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Elsevier

Books in Life sciences

  • Body-on-a-Chip

    Essentials and Applications
    • 1st Edition
    • Anthony Atala + 1 more
    • English
    Body-on-a-Chip: Essentials and Applications provides the reader high-quality information, in a single resource, that is necessary to explore the use of BOC systems from design and development to testing and personalized medicine, to medical research and diagnostics. BOC systems can recapitulate native tissue/ organ architecture, diffusion kinetics of drugs physiological flow conditions etc., similar to what would happen in the body, they are particularly powerful in predicting human efficacy prior to clinical testing of a drug, determining potential toxicity, or in clinical studies to test underlying mechanisms or action or adverse effects. With recent advancements in high-throughput analysis systems and artificial intelligence, it has also become possible to screen several drugs at a time.

  • Glial Mechanisms in Sleep and Circadian Biology

    • 1st Edition
    • Marcos G. Frank
    • English
    Glial Mechanisms in Sleep and Circadian Biology presents a comprehensive and up-to-date discussion of the role of glial cells in numerous, often unexpected, aspects of sleep. It seamlessly links glial cell activity to the multi-system processes that affect sleep. Experts in the field discuss how glial cells influence the sleep-wake cycle, the accumulation and discharge of sleep drive, the timing of sleep and wake across the 24-hour day, and how glial cells may govern important sleep functions (e.g., brain plasticity and metabolism). This is a book that could well change scientists’ and practitioners’ traditional beliefs about the factors underlying sleep.Users will find the book's content at the forefront of one of the hottest topics in basic sleep research. Over the last decade, scientists have made breakthrough discoveries revealing that sleep is not only a product of neurons, but of neuronal-glial interactions.

  • Critical Care in Pregnant Patients

    Ultrasound
    • 1st Edition
    • Jorge Hidalgo + 3 more
    • English
    Critical Care in Pregnant Patients: Ultrasound, a volume in the Critical Care Obstetrics series, is a novel reference to educate physicians, nurses, and all allied healthcare personnel caring for pregnant women with various health compromises. The book's chapters reflect the growing scope of critical care obstetrics and the increasing importance and recognition of the hospital structure's field. All intensivists, regardless of primary discipline, must possess a core set of critical care skills to manage critically ill patients. The book's authors have gathered the best evidence-based material explicitly focused on how ultrasound can successfully manage potential scenarios of common and rare health complications. Users will find the basics of ultrasound and the latest technological advances of ultrasound that foster research and improve health outcomes in pregnant patients.

  • Agricultural Pollination

    The Role of Beneficial Insects in Food Security and Sustainability
    • 1st Edition
    • Habib Ali
    • English
    Agricultural Pollination: The Role of Beneficial Insects in Food Security and Sustainability delves into the intricate relationship between farming and pollinators, as well as other beneficial insects, examining the ways in which their ecological roles can improve crop health and yield, ultimately bolstering food security without environmentally harmful chemical interventions. The book begins with coverage of foundational topics, such as types of key pollinators and their behaviors, and moves into more practical topics, such as creating pollinator-friendly landscapes and emerging technologies in pollination services.Taking a multidisciplinary approach, the book also covers conservation strategies, economic impacts of pollinators, policy recommendations, and community engagement. This timely reference will offer invaluable insights for researchers, students, agricultural industry professionals, and policymakers alike, contributing to the advancement of environmentally-frie... and economically viable agricultural practices.

  • Investigative and Predictive Forensic Microbiology

    • 1st Edition
    • Hirak Ranjan Dash
    • English
    Investigative and Predictive Forensic Microbiology showcases the latest advancements in microbial technology for forensic applications, covering a wide range of topics in forensic microbiology. Sections explore human normal microflora, cover classical methods of analyzing microbes, discuss microbial tools in forensic medicine that address post-mortem analysis, and delve into microbial biomarkers for estimating time of death. Investigative microbiology topics include analyzing body fluids, geolocation prediction using microbes, ancient microbial DNA analysis, biodefense, and emerging infections.The book's final section focuses on challenges and future approaches, covering statistical interpretation of data, regulatory considerations, and ethical implications of forensic microbiology. With contributions from renowned experts in the field, this book is a comprehensive resource for researchers and practitioners in microbiology, genetics, forensic science, and for law enforcement professionals and advanced students.

  • Molecular Targets and Therapeutic Design

    • 1st Edition
    • Volume 153
    • English
    Molecular Targets and Therapeutic Design, Volume 152 provides a comprehensive overview of the current landscape and future directions in the identification and exploitation of molecular targets for the development of new therapeutics. This volume brings together leading experts to discuss the fundamental principles of target discovery, validation, and the strategies used to design molecules that modulate biological pathways in disease. Topics covered in this new release include Recent Strategies and Approaches for the Development of Molecularly Targeted Nanomedicine, Transcriptomic Profiling for Therapeutic Target Discovery in Neuropsychiatric Conditions, Transcriptomic Insights into Hormone-Driven Malignancies: Toward Targeted Therapeutic Strategies, and much more.Additional chapters cover Targeting Kinases in Neurodegenerative Diseases and Cancer: Structural Insights and Therapeutic Strategies, Small molecular therapeutic targets for neurodegenerative diseases, Signaling cascades of Tau protein, Understanding molecular role of lipids for Alzheimer's disease, Clinical Challenges and Therapeutic Strategies in Chordoma, Molecular Characterization and Experimental Models of Chordoma, Disordered Proteins as Fuzzy Viral Drug Targets, amongst other timely topics.

  • An Authoritative Guide to Chronic Pediatric Abdominal Pain

    Pathophysiology, Diagnosis and Management
    • 1st Edition
    • Miguel Saps + 1 more
    • English
    An Authoritative Guide to Chronic Pediatric Abdominal Pain: Pathophysiology, Diagnosis and Management provides a comprehensive and extensive overview of all aspects relevant to the care of children with abdominal pain. It includes chapters tailored to each discipline, level of training, and primary interest (clinical or research), covering daily practice, diagnosis, testing, conventional and complementary treatments, interdisciplinary care, and the transition to adult gastroenterology treatment. The book critically updates the evidence behind these methods and prepares readers to understand more advanced techniques. Topics include early adverse life events, intestinal permeability, visceral hypersensitivity, sex differences, microbiome infections, use of antibiotics, and the microbiome.Informati... on clinical perspectives and management in the emergency department helps inform pediatricians, gastroenterologists, residents, fellows, and nurse practitioners about the scientific basis for prior workups, differential diagnoses, and the rationale behind them. In addition, this book helps clinicians understand the basic research behind these factors, how they influence pathophysiology, clinical presentation, progression, and outcomes.

  • Apolipoprotein E in Health and Disease

    Unravelling its Intricate Roles
    • 1st Edition
    • Dileep Kumar + 2 more
    • English
    Apolipoprotein E in Health and Disease: Unravelling its Intricate Roles delves into the multifaceted functions of Apolipoprotein E (ApoE) across various health conditions and diseases. This comprehensive volume offers an in-depth exploration of ApoE, illuminating its structural insights, functional significance, and genetic variability. Each chapter examines the role of ApoE in different disease contexts, including cardiovascular diseases, Alzheimer's disease, neurological disorders, metabolic syndrome, liver health, cancer, and inflammatory disorders. Key chapters investigate ApoE's impact on lipid metabolism, atherosclerosis, and heart health while also probing its involvement in genetic predispositions and mechanistic implications in Alzheimer's disease. In addition, the book extends its exploration to the broader influence of ApoE on cognitive decline and other neurological conditions, metabolic health, liver function, cancer risk, and immune modulation. With a strong focus on the pharmacogenetics of ApoE, the book paves the way for precision medicine, offering insights into how ApoE genotypes influence medication responses and therapeutic strategies. Future prospects and challenges in harnessing ApoE for disease management are discussed, alongside its role in infectious diseases, genetic engineering innovations, and targeted drug delivery systems.

  • Applying Artificial Intelligence to Computational Biology and Medical Informatics

    • 1st Edition
    • Mohammad Sufian Badar
    • English
    Applying Artificial Intelligence to Computational Biology and Medical Informatics explores the transformative role of AI and machine learning in modern biomedical research and healthcare. The book covers foundational concepts in AI/ML, computational biology, and medical informatics, followed by in-depth chapters on medical imaging, network biology, chemoinformatics, and public health. Other sections address ethical and societal implications, interpretable AI, and real-world case studies, making complex topics accessible through clear language and structured content. Designed for early-career researchers, students, and professionals without prior expertise in computer science or health sciences, this book provides a progressive learning path from basic to intermediate levels.Readers benefit from practical examples, online resources, and a coherent chapter structure that supports both academic study and applied research.

  • Protein Misfolding and Human Diseases

    Deciphering the Central Role of Pathological Aggregation
    • 1st Edition
    • Pranav Kumar Prabhakar + 2 more
    • English
    Protein Misfolding and Human Diseases: Deciphering the Central Role of Pathological Aggregation investigates the misfolding of proteins and implications for a variety of debilitating conditions. The book comprehensively overviews pathological protein aggregation, exploring its mechanisms in specific illnesses, including Alzheimer's disease, Parkinson’s disease, Huntington’s disease, prion diseases, ALS, and systemic amyloidosis. It addresses disrupted cellular pathways and failures in protein homeostasis during aging, delineating the unifying principles across protein conformational disorders. Sections feature structural insights into protein aggregates from amyloid fibrils to inclusion bodies and offer therapeutic strategies to disrupt aggregation pathways, enhance cellular protein quality control, and provide immunotherapy solutions.Finally, the book closes with a discussion of the latest advances in research and considerations for future directions to combat protein aggregation. It will serve as an invaluable reference on the intricacies of protein misfolding and its clinical implications. Researchers, academics and graduate students working across these fields will benefit from this comprehensive guide. Additionally, clinicians and healthcare professionals will find it invaluable for understanding the molecular basis of protein misfolding disorders.

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