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Books in Life sciences

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    • G Protein-Coupled Receptors

      • 1st Edition
      • Volume 132
      • February 26, 2016
      • English
      • Hardback
        9 7 8 0 1 2 8 0 3 5 9 5 5
      • eBook
        9 7 8 0 1 2 8 0 3 6 1 2 9
      G-Protein-Coupled Receptors: Signaling, Trafficking, and Regulation, a new volume in the Methods in Cell Biology series continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers research methods in G-Protein-Coupled Receptors, and includes sections on such topics signaling, trafficking and regulation.

    • Chromatin Signaling and Diseases

      • 1st Edition
      • August 6, 2016
      • Olivier Binda + 1 more
      • English
      • Hardback
        9 7 8 0 1 2 8 0 2 3 8 9 1
      • eBook
        9 7 8 0 1 2 8 0 2 6 0 9 0
      Chromatin Signaling and Diseases covers the molecular mechanisms that regulate gene expression, which govern everything from embryonic development, growth, and human pathologies associated with aging, such as cancer. This book helps researchers learn about or keep up with the quickly expanding field of chromatin signaling. After reading this book, clinicians will be more capable of explaining the mechanisms of gene expression regulation to their patients to reassure them about new drug developments that target chromatin signaling mechanisms. For example, several epigenetic drugs that act on chromatin signaling factors are in clinical trials or even approved for usage in cancer treatments, Alzheimer's, and Huntington's diseases. Other epigenetic drugs are in development to regulate various class of chromatin signaling factors. To keep up with this changing landscape, clinicians and doctors will need to stay familiar with genetic advances that translate to clinical practice, such as chromatin signaling. Although sequencing of the human genome was completed over a decade ago and its structure investigated for nearly half a century, molecular mechanisms that regulate gene expression remain largely misunderstood. An emerging concept called chromatin signaling proposes that small protein domains recognize chemical modifications on the genome scaffolding histone proteins, facilitating the nucleation of enzymatic complexes at specific loci that then open up or shut down the access to genetic information, thereby regulating gene expression. The addition and removal of chemical modifications on histones, as well as the proteins that specifically recognize these, is reviewed in Chromatin Signaling and Diseases. Finally, the impact of gene expression defects associated with malfunctioning chromatin signaling is also explored.

    • Perception of Pixelated Images

      • 1st Edition
      • January 21, 2016
      • Talis Bachmann
      • English
      • Paperback
        9 7 8 0 1 2 8 0 9 3 1 1 5
      • eBook
        9 7 8 0 1 2 8 0 9 5 0 5 8
      Perception of Pixelated Images covers the increasing use of these images in everyday life as communication, socialization, and commerce increasingly rely on technology. The literature in this book is dispersed across a wide group of disciplines, from perception and psychology to neuroscience, computer science, engineering, and consumer science. The book summarizes the research to date, answering such questions as, What are the spatial and temporal limits of perceptual discrimination of pixelated images?, What are the optimal conditions for maximizing information extracted from pixelated images?, and How does the method of pixelation compromise or assist perception?

    • Physical Activity and the Aging Brain

      • 1st Edition
      • December 15, 2016
      • Ronald Ross Watson
      • English
      • Hardback
        9 7 8 0 1 2 8 0 5 0 9 4 1
      • eBook
        9 7 8 0 1 2 8 0 5 2 6 2 4
      Physical Activity and the Aging Brain: Effects of Exercise on Neurological Function is a complete guide to the manifold effects of exercise and physical activity on the aging brain. Cognitive decline and motor impairment, onset of diseases and disorders, and even changes in family structure and social settings that occur as we age can all impact activity levels, yet continued physical activity is crucial for successful neurological functioning. This book examines the role that exercise and physical activity play in halting or modulating the deleterious effects of these numerous aging concerns by first examining the current state of research into how exercise manifests physical changes in the brain. It then discuss how physical activity combines with other lifestyle factors to benefit the aging brain, including nutrition, computerized brain training, and social engagement. Most significantly, it also covers how physical activity can serve as therapy to help alleviate the symptoms of various neurological diseases impacting aging populations, with particular emphasis on Alzheimer’s disease and age-related cognitive decline. The book provides broad coverage of the effects of exercise and physical activity on the aging brain, its therapeutic effects, and the many factors that influence the aging process.

    • Molecular Biological Markers for Toxicology and Risk Assessment

      • 1st Edition
      • June 8, 2016
      • Bruce A. Fowler
      • English
      • Hardback
        9 7 8 0 1 2 8 0 9 5 8 9 8
      • Paperback
        9 7 8 0 1 2 8 0 1 9 0 0 9
      • eBook
        9 7 8 0 1 2 8 0 1 9 0 1 6
      Molecular Biological Markers for Toxicology and Risk Assessment provides an introduction to the exciting field of biomarkers and their use in toxicology and risk assessment. In recent years, new classes of molecular biomarkers capable of detecting early manifestations of ongoing chemical-induced cell injury and cell death have been developed as a result of advances in analytical chemistry, molecular biology, and computational modeling. The interplay between these emergent tools of science has resulted in new insights into initial mechanisms of chemical-induced toxicity and carcinogenicity. Molecular Biological Markers for Toxicology and Risk Assessment guides the reader through a broad range of molecular biological markers, including the "omic" biomarkers, and provides an examination of the various elements in the evolution of these modern tools. It then explores possible ways in which these markers may be applied to advance the field of chemical risk assessment. Since molecular biomarkers and related technologies are inherently complex, the book concludes with a section on risk communication in order that readers may appreciate both the strengths and limitations of molecular biological marker approaches to risk assessment practice.

    • The Resolution Revolution: Recent Advances In cryoEM

      • 1st Edition
      • Volume 579
      • August 25, 2016
      • English
      • Hardback
        9 7 8 0 1 2 8 0 5 3 8 2 9
      • eBook
        9 7 8 0 1 2 8 0 5 4 3 5 2
      cryoEM, a new volume in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers research methods and new developments in recording images, the creation, evaluation and validation of 3D maps from the images, model building into maps and refinement of the resulting atomic structures, and applications of essentially single particle methods to helical structures and to sub-tomogram averaging.

    • International Review of Cell and Molecular Biology

      • 1st Edition
      • Volume 325
      • May 26, 2016
      • English
      • Hardback
        9 7 8 0 1 2 8 0 4 8 0 6 1
      • eBook
        9 7 8 0 1 2 8 0 5 2 2 2 8
      International Review of Cell and Molecular Biology presents comprehensive reviews and current advances in cell and molecular biology, and includes articles that address the structure and control of gene expression, nucleocytoplasmic interactions, control of cell development and differentiation, and cell transformation and growth. The series has a worldwide readership, maintaining a high standard by publishing invited articles on important and timely topics authored by prominent cell and molecular biologists.

    • Endothelium

      • 1st Edition
      • Volume 77
      • July 20, 2016
      • English
      • Hardback
        9 7 8 0 1 2 8 0 4 3 9 6 7
      • eBook
        9 7 8 0 1 2 8 0 4 4 1 5 5
      Endothelium, the new volume in the Advances in Pharmacology series, presents readers with a variety of chapters that cover various endothelium-derived mediators and their changes with gender, and during vascular development, senescence, and hypertensive disorders. Topics include endothelium, nitric oxide, gap junctions, potassium channels, endothelin, vascular development, vascular permeability, gender, aging, and preeclampsia. With contributions from the best authors in the field, the volume is an essential resource for pharmacologists, immunologists, and biochemists alike.

    • Stream Ecosystems in a Changing Environment

      • 1st Edition
      • July 7, 2016
      • Jeremy B. Jones + 1 more
      • English
      • Hardback
        9 7 8 0 1 2 4 0 5 8 9 0 3
      • eBook
        9 7 8 0 1 2 4 0 5 9 1 9 1
      Stream Ecosystems in a Changing Environment synthesizes the current understanding of stream ecosystem ecology, emphasizing nutrient cycling and carbon dynamics, and providing a forward-looking perspective regarding the response of stream ecosystems to environmental change. Each chapter includes a section focusing on anticipated and ongoing dynamics in stream ecosystems in a changing environment, along with hypotheses regarding controls on stream ecosystem functioning. The book, with its innovative sections, provides a bridge between papers published in peer-reviewed scientific journals and the findings of researchers in new areas of study.

    • Controversies In Diabetic Neuropathy

      • 1st Edition
      • Volume 127
      • April 27, 2016
      • English
      • Hardback
        9 7 8 0 1 2 8 0 3 9 1 5 1
      • eBook
        9 7 8 0 1 2 8 0 3 9 4 0 3
      This latest volume in the International Review of Neurobiology series, provides a comprehensive overview of the state-of-the-art research on the topic. It reviews the current knowledge and understanding in the field, presenting a starting point for researchers and practitioners entering the field.

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