Computational Biomechanics of Human Joints delves deep into each joint, covering the anatomical, mechanical, pathological, and therapeutic aspects. Each chapter is dedicated to a specific joint, providing an in-depth understanding of its anatomical structure, biomechanical mechanisms, associated diseases and pathologies, available treatments, surgical interventions, as well as imaging-based modelling and numerical simulation techniques using the finite element method. By integrating modelling and numerical simulation techniques into the exploration of joint biomechanics, this book offers readers an innovative perspective and a thorough understanding of the possibilities afforded by these technological advances. It also highlights the advantages and limitations of these methods and discusses their potential to improve clinical decision-making, optimize personalized treatments, design medical devices, and enhance understanding of the intricate mechanisms of joints.
Quantum Health AI: The Revolution of Medicine, Public Health, and Global Health is the first comprehensive book defining the transformation of the global health ecosystem by the fusion of our most powerful technologies—quantum computing and artificial intelligence—while defending an actionable human-centred approach to doing so responsibly, equitably, and sustainably. We can continue to watch wars, diseases, poverty, polarization, cyber-crime, and climate change only worsen. Our strongest technologies can remain centralized in a small number of companies and countries for their profit and power. Or we can cooperatively put quantum AI to work for the health of all of us, by better managing this technology’s overarching strategic competition between democracies and autocracies, along with the public and private sectors (balancing human security with national security, economic growth with household livelihoods, individual rights with the common good). This book draws on the decade plus of original research and first-hand perspective of the world’s first triple doctorate-trained physician-data scientist and AI ethicist. It unpacks the history, science, values, and political economics framing and driving quantum AI (including its physics, metaphysics, ethics, governance, computing, sensing, communication, materials, and security), the global health ecosystem (healthcare systems, public health agencies, biotechnology companies, and development institutions), and their growing integration, wins, and challenges. This one-stop book provides a global, inclusive, and practical guide for understanding and shaping these societal and technological trends. It thus empowers health, technology, and policy students, practitioners, professionals, researchers, and leaders in organizations, universities, companies, and governments—ultimately to make and maintain the human-centred quantum AI safeguarding and advancing humanity’s health, home, and future.
Biomarkers in Kidney Transplantation: Clinical Aspects and Laboratory Determination provides a focused study on traditional and emerging biomarkers to predict early rejection of kidney transplants supporting appropriate therapeutic interventions. Coverage includes predictive and diagnostic biomarkers for different types of rejections, including biomarkers of acute, chronic/sub chronic rejection or clinical rejection, T-cell mediated rejection, antibody mediated rejection and mixed rejection. Comparisons are provided for broad classification of pharmacokinetic versus pharmacodynamic biomarkers, and differentiation is shown between the susceptibility, diagnostic, predictive, prognostic and monitoring biomarkers.Coverage of the analytical aspects of biomarker measurement, the process of biomarker discovery and their clinical validation addresses both the clinical features of biomarkers as well as the pitfalls of determining such biomarkers in clinical laboratories. By combining all current markers known for kidney transplant in one collection, this easy-to-use reference is perfect for pathologists, clinical pharmacologists, clinical laboratory scientists and all physicians involved in organ transplantation, including immunologists and transplant surgeons.
Flow Cytometry in Immuno-oncology, Volume 173 in the Methods in Cell Biology series, highlights advances in the field, with this new volume presenting interesting chapters on timely topics, Basic principles of Flow cytometry in immuno-oncology, Good practice and methods for flow cytometry in immuno-oncology, Automated flow cytometry in immuno-oncology, Flow cytometric analysis of Tregs in solid tumors, Multiparametric analysis of Tumor infiltrating lymphocytes in solid tumors, Analysis of tumor-infiltrating immune cells in intracranial glioblastoma, Assessing chromosomal abnormalities in leukemias by Imaging flow cytometry, Flow cytometric analysis of cellular alkaline phosphatase in acute myeloid leukemia, and much more.
Glycobiology of the Immune System and Disease explores the integration of state-of-the-art glycobiology and immunology to raise awareness of the multifaceted roles of glycans and lectins in the immune system. Glycobiology is a rapidly growing field in biology, with relevance to biomedicine, biotechnology and basic research. Considering the central role that glycans play in immune interactions, glycoproteins and carbohydrates are becoming the targets of next-generation therapeutics, vaccines and diagnostics. Programmed remodeling of host glycans can modulate infection, autoimmunity, and cancer, while microbial glycoconjugates can serve as canonical innate receptor agonists that induce B cell and T cell activation.This important reference investigates microbial and mammalian glycans and their protein-binding partners (lectins) and shows the role they play in all innate and adaptive immune responses. With its comprehensive overview of the field, this is an important resource for academicians, graduate and post graduate students as well as professors and faculty in the field of research in glycobiology and immunology.
Kidney Development and Regeneration, Volume 163 provides an up-to-date account of kidney development, congenital disease and regeneration. It has an emphasis on areas of the field that have been moving most quickly over the last few years, and that show potential for further rapid discovery. Each chapter is written by leading researchers, and their approaches range from genetics to cell biology to pharmacology to physiology to pathology to mathematical modeling. The volume is essential reading for those working on renal development, regeneration or pathology, and also those researching related aspects in similar organs.
The Vaccine Book: New Insights, Approaches and Technologies, Third Edition provides comprehensive information on the current and future world of vaccines. It reveals the scientific opportunities and potential impact of vaccines, including economic and ethical challenges, problems encountered when producing vaccines, how clinical vaccine trials are designed, and how to introduce vaccines into widespread use. Although vaccines are now available for many diseases, there are still challenges ahead for major diseases such as AIDS, tuberculosis, and malaria. Edited by a new, highly experienced team of editors, the 3rd edition provides new approaches, design, and vaccine platform tools to develop vaccines quicker.This new edition is fully updated and designed for students, researchers, public health offcials, and all others interested in increasing their understanding of vaccines.
Cordyceps Fungus: Scientific Discoveries and Health Products provides a systematic and comprehensive description of the process technology, product quality and beneficial functions, and underlying scientific background of cordyceps. The book covers the development of knowledge and technology in related areas, such as polysaccharides as major bioactive ingredients, biological characteristics, chemical composition and bioactivities, traditional uses and mycelial fermentation of cordyceps sinensis, besides analysis and characterization, bioactivity assessment, anti-inflammation activity, and conclusions and future perspectives of cordyceps fungus.Written by world-leading authorities in the area, this book serves not only as a valuable reference for this special and valuable fungal species, but also for other medicinal fungi.
Primer Design, Volume 57 in the Methods in Microbiology series, highlights new advances in the field, with this new volume presenting interesting chapters on topics such as Methods on discriminating between bacterial strains, Primers to PCR and qPCR techniques, and more.