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Elsevier

Books in Life sciences

  • Hemocompatibility of Biomaterials for Clinical Applications

    Blood-Biomaterials Interactions
    • 1st Edition
    • Christopher Siedlecki
    • English
    Hemocompatibility of Biomaterials for Clinical Applications: Blood-Biomaterials Interactions summarizes the state-of-the-art on this important subject. The first part of the book reviews the latest research on blood composition and response, mechanisms of coagulation, test standards and methods. Next, the book assesses techniques for modifying biomaterial surfaces and developing coatings to improve hemocompatibility. In the final sections, users will find discussions on ways to improve the hemocompatibility of particular classes of biomaterials and a review of methods for improving medical devices.

  • Metagenomics

    Perspectives, Methods, and Applications
    • 1st Edition
    • Muniyandi Nagarajan
    • English
    Metagenomics: Perspectives, Methods, and Applications provides thorough coverage of the growing field of metagenomics. A diverse range of chapters from international experts offer an introduction to the field and examine methods for metagenomic analysis of microbiota, metagenomic computational tools, and recent metagenomic studies in various environments. The emphasis on application makes this text particularly useful for applied researchers, practitioners, clinicians and students seeking to employ metagenomic approaches to advance knowledge in the biomedical and life sciences. Case-study based application chapters examine topics ranging from viral metagenome profiling, metagenomics in oral disease and health, metagenomic insights into the human gut microbiome and metabolic syndromes, and more. Additionally, perspectives on future potential at the end of each chapter provoke new thought and motivations for continued study in this exciting and fruitful research area.

  • Immunology

    Volume 1: Immunotoxicology, Immunopathology, and Immunotherapy
    • 1st Edition
    • M. A. Hayat
    • English
    Immunology, Volume 1: Immunotoxicology, Immunopathology, and Immunotherapy discusses the investment of time, effort and finance that go into making progress in preventing and/or curing serious diseases by using standard treatments (chemotherapy, radiotherapy, surgery, and hormone therapy). The use of these treatments is accompanied by unavoidable, devastating side effects. At the cost of being repetitious, it has to be emphasized that an improved understanding of the immune system, avoidance of unhealthy habits (e.g., smoking, intake of alcohol, perpetual stress, and lack of exercise) and early detection (using biomarkers) are the only three friends we have to at least delay the onset of serious diseases.

  • The Postdoc Landscape

    The Invisible Scholars
    • 1st Edition
    • Audrey J. Jaeger + 1 more
    • English
    The Postdoc Landscape offers historical, international, and domestic examples, solutions, and strategies for addressing the needs of postdoctoral scholars in terms of their presence in government, industry, and the academy. Growing issues and concerns are identified with a clear direction in terms of what practitioners, policymakers, and educators can do to improve the working conditions of postdoctoral scholars. The book includes chapters centered on three themes: the Postdoc Landscape, Postdoc Support and Postdoc Career Literacy, Agency and Choice. This comprehensive reference serves as a guide for scholars, individuals who supervise and mentor postdoctoral scholars and policymakers.

  • Fundamentals of Toxicologic Pathology

    • 3rd Edition
    • Matthew A. Wallig + 3 more
    • English
    Fundamentals of Toxicologic Pathology, Third Edition, presents an essential overview of systems toxicologic pathology in a clear-and-concise manner. Toxicologic pathology integrates toxicology and its interdisciplinary components, including biochemistry, pharmacodynamics and risk assessment to pathology and its related disciplines, such as physiology, microbiology, immunology and molecular biology. This wholly revised and updated edition presents the newest information on the topic, and is an essential reference for advanced students, early career researchers, toxicologic pathologists, pharmaceutical scientists, medical pathologists and clinicians, and anyone involved with drug and device development. The book includes a new section describing the application of toxicologic pathology, such as diagnostic and forensic toxicologic pathology, environmental toxicologic pathology, experimental and industrial toxicologic pathology, and pathology issues in the design of toxicology studies. There are also new chapters on special senses (the eye and ear) and the biochemical and molecular basis of toxicity, among others.

  • The Role of Neuropeptides in Addiction and Disorders of Excessive Consumption

    • 1st Edition
    • Volume 136
    • English
    The Role of Neuropeptides in Addiction and Disorders of Excessive Consumption, Volume 136 in the International Review of Neurobiology series, provides an overview of the top candidate neuropeptides in the modulation of alcohol and drug abuse, also covering eating disorders and obesity. Topics covered in this latest release include Corticotropin Releasing Factor (CRF) and Addictive Behaviors, Dynorphin/Kappa Opioid Receptor Signaling in Pre-clinical Models of Alcohol, Drug, and Food Addiction, The Role of Ghrelin Signaling in Additive Behaviors, The Role of the Melanocortin System in Drug and Eating Disorders, Substance P and the Neurokinin-1 Receptor: The New CRH, and the Role of Neuropeptide Y (NPY) in Drug and Eating Disorders. The book uniquely highlights the overlapping central mechanisms that contribute to both drug and alcohol abuse and eating disorders.

  • Neuropathology

    • 1st Edition
    • Volume 145
    • English
    Neuropathology, Volume 145, the latest release in the Handbook of Clinical Neurology series, includes all the major topics found in a typical neuropathology text, but differentiates itself by providing a thorough overview of the morphological background of neurological disorders for researchers and clinicians who do not specialize in pathology or its clinicopathological aspects. This volume offers strong coverage of brain imaging and advances in molecular pathology and genetics, and is particularly timely given the amount of neuropathological research currently taking place.

  • Northeast Pacific Shark Biology, Research and Conservation Part B

    • 1st Edition
    • Volume 78
    • English
    Northeast Pacific Shark Biology, Research and Conservation, Part B, Volume 78, the latest release in the Advances in Marine Biology series contains updated chapters that focus on a variety of topics, including, but not limited to, an Introduction to Northeast Pacific shark biology, ecology, and conservation, Shark Interactions with Directed and Incidental Fisheries in the Northeast Pacific Ocean: historic and current encounters and challenges for shark conservation, An Introduction to modeling abundance and demographic parameters in shark populations, and Sharks in Captivity: The Role of Husbandry, Breeding, Education and Citizen Science in Shark Conservation. Specialty areas in this longstanding series include marine science, both applied and basic, a wide range of topical areas from all areas of marine ecology, oceanography, fisheries management and molecular biology, and the full range of geographic areas from polar seas, to tropical coral reefs are included making this an ideal reference and resource for postgraduates and researchers in a variety of fields.

  • Selenium and Selenoproteins in Cancer

    • 1st Edition
    • Volume 136
    • Francesco Galli
    • English
    Selenium and Selenoproteins in Cancer, Volume 136, the latest release in the Advances in Cancer Research series, provides invaluable information on the fast-moving field of cancer research. This updated volume includes chapters on The epidemiology of selenium and human cancer, Selenium, epigenetics and cancer, Selenium status and cancer risk, Nutritional aspects of selenium and breast cancer risk: focus on cellular and molecular mechanisms, Selenoproteins in tumorigenesis and cancer progression, Selenoproteins and metastasis, The tumor microenvironment and inflammatory factors, and Selenium-dependent glutathione peroxidases during tumor development. This new release in the series presents original reviews on research regarding the prevention and treatment of cancer with selenium.

  • Side Effects of Drugs Annual

    A Worldwide Yearly Survey of New Data in Adverse Drug Reactions
    • 1st Edition
    • Volume 39
    • English
    Side Effects of Drugs Annual: A Worldwide Yearly Survey of New Data in Adverse Drug Reactions, Volume 39 presents the latest on a variety of topics, with new chapters in this volume covering Central nervous system stimulants and drugs that suppress appetite, Antidepressant drugs, Lithium, Drugs of abuse, Hypnotics and sedatives, Antipsychotic Drugs, Antiepileptic Drugs, Opioid analgesics and narcotic antagonists, Anti-inflammatory and antipyretic analgesics and drugs used in gout, General anesthetics and therapeutic gases, Local anesthetics, Neuromuscular blocking agents and skeletal muscle relaxants, and more. First published in 1977, and continually published as a yearly update, this series provides clinicians and medical investigators with a reliable and critical survey of new data and trends in the area of adverse drug reactions and interactions, with an international team of specialists contributing their expertise each year.

  • Brain Research in Addiction

    • 1st Edition
    • Volume 235
    • English
    Brain Research in Addiction, Volume 235, the latest volume in this groundbreaking series on addiction, presents the neurobiological, pathological, cognitive and evolutionary aspects of addiction, with new chapters covering the Neurobiology of drug intake escalation, the Role of the orexinergic system in reward, Mental time travel and addictive behaviors, An evolutionary perspective on addiction- Addiction is the price we pay for innovation and adaptability, and how Cocaine exposure affects object-place recognition memory in non-human primates. Chapters in this serial are presented by leading researchers from North America, South America, Europe, Africa, Asia and Australia, who present addiction research from the bottom up, including how addiction evolved, basic research on animal models, and the psychiatric, psychological and cognitive characteristics of addictive behaviors in humans.

  • The Complement FactsBook

    • 2nd Edition
    • Scott R. Barnum + 1 more
    • English
    The Complement FactsBook, Second Edition, provides in-depth insights and an overview of the components of the complement system. This new edition highlights the use of newly recommended complement nomenclature, covering new pathways and proteins and adding information on mouse homologs. It is a completely revised and updated edition containing entries on all components of the complement system, and is an excellent source of one-stop shopping for complement information and references. It is the most convenient compilation of biochemical, biological and molecular biology for complementologists and those new in the field. This new edition is expanded to include relevant updates and topics that have evolved since the last edition was published, including C1q and Lectins, C3 Family, Serine Proteases, Serum Regulators of Complement Activation, Cell Surface Proteins, and Terminal Pathway Proteins. Domain Structure diagrams are incorporated to clearly illustrate the relationships between all the complement proteins, both within families and between families.

  • Natural Variation and Clocks

    • 1st Edition
    • Volume 99
    • English
    Natural Variances and Clocks, Volume 99 in the Advances in Genetics series provides the latest information on the rapidly evolving field of genetics, presenting new medical breakthroughs and advances. This updated release includes chapters on a variety of new research, including the Natural variation of the circadian clock in Neurospora, Natural variation and genetics of the photoperiodic timer in the pitcher-plant mosquito, Natural variation in human clocks, and Natural variation in the circadian clock genes in Drosophila and other insects. This series continually publishes important reviews that are ideal for geneticists and their colleagues in affiliated disciplines, critically analyzing future directions.

  • Peptidomics of Cancer-Derived Enzyme Products

    • 1st Edition
    • Volume 42
    • English
    Peptidomics of Cancer-Derived Enzyme Products, Volume 42, the latest in The Enzymes series, is ideal for researchers in biochemistry, molecular and cell biology, pharmacology, and cancer, with this volume featuring high-caliber, thematic articles on the topic of peptidomics of cancer-derived enzyme products. Specific chapters cover Circulating peptidome and tumor-resident proteolysis, Colon tumor secretopeptidome, Chemoenzymatic method for glycomics, Human plasma peptidome for pancreatic cancer, Lipoproteomics and quantitative proteomics, Salivaomics: Protein markers/extracellula... RNA/DNA in saliva, and Enzyme-responsive vectors for cancer therapy.

  • Advances in Applied Microbiology

    • 1st Edition
    • Volume 101
    • English
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  • Nanomaterials for Biosensors

    Fundamentals and Applications
    • 1st Edition
    • Bansi D. Malhotra + 1 more
    • English
    Nanomaterials for Biosensors: Fundamentals and Applications provides a detailed summary of the main nanomaterials used in biosensing and their application. It covers recent developments in nanomaterials for the fabrication of biosensor devices for healthcare diagnostics, food freshness and bioprocessing. The various processes used for synthesis and characterization of nanostructured materials are examined, along with the design and fabrication of bioelectronic devices using nanostructured materials as building blocks. Users will find the fundamentals of the main nanomaterials used in biosensing, helping them visualize a systematic and coherent picture of how nanomaterials are used in biosensors. The book also addresses the role of bio-conjugation of nanomaterials in the construction of nano-biointerfaces for application in biosensors. Such applications, including metal nanoparticles, metal oxide nanoparticles, nanocomposites, carbon nanotubes, conducting polymers and plasmonic nanostructures in biosensing are discussed relative to each nanomaterial concerned. Finally, recent advancements in protein functionalized nanomaterials for cancer diagnostics and bio-imaging are also included.

  • In Loeffler’s Footsteps – Viral Genomics in the Era of High-Throughput Sequencing

    • 1st Edition
    • Volume 99
    • English
    In Loeffler’s Footsteps – Viral Genomics in the Era of High-Throughput Sequencing, Volume 99, the latest in the Advances in Virus Research series, contains new information on the topic, with chapters covering Loeffler 4.0 – diagnostic metagenomics, Detection of a novel orthobunyavirus by metagenomic analysis – the situation after five years, New Squirrel and Rodent Viruses Detected by NGS, Astroviridae – A Growing Family, New Leaves in the Growing Pestivirus Tree, New BTV Serotypes and no End?, and The recently discovered Bokeloh Bat Lyssavirus - Evidence for its continued transmission in Europe. First published in 1953, this series covers a diverse range of in-depth reviews, providing a valuable overview of the current field of virology. The series is a valuable resource for information on all topics of virus research, from bacteriophages to human viruses, with this volume focusing on genomics.

  • Sport and the Brain: The Science of Preparing, Enduring and Winning, Part B

    • 1st Edition
    • Volume 234
    • English
    Sport and the Brain: The Science of Preparing, Enduring and Winning, Part B, Volume 233 reflects recent advancements in the understanding of how elite athletes prepare for, and perform at, peak levels under the demands of competition. Topics discussed in this new release include a section on Exploring the Applicability of the Contextual Interference Effect in Sports Practice, The Resonant System: Linking Brain-body-environme... in Sport Performance, the Effects of Acute High-intensity Exercise on Cognitive Performance in Trained Individuals: A Systematic Review, Moving Concussion Care to the Next Level: The Emergence and Role of Concussion Clinics in the UK, and Neurocognitive Mechanisms of the Flow State. This longstanding series takes a multidisciplinary approach, focusing on aspects of psychology, neuroscience, skill learning, talent development and physiology.

  • Research in the Biomedical Sciences

    Transparent and Reproducible
    • 1st Edition
    • Michael Williams + 2 more
    • English
    Research in the Biomedical Sciences: Transparent and Reproducible documents the widespread concerns related to reproducibility in biomedical research and provides a best practices guide to effective and transparent hypothesis generation, experimental design, reagent standardization (including validation and authentication), statistical analysis, and data reporting. The book addresses issues in the perceived value of the existing peer review process and calls for the need for improved transparency in data reporting. It reflects new guidelines for publication that include manuscript checklists, replication/reproduc... initiatives, and the potential consequences for the biomedical research community and societal health and well-being if training, mentoring, and funding of new generations of researchers and incentives for publications are not improved. This book offers real world examples, insights, and solutions to provide a thought-provoking and timely resource for all those learning about, or engaged in, performing and supervising research across the biomedical sciences.

  • Numerical Methods and Advanced Simulation in Biomechanics and Biological Processes

    • 1st Edition
    • Miguel Cerrolaza + 2 more
    • English
    Numerical Methods and Advanced Simulation in Biomechanics and Biological Processes covers new and exciting modeling methods to help bioengineers tackle problems for which the Finite Element Method is not appropriate. The book covers a wide range of important subjects in the field of numerical methods applied to biomechanics, including bone biomechanics, tissue and cell mechanics, 3D printing, computer assisted surgery and fluid dynamics. Modeling strategies, technology and approaches are continuously evolving as the knowledge of biological processes increases. Both theory and applications are covered, making this an ideal book for researchers, students and R&D professionals.

  • Functional Connectivity, An Issue of Neuroimaging Clinics of North America

    • 1st Edition
    • Volume 27-4
    • Jay J. Pillai
    • English
    This issue of Neuroimaging Clinics of North America focuses on Functional Connectivity, and is edited by Dr. Jay Pillai. Articles will include: Applications of rs-fMRI to presurgical mapping: sensorimotor mapping; Dynamic functional connectivity methods; Machine learning applications to rs-fMRI analysis; Frequency domain analysis of rs-fMRI; Applications of rs-fMRI to epilepsy; Data-driven analysis methods for rs-fMRI; Applications of rs-fMRI to presurgical mapping: language mapping; Limitations of rs-fMRI in the setting of focal brain lesions; Applications of rs-fMRI to neuropsychiatric disease; Applications of rs-fMRI to Traumatic Brain Injury; Applications of rs-fMRI to neurodegenerative disease; Graph theoretic analysis of rs-fMRI; and more!

  • Cancer and Noncoding RNAs

    • 1st Edition
    • Volume 1
    • Jayprokas Chakrabarti + 1 more
    • English
    Cancer and Noncoding RNAs offers an in-depth exploration of noncoding RNAs and their role in epigenetic regulation of complex human disease, most notably cancer. In addition to examining microRNAs, this volume provides a unique evaluation of more recently profiled noncoding RNAs now implicated in carcinogenesis, including lncRNAs, piRNAs, circRNAs, and tRNAs, identifying differences in function between these noncoding RNAs and how they interact with the rest of the epigenome. A broad range of chapters from experts in the field detail epigenetic regulation of various cancer types, along with recent next generation sequencing technologies, genome-wide association studies (GWAS) and bioinformatics approaches. This book will help researchers in genomic medicine and cancer biology better understand the role of noncoding RNAs in epigenetics, aiding in the development of useful biomarkers for diagnosis, prognosis and new RNA-based disease therapies.

  • Back to Basics in Physiology

    Electrolytes and Non-electrolyte Solutes in the Body
    • 1st Edition
    • Juan Pablo Arroyo + 1 more
    • English
    Back to Basics in Physiology: Electrolytes and Non-electrolyte Solutes in the Body exploits the gap that exists in current physiology books. Instead of tackling one particular organ system at a time, the authors tackle specific problems, also evaluating their repercussions on systemic physiology. This original, six chapter book briefly reviews and integrates the basic concepts behind the function of electrolytes in the body, providing a bridge that allows students to understand basic science and its direct translation to the clinical setting, with a final aim of comprehending the basic science behind clinical observations. With the exploding amount of basic science information that is available today to physiology students (undergraduate, nursing, physician associate or medical), there is more and more of a disconnect between the basic and clinical sciences. The book allows students to gain sufficient background knowledge of physiology and its direct application to clinical skills as it is written as lectures in day-to-day language that is easy to comprehend.

  • Cellular Aspects of Membrane Permeability

    International Series of Monographs in Pure and Applied Biology: Modern Trends in Physiological Sciences
    • 1st Edition
    • E. Schoffeniels
    • P. Alexander + 1 more
    • English
    Cellular Aspects of Membrane Permeability describes the state of knowledge on permeability problems and interprets experimental results within the framework of working hypotheses. The book discusses membrane permeability with some biochemical perspective presented to explain the origin and adaptations of animal life. The text explains the process and the driving forces affecting the permeability characteristics of the experimental object. It then discusses the distribution of ions and molecules between two phases separated by a living membrane. Then the text analyzes the chemical nature of the molecular architecture that causes such permeability characteristics. The book addresses the electrical potential profiles of epithelial tissues, and then discusses the conducting membranes. It also explains the relationships between inorganic ions, sugar, amino acids, fatty acids, and bioelectric potentials. The book also explains the physical nature of such chemical nature and structure of living membranes. The text then describes the structure of the cellular surface and the structural organization of the cell. The selection can prove useful for biologists, microbiologists, zoologists, and students and professors of biology and its related disciplines.

  • The Handbook of Histopathological Practices in Aquatic Environments

    Guide to Histology for Environmental Toxicology
    • 1st Edition
    • Pedro M. Costa
    • English
    The Handbook of Histopathological Practices in Aquatic Environments: Guide to Histology for Environmental Toxicology offers readers in aquatic biology and other water-based environmental sciences a comprehensive resource on histopathology, which is a key tool in the growing field of ecotoxicology. This work brings together the necessary knowledge, from sample preparation, to trait identification, and scoring and data treatment. Furthermore, with examples from several groups of organisms (from worms to fish), these practices can be applied across a wide array of aquatic ecosystems. This book provides a step-by-step approach to solving the questions researchers encounter in aquatic biology and related fields.

  • Arachnoid Cysts

    Epidemiology, Biology, and Neuroimaging
    • 1st Edition
    • Knut Wester
    • English
    Intracranial arachnoid cysts are congenital malformations with a predilection for the middle cranial fossa and an estimated prevalence in the general population as high as 1.7%. The common assumption is that these cysts are incidental findings and the symptoms associated with them are not caused by the cyst and consequently, that surgical intervention will not benefit the patient. However, there is now a growing understanding reflected in the international literature among neurologists and neurosurgeons that arachnoid cysts do harm and that the patients’ complaints can be relieved by surgical treatment. Arachnoid Cysts: Epidemiology, Biology, and Neuroimaging gives a broad and updated presentation of the condition, including epidemiology, etiology, biology (including genetics and molecular biology), and neuroimaging of same. This book is written for researchers, residents, and clinical practitioners in clinical neuroscience, neurology, neurosurgery, neuroradiology, and pediatrics.

  • Environmental Causes and Prevention Measures for Alzheimer’s Disease

    • 1st Edition
    • George J. Brewer
    • English
    Environmental Causes and Prevention Measures for Alzheimer’s Disease examines the increased incidence of the disease in developed countries and aims to educate neuroscientists, medical practitioners and other educated individuals on new insights into environmental causation, primarily metals. This book looks into the web of evidence around the hypothesis of copper toxicity and the additional role that a high fat diet plays in disease progression and cognition loss. The data and its implications are discussed, along with potential prevention measures. This book will generate excitement and interest among neuroscientists, medical practitioners and other biomedical researchers.

  • Mutagenicity: Assays and Applications

    • 1st Edition
    • Ashutosh Kumar + 3 more
    • English
    Mutagenicity: Assays and Applications presents an extensive examination of the detection, assessment and future of mutagenicity, particularly as it concerns human health and the environment. Chapters focused on specific types of mutagens or testing methods for their detection collectively explore the current state of human and environmental mutagenesis, future perspectives and regulatory needs. The test procedures for measuring mutagenicity, their advantages and limitations are described with practical and procedural detail, along with their presentation and data processing aspects. It is an essential reference covering the breadth and depth of the field of mutagenicity studies and regulation. By providing both important introductory material and practical assays and applications, this book is useful to graduate students, academic and industry researchers and regulators at various stages of their careers, leading to improved risk assessment and regulation.

  • Endocrine Biomarkers

    Clinicians and Clinical Chemists in Partnership
    • 1st Edition
    • Hossein Sadrzadeh + 1 more
    • English
    Endocrine Biomarkers: Clinical Aspects and Laboratory Determination covers all the pre-analytical variables that can affect test results, both in the clinic and laboratory. Biomarkers of endocrine and bone diseases are discussed from both clinical and laboratory perspectives, and the authors elaborate on the teamwork-based app+roach between the clinician and the laboratory professional in the diagnosis and management of endocrine and bone disorders. Discussions include test utilization, laboratory measurement methods, harmonization and standardization, interpretation of results, and reference intervals. Each chapter ends with a discussion of one or two relevant cases with shared opinions from both a clinician and a clinical chemist. Each chapter also includes a summary box outlining key points and common pitfalls in the use of specific disease biomarkers and tests.

  • Functionalised Cardiovascular Stents

    • 1st Edition
    • Gerard Wall + 2 more
    • English
    Cardiovascular disease is a major cause of mortality in the western world and about half of these deaths are caused by coronary artery disease. One of the most commonly used interventions to treat arterial blockages is to deploy an arterial stent to keep the vessel open. Traditionally, some cardiovascular stents have been associated with serious side-effects, such as thrombosis. This book describes the fundamentals of cardiovascular stents, technologies to functionalize their surfaces and the market status of these important implants. The chapters provide specific focus on the production and evolution of cardiovascular stents, providing essential knowledge for researchers on advances in the field and knowledge of how cardiovascular stents are currently being "functionalized" in order to improve their biocompatibility and minimize negative outcomes in vivo.

  • SPEC – Handbook of Clinical Neurology, Volume 144, Huntington Disease, 12-Month Access, eBook

    • 1st Edition
    • Volume 144
    • English
    Huntington Disease summarizes the most recent findings related to the disease, providing both cutting edge coverage for clinical/research specialists looking to expand their knowledge base of Huntington disease information, as well as solid groundwork for advanced students from various backgrounds (neurology, psychiatry, neuropsychology, genetics). The volume includes all major areas of Huntington disease clinical care and research, whereas many other HD texts focus solely on neurological symptoms. This book also addresses behavioral and cognitive symptoms, brain imaging, and family dynamics and therapeutic alliances in working with individuals affected by HD. Clinical trials are covered extensively, including design considerations for therapeutic studies. The devastating nature of Huntington’s disease is well appreciated throughout the neuroscience, neurology, and psychiatric communities, and a great amount of basic and clinical research is currently taking place. However, much of that occurs in isolated research silos, and it is critical that an interdisciplinary resource be developed to provide in depth information to enhance communication and collaboration. This volume in the Handbook of Clinical Neurology series is that resource.

  • Innovative Technologies for Food Preservation

    Inactivation of Spoilage and Pathogenic Microorganisms
    • 1st Edition
    • Francisco J. Barba + 3 more
    • English
    Innovative Technologies for Food Preservation: Inactivation of Spoilage and Pathogenic Microorganisms covers the latest advances in non-thermal processing, including mechanical processes (such as high pressure processing, high pressure homogenization, high hydrodynamic pressure processing, pressurized fluids); electromagnetic technologies (like pulsed electric fields, high voltage electrical discharges, Ohmic heating, chemical electrolysis, microwaves, radiofrequency, cold plasma, UV-light); acoustic technologies (ultrasound, shockwaves); innovative chemical processing technologies (ozone, chlorine dioxide, electrolysis, oxidized water) and others like membrane filtration and dense phase CO2. The title also focuses on understanding the effects of such processing technologies on inactivation of the most relevant pathogenic and spoilage microorganisms to ensure food safety and stability. Over the course of the 20th century, the interest and demand for the development and application of new food preservation methods has increased significantly. The research in the last 50 years has produced various innovative food processing technologies and the use of new technologies for inactivation of spoilage and/or pathogenic microorganisms will depend on several factors. At this stage of development there is a need to better understand the mechanisms that govern microbial inactivation as induced by new and innovative processing technologies, as well as suitable and effective conditions for inactivating the microorganism.

  • Advances in Parasitology

    • 1st Edition
    • Volume 98
    • English
    Advances in Parasitology, Volume 98, first published in 1963, contains comprehensive and up-to-date reviews on all areas of interest in contemporary parasitology. The latest release in this series contains chapters on The battle against flystrike – past research and new prospects through genomics, Life history, systematics and evolution of the Diplostomoidea Poirier, 1886: progress, promises and challenges emerging from molecular studies, Hook, line and infection: a guide to culturing parasites, establishing infections and assessing immune responses in the three-spined stickleback, and Trypanosoma congolense: a molecular toolkit and resources for studying a major livestock pathogen and model trypanosome. The series includes medical studies of parasites of major influence, such as Plasmodium falciparum and trypanosomes. The series also contains reviews of more traditional areas, such as zoology, taxonomy, and life history, which help to shape current thinking and applications.

  • The Bifidobacteria and Related Organisms

    Biology, Taxonomy, Applications
    • 1st Edition
    • Paola Mattarelli + 3 more
    • English
    The Bifidobacteria and Related Organisms: Biology, Taxonomy, Applications brings together authoritative reviews on all aspects of Bifidobacteria and related genera. Their place within the Phylum Actinobacteria is discussed first, and this is followed by descriptions of the genera Bifidobacterium, Alloscardovia, Aeriscardovia, Bombiscardovia, Gardnerella, Metascardovia, Parascardovia and Scardovia and the currently accredited species within those genera. The increased availability of genome sequences and molecular tools for studying bifidobacteria provides important information about their taxonomy, physiology and interactions with their host. Also considerations about common bifidobacterial core maintenance during the mutual coevolution of a host and its intestinal microbes could be relevant for health claims for the ability of symbiotic gut bacteria to provide health benefits to their host, and for evaluating such claims in scientifically valid experiments. Chemotaxonomy is important to our understanding of these genera and so is considered along with physiological and biochemical aspects before proceeding to examine clinical and other practical aspects. The ability to maintain pure cultures and to grow cells in industrial quantities when required for applications requires that the cells’ environmental and nutritional needs are well understood. Some species are important clinically and as animal digestive tract synbionts—and even play a part in honey production—so these matters are considered along with milk oligosaccharides’ roles in gut flora development in neonates.

  • Kent’s Technology of Cereals

    An Introduction for Students of Food Science and Agriculture
    • 5th Edition
    • Kurt A. Rosentrater + 1 more
    • English
    Kent’s Technology of Cereals: An Introduction for Students of Food Science and Agriculture, Fifth Edition, is a classic and well-established book that continues to provide students, researchers and practitioners with an authoritative and comprehensive study of cereal technology. This new edition has been thoroughly updated with new sections, including extrusion cooking and the use of cereals for animal feed. In addition, it offers information on statistics, new products, the impact of climate changes and genetics, new economic trends, nutrition regulations and new technologies. The book is useful for students, researchers, and industrial practitioners alike, covering the full spectrum of cereal grain production, processing, and use for foods, feeds, fuels, industrial materials, and other uses.

  • Mechanical Circulatory and Respiratory Support

    • 1st Edition
    • Shaun D. Gregory + 2 more
    • English
    Mechanical Circulatory and Respiratory Support is a comprehensive overview of the past, present and future development of mechanical circulatory and respiratory support devices. Content from over 60 internationally-reno... experts focusses on the entire life-cycle of mechanical circulatory and respiratory support – from the descent into heart and lung failure, alternative medical management, device options, device design, implantation techniques, complications and medical management of the supported patient, patient-device interactions, cost effectiveness, route to market and a view to the future. This book is written as a useful resource for biomedical engineers and clinicians who are designing new mechanical circulatory or respiratory support devices, while also providing a comprehensive guide of the entire field for those who are already familiar with some areas and want to learn more. Reviews of the most cutting-edge research are provided throughout each chapter, along with guides on how to design new devices and which areas require specific focus for future research and development.

  • Animals and Human Society

    • 1st Edition
    • Colin G. Scanes + 1 more
    • English
    Animals and Human Society provides a solid, scientific, research-based background to advance understanding of how animals impact humans. Animals have had profound effects on people from the earliest times, ranging from zoonotic diseases, to the global impact of livestock, poultry and fish production, to the influences of human-associated animals on the environment (on extinctions, air and water pollution, greenhouse gases, etc.), to the importance of animals in human evolution and hunter -gatherer communities.As a resource for both science and non-science, Animals and Human Society can be used as a text for courses in Animals and Human Society or Animal Science, or as supplemental material for Introduction to Animal Science. It offers foundational background to those who may have little background in animal agriculture and have focused interest on companion animals and horses. The work introduces livestock production (including poultry and aquaculture) but also includes coverage of companion and lab animals. In addition, animal behavior and animal perception are covered.Animals and Human Society is likewise an excellent resource for researchers, academics, or students newly entering a related field or coming from another discipline and needing foundational information, as well as interested laypersons looking to augment their knowledge on the many impacts of animals in human society.

  • Transfusion Medicine, Apheresis, and Hemostasis

    Review Questions and Case Studies
    • 1st Edition
    • Huy P. Pham + 1 more
    • English
    Transfusion Medicine, Apheresis, and Hemostasis: Review Questions and Case Studies is the collaborative effort that spanned a time period of 2 years and included 50 experts, many whom are national leaders in their respected fields. It also represents the passion and privilege we feel to teach the next generation of physicians in Transfusion Medicine and Apheresis.The main goal for this book is to help the readers build a solid foundation of both basic and advanced conceptual knowledge to prepare for the American Board of Pathology (ABP) certification exam in Transfusion Medicine. This book is not intended to be a substitute for textbooks, original research or review articles, and/or clinical training. Further, since the field of medicine, both from a scientific and regulatory perspective, rapidly changes, the readers are advised to continuously update their knowledge by attending national meetings and reading clinical journals. To equip the readers with the basic knowledge in critical reading and data analysis, which is an essential skill in daily medical practice, a novel chapter titled “Data Interpretation in Laboratory Medicine” was included in this book. In this chapter, the readers are asked to make logical conclusions based on the given data and/or statistical results. Moreover, there is also a chapter on “Practical Calculations in Transfusion Medicine, Apheresis, and Hemostasis” to help consolidate all the necessary formulas commonly used in daily practice for easy reference. These chapters are unique to our book and will not be found in any other currently on the market.All of the questions in this book were originally created by the authors of each chapter. Each question can either be standalone or part of a case scenario representing challenge cases in Transfusion Medicine, Apheresis, and Hemostasis. These questions often represent both rare and common clinical scenarios that the authors have seen during their clinical practice. Each question is then followed by 5 possible answers, with only one being correct (or the best answer). After the question, there is a conceptual explanation followed by a more factual explanation of the right and wrong answers. We gave the individual authors the freedom to choose how they explained the wrong answer choices. Some authors chose to be more direct (e.g. Answer A is incorrect because…), while other authors chose a more conversational style (e.g. Human resources (answer A) includes staffing, selection, orientation, training, and competency assessment of employees). This format is designed to help the student linking the conceptual and factual knowledge together to form a solid foundation for use in clinical practice. At the end of each chapter, there is a list of articles and textbooks that will prove useful to the motivated student who wishes to become an expert in the field. Another special feature to our textbook is the presence of a pre-test and post-test, which are provided to help the readers with self-assessment.As stated above, the main focus of this book is to help the readers preparing for the ABP certification exam in Transfusion Medicine. However, due to the interdisciplinary nature of the field of Transfusion Medicine, Apheresis, and Hemostasis, we believe that this book is also beneficial to and can be used by all clinicians involved in the management of complex transfusion, apheresis, and hemostasis issues, such as hematologists, anesthesiologists, surgeons, and critical care physicians. We further believe that it is a helpful guide for these specialists to prepare for their own specialty certification exam, when the topics are related to Transfusion Medicine, Apheresis, and Hemostasis.

  • Advances in Molecular Toxicology Vol 11

    • 1st Edition
    • Volume 11
    • English
    Advances in Molecular Toxicology, Volume 11, features the latest advances in the subspecialties of the broad area of molecular toxicology. This series details the study of the molecular basis of toxicology by which a vast array of agents encountered in the human environment, and produced by the human body, manifest themselves as toxins. The book is not strictly limited to documenting these examples, but also covers the complex web of chemical and biological events that give rise to toxin-induced symptoms and disease. The new technologies that are being harnessed to analyze and understand these events are also reviewed by leading experts in the field.

  • Chordomas and Chondrosarcomas of the Skull Base and Spine

    • 2nd Edition
    • Griffith R. Harsh IV + 1 more
    • English
    Chordomas and Chondrosarcomas of the Skull Base and Spine, Second Edition, is a major reference and guide for neurosurgeons, medical oncologists, neuroscientists, orthopedic surgeons, head and neck surgeons and radiation oncologists that treat patients and research chordomas and chondrosarcomas of the axial skeleton. This book is the unique result of the collaboration of multidisciplinary specialists from a wide variety of fields (neurological sciences, medical oncology, molecular biology, orthopedics and radiation oncology), offering the most relevant information about chordomas and chondrosarcomas of the axial skeleton from each of these fields condensed into one single volume. It contains new medical knowledge and scientific advances regarding the treatment of these types of tumors. Additionally, the book includes chapters written by the Chordoma Foundation and Sarcoma Foundation of America, providing the most valuable information and support for patients and their relatives.

  • New and Future Developments in Microbial Biotechnology and Bioengineering

    Penicillium System Properties and Applications
    • 1st Edition
    • Vijai G. Gupta + 1 more
    • English
    New and Future Developments in Microbial Biotechnology and Bioengineering: Penicillium System Properties and Applications covers important research work on the applications of penicillium from specialists from an international perspective. The book compiles advancements and ongoing processes in the penicillium system, along with updated information on the possibilities for future developments. All chapters are derived from current peer reviewed literature as accepted by the international scientific community. These important fungi were found to secrete a range of novel enzymes and other useful proteins, and are still being extensively studied and improved for specific use in the food, textile, pulp and paper, biocellulosic ethanol production and other industries. The book caters to the needs of researchers/academic... dealing with penicillium spp. related research and applications, outlining emerging issues on recent advancements made in the area of research and its applications in bioprocess technology, chemical engineering, molecular taxonomy, biofuels/bioenergy research and alternative fuel development. In addition, the book also describes the identification of useful compound combinations/enzyme cocktails and the fermentation conditions required to obtain them at an industrial scale. Finally, the book provides updated information on the best utilization of these fungi as a natural tool to meet the next challenges of biotechnology.

  • Current Developments in Biotechnology and Bioengineering

    Current Advances in Solid-State Fermentation
    • 1st Edition
    • Ashok Pandey + 2 more
    • English
    Current Developments in Biotechnology and Bioengineering: Current Advances in Solid-State Fermentation provides knowledge and information on solid-state fermentation involving the basics of microbiology, biochemistry, molecular biology, genetics and principles of genetic engineering, metabolic engineering and biochemical engineering. This volume of the series is on Solid-State fermentation (SSF), which would cover the basic and applied aspects of SSF processes, including engineering aspects such as design of bioreactors in SSF. The book offers a pool of knowledge on biochemical and microbiological aspects as well as chemical and biological engineering aspects of SSF to provide an integrated knowledge and version to the readers.

  • Biotechnology for Sustainable Agriculture

    Emerging Approaches and Strategies
    • 1st Edition
    • Ram Lakhan Singh + 1 more
    • English
    Biotechnology for Sustainable Agriculture: Emerging Approaches and Strategies is an outstanding collection of current research that integrates basic and advanced concepts of agricultural biotechnology with future development prospects. Using biotechnology with sustainable agriculture effectively contributes to gains in agricultural productivity, enhanced food security, reduced poverty and malnutrition, and more ecologically sustainable means of food production. Written by a panel of experts, this book is unique in its coverage of the broad area of biotechnology for sustainable agriculture. It includes intriguing topics and discussions of areas such as recombinant DNA technology and genetic engineering.

  • Comparative Mammalian Haematology

    Cellular Components and Blood Coagulation of Captive Wild Animals
    • 1st Edition
    • C. M. Hawkey
    • English
    Comparative Mammalian Haematology: Cellular Components and Blood Coagulation of Captive Wild Mammals presents a critical review of the hematology of the vertebrates. It discusses the characteristics of blood components of primates; the features of the red cells of carnivores; and the different species of canine. The book covers the blood components of cats, monkeys, bears, mouse, horse, rhinoceros, pig, llama, boars, camels, and deer. The book can provide useful information to hematologists, biologists, students, and researchers.

  • Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging

    Volume 12
    • 1st Edition
    • M. A. Hayat
    • English
    Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging, Volume 12 discusses and details almost all aspects of the autophagy machinery in the context of health, cancer and other pathologies. Autophagy is more widely accepted as beneficial given its role in eliminating ‘toxic assets’ and promoting cell viability, hence, it has emerged as a new and potent modulator of disease progression that is both scientifically intriguing and clinically relevant. As the latest release in the Autophagy book series, users will find a detailed explanation of the role of molecular mechanisms.

  • The Natural Anti-Gal Antibody as Foe Turned Friend in Medicine

    • 1st Edition
    • Uri Galili
    • English
    The Natural Anti-Gal Antibody as Foe Turned Friend in Medicine provides a comprehensive review of the natural anti-Gal antibody, which is the most abundant antibody in humans constituting ~1% of immunoglobulins and the carbohydrate antigen it recognizes, the α-gal epitope. It discusses the discovery of this antigen/antibody system, its evolution in mammals, the pathological effects of this antibody, and its possible use in various therapies in humans. Most significantly, the book discusses microbial and regenerative therapies in which an antibody present in all humans may be harnessed as an in vivo pharmaceutical agent that enables a wide variety of therapies. Some of these therapies are described as experimental studies that are compiled in this book, other already studied therapies in the area of cancer immunotherapy are also included in this book.

  • Northeast Pacific Shark Biology, Research and Conservation Part A

    • 1st Edition
    • Volume 77
    • English
    Northeast Pacific Shark Biology, Research and Conservation, Part A, Volume 77 highlights the biological attributes of, and the conservation efforts targeted at, populations of vulnerable sharks in the Northeastern Pacific Ocean bordering the west coast of the United States, one of the most economically and ecologically important oceanic regions in the world. Updates in this new volume include chapters on Biodiversity, Conservation and Life History of Northeastern Pacific Chondrichthyans, a Review of current genetic analyses of Northeast Pacific sharks and conservation implications, and a section on the Trophodynamics and ecological impacts of eastern North Pacific sharks.

  • miRNA and Cancer

    • 1st Edition
    • Volume 135
    • English
    miRNA and Cancer, Volume 135, the latest volume in the Advances in Cancer Research series, provides invaluable information on the exciting and fast-moving field of cancer research. This volume presents original reviews on research bridging oncology and gene expression, and includes specific chapters on Non-coding RNAs as Biomarkers of Cancer, The Enigma of microRNA Regulation in Cancer, Animal Models to Study microRNA functions, Non-coding RNAs and Cancer, microRNAs in Cancer Susceptibility, ts-RNAs versus microRNAs, microRNAs and AML, and microRNAs and Epigenetics.

  • Immunity and Inflammation in Health and Disease

    Emerging Roles of Nutraceuticals and Functional Foods in Immune Support
    • 1st Edition
    • Shampa Chatterjee + 2 more
    • English
    Immunity and Inflammation in Health and Disease: Emerging Roles of Nutraceuticals and Functional Foods in Immune Support provides a comprehensive description of the various pathways by which the vertebrate immune system works, the signals that trigger immune response and how fnew and novel nutraceuticals and functional foods, can be used to contain inflammation and also to boost immunity and immune health. Inflammation is a tool to fight pathogens and the vertebrate immune system has a very complex network of cells to achieve this. However inflammation that goes awry is also the leding cause of several diseases ranging from cardiovascular diseases to diabetes. This book covers the entire gamut from the various cellular players in the inflammation-immune response to its ramifications in terms of protection against pathogens as well as in onset of metabolic, aging and auto-immune related diseases. Finally, the balancing role of dietary nutrients between host defence and immune support is also showcased. The first three scetions explain the various components of the immune system and their modes of activation. The fourth section deals with the ramifications of a robust and execessive inflammatory response. The fifth section is focused on the association between nutrition and immunity and how deficiencies in certain nutrients may affect immunocompetence. The sixth section chapters represent a vision of paradigm shifts within the field and discusses possible future directions. This bool will be a valuable reference for researchers studying immune health either in academia, or in the nutraceutical or functional food industries. Product developers in nutraceutical, supplement, functional food, and health food companies will also appreciate the information presented here.

  • Sterol Regulation of Ion Channels

    • 1st Edition
    • Volume 80
    • English
    Sterol Regulation of Ion Channels, Volume 80, the latest in the Current Topics in Membranes series provides outstanding content to the scientific community on relevant topics that relate to the broad field of membranes. Topics of note in this new release include Membrane structure and general mechanisms of sterol regulation of ion channels, the Regulation of ion channels by sterols as boundary lipids, the Differential effects of sterols on ion channels: specific vs. non-specific interactions, the Structural determinants of cholesterol-ion channels interactions, and the Regulation of Ca2+-sensitive K+ channels by cholesterol and bile acids via distinct channel subunits and sites, amongst other specialized chapters. The serial is targeted towards scientists and researchers in biochemistry and molecular and cellular biology, providing the necessary membrane research to assist them in discovering the current state of a particular field. The authors and editors associated with the Current Topics in Membranes series are recognized as world-renowned scientists in their respective fields, making CTM one of the premier serials on membranes

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