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Elsevier

Books in Life sciences

  • A Comprehensive Guide for the Novice Researcher in Clinical Trials

    • 1st Edition
    • Miltiadis Lytras + 2 more
    • English
    A Comprehensive Guide for Novice Researcher in Clinical Trials is a must-have resource for individuals embarking on the journey of clinical research. This book is tailored for beginners, offering a clear and structured introduction to the vital principles, methodologies, and skills required to design and conduct robust clinical trials. Spanning 13 chapters, it meticulously covers the entire clinical trial process, emphasizing Good Clinical Practice (GCP) standards. From foundational research concepts to advanced trial strategies, the guide empowers readers to confidently navigate the complexities of clinical trials and contribute meaningfully to the field of healthcare.In addition to its foundational content, the book addresses a variety of important topics, such as ethical considerations, regulatory compliance, and the development of trial protocols. It explores different trial designs, types of bias, and the historical evolution of clinical research. Practical sections on data management, monitoring, statistical analysis, and project management offer readers hands-on guidance for real-world application. Notably, the book includes a dedicated focus on regulatory affairs in Saudi Arabia, making it particularly valuable for health professionals in that region.

  • Arginase: Structure, Function, and Therapeutic Targeting

    • 1st Edition
    • Volume 740
    • English
    This volume of Methods in Enzymology, entitled “Arginase: Structure, Function, and Therapeutic Targeting,” provides a comprehensive, methodology-driven perspective on arginase research spanning molecular, biochemical, and translational domains.The volume is organized into four sections that reflect the breadth of the field, spanning structural and mechanistic enzymology, inhibitor design and therapeutic development, clinical and metabolic aspects of arginine biology, and the evolutionary and functional diversity of arginase and related enzymes. Chapters cover experimental approaches to enzyme expression, purification, and structural characterization; synthetic and computational strategies for inhibitor discovery; and emerging therapeutic modalities, including antibody-based targeting of specific arginase isoforms, advanced delivery systems, and engineered enzyme formulations.Importa... the volume extends beyond classical views of arginase as an enzyme of arginine metabolism, highlighting its broader structural and functional context within the ureohydrolase superfamily and related guanidinohydrolase enzymes, including alternative substrates, catalytic diversity, and roles in microorganisms and plants. These perspectives emphasize arginase function in nitrogen metabolism, host–pathogen interactions, and environmental and physiological adaptation.By integrating contributions from both academia and industry, this volume emphasizes reproducible methodologies and provides a cohesive “from enzyme to organism” framework, connecting fundamental structure–function relationships with applications in metabolism, vascular biology, and therapeutic development.

  • Lo esencial en farmacología. Cursos Crash

    • 6th Edition
    • Catrin Page
    • Spanish
    Con una fórmula que ha demostrado su éxito a lo largo de los últimos 25 años, cada volumen de la serie se ha actualizado por completo para facilitar el estudio. La serie está escrita por estudiantes de últimos cursos y recién graduados que acaban de superar sus exámenes, y toda la información ha sido cuidadosamente revisada por profesores universitarios. Este volumen de la serie se ha mejorado para satisfacer las necesidades de los estudiantes de Medicina actuales, y las de los estudiantes y profesionales de otras disciplinas sanitarias que requieran un acceso rápido a los aspectos esenciales de la farmacología. Cada capítulo guía de forma sucinta por todos los temas curriculares, integrando los aspectos clínicos con la ciencia básica relevante y evitando los detalles innecesarios o confusos. Los cuadros destacados a lo largo del texto ofrecen los apuntes, las sugerencias y los puntos clave esenciales. Se incluye una sección de autoevaluación totalmente revisada y adaptada a los últimos formatos de exámenes para comprobar los conocimientos y para ayudar en la preparación de las pruebas. Completamente revisada y actualizada, esta sexta edición ofrece un recurso accesible de aprendizaje y repaso que facilite la compresión de los principios y las aplicaciones de la farmacología en todas las áreas de la medicina y la cirugía. Comienza con un capítulo introductorio sobre los principios básicos de la farmacología. En el resto de los capítulos, se describen los efectos de los fármacos en los distintos sistemas orgánicos y se incluyen actualizaciones sobre los avances farmacológicos más recientes en medicina (p. ej., las nuevas terapias dirigidas en oncología y enfermedades inflamatorias, así como los nuevos tratamientos utilizados en el manejo de la diabetes y la insuficiencia cardíaca). La sección de autoevaluación se ha actualizado para reflejar el contenido y el estilo de varios exámenes de pre- y posgrado. Las preguntas de autoevaluación se centran en la farmacología clínica y su aplicación a casos reales de la práctica clínica.

  • Encyclopedia of Cardiovascular Research and Medicine

    • 2nd Edition
    • Vasan Ramachandran S. + 1 more
    • English
    Now in its second edition, the Encyclopedia of Cardiovascular Research and Medicine is a four‑volume print and online reference that brings together the essential knowledge needed to understand the heart and vascular system. Designed for students, clinicians, researchers, and instructors, it offers clear, authoritative coverage of how the cardiovascular system develops, functions, becomes injured, and can be repaired. Because cardiovascular disease remains the world’s leading cause of death, this edition provides the up‑to‑date scientific and clinical insights needed to support research, inform care, and improve outcomes.This revised edition includes around 180 expert articles spanning cardiac development and regeneration, vascular biology, genetics and omics technologies, coronary and acute cardiac syndromes, heart failure, electrophysiology and device therapies, imaging, population health, and modern research methods. By spanning basic, clinical, and population sciences, the encyclopedia supports a wide range of users from those seeking introductory knowledge to specialists pursuing advanced expertise in cardiovascular medicine.

  • Cholinergic Drugs for Alzheimer's Disease

    From Central Cholinergic Neurotransmission to Drug Therapies and Natural Products with Multitarget Actions
    • 1st Edition
    • Cheorl-Ho Kim
    • English
    Cholinergic Drugs for Alzheimer’s Disease: From Central Cholinergic Neurotransmission to Drug Therapies and Natural Products with Multitarget Actions addresses the urgent need for advanced resources in neuropharmacology. The first section presents mechanistic insights into cholinergic drugs, current hypotheses for Alzheimer’s Disease progression, neurotransmitter systems, receptor biology, and the evolution of acetylcholinesterase inhibitors, including hybrid and multi-target drugs. It also covers clinical status, neuromuscular blockers, non-adrenergic neurotransmitters, protein kinase inhibitors, inflammation modulation, NMDA antagonism, biomarkers, and AI-assisted drug discovery.The second section explores natural alkaloidal and non-alkaloidal compounds, molecular docking, SAR analysis, and daily consumable resources, with the third section investigating marine-derived AChE inhibitors, dual- and multi-target drug concepts, and emerging therapeutic compounds. This book equips the scientific community with a robust foundation for understanding and innovating in Alzheimer’s Disease therapy. By integrating molecular biology, pharmacology, and computational approaches, it empowers researchers and clinicians to address treatment challenges, optimize drug design, and leverage natural products for multifactorial intervention.

  • Biofabrication and Synthetic Biology in Medicinal Plants

    Advances in Biotechnology and Breeding
    • 1st Edition
    • Eti Sharma + 2 more
    • English
    Biofabrication and Synthetic Biology in Medicinal Plants: Advances in Biotechnology and Breeding presents recent technological advances for enhancing medicinal plants as sources of plant-based biopharmaceuticals. It covers biofabrication, synthetic biology, modern biotechnological tools, and innovative breeding strategies tailored for medicinal plant improvement. While these technologies are well established in crop plants, their application in medicinal plants remains underexplored. Medicinal plants are rich sources of therapeutic compounds traditionally used across cultures to treat a wide range of diseases and health conditions. These plants produce diverse bioactive molecules, including terpenoids, flavonoids, alkaloids, and phenolics, many of which exhibit significant pharmacological potential. For centuries, medicinal and aromatic plants have played a vital role in human healthcare and continue to be valued globally. Recent advances in synthetic biology, metabolic engineering, and biotechnology promise to enhance the production, quality, and efficacy of these bioactive compounds, addressing unmet medical needs and contributing to sustainable healthcare. This book compiles insights from leading experts, offering a comprehensive reference for researchers, early-career scientists, students, and professionals working in medicinal plant biotechnology and breeding.

  • Stem Cell-Mediated Regulation of Pyroptosis

    • 1st Edition
    • Debalina Bhattacharya + 1 more
    • English
    Stem Cell-Mediated Regulation of Pyroptosis investigates the role of pyroptosis in various types of stem cells and stem cell-derived exosomes, considering how they can accelerate tissue repair and regeneration in inflammatory diseases. The book begins with an introduction to the mechanisms of pyroptosis and methods available for its detection. It then considers pyroptosis and its relationship to stem cells before delving into the interaction across various conditions, ranging from cerebral injury, spinal injury, cardiac injury, osteoarthritis, cancer, and more. Users will find the latest research and future directions in the study of stem cells and pyroptosis, thus enabling further understanding of the cellular mechanisms underlying this form of cell death and the clinical significance of stem cells in the context of pyroptosis-induced diseases. Therapeutic implications and potential strategies targeting this pathway for the treatment of such conditions are also considered, providing a comprehensive reference that will be useful to researchers working across cell biology, regenerative medicine, immunology, therapeutics, and other related fields.

  • Técnicas en histología y biología celular

    • 3rd Edition
    • Luis Montuenga Badía + 2 more
    • Spanish
    Esta nueva edición de Técnicas en histología y biología celular, completamente actualizada, desarrolla de modo asequible los fundamentos teóricos y metodológicos de las técnicas más relevantes en histología y biología celular, incluyendo aquellas técnicas de biología molecular relacionadas con ambas disciplinas. Presenta los fundamentos de las diversas metodologías a estudiantes del ámbito de las ciencias biológicas, la bioquímica y la biomedicina, así como a técnicos de anatomía patológica y otros profesionales biosanitarios que deseen conocer estas técnicas con un abordaje avanzado. Asimismo, proporciona a los investigadores, técnicos o clínicos que se inician en el campo del laboratorio o la investigación biológica y biomédica la información necesaria para introducirse con seguridad en el ámbito del análisis microscópico y la biología celular, incluidas sus bases moleculares. Incluye capítulos sobre procesamiento y tinción de las muestras; inmunolocalización; hibridación in situ de ácidos nucleicos; cultivo de tejidos; técnicas multiómicas; microscopía confocal, electrónica y de fuerza atómica; análisis de imagen; ingeniería tisular, etc. Así mismo, la nueva edición presenta numerosas imágenes originales y esquemas que ilustran los conceptos básicos y muestran ejemplos prácticos del uso de las diversas técnicas. Ofrece acceso a la versión digital del libro a travésde https://online.vital... con nuevos recursos didácticos asociados a cada uno de los temas, incluyendo actividades y casos prácticos, preguntas de autoevaluación, imágenes complementarias, bibliografía adicional y enlaces de interés.

  • Retina Structure, Function, and Genetics

    • 1st Edition
    • Volume 217
    • Machelle T. Pardue
    • English
    Retina Structure, Function, and Genetics focuses on recent research on the ocular structure responsible for visual function. Introductory chapters cover epidemiology and genetics of the retina, while structural chapters cover development, anatomy, the fovea, retinal cell types, and vasculature. Additional content covers neurotransmitters and circuits, phototransduction, ganglion cell physiology, higher order visual processing, and color and spatial vision.

  • Applied Advanced Technologies in Marine Fish Aquaculture

    • 1st Edition
    • Daniel Benetti
    • English
    Applied Advanced Technologies in Marine Fish Aquaculture provides detailed overviews on the most advanced technologies for full-cycle production of marine fish, from hatchery to market. The book describes original technical protocols that were improved over the years to assist the reader in all stages of aquaculture projects development, from inception to operation, at both research and commercial scales.Professor Daniel Benetti conveys here all his extensive and successful experience working with dozens of commercially important marine fish species in several countries throughout the world. He addresses all basic and applied aspects of marine fish aquaculture, presenting the most advanced methods and protocols for all stages of the production cycle, from broodstock reproduction and management to spawning, larval rearing and early developmental stages including nursery and growout methods.Applied Advanced Technologies in Marine Fish Aquaculture is innovative as it takes a practical, applied approach of merging science and technology of tropical and subtropical marine fish aquaculture into a state-of-the-art compendium with detailed guidelines that will serve as seminal reference for students, researchers, managers, investors, consultants, government officers and other professionals working in the field worldwide

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