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Elsevier

Books in Life sciences

  • The Link Between Obesity and Cancer

    • 1st Edition
    • Raman Mehrzad
    • English
    The Link between Obesity and Cancer provides a comprehensive review on the relationship between obesity and cancer, presenting global perspectives on obesity and cancer incidence that are followed by in-depth discussions on cancers for which we have new evidence of a causal relationship with obesity. Readers will gain fundamental knowledge on which cancer types are related to obesity. In addition, this updated resource provides significant knowledge for clinicians on when to act, along with specific management guidelines for patients, as well as how to understand potential risk factors and how to directly or indirectly minimize these risks. The book also provides never-before-publish... scientific data for any researcher in the field, identifying molecular mechanisms and links behind the development of malignancy and promoting research in new and effective target pathways in developing therapeutic strategies.

  • Artificial Intelligence for Neurological Disorders

    • 1st Edition
    • Ajith Abraham + 3 more
    • English
    Artificial Intelligence for Neurological Disorders provides a comprehensive resource of state-of-the-art approaches for AI, big data analytics and machine learning-based neurological research. The book discusses many machine learning techniques to detect neurological diseases at the cellular level, as well as other applications such as image segmentation, classification and image indexing, neural networks and image processing methods. Chapters include AI techniques for the early detection of neurological disease and deep learning applications using brain imaging methods like EEG, MEG, fMRI, fNIRS and PET for seizure prediction or neuromuscular rehabilitation. The goal of this book is to provide readers with broad coverage of these methods to encourage an even wider adoption of AI, Machine Learning and Big Data Analytics for problem-solving and stimulating neurological research and therapy advances.

  • Covid-19 and Parkinsonism

    • 1st Edition
    • Volume 165
    • English
    Covid-19 and Parkinsonism, Volume 165 in the International Review in Neurobiology series, highlights new advances in the field with this new volume presenting interesting chapters that cover a variety of topics, including Parkinsonism associated with viral infections, Covid-19 and nervous system pathology: bench to bedside, Prevalence of Covid-19 in Parkinson’s Disease: acute settings and hospital, Covid-19 and Parkinson’s Disease: clinical features, long COVID, Smell deficits in Covid-19 and possible links with Parkinson’s Disease, Spotlight on non-motor symptoms and Covid-19, and a Summary of treatment paradigms in Parkinson’s Disease patients and Covid-19. Additional sections cover Covid-19 and Parkinson’s Disease: nursing care, vaccination, telemedicine services, impact on advanced therapies, Covid-19-induced parkinsonism: Real life phenoconversion cases, Loneliness and impact of lockdown on Parkinson’s Disease patients during the Covid-19 pandemic, Parkinson’s Disease and Covid-19: Impact of ethnicity and palliative care, and more.

  • Image Atlas of COVID-19

    • 1st Edition
    • Meiyun Wang + 1 more
    • English
    Image Atlas of COVID-19 covers this novel and emerging respiratory infectious disease. Although the gold standard for clinical diagnosis of COVID-19 remains the nucleic acid test for SARS-CoV-2, chest CT scans have been widely used in the diagnosis and treatment of COVID-19 as simple and fast diagnostic methods. The latter has proven crucial when faced with a large volume of symptomatic and asymptomatic patients. The imaging manifestations of COVID-19 have some specific characteristics, hence a better understanding of imaging findings is of great value for detecting lesions, evaluating lesion severity, diagnosis and differential diagnosis, and assessment of therapeutic options and prognosis.

  • Outbreaks, Epidemics, and Health Security

    COVID-19 and Ensuring Future Pandemic Preparedness in Ireland and the World
    • 1st Edition
    • Sebastian Kevany + 1 more
    • English
    Outbreaks, Epidemics, and Health Security: Ensuring Future Preparedness for Small Island Nations and the World reviews the many lessons learned from the COVID-19 pandemic. Topics include epidemic preparedness, the politics of epidemics, health security, anti-vaccine campaigns, vaccine preparedness, the need for detailed information sharing and infection tracking versus protected health information, the effects on international relations, the need for intelligence assets to contribute to global health, and the development of biodefense shields.

  • Febrile Seizures

    New Concepts and Consequences
    • 2nd Edition
    • Tallie Z. Baram + 2 more
    • English
    Febrile seizures are the most common seizures in infants and children worldwide, This fact provides strong impetus to study and understand them and their consequences, and consider their treatment. These topics were the focus of the first edition of this book. The 20 years since the publication of this first edition have witnessed an explosion of new information about febrile seizures, meriting this new edition. Key advances have been made in the genetics and neurobiological underpinnings of febrile seizures and especially the very long fever-related seizures called febrile status epilepticus. The role of neuroinflammatory factors in the emergence of these seizures and their consequences, the demonstration of unique clinical and neuroradiological aspects of febrile status epilepticus, and the prospect of predictive (bio)markers to identify and characterize cognitive and epilepsy outcomes are exciting and important. In this edition, the authors and editors tackle these developments in chapters addressing the questions of parents, physicians, allied health care professionals and basic and translational scientists. 　

  • Mass Production of Beneficial Organisms

    Invertebrates and Entomopathogens
    • 2nd Edition
    • Juan A. Morales-Ramos + 2 more
    • English
    Mass Production of Beneficial Organisms: Invertebrates and Entomopathogens, Second Edition explores the latest advancements and technologies for large-scale rearing and manipulation of natural enemies while presenting ways of improving success rate, predictability of biological control procedures, and demonstrating their safe and effective use. Organized into three sections, Parasitoids and Predators, Pathogens, and Invertebrates for Other Applications, this second edition contains important new information on production technology of predatory mites and hymenopteran parasitoids for biological control, application of insects in the food industry and production methods of insects for feed and food, and production of bumble bees for pollination.Benefici... organisms include not only insect predators and parasitoids, but also mite predators, nematodes, fungi, bacteria and viruses. In the past two decades, tremendous advances have been achieved in developing technology for producing these organisms. Despite that and the globally growing research and interest in biological control and biotechnology applications, commercialization of these technologies is still in progress. This is an essential reference and teaching tool for researchers in developed and developing countries working to produce “natural enemies” in biological control and integrated pest management programs.

  • Cardio-Hepatology

    Connections Between Hepatic and Cardiovascular Disease
    • 1st Edition
    • Tatsunori Taniguchi + 1 more
    • English
    Cardio-Hepatology: Connections Between Hepatic and Cardiovascular Disease provides a direct relationship between the cardiac and hepatic pathologies providing the link between the heart and liver and showing how liver diseases predispose to impairment in heart functioning and vice versa. Considering the growing number of patients living (and living longer) with heart failure and/or congenital heart disease, it is important to know when and how to test for liver disease in this population, how to interpret abnormal test results, and what management is appropriate. Coverage includes what should be done for patients to limit, avoid, or postpone the impairment in the liver functioning induced by heart diseases and the impairment in the heart functioning induced by liver diseases, on the basis of scientific-exposed evidence and pathophysiology knowledge. This comprehensive, extended review of the medical literature is perfect for researchers interested in the connection between cardiology and hepatology as well as clinicians making therapeutic decisions for patients suffering from heart or liver chronic diseases.

  • Semantic Models in IoT and eHealth Applications

    • 1st Edition
    • Sanju Tiwari + 2 more
    • English
    Semantic Models in IoT and eHealth Applications explores the key role of semantic web modeling in eHealth technologies, including remote monitoring, mobile health, cloud data and biomedical ontologies. The book explores different challenges and issues through the lens of various case studies of healthcare systems currently adopting these technologies. Chapters introduce the concepts of semantic interoperability within a healthcare model setting and explore how semantic representation is key to classifying, analyzing and understanding the massive amounts of biomedical data being generated by connected medical devices. Continuous health monitoring is a strong solution which can provide eHealth services to a community through the use of IoT-based devices that collect sensor data for efficient health diagnosis, monitoring and treatment. All of this collected data needs to be represented in the form of ontologies which are considered the cornerstone of the Semantic Web for knowledge sharing, information integration and information extraction.

  • De Novo Peptide Design

    Principles and Applications
    • 1st Edition
    • Vibin Ramakrishnan + 2 more
    • English
    De novo Peptide Design: Principles and Applications presents the latest developments in the fields of therapeutic peptides and bio-nanotechnology. The title focuses on the design of peptides, particularly how peptides may be tailored to specific functions. It includes computational and experimental protocols to assist in the design of peptides. Sections cover the basics of protein and peptide structure, modeling and simulation, solid phase peptide synthesis, peptide-based antibiotics, drug delivery, peptide nanomaterials, aromatic interactions directing nano-assembly, protein/peptide aggregation, therapeutic interventions against protein/peptide aggregation diseases, peptide based hydrogels, computational tools and algorithms for peptide design, and experimental protocols in peptide chemistry. In addition, the book covers key aspects in peptide design, providing a solution for researchers working within the 'peptidic universe' to create new therapeutic agents.

  • Collective Memory

    • 1st Edition
    • Volume 274
    • English
    Collective Memory, Volume 274 in the Progress in Brain Research series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of interesting topics, including Deriving testable hypotheses through an analogy between individual and collective memory and updated information on Collective future thinking: Current research and future directions.

  • Neurotoxicity of Drugs of Abuse

    • 1st Edition
    • Volume 8
    • English
    Neurotoxicity of Drugs of Abuse, Volume Eight provides carefully crafted reviews on the disruptive impact of drugs of abuse on the central nervous system. The neurotoxicity potential of several agents including marijuana, fentanyl, and ketamine are carefully reviewed, and their short-term and chronic effects are categorized. Pharmacokinetic profiles as well as mechanisms of action for these and other drugs of abuse such as alcohol and nicotine are also evaluated. The implications of short and long-term abuse for agents such as PCP are also characterized. The reader will come away with a fuller understanding of the adverse effects of drugs of abuse on the nervous system.

  • Mangroves with Therapeutic Potential for Human Health

    Global Distribution, Ethnopharmacology, Phytochemistry, and Biopharmaceutical Application
    • 1st Edition
    • Nabeelah Bibi Sadeer + 1 more
    • English
    Mangroves with Therapeutic Potential for Human Health: Global Distribution, Ethnopharmacology, Phytochemistry, and Biopharmaceutical Applications explores, for the first time in a book, the exciting potential of mangroves for therapeutic applications in medicine and pharmacology. This authoritative, illustrated and clearly written book pairs the fascinating biodiversity of mangroves with their promising pharmacological propensities. Providing a comprehensive and authoritative overview, the book explores the important aspects related to mangroves, including global distribution, medicinal values and pharmaceutical applications in one source. This book is a valuable resource for researchers, academics in the field of herbal medicine, pharmacology, pharmacognosy, medicinal chemistry, biochemistry, natural product chemistry, ethnopharmacology, biotechnology, marine biology, microbiology, as well as professionals in the pharmaceutical industries.

  • Bradley y Daroff. Neurología clínica

    • 8th Edition
    • Joseph Jankovic + 3 more
    • Spanish
    La nueva edición de Bradley y Daroff. Neurología clínica es una práctica herramienta de consulta para neurólogos tanto en ejercicio como en formación. Proporciona, con un estilo claro y directo, información actualizada basada en la evidencia, reforzada por contenidos interactivos, así como algoritmos de tratamiento y numerosas imágenes, que le ayudarán a estar al día en esta especialidad rápidamente cambiante. Esta obra en dos volúmenes es ideal para la consulta diaria, ya que presenta los contenidos organizados por síntomas/signos de presentación y por entidades patológicas específicas, lo cual agiliza el acceso a la información y, por tanto, la toma de decisiones clínicas. Más de 150 colaboradores, dirigidos por Joseph Jankovic, John C. Mazziotta, Scott L. Pomeroy y Nancy J. Newman, proporcionan directrices actualizadas para diagnosticar y tratar eficazmente los distintos trastornos neurológicos.

  • Advances in Microbial Physiology

    • 1st Edition
    • Volume 81
    • English
    Advances in Microbial Physiology, Volume 81 highlights new advances in the field with this new release presenting interesting chapters written by an international board of authors. Updates in this release include sections on Antibiotic tolerance, Lanthanides in bacterial proteins, Bacterial toxins and host-microbe interactions, and Nitric oxide.

  • Oncogenic Viruses Volume 2

    Medical Applications of Viral Oncology Research
    • 1st Edition
    • Moulay Mustapha Ennaji
    • English
    Oncogenic Viruses: Medical Applications of Viral Oncology Research, Volume Two builds on the introductory overview of Volume One, Oncogenic Viruses: Fundamentals of Oncogenic Viruses. It looks at recent advances and medical application of research studies on oncoviruses, including examining oncoviruses on a molecular level, covers diagnostic and prognostic viral biomarkers and identifying biomarkers in specific human cancers, and delves into prevention, treatment and the future of cancer therapy of oncoviruses, antiviral activities and vaccination strategies. Advanced topics and the future direction of oncovirology round out the book. This book is a comprehensive reference for researchers and practitioners engaged in learning more about the role of oncogenic viruses in the pathogenesis of human cancers and how that information can be applied to identify strategies for prevention and treatment.

  • Case Studies on the Business of Nutraceuticals, Functional and Super Foods

    • 1st Edition
    • Cristina Santini + 2 more
    • English
    A volume in the Consumer Science and Strategic Marketing Series, Case Studies on the Business of Nutraceuticals considers nutraceuticals from a strategic marketing perspective, exploring consumer needs and trends as a pathway to defining novel opportunities in developing and marketing these products.In addition to highlighting the importance of consumer needs in shaping a market strategy for nutraceuticals, this book also defines emerging trends and explores recent developments in the nutraceutical industry.Containing 11 chapters, this book, explores the competitive landscape of the global and European nutraceutical market, focusing on key market drivers, consumer and product trends, and marketing and technological challenges.Case Studies on the Business of Nutraceuticals outlines the processes that lead to the introduction of new products and the entrance of new competitors in the market and highlights how a market strategy that’s focused on consumers’ needs can contribute to a company’s strategy.The case studies and examples contained in this book demonstrate how companies can employ consumer science strategies to revise existing or develop new products and are sure to be a welcomed resource by new product developers, policy makers, food scientists, academicians, and students studying related fields.

  • Bioactive Lipids

    • 1st Edition
    • Manuela Pintado + 4 more
    • English
    Bioactive Lipids presents the topic of bioactive lipids from a functional food development perspective. This book explores the potential of dietary lipids to understand how such bioactive compounds can be used in the development of functional foods and nutraceuticals. The book includes case studies to enable readers to understand the potential of several dietary lipids and the possibilities regarding their incorporation into several food matrices. Bioactive Lipids will be a welcome reference for researchers, lecturers and students from the food science and nutrition fields.

  • Oncogenic Viruses Volume 1

    Fundamentals of Oncoviruses
    • 1st Edition
    • Moulay Mustapha Ennaji
    • English
    Oncogenic Viruses: Fundamentals of Oncoviruses provides an overview of the history of human oncoviruses, how to discover and define an oncovirus, how viruses cause cancer in general, their oncogenic mechanisms and epidemiology, and the cancer biology of oncoviruses. The book is organized into five main parts that include history and discovery of virus-tumor complications, taxonomy and classification of oncoviruses, oncoviruses around the world, including epidemiology statistics and current methods. Finally, the book looks at the molecular epidemiology of DNA and RNA viruses and their role in the pathogenesis of human cancers.

  • Translational Autoimmunity, Volume 5

    Challenges for Autoimmune Diseases
    • 1st Edition
    • Nima Rezaei
    • English
    Translational Autoimmunity: Challenges for Autoimmune Diseases, Fifth Edition addresses diagnostic approaches, therapeutic opportunities, and prognostic markers of different autoimmune diseases. This updated volume discusses autotoxicity, systems immunology, the prognostic significance of disease-specific autoantibodies, along with translational research to novel therapeutic policy in autoimmune diseases. From an introduction, to challenges and insights on the systems immunology of infectious and autoimmune diseases, new targets of treatments, and the role of autoantibodies in diagnosis and evolution, this book provides insights on many challenges researchers and clinicians are facing.

  • Advances in Food Rheology and Its Applications

    Development in Food Rheology
    • 2nd Edition
    • Jasim Ahmed + 1 more
    • English
    Advances in Food Rheology and Its Applications: Development in Food Rheology, Second Edition presents the latest advances in the measurement and application of food rheology, one of the most important tools for food companies when characterizing ingredients and final products, and a predictor of product performance and consumer acceptance. This second edition provides coverage of new rheological measurement techniques, including ultrasonic measurements of rheological properties of food and NMR approach, and precision in data handling, including coverage of mathematical modeling of rheological properties. As the range of food products has also broadened as a result of consumer demands and preference, this second edition includes a series of new chapters on dairy and plant-based foods. The amalgamation between food texture and sensory attributes will also be addressed. In addition, coverage of the correlation between rheological behavior and modeling of the fluid in a human stomach and food digestion will be assessed. A special focus has given on rheology of gel systems, including, food hydrogels, bigel and organogels. Written for food scientists, food technologists, sensory scientists, and others working in academia and industry, Advances in Food Rheology and Its Applications: Development in Food Rheology, Second Edition will be a welcomed and updated reference.

  • Value-Addition in Beverages through Enzyme Technology

    • 1st Edition
    • Mohammed Kuddus + 1 more
    • English
    Value-Addition in Beverages through Enzyme Technology covers the potential impact of new enzymes and enzyme technology on the beverages sector. The book brings together novel sources and technologies regarding all aspects of enzymes for value addition in beverage production and processing. Sections primarily focus on alcoholic (e.g., beer, wine, cider, and distilled spirits) and non-alcoholic beverages (e.g., fruit juices, milk-based, tea, coffee, ready to drink and functional foods), but also cover innovative enzyme technologies to keep endogenous enzymes under control. It is essential reading for researchers and scientists, including food and beverage biotechnologists and students studying enzyme biotechnology and food-related courses. This book will comprise updated research from various independent scientists from around the world who are working on value-addition and production of beverage products using enzyme technology.

  • Basic Life Science Methods

    A Laboratory Manual for Students and Researchers
    • 1st Edition
    • Javeed Ahmad Tantray + 3 more
    • English
    Basic Life Science Methods: A Laboratory Manual for Students and Researchers presents forty of the most executed life science assays. The authors use a consistent structure to cover the preparation, execution and analysis of data from each method. Assays include estimation of cholesterol fractions, C-Reactive Protein, Genomic DNA isolation, Agarose Gel Electrophoresis, RT-PCR, DNA solution preparation, how to design primers, and enzyme-linked immunosorbent assay (ELISA). This book provides a complete reference containing step-by-step instructions on how to run life science assays. Laboratory staff can also benefit of the book as a training resource.

  • Computational Models in Biomedical Engineering

    Finite Element Models Based on Smeared Physical Fields: Theory, Solutions, and Software
    • 1st Edition
    • Milos Kojic + 2 more
    • English
    Computational Models in Biomedical Engineering: Finite Element Models Based on Smeared Physical Fields: Theory, Solutions, and Software discusses novel computational methodologies developed by the authors that address a variety of topics in biomedicine, with concepts that rely on the so-called smeared physical field built into the finite element method. A new and straightforward methodology is represented by their Kojic Transport Model (KTM), where a composite smeared finite element (CSFE) as a FE formulation contains different fields (e.g., drug concentration, electrical potential) in a composite medium, such as tissue, which includes the capillary and lymphatic system, different cell groups and organelles. The continuum domains participate in the overall model according to their volumetric fractions. The governing laws and material parameters are assigned to each of the domains. Furthermore, the continuum fields are coupled at each FE node by connectivity elements which take into account biological barriers such as vessel walls and cells.

  • 3D Bioprinting in Tissue and Organ Regeneration

    • 1st Edition
    • Yang Wu + 2 more
    • English
    3D Bioprinting in Tissue and Organ Regeneration covers state-of-the-art advances and applications in bioprinting. Beginning with an introduction that considers techniques, bioinks and construct design, the authors then move onto a detailed review of applications of bioprinting in different biomedical fields (skin, cartilage, bone, vascularized tissue, etc.). This is followed by a chapter overview of intraoperative bioprinting, which is widely considered one of the important future trends in this area. Finally, the authors tackle ethical and regulation concerns regarding the utilization of bioprinting.The book is written by three global experts for an audience of students and professionals with some basic knowledge of bioprinting, but who seek a deeper understanding of the biomedical applications involved in bioprinting.

  • A Mathematical Approach to Special Relativity

    • 1st Edition
    • Ahmad Shariati
    • English
    A Mathematical Approach to Special Relativity introduces the mathematical formalisms of special and general relativity. Developed from the author’s experience teaching physics to students across all levels, the valuable resource introduces key concepts, building in complexity and using increasingly advanced mathematical tools as it progresses. Without assuming a background in calculus, the text begins with symmetry, before delving more deeply into Galilean relativity. Throughout, the book provides examples and useful "Guides to the Literature." This unique text emphasizes the experimental consequences and verifications of the underpinning theory in order to provide students with a solid foundation in this key area.

  • Quantum Mechanics, Cell-Cell Signaling, and Evolution

    • 1st Edition
    • John S. Torday
    • English
    Quantum Mechanics, Cell-Cell Signaling, and Evolution offers a detailed accounting of the latest research and theorizing on the integration of quantum physics with biological action to produce a novel perspective on evolution. The book advocates for a paradigm shift towards understanding biology and medicine causally as predictive sciences, presenting quantum mechanics and physiology as vertically integrated. The author has taken a unique approach to the question of how and why evolution occurred. The account is based on extensive knowledge of lipid physical chemistry, and its role in the evolution of the lung under the influence of hormonal effects on structure and function. The title arranges lipid biochemistry and biophysics into an integrated explanation, guiding readers from the immersion of lipids in water as the origin of life, to lung surfactant in alveolar homeostasis, and leading to a new understanding of how consciousness interacts with the laws of nature. This volume argues for a novel understanding of evolutionary processes based on fundamental science and positions itself as seeking consilience among research disciplines. Starting from the origins of the cosmos, the author proceeds through nucleosynthesis and Endosymbiosis Theory, to finally describe consciousness in relation to natural law.

  • Advances in Genetics

    • 1st Edition
    • Volume 109
    • Gerald R. Smith
    • English
    Advances in Genetics, Volume 109 in this ongoing series, highlights new advances in the field, with this new volume presenting interesting chapters written by an international board of authors. Chapters in this new release include Epigenetic regulation of angiogenesis in tumor progression, RecBCD and Chi hotspots as determinants of self vs. non-self: A re-evaluation, Horizontal gene transfer to plants from Agrobacterium and related bacterial species, and more.

  • Discoveries in Pharmacology - Volume 1 - Nervous System and Hormones

    • 2nd Edition
    • Clive Page + 2 more
    • English
    Discoveries in Pharmacology: Volume 1: Nervous system and hormones (2nd Ed.) presents selected articles from the historic Discoveries in Pharmacology series enhanced with commentary from contemporary scholars about the reception and importance of the chapter along with an updated bibliography on the subject with contributions from a Nobel Prize winner and other pioneers in Pharmacology. The Discoveries in Pharmacology series brought acknowledged experts in their fields together to provide first-hand accounts of important pharmacological discoveries discussing the scientific background and stories behind these pivotal moments. They allow a true understanding of the means by which pharmacological discoveries are made. This volume brings forth discussions on key discoveries in psycho- and neuro-pharmacology, haemodynamics, and hormones including chapters on antipsychotic agents by Nobel winner Anders Carlsson, Willy Haefely on benzodiazepine, and butyrophenone-type neuroleptics by P. A. J. Janssen and J. P. Tollenaere. Academic and industry researchers in pharmacology and medicine, as well as advanced students in the area will find this series a useful teaching tool and launch to new discoveries. Chapters can also be used to supplement course material in pharmacology and medical courses. It will also be of interest to those who are interested in the history of medicine.

  • Phenotyping of Human iPSC-derived Neurons

    Patient-Driven Research
    • 1st Edition
    • Elizabeth D. Buttermore
    • English
    Phenotyping of Human iPSC-derived Neurons: Patient-Driven Research examines the steps in a preclinical pipeline that utilizes iPSC-derived neuronal technology to better understand neurological disorders and identify novel therapeutics, also providing considerations and best practices. By presenting example projects that identify phenotypes and mechanisms relevant to autism spectrum disorder and epilepsy, this book allows readers to understand what considerations are important to assess at the start of project design. Sections address reproducibility issues and advances in technology at each stage of the pipeline and provide suggestions for improvement. From patient sample collection and proper controls to neuronal differentiation, phenotyping, screening, and considerations for moving to the clinic, these detailed descriptions of each stage of the pipeline will help everyone, regardless of stage in the pipeline. In recent years, drug discovery in the neurosciences has struggled to identify novel therapeutics for patients with varying indications, including epilepsy, chronic pain, and psychosis. Current treatment options for such patients are decades old and offer little relief with many side effects. One explanation for this lull in novel therapeutics is a lack of novel target identification for neurological disorders (and target identification requires exemplar preclinical data). To improve on the preclinical work that often relies on rodent modeling, the field has begun utilizing patient-derived induced pluripotent stem cells (iPSCs) to differentiate neurons in vitro for preclinical characterization of neurological disease and target identification.

  • Plasma Membrane Shaping

    • 1st Edition
    • Shiro Suetsugu
    • English
    Plasma Membrane Shaping summarizes current knowledge on how cells shape their membrane. Organized in four sections, the book opens with a broad overview of the plasma membrane, its composition, usual shapes and substructures, Actin/WASP/arp2/3 structures, BAR domains, and Ankyrin repeat domains, dynamin, and phospholipid signaling. Other sections cover the shaping of the plasma membrane for transport processes, discussions on exosomes, microvesicles, and endosomes, clathrin-coated pits, caveolae, and other endocytic pits, membrane deformation for cell movement, and some of the most current dry and wet lab research techniques to investigate cellular membrane shaping. This is an ideal resource for new researchers coming into this area as well as for graduate students. The methods section will be of interest to both microscopists and computer scientists dedicated to the visualization, data collection, and analysis of plasma membrane shaping experiments.

  • Advances in Automated Diagnosis of Intestinal Parasites of Animals and Humans

    • 1st Edition
    • Volume 118
    • English
    Advances in Parasitology, Volume 116, the latest release in this ongoing series, includes medical studies of parasites of major influence, along with reviews of more traditional areas, such as zoology, taxonomy and life history. Chapters in this update include Landscape analysis of available diagnostic tests for STH: how far are we from the WHO TPPS? and Challenges and solutions for the diagnosis of animal and human Strongyloides stercoralis infection.

  • Asthma in the 21st Century

    New Research Advances
    • 1st Edition
    • Rachel Nadif
    • English
    Asthma in the 21st Century: New Research Advances provides an overview on asthma, with discussions on its heterogeneity, risk factors and their interrelations, and e-health in an aging world based on current research knowledge. The book covers heterogeneity of the disease beyond severe asthma, new risk factors, new diagnoses with climate change, a focus on chemical exposures at home, e-health and links with aging, and notable advances in key areas such as diet and microbiota, the genetics of asthma, and the asthma versus COPD debate. Worldwide, the total number of asthma sufferers is estimated to be ~270 million with an additional 100 million expected to develop asthma by 2025, and asthma is the most common chronic disease among children. There are a number of clinical books available on asthma, but none with much discussion on current scientific findings and new disease understanding. Yet, the concept of asthma has evolved quickly in the past 5–10 years, with many clinicians struggling to keep up with new scientific findings.

  • Handbook of Epigenetics

    The New Molecular and Medical Genetics
    • 3rd Edition
    • Trygve O. Tollefsbol
    • English
    Handbook of Epigenetics: The New Molecular and Medical Genetics, Third Edition provides a comprehensive analysis of epigenetics, from basic biology to clinical application. This new edition has been fully revised to cover the latest and evolving topics in epigenetics, with chapters updated and new chapters added on topics such as single-cell epigenetics, DNA methylation clocks in age-related diseases, transposable elements and epigenetics, X chromosome inactivation, and the epigenetics of drug addiction, among other topics. Throughout this edition, greater emphasis falls on epigenomic analyses and incorporating multi-omics approaches rather than gene-specific analyses. In addition, this edition has also been enhanced with step-by-step instructions in research methods, as well as easy-to-digest disease case studies and clinical trials that provide context and applied examples of recent advances in disease understanding and epigenetic therapeutics. These features empower researchers to reproduce the approaches and studies discussed and aid clinical translation. Live links across chapters tie in relevant external datasets and resources.

  • Current Applications, Approaches and Potential Perspectives for Hemp

    Crop Management, Industrial Usages, and Functional Purposes
    • 1st Edition
    • Ivan Francisco Garcia Tejero + 1 more
    • English
    Current Applications, Approaches and Potential Perspectives for Hemp: Crop Management, Industrial Usages, and Functional Purposes presents the latest in the rapidly growing interest for hemp cultivation and its sustainable applications for humans. This book gathers research and review chapters that analyze research trends and current agricultural issues. It then proposes alternative solutions and describes current and future applications for this raw material. This book will be extremely beneficial for researchers, academics, policymakers, technicians and other stakeholders interested in this crop development and its applications. Cannabis sativa is considered as a proper and alternative crop because of its wide range of applications and marketability, especially when developed for biomedical applications. Thus, many producers and technicians are trying to find relevant information about this crop development and usages in order to be considered viable in the future.

  • Neuroinflammation in Vascular Dementia

    • 1st Edition
    • Gary Rosenberg
    • English
    Neuroinflammation in Vascular Dementia describes the molecular mechanisms that drive this transition to mixed pathology, along with the newer lifestyle and pharmacological approaches that can reduce the incidence of dementia. The book describes the practical aspects of neuroimaging methods, along with novel neuroimaging methods, using MRI, that are becoming important clinically. The author also discusses how the diagnosis of dementias will be greatly aided by biomarkers from neuroimaging, blood and CSF biochemistry and neuropsychological testing in the future. This information will be used in precision medicine to design treatment strategies based on the most likely causes of the disease. Dementia research has undergone dramatic growth driven by current and projected increases in the aging of the population, and thus leading to a larger number of patients with dementia by 2050. Hence, advances in neuroimaging, brain chemistry, and genetics have accelerated our understanding of diseases that lead to cognitive decline.

  • Disorders of Protein Synthesis

    • 1st Edition
    • Volume 132
    • Rossen Donev
    • English
    Disorders of Protein Synthesis, Volume 132 in the Advances in Protein Chemistry and Structural Biology series, highlights new advances in the field, with this new volume presenting interesting chapters written by an international board of authors.

  • Clinical PET/MRI

    • 1st Edition
    • Onofrio Antonio Catalano
    • English
    Clinical PET/MR presents the state-of-the-art of PET/MR, guiding the reader from how to scan patients, how to read and report the studies, and how keep an eye on what is clinically relevant for a patient’s care. Each chapter starts with the clinical scenario and then moves to pertinent imaging, addressing the need of a clinical PET/MR book written by world experts in both clinical and imaging fields. It discusses the clinical application of PET/MR in diverse subspecialties such as head and neck, neurology, cardiovascular, pediatrics, chest, bone, hematology, breast, hepatobiliary pancreatic, genitourinary, gynecology, and gastrointestinal tract. This book is a valuable resource for radiologists, oncologists and members of the biomedical field who need to learn more about clinical applications of PET/MR.

  • Snack Foods

    Processing and Technology
    • 1st Edition
    • Suvendu Bhattacharya
    • English
    Snack Foods: Processing and Technology presents the use of different raw materials, processing technologies, quality attributes of snacks, machinery requirements, and innovative thoughts for future product development. These items are discussed in 15 chapters, including recent technologies leading to the industrial production of popular snacks and healthy products. The discussion on artistic snacks and troubleshooting are the new addi>tions. This book will be of use to entrepreneurs, academic and research institutes, professionals in the field, and personnel from industries.

  • How Synthetic Drugs Work

    Insights into Molecular Pharmacology of Classic and New Pharmaceuticals
    • 1st Edition
    • Imran Kazmi + 4 more
    • English
    How Synthetic Drugs Work: Insights into Molecular Pharmacology of Classic and New Pharmaceuticals provides comprehensive, structured access to robust information on molecular pharmacology for clinicians, research scientists and advanced health care students. The book covers the foundations of molecular pharmacology and the main drug classes, including detailed information on their mechanisms of action and the application of molecular pharmacology in drug development. This book is an ideal reference for graduate students and researchers in pharmacology, however, researchers in corporate settings will also benefit from the book's structured and detailed coverage of mechanisms of action of synthetic drugs.

  • An Insider's Perspective of Prostate Cancer

    Understanding Effects, Management Options and Consequences
    • 1st Edition
    • Robert Alexander (‘Frank’) Gardiner
    • English
    An Insider’s Perspective of Prostate Cancer: Understanding Effects, Management Options and Consequences provides scientifically based information on the management and treatment of prostate cancer. The text is designed to be neither prescriptive nor proscriptive, providing succinct, yet comprehensive details in ‘bite size chunks’ for ready assimilation and application. Sections cover recent approaches the prostate cancer landscape has made by providing background statistical and anatomical information that is followed by relevant genetic, immunological and background data. The book then proceeds to explain the mechanisms involved with cancer development and the spread and metastases that can occur in a minority of those diagnosed. In addition to acknowledging the importance of psychological effects of diagnosis and management interventions, the undervalued benefits of exercise are also emphasized, including information on holistic management. This comprehensive approach makes this a perfect reference for up-to-date information on all aspects of prostate cancer and its management.

  • MRNA-Based Therapeutics

    • 1st Edition
    • Volume 372
    • English
    MRNA-Based Therapeutics, Volume 372 in the International Review of Cell and Molecular Biology series, covers topics surrounding the effect of different metabolic situations, their contribution to metabolic modulation, and their impact on tumor growth. Specific chapters in this release include New era of nucleic acid therapies: Clinical applications and perspectives, Messenger RNA as personalized therapy: time of truth for rare metabolic disease, Applications of Self-Replicating RNA, mRNA therapy in PKU, Advances in gene-editing technologies, mRNA delivery technologies: towards clinical translation, Advances in mRNA vaccines, and more.

  • Tailor-Made Polysaccharides in Drug Delivery

    • 1st Edition
    • Amit Kumar Nayak + 1 more
    • English
    Tailor-Made Polysaccharides in Drug Delivery provides extensive details on all the vital precepts, basics and fundamental aspects of tailored polysaccharides in the pharmaceutical and biotechnological industry for understanding and developing high quality products. The book offers a comprehensive resource to understand the potential of the materials in forming new drug delivery methods. It will be useful to pharmaceutical scientists, chemical engineers, and regulatory scientists and students actively involved in pharmaceutical product and process development of tailored-made polysaccharides in drug delivery applications.The utilization of natural polymeric excipients in numerous healthcare applications demand the replacement of the synthetic polymers with the natural ones due to their biocompatibility, biodegradability, economic extraction and readily availability. The reality behind the rise in importance of these natural materials is that these sources are renewable if grown in a sustainable means and they can tender incessant supply of raw materials. Amongst these natural polymers, polysaccharides are considered as excellent excipients because of its non-toxic, stable, biodegradable properties. Several research innovations have been made on applications of polysaccharides in drug delivery.

  • Palm Trees and Fruits Residues

    Recent Advances for Integrated and Sustainable Management
    • 1st Edition
    • Mejdi Jeguirim + 2 more
    • English
    Palm Trees and Fruits Residues: Recent Advances for Integrated and Sustainable Management places the wastes of palm trees and fruit residues in the international context of sustainable development, providing sustainable applications that are detailed based on sector to help readers from specific fields identify applications. Furthermore, successful processing case studies using valorization are presented. As the expansion of palm tree fruit crops processing industries (manufacture of syrup, honey, non-alcoholic beverages, flours, confectionery products, fruit paste, etc.) is generating growing quantities of wastes in different forms, this book covers sustainable aspects. Written by an international team of contributors, this title is aimed at professionals and enterprises who aspire to develop real, high-scale industrial applications for palm tree and fruit residue valorization.

  • The Neurosurgical Consult Book

    • 1st Edition
    • Risheng Xu + 2 more
    • English
    Written by neurosurgery residents for neurosurgery residents and other providers, The Neurosurgical Consult Book focuses on the initial care and treatment of the neurosurgical consult patient, providing the key guidance you need when quick clinical management decisions are critical. You will learn to recognize the acuity of patient presentation and determine how to immediately triage the needs of the patient at an appropriate level of care. This portable, practical guide helps you quickly steer neurosurgical patients to medical stability and safety until a definitive treatment plan is implemented.

  • Radiation Oncology and Radiotherapy, Part A

    • 1st Edition
    • Volume 172
    • English
    Radiation Oncology and Radiotherapy, Part A, Volume 172 in the Methods in Cell Biology series, highlights advances in the field, with this new volume presenting interesting chapters on timely topics, including DNA damage quantification by the COMET assay, Immunofluorescence microscopy-assisted quantification of ATM and ATR activation in irradiated cells, Immunoblotting-based characterization of the DNA damage response, Assessment of lipid peroxidation in irradiated cells, A simple method to assess clonogenic survival of irradiated cancer cells, Quantification of beta-galactosidase activity as a marker of radiation-driven cellular senescence, Cytofluorometric assessment of cell cycle progression in irradiated cells, and more. Other sections cover Assessment of transcription inhibition as a characteristic of immunogenic cell death, Assessment of eIF2α phosphorylation during immunogenic cell death, Quantification of cytosolic DNA species by immunofluorescence and automated image analysis, Flow cytometry-assisted quantification of CALR exposure during immunogenic cell death, Interference of immunogenic anticancer therapy by artificially controlled calreticulin secretion from tumor cells, along with many additional topics of interest.

  • Advances in Food and Nutrition Research

    • 1st Edition
    • Volume 102
    • Fidel Toldra
    • English
    Advances in Food and Nutrition Research, Volume 102 provides the latest advances on the identification and characterization of emerging bioactive compounds with putative health benefits, along with up-to-date information on food science. Chapters in this new release include Stability of polyphenols in food processing, Contribution of polysaccharides from crustacean on fermented food products, Food application of pigments from extremophile microorganisms, Recent advances in the development of healthier meat products, Food proteins in blood glucose control, Milk biomarker metabolomics and its application in milk origin, safety and quality control, Food Authenticity through protein and metabolic markers, and more.

  • Neuropalliative Care

    PART I
    • 1st Edition
    • Volume 190
    • English
    Neuropalliative Care, Part One, Volume 190 covers a type of care that is given when there is no cure for the neurological disorder and the patient is in distress. It provides a scholarly background of neuropalliative care, from historic underpinnings to its practice in various geographical regions, along with best practices for specific neurological disorders. It covers the work of multi or interdisciplinary teams whose care is intended to make the patient as comfortable as possible and includes partners and families in treatment plans.

  • Beauty, Aging and AntiAging

    • 1st Edition
    • Ibrahim Vargel + 1 more
    • English
    Beauty, Aging and AntiAging covers novel and updated research and treatment options regarding the effects of aging on human physiology. Beauty perception and related molecular pathways are reviewed, along with current medical and surgical approaches to aging. The first part of the book focuses on beauty, youth, aging and its effects on the human body. In the second part, various restorative treatment approaches are reviewed in detail. Particularly, invasive treatment options and molecular pathophysiology of aging are covered in this book.

  • Neurologic Localization and Diagnosis

    • 1st Edition
    • Eli E. Zimmerman + 3 more
    • English
    Written for a wide range of neurology and non-neurology clinicians and residents, Neurologic Localization and Diagnosis: Differential Diagnosis by Complaint-Based Approach is a concise, easy-to-use guide to establishing a neurologic diagnosis. This unique learning resource uses an algorithmic, complaint-based approach to localizing the condition, developing a list of differential diagnoses, and focusing further evaluation on establishing the diagnosis. Leading neurologists provide up-to-date, practical guidance for neurology residents, medical students, and neurologists, as well as nurse practitioners, physician assistants, and non-neurology physicians.

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