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Books in Life sciences

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    • Translating MicroRNAs to the Clinic

      • 1st Edition
      • September 17, 2016
      • Jeffrey Laurence
      • English
      • Hardback
        9 7 8 0 1 2 8 0 0 5 5 3 8
      • eBook
        9 7 8 0 1 2 8 0 0 5 5 4 5
      Translating microRNA to the Clinic reviews the possibilities of current methodological tools and experimental approaches used by leading translational researchers. The book features the uses of micro ribonucleic acid as deployed in cancer targeting in biomarkers, diabetes, cardiovascular disease, and neurodegeneration, among many others. Pedagogically, the work concentrates on the latest knowledge, laboratory techniques, and experimental approaches used by translational research leaders in this field, promoting a cross-disciplinary communication between the sub-specialities of medicine, but in common with other books on the topic. In addition, the book emphasizes recent innovations, critical barriers to progress, the new tools that are being used to overcome them, and specific areas of research that require additional study to advance the field as a whole.

    • Nutraceuticals

      • 1st Edition
      • January 21, 2016
      • Ramesh C. Gupta
      • English
      • Hardback
        9 7 8 0 1 2 8 0 2 1 4 7 7
      • eBook
        9 7 8 0 1 2 8 0 2 1 6 5 1
      Nutraceuticals: Efficacy, Safety and Toxicity brings together all current knowledge regarding nutraceuticals and their potential toxic effects as written by the scientists at the forefront of their study. Users will find an introduction to nutraceuticals, herbal medicines, ayurvedic medicines, prebiotics, probiotics, and adaptogens, along with their use and specific applications. This essential reference then discusses the mechanism of action for the judicious use of these nutraceuticals and the best tools for their evaluation before detailing the safety and toxicity of nutraceuticals and their interactions with other therapeutic drugs. Finally, and crucially, regulatory aspects from around the world are covered, providing a comprehensive overview of the most effective tools for the evaluation, safety, and toxicity of nutraceuticals, prebiotics, probiotics, and alternative medicines.

    • Bacterial Endotoxins

      • 1st Edition
      • June 14, 2016
      • Solomon Kadis + 2 more
      • English
      • Paperback
        9 7 8 1 4 8 3 2 0 2 4 6 4
      • eBook
        9 7 8 1 4 8 3 2 1 5 8 9 1
      Microbial Toxins, Volume V: Bacterial Endotoxins covers the physiology, pathology, and immunology of bacterial endotoxins. The book discusses the relationship of lipopolysaccharide structure to bacterial virulence; the importance of blood-group and Forssman antigenic determinants in interactions between human and microbes; and the chemical modification of endotoxin and inactivation of its biological properties. The text also describes the effects of endotoxic lipopolysaccharides on the complement system; the host-dependent detoxification of bacterial endotoxin; and the metabolic effects of bacterial endotoxins. The release of vasoactive agents and the vascular effects of endotoxin are also considered. The book further tackles the febrile response to endotoxin; some major aspects and the relationship between shock and endotoxemia; as well as the effects of lipopolysaccharides (endotoxins) on the susceptibility to infections. The text also encompasses the role of hypersensitivity and tolerance in reactions to endotoxins. Pathologists, immunologists, physiologists, and microbiologists will find the book invaluable.

    • Biochar Application

      • 1st Edition
      • May 7, 2016
      • T. Komang Ralebitso-Senior + 1 more
      • English
      • Hardback
        9 7 8 0 1 2 8 0 3 4 3 3 0
      • eBook
        9 7 8 0 1 2 8 0 3 4 3 6 1
      Biochar Application: Essential Soil Microbial Ecology outlines the cutting-edge research on the interactions of complex microbial populations and their functional, structural, and compositional dynamics, as well as the microbial ecology of biochar application to soil, the use of different phyto-chemical analyses, possibilities for future research, and recommendations for climate change policy. Biochar, or charcoal produced from plant matter and applied to soil, has become increasingly recognized as having the potential to address multiple contemporary concerns, such as agricultural productivity and contaminated ecosystem amelioration, primarily by removing carbon dioxide from the atmosphere and improving soil functions. Biochar Application is the first reference to offer a complete assessment of the various impacts of biochar on soil and ecosystems, and includes chapters analyzing all aspects of biochar technology and application to soil, from ecogenomic analyses and application ratios to nutrient cycling and next generation sequencing. Written by a team of international authors with interdisciplinary knowledge of biochar, this reference will provide a platform where collaborating teams can find a common resource to establish outcomes and identify future research needs throughout the world.

    • Obesity, An Issue of Endocrinology and Metabolism Clinics of North America

      • 1st Edition
      • Volume 45-3
      • August 18, 2016
      • Caroline M. Apovian + 1 more
      • English
      • Hardback
        9 7 8 0 3 2 3 4 6 2 5 5 6
      • eBook
        9 7 8 0 3 2 3 4 6 2 7 6 1
      This issue of Endocrinology and Metabolism Clinics, guest edited by Drs. Caroline M. Apovian and Nawfal Istfan, is devoted to Obesity. Articles in this comprehensive issue include: Guidelines for Obesity Management; Obesity is a Disease; Pharmacotherapy for Obesity; Bariatric Surgery Mechanisms; Diabetes Treatment in the Patient with Obesity; Adipose Tissue: Inflammation and the Endocrine Organ; Behavioral Treatment of the Patient with Obesity; The Role of Macronutrient Content in the Diet for Weight Loss and Weight Maintenance; Substrate Oxidation and Brown Adipose Tissue; Brown and Beige Adipose Tissue: Therapy for Obesity?; Ethnic Differences in Diabetes Lipids HTN and Obesity; Genetics of Bariatric Surgery Outcomes; Leptin and Hormones: Energy Homeostatis; Bariatric Surgery Clinical Outcomes; Medical Devices for Obesity; Adolescent Bariatric Surgery; Psychological Aspects of Obesity; and Nutrient Timing.

    • A Historical Introduction to Mathematical Modeling of Infectious Diseases

      • 1st Edition
      • October 18, 2016
      • Ivo M. Foppa
      • English
      • Paperback
        9 7 8 0 1 2 8 0 2 2 6 0 3
      • eBook
        9 7 8 0 1 2 8 0 2 4 9 9 7
      A Historical Introduction to Mathematical Modeling of Infectious Diseases: Seminal Papers in Epidemiology offers step-by-step help on how to navigate the important historical papers on the subject, beginning in the 18th century. The book carefully, and critically, guides the reader through seminal writings that helped revolutionize the field. With pointed questions, prompts, and analysis, this book helps the non-mathematician develop their own perspective, relying purely on a basic knowledge of algebra, calculus, and statistics. By learning from the important moments in the field, from its conception to the 21st century, it enables readers to mature into competent practitioners of epidemiologic modeling.

    • Genetics and Molecular Biology of Entomopathogenic Fungi

      • 1st Edition
      • Volume 94
      • April 27, 2016
      • English
      • Hardback
        9 7 8 0 1 2 8 0 4 6 9 4 4
      • eBook
        9 7 8 0 4 4 4 6 3 7 2 3 9
      Advances in Genetics provides the latest information on the rapidly evolving field of genetics, presenting new medical breakthroughs that are occurring as a result of advances in our knowledge of the topic. The book continually publishes important reviews of the broadest interest to geneticists and their colleagues in affiliated disciplines, critically analyzing future directions, This thematic volume focuses on the advances and the future potential of the rapidly growing field of entomopathogenic fungi. With a focus on the genetics and molecular biology behind the progress, techniques developed to study all aspects of these fungi will be highlighted, and topics will span from systematics of fungi to how a fungus infects an insect and how that insect responds.

    • Biotechnology of Microbial Enzymes

      • 1st Edition
      • July 21, 2016
      • Goutam Brahmachari + 2 more
      • English
      • Paperback
        9 7 8 0 1 2 8 0 3 7 2 5 6
      • eBook
        9 7 8 0 1 2 8 0 3 7 4 6 1
      Biotechnology of Microbial Enzymes: Production, Biocatalysis and Industrial Applications provides a complete survey of the latest innovations on microbial enzymes, highlighting biotechnological advances in their production and purification along with information on successful applications as biocatalysts in several chemical and industrial processes under mild and green conditions. Applications of microbial enzymes in food, feed, and pharmaceutical industries are given particular emphasis. The application of recombinant DNA technology within industrial fermentation and the production of enzymes over the last 20 years have produced a host of useful chemical and biochemical substances. The power of these technologies results in novel transformations, better enzymes, a wide variety of applications, and the unprecedented development of biocatalysts through the ongoing integration of molecular biology methodology, all of which is covered insightfully and in-depth within the book.

    • Atlas of Histology of the Juvenile Rat

      • 1st Edition
      • May 4, 2016
      • George A Parker + 1 more
      • English
      • Hardback
        9 7 8 0 1 2 8 0 2 6 8 2 3
      • eBook
        9 7 8 0 1 2 8 0 2 6 9 6 0
      Atlas of Histology of the Juvenile Rat should be of interest to toxicologic pathologists, toxicologists, and other biological scientists who are interested in the histomorphology of juvenile rats. For several decades the laboratory rat has been used extensively in nonclinical toxicology studies designed to detect potential human toxicity of drugs, agrochemicals, industrial chemicals, and environmental hazards. These studies traditionally have involved young adult rats that are 8-10 weeks of age as studies are started. It is becoming increasingly apparent that children and young animals may have different responses to drug/chemical exposures, therefore, regulatory agencies are emphasizing toxicology studies in juvenile animals. While the histologic features of organs from young adult and aged laboratory rats are well known, less is known about the histologic features of organs from juvenile rats. Final histologic maturity of many organs is achieved postnatally, thus immature histologic features must be distinguished from chemical- or drug-related effects. While this postnatal organ development is known to exist as a general concept, detailed information regarding postnatal histologic development is not readily available. The Atlas includes organs that are typically sampled in nonclinical toxicology studies and presents the histologic features at weekly intervals, starting at birth and extending through postnatal day 42.

    • Congenital Heart Disease and Neurodevelopment

      • 1st Edition
      • May 3, 2016
      • Christopher McCusker + 1 more
      • English
      • Paperback
        9 7 8 0 1 2 8 0 1 6 4 0 4
      • eBook
        9 7 8 0 1 2 8 0 1 7 9 2 0
      Congenital Heart Disease and Neurodevelopment: Understanding and Improving Outcomes brings together the work of leading researchers from the U.K., Europe, and the U.S. to provide a comprehensive examination of the causes, risks, and neurodevelopmental and psychological outcomes in children with congenital heart disease. The book includes longitudinal studies which have tracked outcomes from birth through late childhood and explores the emergent phenotype and etiologies, risk, and protective factors that strengthen proposed models. Medical and surgical advances have meant that greater numbers of children with even the most severe congenital heart disease (CHD) now survive well into adulthood. Studies over the past 20 years have suggested certain neurodevelopmental and psychological features are common, with clinical interventions being internationally articulated. The U.K. Belfast Center has developed and evaluated unique early intervention programs to circumvent the common problems discerned and promote optimal adjustment and outcomes. The first edition of Congenital Heart Disease and Neurodevelopment: Understanding and Improving Outcomes describes these programs in detail and outlines promising results obtained by researchers worldwide. Such interventions, together with the U.S. consensus statement (Circulation, 2012) on neurodevelopmental screening, hold great promise for clinical interventions.

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