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Elsevier

Books in Life sciences

  • Regulatory Affairs in the Pharmaceutical Industry

    • 1st Edition
    • Javed Ali + 1 more
    • English
    Regulatory Affairs in the Pharmaceutical Industry is a comprehensive reference that compiles all the information available pertaining to regulatory procedures currently followed by the pharmaceutical industry. Designed to impart advanced knowledge and skills required to learn the various concepts of regulatory affairs, the content covers new drugs, generic drugs and their development, regulatory filings in different countries, different phases of clinical trials, and the submission of regulatory documents like IND (Investigational New Drug), NDA (New Drug Application) and ANDA (Abbreviated New Drug Application). Chapters cover documentation in the pharmaceutical industry, generic drug development, code of Federal Regulation (CFR), the ANDA regulatory approval process, the process and documentation for US registration of foreign drugs, the regulation of combination products and medical devices, the CTD and ECTD formats, and much more.

  • State of the Art on Grammatical Inference Using Evolutionary Method

    • 1st Edition
    • Hari Mohan Pandey
    • English
    State of the Art on Grammatical Inference Using Evolutionary Method presents an approach for grammatical inference (GI) using evolutionary algorithms. Grammatical inference deals with the standard learning procedure to acquire grammars based on evidence about the language. It has been extensively studied due to its high importance in various fields of engineering and science. The book's prime purpose is to enhance the current state-of-the-art of grammatical inference methods and present new evolutionary algorithms-based approaches for context free grammar induction. The book's focus lies in the development of robust genetic algorithms for context free grammar induction. The new algorithms discussed in this book incorporate Boolean-based operators during offspring generation within the execution of the genetic algorithm. Hence, the user has no limitation on utilizing the evolutionary methods for grammatical inference.

  • Current Research in Neuroadaptive Technology

    • 1st Edition
    • Stephen H. Fairclough + 1 more
    • English
    Current Research in Neuroadaptive Technology provides readers with insight into the state-of-the-art field of neuroadaptive technology. The book covers the breadth and depth of current research in this field, covering a range of application domains in sufficient technical detail. The multidisciplinary character of this field means that the publication of key research is often fragmented across specialist journals. Here, the editors have consolidated current research, carefully selecting key topics that are clustered around the concept of neuroadaptive technology. In summary, the book meets the needs of readers by consolidating multidisciplinary research around a nascent technological concept. The topic of neuroadaptive technology is novel and contemporary and editors Dr. Stephen H. Fairclough and Dr. Thorsten O. Zander have captured issues related to this emerging technology at the point of inception. It is a key reference for biomedical engineers and researchers in neural engineering, biomedical engineering, computer science, and mathematics.

  • Emerging Plant Growth Regulators in Agriculture

    Roles in Stress Tolerance
    • 1st Edition
    • M. Naeem + 1 more
    • English
    Emerging Plant Growth Regulators in Agriculture: Roles in Stress Tolerance presents current PGR discoveries and advances for agricultural applications, providing a comprehensive reference for those seeking to apply these tools for improved plant health and crop yield. As demand for agricultural crops and improved nutritional requirement continue to escalate in response to increasing population, plant researchers have focused on identifying scientific approaches to minimize the negative impacts of climate change on agriculture crops. Among the various applied approaches, the application of plant growth regulators (PGRs) have gained significant attention for their ability to enhance stress tolerance mechanisms. This book was developed to provide foundational and emerging information to advance the discovery of novel, cost-competitive, specific and effective PGRs for applications in agriculture.

  • Integrated Population Models

    Theory and Ecological Applications with R and JAGS
    • 1st Edition
    • Michael Schaub + 1 more
    • English
    Integrated Population Models: Theory and Ecological Applications with R and JAGS is the first book on integrated population models, which constitute a powerful framework for combining multiple data sets from the population and the individual levels to estimate demographic parameters, and population size and trends. These models identify drivers of population dynamics and forecast the composition and trajectory of a population. Written by two population ecologists with expertise on integrated population modeling, this book provides a comprehensive synthesis of the relevant theory of integrated population models with an extensive overview of　practical applications, using Bayesian methods by means of case studies. The book contains fully-documented, complete code for fitting all models in the free software, R and JAGS. It also includes all required code for pre- and post-model-fitting analysis. Integrated Population Models is an invaluable reference for researchers and practitioners involved in population analysis, and for graduate-level students in ecology, conservation biology, wildlife management, and related fields.　The text is ideal for self-study and advanced graduate-level courses.

  • Epigenetics in Precision Medicine

    • 1st Edition
    • Volume 30
    • Jose Luis Garcia-Gimenez
    • English
    In recent years, knowledge of epigenetic mechanisms underlying disease onset and progression has proven crucial for the development of novel early diagnosis and prognosis biomarkers for patient stratification and precision medicine. Epigenetics in Precision Medicine, a new volume in the Translational Epigenetics series, provides a thorough discussion and overview of current developments in clinical epigenetics with special emphasis on epigenetic biomarkers that can be used for clinical diagnosis, prognosis, patient stratification, and treatment monitoring. Disease types discussed include cancer, metabolic disorders, neurodegenerative diseases, bone disease, and immune-related disorders. The book examines the challenges of advancing epigenetics research and translating findings to the clinic and drug discovery in each of these areas, as well as current solutions; chapter authors discuss how to leverage epigenomic technologies, applications, and tools, such as next-generation sequencing, to discover new epigenetic biomarkers in disease and drug studies. Epigenetics in Precision Medicine focuses on complex epigenetic mechanisms in several pathologies, and explores how epigenetics can power the advance of precision medicine, not only by improving in vitro diagnostic and prognostic tools, but by providing new therapeutic approaches to treat human disease.

  • The DNA Replication-Repair Interface

    • 1st Edition
    • Volume 661
    • English
    Replication-Coupled Repair, Volume 661 in the Methods in Enzymology series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics, including the Repair of replication-born DNA breaks by sister chromatid recombination, High resolution and high throughput DNA cyclization measurements to interrogate DNA bendability, A programmable detection method for genomic signatures: from disease diagnosis to genome editing, Characterization of the telomerase modulating activities of yeast DNA helicases, Eukaryotic DNA replication with purified budding yeast proteins, Single molecule studies of yeast Rad51 paralogs, Light activation and deactivation of Cas9 for DNA repair studies, and more. Other chapters explore MIDAS: Direct sequencing to map mitotic DNA synthesis and common fragile sites at high precision, Studying the DNA damage response in embryonic systems, GLASS-ChIP to map Mre11 cleavage sites in the human genome, New chemical biology approaches to trap reaction intermediates in living cells, Single-molecule imaging approaches for monitoring replication fork conflicts at genomic DNA G4 structures and R-loops in human cells, Monitoring the replication of structured DNA through heritable epigenetic change, Visualizing replication fork encounters with DNA interstrand crosslinks, and much more.

  • Safety Risk Management for Medical Devices

    • 2nd Edition
    • Bijan Elahi
    • English
    Safety Risk Management for Medical Devices, Second Edition teaches the essential safety risk management methodologies for medical devices compliant with the requirements of ISO 14971:2019. Focusing exclusively on safety risk assessment practices required in the MedTech sector, the book outlines sensible, easily comprehensible, state-of the-art methodologies that are rooted in current industry best practices, addressing safety risk management of medical devices, thus making it useful for those in the MedTech sector who are responsible for safety risk management or need to understand risk management, including design engineers, product engineers, development engineers, software engineers, Quality assurance and regulatory affairs. Graduate-level engineering students with an interest in medical devices will also benefit from this book. The new edition has been fully updated to reflect the state-of-the-art in this fast changing field. It offers guidance on developing and commercializing medical devices in line with the most current international standards and regulations.

  • Current Progress in iPSC Disease Modeling

    • 1st Edition
    • Alexander Birbrair
    • English
    Current Progress in iPSC Disease Modeling, Volume Fourteen in the Advances in Stem Cell Biology series, is a timely and expansive collection of information and new discoveries in the field. This new volume addresses advances in research on how induced pluripotent stem cells are used for the creation of new tissues and organs. The creation of iPSC technology allowed the development of disease-specific human pluripotent stem cells. These cells allow researchers to study questions once impossible for some human diseases. This volume addresses iPSCs for vascular tissue engineering, bioprinting, derived lung organoids for pulmonary disorders, skeletal muscle engineering, human kidney organoids, and more. It is written for researchers and scientists in stem cell therapy, cell biology, regenerative medicine and organ transplantation, and is contributed by world-renowned authors in the field.

  • Foundations of Sleep Health

    • 1st Edition
    • F. Javier Nieto + 1 more
    • English
    Foundations of Sleep Health presents sleep health as a critical element of overall individual and population health. Sleep disorders are an increasing problem plaguing more than 40 million Americans. Sleep impacts numerous biological functions and plays a critical role in brain development, including learning and memory consolidation, cognitive functioning, and emotion regulation. This book provides an historic and current overview of the state of sleep health with an emphasis on the interplay between several levels of determinants and factors that influence sleep health. The text provides students in the health professions with in-depth discussion on the theory, research, and practice of sleep health, while also detailing mechanisms, hypotheses, and determinants of sleep and ways to improve sleep health.

  • iPSC Derived Progenitors

    • 1st Edition
    • Alexander Birbrair
    • English
    iPSC Derived Progenitors, Volume Thirteen in the Advances in Stem Cell Biology series is a timely collection of information and new discoveries in the field of stem cell biology. The book addresses the importance of induced pluripotent stems cells and how can they be differentiated into different progenitors. Progenitors cells are often the first-step to making more differentiating cell types. This volume addresses iPSCs derived from bone, dental pulp, craniofacial, neural stem cells, otic, cardiac, and much more. The volume is written for researchers and scientists in stem cell therapy, cell biology, regenerative medicine, organ transplantation, and is contributed by world-renowned authors.

  • AI, Edge and IoT-based Smart Agriculture

    • 1st Edition
    • Ajith Abraham + 4 more
    • English
    AI, Edge, and IoT Smart Agriculture integrates applications of IoT, edge computing, and data analytics for sustainable agricultural development and introduces Edge of Thing-based data analytics and IoT for predictability of crop, soil, and plant disease occurrence for improved sustainability and increased profitability. The book also addresses precision irrigation, precision horticulture, greenhouse IoT, livestock monitoring, IoT ecosystem for agriculture, mobile robot for precision agriculture, energy monitoring, storage management, and smart farming. The book provides an overarching focus on sustainable environment and sustainable economic development through smart and e-agriculture. Providing a medium for the exchange of expertise and inspiration, contributions from both smart agriculture and data mining researchers around the world provide foundational insights. The book provides practical application opportunities for the resolution of real-world problems, including contributions from the data mining, data analytics, Edge of Things, and cloud research communities working in the farming production sector. The book offers broad coverage of the concepts, themes, and instruments of this important and evolving area of IOT-based agriculture, Edge of Things and cloud-based farming, Greenhouse IOT, mobile agriculture, sustainable agriculture, and big data analytics in agriculture toward smart farming.

  • The Neurobiology, Physiology, and Psychology of Pain

    • 1st Edition
    • Rajkumar Rajendram + 3 more
    • English
    The Neurobiology, Physiology and Psychology of Pain focuses on bettering readers’ understanding of acute and chronic pain. Featuring chapters on neurotransmitters, pharmacology, and brain imaging, this volume discusses, in detail, the mechanisms of pain and experimental studies undertaken to better understand the pathways involved. The translational work in this area has applicability for neurologists, anesthesiologists, pharmacologists, and anyone working in the intersection of these areas. This volume is integral for anyone interested in the molecular underpinnings of pain at every level.

  • COVID-19: Tackling Global Pandemics through Scientific and Social Tools

    • 1st Edition
    • S. Chatterjee
    • English
    Coronavirus disease 2019 (COVID-19) is an infectious disease caused by SARS-CoV-2. It was first identified in December 2019 in Wuhan, Hubei, China, and has resulted in an ongoing pandemic. As of July 2020, more than 13.8　million cases have been reported across 188 countries and territories, resulting in more than 590,000 deaths. COVID 19: Tackling Global Pandemics through Scientific and Social Tools, is an amalgamation of scientific and social perspective. The book provides a selection of handpicked themes and topics relevant to COVID 19 pandemic across various disciplines delivered by experts in the domain. The Opinion section is a unique component of this book discussing important issues concerning the COVID 19. COVID 19: Tackling Global Pandemics through Scientific and Social Tools serves as single source of information ranging from clinical research to social science and even biotechnology to engineering in a single platform. But there is scarcity of a quality document that summarizes various aspects of a single event. Therefore, the purpose of this book is to provide scientific and social information on COVID 19 to all sectors of readers i.e. from students to researchers and even policy makers Divided into 13 chapters, the book begins with an in-depth introduction to the highly infectious disease COVID19. Followed by chapters on interventions, vaccine development, prevention and control COVID 19: Tackling Global Pandemics through Scientific and Social Tools also provides insights to current global situation, mathematical models and social factors like distancing and hand-washing. The book closes with a review on the use of artificial intelligence and engineered intervention. All are presented in a practical short format, making this volume a valuable resource for very broad academic audience.

  • Features and Assessments of Pain, Anesthesia, and Analgesia

    • 1st Edition
    • Rajkumar Rajendram + 3 more
    • English
    Features and Assessments of Pain, Anaesthesia and Analgesia examines the syndromes of pain and how they interlink with anesthesia and analgesics. The book covers assessments, screening and resources, and provides applications to related areas of medicine. It explores how the perception of pain results from a multifaceted interaction between illness beliefs, age, gender, time of onset, stress, socioeconomic status, and any number of other factors. In addition, the book scrutinizes how the neuroscience of pain in one condition may be relevant to understanding pain observed in other conditions.

  • Healthcare Strategies and Planning for Social Inclusion and Development

    Volume 1: Health for All - Challenges and Opportunities in Healthcare Management
    • 1st Edition
    • Basanta Kumara Behera + 2 more
    • English
    Healthcare Strategies and Planning for Social Inclusion and Development: Volume One: Health for All - Challenges and Opportunities in Healthcare Management examines health care management, particularly in developing countries, along with the key aspects of universal health required to address current global health issues. This new volume begins with an overview of the concept and definition of “Health for All.” The book covers how international organizations like the WHO support national health authorities in managing their core healthcare systems, support healthcare workforces, utilize technologies like health information systems, ensure health coverage and funding, and provide primary healthcare education. This volume is a useful resource to graduate students in public health and health care policy, public health professionals, health and social work researchers, and health policy makers interested in global health and primary healthcare services, particularly in developing countries.

  • Sturkie's Avian Physiology

    • 7th Edition
    • Colin G. Scanes + 1 more
    • English
    Sturkie's Avian Physiology, Seventh Edition is the classic comprehensive single volume on the physiology of domestic as well as wild birds. This latest edition is thoroughly revised and updated and features several new chapters with entirely new content on such topics as vision, sensory taste, pain reception, evolution, and domestication. Chapters throughout have been greatly expanded due to the many recent advances in the field. This book is written by international experts in different aspects of avian physiology. For easy reading and searches, this book is structured under a series of themes, beginning with genomic studies, sensory biology and nervous systems, and major organs. The chapters then move on to investigate metabolism, endocrine physiology, reproduction, and finally cross-cutting themes such as stress and rhythms. New chapters on feathers and skin are featured as well. Sturkie’s Avian Physiology, Seventh Edition is an important resource for ornithologists, poultry scientists, and other researchers in avian studies. It is also useful for students in avian or poultry physiology, as well as avian veterinarians.

  • Advances in Aggregation Induced Emission Materials in Biosensing and Imaging for Biomedical Applications - Part A

    • 1st Edition
    • Volume 184
    • English
    Advances in Aggregation Induced Emission Materials in Biosensing and Imaging for Biomedical Applications - Part A Volume 184, highlights many aspects of AIE materials that can help future investigators, researchers, students and stakeholders perform research with ease. Emitting light is a fascinating photophysical phenomenon, its different forms have brought the attention of various disciplines of natural sciences for centuries. In the modern era of scientific generation, short-lived fluorescence light and its long-lived counterpart phosphorescence light has been employed for several chemo-sensing, bio-sensing, and bioimaging applications. The aggregation induced emission (AIE) phenomenon has appeared as a wand of modern science to convert aggregation-caused quenching (ACQ) materials into AIE active materials for a wide range of biomedical applications including biosensing, bioimaging and localization of molecules for better understanding of molecular mechanisms. This volume covers a wide range of topics which are not currently available in a single volume, including ACQ & AIE concept development; intracellular pH, temperature and viscosity sensing; imaging of cell membrane, lipid droplet, lysosome, and mitochondria; biosensing and Imaging of bacteria; nucleus and nucleic acid imaging.

  • Nanoparticle Therapeutics

    Production Technologies, Types of Nanoparticles, and Regulatory Aspects
    • 1st Edition
    • Prashant Kesharwani + 1 more
    • English
    Nanoparticle therapeutics: Production Technologies, Types of Nanoparticles, and Regulatory Aspects employs unique principles for applications in cell-based therapeutics, diagnostics and mechanistics for the study of organ physiology, disease etiology and drug screening of advanced nanoparticles and nanomaterials. The book focuses on the extrapolation of bioengineering tools in the domain of nanotechnology and nanoparticles therapeutics, fabrication, characterization and drug delivery aspects. It acquaints scientists and researchers on the experiential and experimental aspects of nanoparticles and nanotechnology to equip their rational application in various fields, especially in differential diagnoses and in the treatment of diverse diseased states. This complete resource provides a holistic understanding of the principle behind formation, characterization, applications, regulations and toxicity of nanoparticles employing myriad principles of nanotechnology. Investigators, pharmaceutical researchers, and advanced students working on technology advancement in the areas of designing targeted therapies, nanoscale imaging systems and diagnostic modalities in human diseases where nanoparticles can be used as a critical tool for technology advancement in drug delivery systems will find this book useful.

  • Recent Trends in Computer-aided Diagnostic Systems for Skin Diseases

    Theory, Implementation, and Analysis
    • 1st Edition
    • Saptarshi Chatterjee + 2 more
    • English
    Recent Trends in Computer-aided Diagnostic Systems for Skin Diseases: Theory, Implementation, and Analysis provides comprehensive coverage on the development of computer-aided diagnostic (CAD) systems employing image processing and machine learning tools for improved, uniform evaluation and diagnosis (avoiding subjective judgment) of skin disorders. The methods and tools are described in a general way so that these tools can be applied not only for skin diseases but also for a wide range of analogous problems in the domain of biomedical systems. Moreover, quantification of clinically relevant information that can associate the findings of physicians/experts is the most challenging task of any CAD system. This book gives all the details in a step-by-step form for different modules so that the readers can develop each of the modules like preprocessing, feature extraction/learning, disease classification, as well as an entire expert diagnosis system themselves for their own applications.

  • Recombinant Protein Expression: Eukaryotic hosts

    • 1st Edition
    • Volume 660
    • English
    Recombinant Protein Expression, Part B, Volume 660 in the Methods in Enzymology series, highlights new advances in the field with this new volume presenting interesting chapters on Multiplexed analysis protein: Protein interactions of polypeptides translated in Leishmania cell-free system, MultiBac system and its applications, performance and recent, Production of antibodies in Shuffle, Designing hybrid-promoter architectures by engineering cis-acting DNA sites to enhance transcription in yeast, Designing hybrid-promoter architectures by engineering cis-acting DNA sites to deregulate transcription in yeast, Antibody or protein-based vaccine production in plants, Cell-free protein synthesis, Plant-based expression of biologic drugs, and much more. Additional sections cover the Use of native mass spectrometry to guide detergent-based rescue of non-native oligomerization by recombinant proteins, Advancing overexpression and purification of recombinant proteins by pilot optimization through tandem affinity-buffer exchange chromatography online with native mass spectrometry, Method for High-Efficiency Fed-batch cultures of recombinant Escherichia coli, Method to transfer Chinese hamster ovary (CHO) shake flask experiments to the ambr® 250, and Expression of recombinant antibodies in Leishmania tarentolae.

  • Effects of Peri-Adolescent Licit and Illicit Drug Use on the Developing CNS: Part II

    • 1st Edition
    • Volume 161
    • English
    Effects of Peri-Adolescent Licit and Illicit Drug Use on the Developing CNS: Part II, Volume 161, in the International Review on Neurobiology serial highlights new advances, with this volume presenting chapters on topics including Introduction to Effects of Peri-Adolescent Licit and Illicit Drug Use on the Developing CNS, Peri-adolescent Exposure to (Meth)amphetamine in Animal Models, The Impact of Adolescent Nicotine Exposure on Alcohol Use During Adulthood: The Role of Neuropeptides, Cannabis Exposure During Adolescence: A uniquely Sensitive Period for Neurobiological Effects, The Stoned Age: Sex Differences in the Effects of Adolescent Cannabinoid Exposure on Prefrontal Cortex Structure and Function in Animal Models, and more.

  • Side Effects of Drugs Annual

    A Worldwide Yearly Survey of New Data in Adverse Drug Reactions
    • 1st Edition
    • Volume 43
    • Sidhartha D. Ray
    • English
    Side Effects of Drugs Annual: A Worldwide Yearly Survey of New Data in Adverse Drug Reactions, Volume 43, first published in 1977, and continually published as a yearly update to the voluminous encyclopedia Meyler's Side Effects of Drugs, presents clinicians and medical investigators with a critical survey of new data and trends in adverse drug reactions and interactions. Topics covered in this new release include Central Nervous System Stimulants and Drugs that Suppress Appetite, Antidepressants, Lithium, Drugs of Abuse, Hypnotics and Sedatives, Antipsychotic Drugs, Antiepileptics, Opioid Analgesics and Narcotic Antagonists, Anti-Inflammatory and Antipyretic Analgesics and Drugs Used in Gout, and much more.

  • Progress in Genomic Medicine

    From Research to Clinical Application
    • 1st Edition
    • Moyra Smith
    • English
    Progress in Genomic Medicine: From Research to Clinical Application provides a careful synthesis of the foundations, current trends and translational challenges in genomic medicine, clarifying pathways forward and enabling genomic medicine research and implementation across clinical settings and treatment development. Sections address the history and growth of genetic medicine, with a discussion of key studies in syndrome delineations, inherited diseases, biochemical genetics, and chromosome abnormalities, overview clinical applications made possible through genomic advances, with chapters on DNA sequencing for clinical genetic diagnosis, genotype-phenotype correlations in individuals and across populations, new-born screening for treatable genetic disorders, and more. In addition, social, ethical and public health aspects of applying genomic technologies are included throughout. Here, Dr. Smith applies her experience and participation in the field, across its major milestones, to put current research, clinical advances, and ongoing questions in context.

  • Advances in Applied Microbiology

    • 1st Edition
    • Volume 117
    • Geoffrey M. Gadd + 1 more
    • English
    Advances in Applied Microbiology, Volume 117 continues the comprehensive reach of this widely read and authoritative review source in microbiology. Users will find invaluable references and information on a variety of areas relating to the topic of microbiology.

  • Advances in Clinical Chemistry

    • 1st Edition
    • Volume 105
    • Gregory S. Makowski
    • English
    Advances in Clinical Chemistry, Volume 105, the latest installment in this internationally acclaimed series, contains chapters authored by world-renowned clinical laboratory scientists, physicians and research scientists. The serial discusses the latest and most up-to-date technologies related to the field of clinical chemistry, with this new release focusing on IgG N-glycans, Extracellular Vesicles: Potential Impact on Cardiovascular Diseases, Advances in Bone Turnover Markers, Matrix Metalloproteinases and Tissue Inhibitors of Matrix Metalloproteinases in Kidney Disease, and The Prothrombotic State in Cancer.

  • Introductory Microbiology Lab Skills and Techniques in Food Science

    • 1st Edition
    • Cangliang Shen + 1 more
    • English
    Introductory Microbiology Lab Skills and Techniques in Food Science covers topics on isolation, identification, numeration and observation of microorganisms, biochemistry tests, case studies, clinical lab tasks, and basic applied microbiology. The book is written technically with figures and photos showing details of every lab procedure. This is a resource that is skills-based focusing on lab technique training. It is introductory in nature, but encourages critical thinking based on real case studies of what happens in labs every day and includes self-evaluation learning questions after each lab section. This is an excellent guide for anyone who needs to understand how to apply microbiology to the lab in a practical setting.

  • Emery and Rimoin’s Principles and Practice of Medical Genetics and Genomics

    Perinatal and Reproductive Genetics
    • 7th Edition
    • Reed E. Pyeritz + 2 more
    • English
    **Selected for Doody’s Core Titles® 2024 in Clinical Genetics**Emery and Rimoin’s Principles and Practice of Medical Genetics and Genomics: Perinatal and Reproductive Genetics, Seventh Edition includes the latest information on seminal topics such as prenatal diagnosis, genome and exome sequencing, public health genetics, genetic counseling, and management and treatment strategies in this growing field. The book is ideal for medical students, residents, physicians and researchers involved in the care of patients with genetic conditions. This comprehensive, yet practical resource emphasizes theory and research fundamentals related to applications of medical genetics across the full spectrum of inherited disorders and applications to medicine more broadly.Chapters from leading international researchers and clinicians focus on topics ranging from single gene testing to whole genome sequencing, whole exome sequencing, gene therapy, genome editing approaches, FDA regulations on genomic testing and therapeutics, and ethical aspects of employing genomic technologies.

  • Scientific Perspectives of Tea Plant Horticulture and Productivity

    • 1st Edition
    • L. Manivel
    • English
    Scientific Perspectives of Tea Plant Horticulture and Productivity is a complete, step-by-step guide on how to maximize tea plant growth, yield and quality. Chapters focus on the methods of cultivation, soil and water management, plant physiology, plant protection and weed control, problems from pollution and climate change, and eco-friendly remedial actions. This is an essential read for plant biologists and tea horticulturalists as the tea industry is struggling due to high production costs, changing climates and diminishing plant yields, with countries in Asia declaring the industry at ‘crisis point.’ Horticulturalists need solutions to problems with plant productivity, quality, stress management and eco-friendly cultivation practices. There have been several technological advances in the field and horticulturalists need guidance on how best to implement new technologies, hence the importance of this new resource.

  • Advances in Marine Biology

    • 1st Edition
    • Volume 90
    • Jean-Francois Hamel
    • English
    The Oceanography of the Eastern English Channel: Past, Present and Future, Volume 90 in the Advances in Marine Biology series, is the latest release in a series that has been providing in-depth and up-to-date reviews on all aspects of marine biology since 1963. Readers will find updates on many topics that will appeal to postgraduates and researchers in marine biology, fisheries science, ecology, zoology and biological oceanography. Chapters in this new release include Marine Environmental DNA: Approaches, Applications, and Opportunities, and The Biology and Ecology of the Banana Prawns.

  • Foundations of Colorectal Cancer

    • 1st Edition
    • Alejandro Pazos Sierra
    • English
    Foundations of Colorectal Cancer provides a holistic and comprehensive dive into colorectal cancer, discussing the contributions of each discipline that studies it, allowing its understanding from the most demographic and ethical facts, to the treatment process, its varieties and genetic background. Written by experts in diverse areas such as cancer research, oncology, genetics, biochemistry, psychology, social sciences, bioinformatics and palliative care, the book brings real-world experiences to help readers with any challenge they may face when dealing with patients or during their research workflow.The content is split into nine sections: Clinical manifestations and disease detection, covering primary and secondary prevention, and the role of primary care; Diagnosis and staging, discussing endoscopy, colonoscopy, molecular pathology, and anatomopathological diagnosis; Treatment, including endoscopic, surgical, radiological, and postoperative approaches; Molecular and biological mechanisms, with the role of intestinal microbiota, stem cells and signaling pathways; New diagnostic methods, encompassing biomarkers and bioinformatics tools for research; Biobanks, with an overview of their regulations and importance in the research; Epidemiological studies, focusing on incidence and mortality globally and by regions; Hereditary colorectal cancer, differentiating nonpolyposis and polyposis types; and Addressing the consequences of colorectal cancer, covering psychological effects, nutrition and ethical issues.

  • Bark Beetle Management, Ecology, and Climate Change

    • 1st Edition
    • Kamal J.K. Gandhi + 1 more
    • English
    Bark Beetle Management, Ecology, and Climate Change provides the most updated and comprehensive knowledge on the complex effects of global warming upon the economically and ecologically important bark beetle species and their host trees. This authoritative reference synthesizes information on how forest disturbances and environmental changes due to current and future climate changes alter the ecology and management of bark beetles in forested landscapes. Written by international experts on bark beetle ecology, this book covers topics ranging from changes in bark beetle distributions and addition of novel hosts due to climate change, interactions of insects with altered host physiology and disturbance regimes, ecosystem-level impacts of bark beetle outbreaks due to climate change, multi-trophic changes mediated via climate change, and management of bark beetles in altered forests and climate conditions. Bark Beetle Management, Ecology, and Climate Change is an important resource for entomologists, as well as forest health specialists, policy makers, and conservationists who are interested in multi-faceted impacts of climate change on forest insects at the organismal, population, and community-levels.

  • Recombinant Protein Expression: Prokaryotic hosts and cell-free systems

    • 1st Edition
    • Volume 659
    • English
    Recombinant Protein Expression, Part A, Volume 659 in the Methods in Enzymology series, highlights new advances in the field with this new volume presenting interesting chapters on Multiplexed analysis protein: Protein interactions of polypeptides translated in Leishmania cell-free system, MultiBac system and its applications, performance and recent, Production of antibodies in Shuffle, Designing hybrid-promoter architectures by engineering cis-acting DNA sites to enhance transcription in yeast, Designing hybrid-promoter architectures by engineering cis-acting DNA sites to deregulate transcription in yeast, Antibody or protein-based vaccine production in plants, Cell-free protein synthesis, Plant-based expression of biologic drugs, and much more. Additional sections cover the Use of native mass spectrometry to guide detergent-based rescue of non-native oligomerization by recombinant proteins, Advancing overexpression and purification of recombinant proteins by pilot optimization through tandem affinity-buffer exchange chromatography online with native mass spectrometry, Method for High-Efficiency Fed-batch cultures of recombinant Escherichia coli, Method to transfer Chinese hamster ovary (CHO) shake flask experiments to the ambr® 250, and Expression of recombinant antibodies in Leishmania tarentolae.

  • Biomolecular Interactions Part A

    • 1st Edition
    • Volume 166
    • English
    Biomolecular Interactions: Part A, Volume 166, the latest release in the Methods in Cell Biology series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics in cell biology. Each chapter is written by an international board of authors.

  • Red Panda

    Biology and Conservation of the First Panda
    • 2nd Edition
    • Angela R. Glatston
    • English
    Red Panda: Biology and Conservation of the First Panda, Second Edition, provides the most up-to-date research, data, and conservation solutions for the red pandas, Ailurus species. Since the publication of the previous edition in 2010, the International Union for Conservation of Nature (IUCN) updated the threat level of red pandas, and they are now considered to be endangered. This latest edition is updated to provide an in-depth look at the scientific and conservation-based issues urgently facing the red panda today. Led by one of the world’s leading authorities and advocates for red panda conservation, this new edition includes data from the Population and Habitat Viability (PHVA) workshops conducted in three of the species’ range states, Nepal, China, and India; these workshops utilized firsthand information on the decrease of red panda populations due to factors including deforestation, illegal pet trade, human population growth, and climate change. This book also includes updated information from the first edition on reproduction, anatomy, veterinary care, zoo management, and fossil history.

  • Mechanisms of Cell Death and Opportunities for Therapeutic Development

    • 1st Edition
    • Diaqing Liao
    • English
    Mechanisms of Cell Death and Opportunities for Therapeutic Development, volume four in the Perspectives in Translational Cell Biology series, offers content for professors, students and researchers across basic and translational biology. The book covers fundamental mechanisms, ranging from different forms of cell death and drug development, to efforts for treating disease, providing a valuable resource for readers interested in understanding cell death and relevant translational research. The book's editor, Diaqing Liao, has over twenty years’ experience teaching topics of cell death.

  • Biosensors for Single-Cell Analysis

    • 1st Edition
    • Jian Chen + 1 more
    • English
    Biosensors for Single-Cell Analysis explores a wide range of biosensor technologies and their applications in single-cell characterization and analysis. Sections cover key biophysical and chemical single-cell properties that consider proteomic, metabolic, electrical, mechanical and optical properties. Each chapter features key definitions and case studies, providing detailed guidance for researchers who want to replicate covered solutions in their work. Tutorial sections, evaluations of the current state-of-the-field and future developments are also included. Microfluidic approaches to characterization, such as microfluidic impedance flow cytometry and microfluidic flow cytometry are considered alongside more conventional approaches, such as mass spectroscopy, fluorescent and mass flow cytometry. Additionally, key types of biosensors are covered, including atomic force microscopy, micropipette aspiration, optical tweezers, microfluidic hydrodynamic stretchers, microfluidic constriction channel and microfluidic optical stretchers.

  • Chitosan in Drug Delivery

    • 1st Edition
    • Md Saquib Hasnain + 2 more
    • English
    Chitosan in Drug Delivery provides thorough insights into chitosan chemistry, collection, chemical modifications, characterization and applications in the pharmaceutical industry and healthcare fields. The book explores molecular weight, degree of deacetylation and molecular geometry, emphasizing recent advances in the field as written by academic, industry and regulatory scientists. It will be a useful resource for pharmaceutical scientists, including industrial pharmacists, analytical scientists, postgraduate students, health care professionals and regulatory scientists actively involved in pharmaceutical product and process development in natural polymers containing drug delivery.

  • Advances in Food Security and Sustainability

    • 1st Edition
    • Volume 6
    • Marc J. Cohen
    • English
    Advances in Food Security and Sustainability, Volume Six looks at the challenges, constraints and solutions necessary to maintain a healthy and accessible food supply in different communities. This ongoing series addresses a wide range of issues on food sustainability and security, with chapters in this release covering the Significance of Short Food Supply Chains During Pandemic Times, Food Security Challenges and Opportunities in Indonesia Post COVID-19, Understanding the genetic diversity and association mapping of nutritional traits in graminaceous crops: Progress and prospects, and Traditional foods and food security: Actors, production, and the challenge of integration into markets before and after the pandemic.

  • Tomato Processing by-Products

    Sustainable Applications
    • 1st Edition
    • Mejdi Jeguirim + 1 more
    • English
    In addition to being served as a fresh vegetable, tomato is also consumed in the form of various processed products, such as paste, juice, sauce, puree and ketchup. Generally, in processing these products, different by-products including peels, seeds and pulps are produced. The rational disposal of Tomato waste represents not only a resource problem but also an environmental and economic one for the Tomato Processing Industry. Tomato Processing By-Products: Sustainable Applications indicates the alternative sustainable solutions for the recovery of tomato processing by-products as a source for animal feed and valuable components as well as their possible approaches for value-added utilization in energy, environmental and agricultural applications. Aimed at agricultural or food engineers who work in the Tomato processing industry and are seeking to improve their by-products management by actively utilizing them in effective applications.

  • Nutraceutical and Functional Food Components

    Effects of Innovative Processing Techniques
    • 2nd Edition
    • Charis M. Galanakis
    • English
    Nutraceutical and Functional Food Components: Effects of Innovative Processing Techniques, Second Edition highlights the impact of recent food industry advances on the nutritional value, functional properties, applications, bioavailability, and bioaccessibility of food components. This second edition also assesses shelf-life, sensory characteristics, and the profile of food products. Covering the most important groups of food components, including lipids, proteins, peptides and amino acids, carbohydrates, dietary fiber, polyphenols, carotenoids, vitamins, aromatic compounds, minerals, glucosinolates, enzymes, this book addresses processing methods for each. Food scientists, technologists, researchers, nutritionists, engineers and chemists, agricultural scientists, other professionals working in the food industry, as well as students studying related fields, will benefit from this updated reference.

  • The Evolutionary Ecology of Invasive Species

    • 1st Edition
    • Johannes Le Roux
    • English
    The Evolutionary Ecology of Invasive Species offers new insights into the mechanisms that underlie rapid evolution in these species. The book provides a comprehensive overview of achievements in the field during the boom of information over the past two decades and includes discussions of possible future directions for the study of evolution in invasive species. Written by an international expert in invasion ecology, population genetics, and evolutionary biology, the book explores the roles of preadaptation, phenotypic plasticity, selection, and stochastic processes in driving rapid evolution. The book draws insights from a wide spectrum of invasive microbes, plants, and animals, covering many of the planet’s biogeographic regions and discusses the evolutionary consequences for native species in response to biological invasions. A valuable resource to researchers and students in evolutionary biology, invasive species biology, and global change biology, this text suggests future research directions related to the evolutionary biology, impacts, and management of invasive species.

  • TDP-43 and Neurodegeneration

    From Bench to Bedside
    • 1st Edition
    • Vijay Kumar + 1 more
    • English
    Aggregates of the TAR DNA binding protein 43 (TDP-43), are hallmark features of the neurodegenerative diseases Amyotrophic Lateral Sclerosis (ALS) and frontotemporal dementia (FTD), with overlapping clinical, genetic and pathological features. TDP-43 and Neurodegeneration: From Bench to Bedside summarizes new findings in TDP-43 pathobiology and proteinopathies. The book summarizes TDP-43’s structure, function, biology, misfolding, aggregation, pathogenesis and therapeutics. It includes autophagy-mediated therapy, role of stress granule, novel genetic, cell culture-based models, systems biology for precision medicine, development of stem cells and mechanism-based therapies that can target ALS and other related neurodegenerative diseases. This book is written for neuroscientists, neurologists, clinicians, advanced graduate students, drug discovery researchers, as well as cellular and molecular biologists involved in ALS, motor neuron disease (MND) and other neurodegenerative disorders.

  • Clinical Signs in Humans and Animals Associated with Minerals, Trace Elements and Rare Earth Elements

    • 1st Edition
    • Mike Davies
    • English
    The first book to compile the clinical signs associated with deficiencies, toxicities, imbalances, or exposures to minerals, trace elements, and rare earth elements in humans and animal species, Clinical Signs in Humans and Animals Associated With Minerals, Trace Elements, and Rare Earth Elements aims to increase awareness to improve diagnosis and to encourage further investigation based on comparative data. Written by an experienced veterinary clinician having worked in private practice, academia, and pharmaceutical and pet food industries, this book includes data on humans and primates, as well as companion animals, horses, rabbits, reptiles, ruminants, poultry, fish, and species typical in zoo populations. The subject material is divided into three sections to provide easy access to information on clinical signs, specific elements, or species. This book is written for medical and veterinary researchers, clinicians, and practitioners, specifically those working with animal nutrition and animal feed health. Academics and public health scientists will also benefit from the book’s information and data on rehabilitating and maintaining animal health.

  • Porous Silicon for Biomedical Applications

    • 2nd Edition
    • Hélder A. Santos
    • English
    Porous Silicon for Biomedical Applications, Second Edition, provides an updated guide to the diverse range of biomedical applications of porous silicon, from biosensing and imaging to tissue engineering and cancer therapy. Across biomedical disciplines, there is an ongoing search for biomaterials that are biocompatible, modifiable, structurally sound, and versatile. Porous silicon possesses a range of properties that make it ideal for a variety of biomedical applications, such as controllable geometry, tunable nanoporous structure, large pore volume/high specific surface area, and versatile surface chemistry. This book provides a fully updated and detailed overview of the range of biomedical applications for porous silicon. Part One offers the reader a helpful insight into the fundamentals and beneficial properties of porous silicon, including thermal properties and stabilization, photochemical and nonthermal chemical modification, protein modification, and biocompatibility. The book then builds on the systematic detailing of each biomedical application using porous silicon, from bioimaging and sensing to drug delivery and tissue engineering. This new edition also includes new chapters on in-vivo assessment of porous silicon, photodynamic and photothermal therapy, micro- and nanoneedles, Raman imaging, cancer immunotherapy, and more. With its acclaimed editor and international team of expert contributors, Porous Silicon for Biomedical Applications, Second Edition, is a technical resource and indispensable guide for all those involved in the research, development, and application of porous silicon and other biomaterials, while providing a comprehensive introduction for students and academics interested in this field.

  • Effects of Peri-Adolescent Licit and Illicit Drug Use on the Developing CNS Part I

    • 1st Edition
    • Volume 160
    • English
    Effects of Peri-Adolescent Licit and Illicit Drug Use on the Developing CNS, Volume 161 in the International Review on Neurobiology series, highlights new advances in the field, with this new volume presenting interesting chapters on topics including Cannabis Exposure During Adolescence: A Uniquely Sensitive Period for Neurobiological Effects, The Stoned-Age: A Systematic Review of the Neurobiological Effects of Adolescent Cannabinoid Exposure on Preclinical Animal Models, Genetic Influences Impacting Nicotine Use and Abuse During Adolescence: Insights from Human and Animal Studies, the Impact of Adolescent Nicotine Exposure on Adulthood Alcohol Consumption: The Role of Neuropeptides, and much more. Additional chapters cover The Role of Sex in the Persistent Effects of Adolescent Alcohol Exposure on Behavior and Neurobiology in Rodents, The Effects of Peri-Adolescent Alcohol Use on the Developing Hippocampus, Regulation of Glutamate Signaling in the Extended Amygdala by Adolescent Alcohol Exposure, Peri-Adolescent Binge Drinking Effects on Hippocampal Neurogenesis, Neuroepigenetic Consequences of Adolescent Ethanol Exposure, Adolescent Neuroimmunity and Its Interaction with Alcohol, and much more.

  • Forensic Toxicology

    Principles and Concepts
    • 2nd Edition
    • Nicholas T. Lappas + 1 more
    • English
    **Selected for Doody’s Core Titles® 2024 in Toxicology**The second edition of Forensic Toxicology: Principles and Concepts takes the reader back to the origins of forensic toxicology providing an overview of the largely unchanging principles of the discipline. The text focuses on the major tenets in forensic toxicology, including an introduction to the discipline, principles of forensic toxicology including pharmacokinetics, pharmacodynamics, drug interactions and toxicogenomics, fundamentals of forensic toxicology analysis, types of interpretations based on analytical forensic toxicology results, and reporting from the laboratory to the courtroom. Also included in the second edition is a Unit focused on the forensic toxicology of individual drugs of abuse.

  • Translational Autoimmunity, Volume 1

    Etiology of Autoimmune Diseases
    • 1st Edition
    • Nima Rezaei
    • English
    Translational Autoimmunity: Etiology of Autoimmune Diseases is the first volume of the Translational Immunology book series. To attain its purpose as a detailed translational step to tackle autoimmunity, this volume sufficiently addresses basic questions on how the immune system is designed to distinguish self from nonself. It discusses the known mechanisms that lead to the maintenance of self-tolerance, presents potential triggers and malfunctions that impede normal immune processes, and demonstrates how the immune system induces an autoreactive state that results in the recognition of self-antigens seen in autoimmune conditions.

  • Viral Replication Enzymes and their Inhibitors Part A

    • 1st Edition
    • Volume 49
    • English
    Viral Replication Enzymes and their Inhibitors Part A, Volume 49, the latest release in the Enzymes series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of related topics.

  • Cellular Mechanotransduction Mechanisms in Cardiovascular and Fibrotic Diseases

    • 1st Edition
    • Volume 87
    • English
    Endothelial Signaling, Mechanotransduction, Vascular Biology and Atherosclerosis, Volume 87, the latest release in the Current Topics in Membranes series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics. Each chapter is written by an international board of authors.

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