Life sciences print books and ebooks | Elsevier

Cancer Stem Cells

1st Edition
August 16, 2016
Huiping Liu + 1 more
English
Hardback
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eBook
9 7 8 0 1 2 8 0 3 9 3 4 2

Cancer Stem Cells: Targeting the Roots of Cancer, Seeds of Metastasis, and Sources of Therapy Resistance introduces the basic concepts and advanced understanding of cancer stem cells, covering general overviews, organ-specific identifications, and their characteristic mechanisms. The book also explores innovative therapeutic strategies in preclinical and clinical trials to target cancer stem cells, remove the roots of cancer, eliminate the seeds of metastasis, overcome the resistance of therapies, and contribute to the eradication of cancer. The book includes contributions from leading, worldwide experts in the field, helping readers embrace new hope in their quest to eradicate cancer with emerging clinical trials on treating cancer stem cells in combination with other therapies.

Nutritional Pathophysiology of Obesity and its Comorbidities

1st Edition
September 1, 2016
Susan Ettinger
English
Hardback
9 7 8 0 1 2 8 0 3 0 1 3 4
eBook
9 7 8 0 1 2 8 0 3 0 3 4 9

Nutritional Pathophysiology of Obesity and Its Comorbidities: A Case-Study Approach challenges students and practitioners to understand the role of nutrients within the pathophysiology and development of disease, specifically those diseases which develop as a result of obesity. Through a case-based approach, the author presents complex clinical scenarios that require multiple treatment strategies, including targeted diet modification as an adjuvant to medical therapy. The book is divided into 9 modules and 5 appendices each of which covers aspects of obesity and its comorbidities. Within each module, a case is detailed with relevant history, laboratory and physical data, and follow-up information. Each case is followed by a resource section which delineates current understanding of the pathophysiology of the condition, as well as the actions of nutrients and food components shown to modify these processes. A "further readings" section cites current supporting clinical and basic literature as well as published guidelines.

Electrophysiology and Microinjection

1st Edition
Volume 4
July 2, 2016
P. Michael Conn
English
eBook
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Electrical activity is central to the functioning and nature of neural cells. Every effort has been made in this volume to provide representative examples of useful techniques that have made this area a productive component of the neurosciences.

Decision Neuroscience

1st Edition
September 27, 2016
Jean-Claude Dreher + 1 more
English
Hardback
9 7 8 0 1 2 8 0 5 3 0 8 9
eBook
9 7 8 0 1 2 8 0 5 3 3 1 7

Decision Neuroscience addresses fundamental questions about how the brain makes perceptual, value-based, and more complex decisions in non-social and social contexts. This book presents compelling neuroimaging, electrophysiological... lesional, and neurocomputational models in combination with hormonal and genetic approaches, which have led to a clearer understanding of the neural mechanisms behind how the brain makes decisions. The five parts of the book address distinct but inter-related topics and are designed to serve both as classroom introductions to major subareas in decision neuroscience and as advanced syntheses of all that has been accomplished in the last decade. Part I is devoted to anatomical, neurophysiological, pharmacological, and optogenetics animal studies on reinforcement-guided decision making, such as the representation of instructions, expectations, and outcomes; the updating of action values; and the evaluation process guiding choices between prospective rewards. Part II covers the topic of the neural representations of motivation, perceptual decision making, and value-based decision making in humans, combining neurcomputational models and brain imaging studies. Part III focuses on the rapidly developing field of social decision neuroscience, integrating recent mechanistic understanding of social decisions in both non-human primates and humans. Part IV covers clinical aspects involving disorders of decision making that link together basic research areas including systems, cognitive, and clinical neuroscience; this part examines dysfunctions of decision making in neurological and psychiatric disorders, such as Parkinson’s disease, schizophrenia, behavioral addictions, and focal brain lesions. Part V focuses on the roles of various hormones (cortisol, oxytocin, ghrelin/leptine) and genes that underlie inter-individual differences observed with stress, food choices, and social decision-making processes. The volume is essential reading for anyone interested in decision making neuroscience. With contributions that are forward-looking assessments of the current and future issues faced by researchers, Decision Neuroscience is essential reading for anyone interested in decision-making neuroscience.

Introduction to the Principles of Drug Design

1st Edition
June 14, 2016
H. J. Smith + 1 more
English
Paperback
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eBook
9 7 8 1 4 8 3 1 8 3 5 0 3

Introduction to the Principles of Drug Design provides a framework of fundamental drug design and principles into which drugs following on developments may be fitted. This book presents the rationales behind the design of drugs. Organized into nine chapters, this book begins with an overview of how the body handles a drug in terms of absorption, metabolism, distribution, and excretion. This text then examines the critical drug activity at the receptor site, which is usually related to blood and other distribution fluid levels. Other chapters consider the factors involved in binding a drug, metabolite, or substrate to a receptor. The final chapter deals with the design of chemotherapeutic agent for clinical use in the treatment of human infections. This book is intended for use in undergraduate pharmacy courses in medicinal chemistry and as an aid in similar courses in biochemistry and pharmacology. Graduates in chemistry just entering the pharmaceutical industry will also find this book useful.

Healthgrain Methods

1st Edition
May 12, 2016
Peter Shrewry
English
Paperback
9 7 8 1 8 9 1 1 2 7 7 0 0
eBook
9 7 8 0 1 2 8 1 0 4 5 3 8

The explosion of interest around the health benefits of whole grains has led to a new focus on the bioactive components of cereals, including their location and physiological effects. Grains are an important source of minerals (notably selenium, iron and zinc) and vitamins, such as folate. These nutrients are often degraded or removed by the milling or polishing of the grain to provide refined products. Measurements of these components require methodologies for analysis that must be accurate and reproducible and that provide adequate samples to allow wide screening. The work of the 47 prominent international food scientists presented in this comprehensive volume is the direct result of the European Union’s Framework 6 HEALTHGRAIN program which focuses on the role of wholegrain cereals in reducing the risk of metabolic syndrome-related diseases. The development of routine analytical methods for this group of essential phytochemical and dietary fiber components will help food companies improve the health benefits of their products as well as their abilities to measure the bioactive ingredients in cereal-based foods.

Forest Management and Planning

2nd Edition
December 29, 2016
Pete Bettinger + 3 more
English
Hardback
9 7 8 0 1 2 8 0 9 4 7 6 1
eBook
9 7 8 0 1 2 8 0 9 7 0 6 9

Forest Management and Planning, Second Edition, addresses contemporary forest management planning issues, providing a concise, focused resource for those in forest management. The book is intermixed with chapters that concentrate on quantitative subjects, such as economics and linear programming, and qualitative chapters that provide discussions of important aspects of natural resource management, such as sustainability. Expanded coverage includes a case study of a closed canopy, uneven-aged forest, new forest plans from South America and Oceania, and a new chapter on scenario planning and climate change adaptation.

Skin Diseases of Cattle in the Tropics

1st Edition
June 8, 2016
Mohamed Elamin Hamid
English
Paperback
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eBook
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Skin Diseases of Cattle in the Tropics: A Guide to Diagnosis and Treatment is a clinical and practical guide to help animal scientists, field veterinarians, veterinary students, and technicians make appropriate and differential diagnoses. It features quizzes of clinical cases, along with multiple images of characteristic lesions and laboratory findings of major skin diseases (and diseases with skin manifestations) that are prevalent in tropical areas, notably the Sub-Saharan African countries. This self-learning and easy-to-use instructional guide, a unique offering in the field of animal science and veterinary medicine, provides essential and foundational information about relevant skin conditions that are followed by illustrated flow charts of laboratory diagnoses and summaries of respective diseases. This title makes the subject accessible for practicing veterinarians and animal scientists, and is particularly useful for those who have neither seen nor had the chance to see these diseases in the field or clinics. Such diseases are important not only in the tropics, but may be encountered in many countries in subtropical and temperate zones.

Atlas of Histology of the Juvenile Rat

1st Edition
May 4, 2016
George A Parker + 1 more
English
Hardback
9 7 8 0 1 2 8 0 2 6 8 2 3
eBook
9 7 8 0 1 2 8 0 2 6 9 6 0

Atlas of Histology of the Juvenile Rat should be of interest to toxicologic pathologists, toxicologists, and other biological scientists who are interested in the histomorphology of juvenile rats. For several decades the laboratory rat has been used extensively in nonclinical toxicology studies designed to detect potential human toxicity of drugs, agrochemicals, industrial chemicals, and environmental hazards. These studies traditionally have involved young adult rats that are 8-10 weeks of age as studies are started. It is becoming increasingly apparent that children and young animals may have different responses to drug/chemical exposures, therefore, regulatory agencies are emphasizing toxicology studies in juvenile animals. While the histologic features of organs from young adult and aged laboratory rats are well known, less is known about the histologic features of organs from juvenile rats. Final histologic maturity of many organs is achieved postnatally, thus immature histologic features must be distinguished from chemical- or drug-related effects. While this postnatal organ development is known to exist as a general concept, detailed information regarding postnatal histologic development is not readily available. The Atlas includes organs that are typically sampled in nonclinical toxicology studies and presents the histologic features at weekly intervals, starting at birth and extending through postnatal day 42.

Fenner and White's Medical Virology

5th Edition
November 9, 2016
Christopher J. Burrell + 2 more
English
Hardback
9 7 8 0 1 2 3 7 5 1 5 6 0
eBook
9 7 8 0 1 2 3 7 5 1 5 7 7

Fenner and White's Medical Virology, Fifth Edition provides an integrated view of related sciences, from cell biology, to medical epidemiology and human social behavior. The perspective represented by this book, that of medical virology as an infectious disease science, is meant to provide a starting point, an anchor, for those who must relate the subject to clinical practice, public health practice, scholarly research, and other endeavors. The book presents detailed exposition on the properties of viruses, how viruses replicate, and how viruses cause disease. These chapters are then followed by an overview of the principles of diagnosis, epidemiology, and how virus infections can be controlled. The first section concludes with a discussion on emergence and attempts to predict the next major public health challenges. These form a guide for delving into the specific diseases of interest to the reader as described in Part II. This lucid and concise, yet comprehensive, text is admirably suited to the needs of not only advanced students of science and medicine, but also postgraduate students, teachers, and research workers in all areas of virology.

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