  • Drug Design and Discovery in Alzheimer’s Disease

    • 1st Edition
    • Atta-ur Rahman + 1 more
    • English
    Drug Design and Discovery in Alzheimer’s Disease includes expert reviews of recent developments in Alzheimer's disease (AD) and neurodegenerative disease research. Originally published by Bentham as Frontiers in Drug Design and Discovery, Volume 6and now distributed by Elsevier, this compilation of the sixteen articles, written by leading global researchers, focuses on key developments in the understanding of the disease at molecular levels, identification and validation of molecular targets, as well as innovative approaches towards drug discovery, development, and delivery. Beginning with an overview of AD pharmacotherapy and existing blockbuster drugs, the reviews cover the potential of both natural and synthetic small molecules; the role of cholinesterases in the on-set and progression of AD and their inhibition; the role of beta-site APP clearing enzyme-1 (BACE-1) in the production of β-amyloid proteins, one of the key reasons of the progression of AD; and other targets identified for AD drug discovery.

  • Food Safety and Quality Systems in Developing Countries

    Volume One: Export Challenges and Implementation Strategies
    • 1st Edition
    • André Gordon
    • English
    Food Safety and Quality Systems in Developing Countries, Volume One: Export Challenges and Implementation Strategies considers both the theoretical and practical aspects of food safety and quality systems implementation by major world markets and new and emerging markets in developing countries. This reference examines issues facing exporters and importers of traditional foods the characteristics of the food and its distribution channels, and market access from a historical and current context to present best practices. This must-have reference offers real-life, practical approaches for foods from around the world, offering help to those who have found it difficult to implement sustainable, certifiable food safety and quality systems into their businesses and provides scientifically sound solutions to support their implementation.

  • Recent Advances in Medicinal Chemistry, Volume 1

    • 1st Edition
    • Atta-ur Rahman + 2 more
    • English
    Originally published by Bentham and now distributed by Elsevier, Recent Advances in Medicinal Chemistry, Volume 1 covers leading-edge research and recent developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, drug targets, and natural product research and structure-activity relationship studies. The fourteen updated reviews include unique experimental data and references, and each article highlights an important topic in current medicinal chemistry research. Topics covered include: aureolic acid group of anti-cancer antibiotics and non-steroidal anti-inflammatory drugs; aromatase inhibitors in adjuvant endocrine treatment of early-stage breast cancer in postmenopausal women; Rho GTPases and statins in targeting and developing therapies for tumors; and more.

  • Person-Centered Communication with Older Adults

    The Professional Provider's Guide
    • 1st Edition
    • Timothy A. Storlie
    • English
    Providers serving older adults face a growing problem. Older adults are becoming increasingly dissatisfied with service quality citing deficits in provider communication and relationship skills. The author argues this dissatisfaction is largely related to three widespread issues: ageism, use of professional jargon, and age-related changes in the older adult. To address these concerns, Dr. Storlie advocates adoption of an evidence-based, person-centered approach to communication. The benefits of person-centered communication are many. They can increase older adult satisfaction with provider services, enhance mutual respect and understanding, improve accuracy of information exchanged, positively impact service outcomes, increase compliance with provider recommendations, and reduce the frustration and stress often experienced by both provider and older adult. Rare to this genre, readers are introduced to several under-explored topics within the field of communication, along with methods for applying concepts from research findings into these topics to enhance the quality of interpersonal communication. Topics include the role of mental imagery in the communication process, the influence of neurocardiology on relationships, and controversial findings from research into quantum physics. The book concludes by highlighting progress made in narrowing the interpersonal communication gap and forecasts how communications-orien... technological advances might improve quality of life for 21st century older adults and the providers who serve them. Utilizing interdisciplinary case studies to illustrate common problematic situations, this book provides detailed exercises that explain how providers can integrate person-centered communication into their practices to improve provider-older adult interactions. Written in a style designed to maximize learning, it helps providers find the information they need, understand what they read, and apply what they’ve learned to improve professional communication. Person-Centered Communication with Older Adults is an essential guide for today’s healthcare professionals and other aging-services providers, and also for the educators who help to prepare the providers of tomorrow.

  • Gene Therapy for Viral Infections

    • 1st Edition
    • Patrick Arbuthnot
    • English
    Gene Therapy for Viral Infections provides a comprehensive review of the broader field of nucleic acid and its use in treating viral infections. The text bridges the gap between basic science and important clinical applications of the technology, providing a systematic, integrated review of the advances in nucleic acid-based antiviral drugs and the potential advantages of new technologies over current treatment options. Coverage begins with the fundamentals, exploring varying topics, including harnessing RNAi to silence viral gene expression, antiviral gene editing, viral gene therapy vectors, and non-viral vectors. Subsequent sections include detailed coverage of the developing use of gene therapy for the treatment of specific infections, the principles of rational design of antivirals, and the hurdles that currently face the further advancement of gene therapy technology.

  • Epigenetic Technological Applications

    • 1st Edition
    • Yujun George Zheng
    • English
    Epigenetic Technological Applications is a compilation of state-of-the-art technologies involved in epigenetic research. Epigenetics is an exciting new field of biology research, and many technologies are invented and developed specifically for epigenetics study. With chapters covering the latest developments in crystallography, computational modeling, the uses of histones, and more, Epigenetic Technological Applications addresses the question of how these new ideas, procedures, and innovations can be applied to current epigenetics research, and how they can keep pushing discovery forward and beyond the epigenetic realm.

  • Knowledge Driven Development

    Private Extension and Global Lessons
    • 1st Edition
    • Yuan Zhou + 1 more
    • English
    Knowledge Driven Development: Private Extension and Global Lessons uses actual cases written specifically to study the role and capacity of private companies in knowledge sharing and intensification through agricultural extension. Descriptions of specific models and approaches are teased out of complex situations exhibiting a range of agricultural, regulatory, socio-economic variables. Illustrative cases focus on a particular agricultural value chain and elaborate the special feature of the associated private extension system. Chapters presenting individual cases of private extension also highlight specific areas of variations and significant deviance. Each chapter begins with a section describing the background and agricultural context of the case, followed by a description of the specific crop value chain. Based on understanding of this context, extension models and methods by private companies receive deeper analysis and definition in the next section. This leads to a discussion of the private extension with respect to its relevance, efficiency, effectiveness, equity, sustainability and impact. Following that, comparison with public extension, the uniqueness of the knowledge intensification model, and lessons for its replication and scaling up are elaborated. The final chapter summarizes the major results from the ten cases presented, looking at the trends, commonalities and differences of various extension approaches and the general lessons for success or failure. It concludes with a set of messages around value creation, integrated services, market links, inclusive innovation, and capacity development.

  • Trigeminocardiac Reflex

    • 1st Edition
    • Tumul Chowdhury + 1 more
    • English
    Trigeminocardiac Reflex is a comprehensive tutorial reference to the science, diagnosis, and possible treatment of the trigeminocardiac reflex (TCR) that is usually initiated when the trigeminal nerve is disturbed during intercranial surgery. Since first reported in 1999 by co-Editor Bernhard Schaller, the research focused on TCR is expanding. While its instance is rare, new discoveries are not only increasing diagnosis, but also providing more effective treatment protocols. This text is ideal as a reference for clinical and research neurologists, as a general introduction for clinical presentation, and as a foundation for new research.

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