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Elsevier

Books in Life sciences

  • Capsaicin, the Pungent Principle in Hot Pepper

    From Basic Pharmacology to Therapeutic Applications
    • 1st Edition
    • Arpad Szallasi
    • English
    Capsaicin, the Pungent Principle in Hot Pepper: From Basic Pharmacology to Therapeutic Applications explores capsaicin's biological and pharmacological characteristics, from its discovery and isolation to its receptor identification and antagonists. The book's structure is divided into three sections, starting with the historical development of research on capsaicin. This foundational section provides a thorough understanding of the compound's journey from a simple pungent ingredient to a significant element in pharmacological studies. The second part of the book delves into capsaicin’s biological effects and pharmacology, covering areas such as nociception, pain, salivary secretion, body temperature regulation, and blood pressure regulation.Finally, the book examines the clinical applications of capsaicin, discussing potential future developments in desensitization, pain relief, injections, effects on the tumor microenvironment, appetite control, and longevity. This book is invaluable for pharmacology researchers and clinicians in pain management and cancer, offering insights into the unique characteristics and therapeutic potential of capsaicin.

  • Encyclopedia of Cardiovascular Research and Medicine

    • 2nd Edition
    • Vasan Ramachandran S. + 1 more
    • English
    Now in its second edition, the Encyclopedia of Cardiovascular Research and Medicine is a four‑volume print and online reference that brings together the essential knowledge needed to understand the heart and vascular system. Designed for students, clinicians, researchers, and instructors, it offers clear, authoritative coverage of how the cardiovascular system develops, functions, becomes injured, and can be repaired. Because cardiovascular disease remains the world’s leading cause of death, this edition provides the up‑to‑date scientific and clinical insights needed to support research, inform care, and improve outcomes.This revised edition includes around 180 expert articles spanning cardiac development and regeneration, vascular biology, genetics and omics technologies, coronary and acute cardiac syndromes, heart failure, electrophysiology and device therapies, imaging, population health, and modern research methods. By spanning basic, clinical, and population sciences, the encyclopedia supports a wide range of users from those seeking introductory knowledge to specialists pursuing advanced expertise in cardiovascular medicine.

  • Computer-Aided Drug Design in Modern Drug Discovery

    • 1st Edition
    • Yinuo Wu + 2 more
    • English
    Computer-Aided Drug Design in Modern Drug Discovery offers an in-depth exploration of CADD, featuring real-world case studies and practical examples that empower researchers to effectively harness this technology in drug discovery and development. Exploring the intricacies of CADD, the book comprises several key chapters, beginning with an introduction to its methods and evolution that is followed by a thorough examination of the integration of artificial intelligence in drug design. Subsequent chapters cover various CADD approaches, including ligand-based, structure-based, and fragment-based design, alongside AI-driven compound generation and drug screening.The book also showcases a selection of marketed drugs developed with CADD or AI, such as Captopril, Tirofiban, and Crizotinib, providing invaluable insights into the successes and challenges faced in real-world applications. Finally, the discussion of emerging trends and future directions in CADD and AI highlights the ongoing evolution of these methodologies and their integration with traditional drug development processes.

  • Molecular Mechanisms of Spermatogenesis

    • 1st Edition
    • Volume 168
    • English
    Molecular Mechanisms of Spermatogenesis, Volume 168 provides a comprehensive overview of the molecular mechanisms that govern spermatogenesis, the complex process through which sperm cells are produced in the male testes. Sections in this new release include: From undifferentiated gonads to ovaries and testes, Molecular regulation of germ-somatic cell interactions: insights from spatial transcriptomics, All about the mammalian germline cyst, Stem cell competition, Genetic and epigenetic regulation of cell fate determination of human spermatogonial stem cells, A Sertoli Valve niche at the Terminal End of Seminiferous Tubules for Mammalian Spermatogenic Stem Cells, The formation and function of the synaptonemal complex, and more.Additional sections cover Meiotic crossover control: interplay between the recombination process and chromosome organization, Drosophila spermiogenesis, New Insights on the Biogenesis and Functional Importance of the Sperm Cytoplasmic Droplet, Asymmetric male meiosis in genetics and evolution, Current understanding of adult stem cells in Leydig cell biology, Unraveling the complexity of spermatogenesis from single-cell perspective, and much more.

  • Advances in Tablet Manufacturing Technologies

    • 1st Edition
    • Honey Goel + 2 more
    • English
    Advances in Tablet Manufacturing Technologies consolidates cutting-edge information on the latest technologies in tablet design and manufacturing, addressing the pressing need for innovation in an increasingly complex global market. The book is structured to provide a thorough understanding of tablet technology, beginning with foundational concepts and progressing through specialized topics. Key sections explore the historical context of tablet development, the significance of pharmaceutical excipients, preformulation aspects, and the physics of tablet compression. Subsequent chapters explore advanced topics, including coated tablets, modified-release formulations, organ-specific tablets, and state-of-the-art innovations like 3D printed tablets.Each chapter is enriched with practical examples and case studies, ensuring that readers can apply theoretical knowledge to real-world scenarios. With contributions from a diverse group of national and international experts, this book is an invaluable asset for scientists in academia and industry alike. It elucidates preformulation parameters, outlines regulatory frameworks, and discusses recent advances in excipient technology and in-process testing equipment.

  • Biofabrication and Synthetic Biology in Medicinal Plants

    Advances in Biotechnology and Breeding
    • 1st Edition
    • Eti Sharma + 2 more
    • English
    Biofabrication and Synthetic Biology in Medicinal Plants: Advances in Biotechnology and Breeding introduces readers to the technological advances in medicinal plants for improving plant-based bio drugs. Chapters cover various aspects of bio fabrication, synthetic biology as well as advance biotechnology- based breeding in medicinal plants. These technologies are very well explored in crop plants but not well studied in medicinal plants. Medicinal plants have enormous therapeutic compounds traditionally used in various cultures for the treatment of many diseases and health conditions. These plants produce a wide range of bioactive compounds including terpenoids, flavonoids, alkaloids and phenolic compounds which exhibit pharmacological effects on the human body. Medicinal and aromatic plant-based medicines have been used for centuries and continue to play a significant role in human healthcare. Advances in this area recently hold promise for addressing unmet medical needs, improving healthcare outcomes, and promoting sustainable approach to health and wellness of human population worldwide. Biofabrication and Synthetic Biology in Medicinal Plants: Advances in Biotechnology and Breeding is written by international experts in the field for a diverse audience of scientific researchers, early career professionals, students and experts working in the field of synthetic biology of medicinal plants.

  • Designer Crops

    Implications of Artificial Intelligence and Modern Biotechnological Methods
    • 1st Edition
    • Santosh Kumar Upadhyay
    • English
    Designer Crops: Implications of Artificial Intelligence and Modern Biotechnological Methods explores the global impact of environmental challenges and climate change on crop productivity. This comprehensive guide reveals how abiotic and biotic stresses and shifting climatic conditions have significantly affected traditional cropping systems and crop yields worldwide. This book discusses designer crops and climate-resilient and super cropping systems by applying diverse information from biotechnology, crop breeding, machine learning, and automation in agriculture. It showcases the evolution of technologies such as high-throughput genome sequencing, artificial intelligence, and precision breeding, revolutionizing crop design for enhanced disease resistance, nutritional value, and increased yields.In addition, it examines modern biotechnological tools and speed breeding strategies, offering a glimpse into the promising future of super crop development. Contributions from leading global experts on artificial intelligence in agriculture, machine learning for smart agricultural practices, and climate-resilient cropping strategies make this book a must have for upper-level undergraduate students in the fields of crop science, biotechnology, and sustainable agriculture. It will also be useful for researchers and professionals working in food technology, agricultural automation, and environmental consulting.

  • Arginase: Structure, Function, and Therapeutic Targeting

    • 1st Edition
    • Volume 740
    • English
    This volume of Methods in Enzymology, entitled “Arginase: Structure, Function, and Therapeutic Targeting,” provides a comprehensive, methodology-driven perspective on arginase research spanning molecular, biochemical, and translational domains.The volume is organized into four sections that reflect the breadth of the field, spanning structural and mechanistic enzymology, inhibitor design and therapeutic development, clinical and metabolic aspects of arginine biology, and the evolutionary and functional diversity of arginase and related enzymes. Chapters cover experimental approaches to enzyme expression, purification, and structural characterization; synthetic and computational strategies for inhibitor discovery; and emerging therapeutic modalities, including antibody-based targeting of specific arginase isoforms, advanced delivery systems, and engineered enzyme formulations.Importa... the volume extends beyond classical views of arginase as an enzyme of arginine metabolism, highlighting its broader structural and functional context within the ureohydrolase superfamily and related guanidinohydrolase enzymes, including alternative substrates, catalytic diversity, and roles in microorganisms and plants. These perspectives emphasize arginase function in nitrogen metabolism, host–pathogen interactions, and environmental and physiological adaptation.By integrating contributions from both academia and industry, this volume emphasizes reproducible methodologies and provides a cohesive “from enzyme to organism” framework, connecting fundamental structure–function relationships with applications in metabolism, vascular biology, and therapeutic development.

  • Técnicas en histología y biología celular

    • 3rd Edition
    • Luis Montuenga Badía + 2 more
    • Spanish
    Esta nueva edición de Técnicas en histología y biología celular, completamente actualizada, desarrolla de modo asequible los fundamentos teóricos y metodológicos de las técnicas más relevantes en histología y biología celular, incluyendo aquellas técnicas de biología molecular relacionadas con ambas disciplinas. Presenta los fundamentos de las diversas metodologías a estudiantes del ámbito de las ciencias biológicas, la bioquímica y la biomedicina, así como a técnicos de anatomía patológica y otros profesionales biosanitarios que deseen conocer estas técnicas con un abordaje avanzado. Asimismo, proporciona a los investigadores, técnicos o clínicos que se inician en el campo del laboratorio o la investigación biológica y biomédica la información necesaria para introducirse con seguridad en el ámbito del análisis microscópico y la biología celular, incluidas sus bases moleculares. Incluye capítulos sobre procesamiento y tinción de las muestras; inmunolocalización; hibridación in situ de ácidos nucleicos; cultivo de tejidos; técnicas multiómicas; microscopía confocal, electrónica y de fuerza atómica; análisis de imagen; ingeniería tisular, etc. Así mismo, la nueva edición presenta numerosas imágenes originales y esquemas que ilustran los conceptos básicos y muestran ejemplos prácticos del uso de las diversas técnicas. Ofrece acceso a la versión digital del libro a travésde https://online.vital... con nuevos recursos didácticos asociados a cada uno de los temas, incluyendo actividades y casos prácticos, preguntas de autoevaluación, imágenes complementarias, bibliografía adicional y enlaces de interés.

  • Food and Consumer Behavior

    A Comprehensive Reference
    • 1st Edition
    • Herbert L. Meiselman
    • English
    What and how we eat has big implications for our health, our society and the environment. Therefore, it is crucial that we understand what people eat, the reasons why people eat the way they do, and how we can best change food consumer practices. Food is the biggest business in the world, but until recently the emphasis has been on food science and technology (the food product) and not on the food consumer. But there has been a lot of progress in the past 10-20 years on consumer research for foods. There is currently no reference that pulls together these developments. Food and Consumer Behavior: A Comprehensive Reference will emphasise methods for studying consumer responses to foods. The book will also emphasise cross-cultural approaches to studying consumer food behaviour, with the goal of extending the field to all parts of the globe, including Asia and Africa.

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