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Books in Life sciences

  • Animal Models of Disease Part E

    • 1st Edition
    • Volume 203
    • English
    Animal Models of Disease, Part E, Volume 203 in the Methods in Cell Biology series presents significant advancements in understanding disease mechanisms through animal models. This volume features chapters on timely topics such as characterizing tumor-infiltrating group 1 innate lymphoid cells in PyMT breast tumors and using zebrafish to unravel the molecular mechanisms of Alzheimer’s disease. The book also covers colitis mouse models and appropriate models for studying diabetes pathophysiology, demonstrating its comprehensive approach to current research.Additional sections cover evaluating polyglutamine protein aggregation in transgenic Caenorhabditis elegans models of Huntington's disease and studying tumor responses to radioimmunotherapy in ovarian cancer models. It also highlights the antimicrobial regime for gut microbiota depletion in mice and the biodistribution of metallic nanoparticles for lymphoma studies. This book is an essential resource for researchers seeking to explore disease mechanisms and therapeutic approaches through animal models.
  • Vaccinology and Immunizations

    • 1st Edition
    • Jahangir Moini + 2 more
    • English
    Vaccinology and Immunizations is a thorough resource on the immune system, the history of vaccines, vaccine preparation, the process of vaccine approval, and the prevention and eradication of diseases. It also includes chapters on vaccine safety and errors, and complete information on pediatric and adult immunizations. There is also discussion on elderly immunology and immunization for people who are seeking to travel abroad, as well as timely information about COVID-19.Its focus on the innate and adaptive defense systems of the body will ensure understanding of human immunity and how immunizations are effective. There is a variety of available titles related to vaccinology and immunizations, but many are now outdated. Vaccinology and Immunizations provides a new, updated resource that is widely needed, and will be welcomed by students of undergraduate, graduate and master level in vaccinology or immunology, and would also be of interest to nurses, researchers, and pharmacists.
  • Basic Principles of Drug Discovery and Development

    • 3rd Edition
    • Benjamin E. Blass
    • English
    Basic Principles of Drug Discovery and Development, Third Edition presents a unique overview of the drug discovery and development program not available elsewhere. Each chapter provides sufficient technical details on the topics covered so that non-experts will have the tools and information necessary to interact and exchange information with colleagues across the entire spectrum of the drug discovery and development process. The drug discovery and development process involves individuals and teams with a wide array of expertise ranging from basic sciences (medicinal chemistry, biology) to applied science (pharmacology, pharmacokinetics, clinical sciences) to business driven fields (regulatory affairs, intellectual property experts, marketing specialists).The success or failure of a program focused on bringing a new medication to market often depends on clear communication between individuals and teams with vastly different expertise. As a result, it is critical that experts in one aspect of drug discovery and development (e.g., medicinal chemists) have a working understanding of the wide range of disciplines that take part in the overall process.
  • Stress: Psychopathology and Psychiatry

    • 1st Edition
    • George Fink
    • English
  • Cybersecurity for Healthcare Systems in the Internet of Medical Things Era

    • 1st Edition
    • Janmenjoy Nayak + 2 more
    • English
    Cybersecurity for Healthcare Systems in the Internet of Medical Things Era is driven by the imperative to address the intricate convergence of healthcare, technology, and security. In response to the burgeoning challenges presented by the Internet of Medical Things (IoMT), this book is designed to be an indispensable resource for computer systems experts, healthcare staff, and executives. It goes beyond the surface, offering strategic insights and actionable strategies that encompass not only the IoMT landscape but also the intersection of artificial intelligence, signal processing, and cyber security. Cybersecurity for Healthcare Systems in the IoMT Era serves as a problem-solving compass for a diverse readership in the healthcare landscape. For healthcare professionals and IT leaders, the book untangles the complexities of integrating and securing Internet of Medical Things (IoMT) devices, offering a roadmap for understanding and navigating this rapidly evolving terrain. Biomedical engineers, burdened with strategic and everyday decisions, find in this book strategic insights and actionable strategies, empowering them to make informed choices amidst the ever-changing challenges posed by technology and cybersecurity threats. The authors present a comprehensive guide that not only elucidates the challenges and opportunities presented by IoMT but also explores how the synergy of AI and signal processing can elevate healthcare systems. This integration is crucial in deciphering the intricate nuances of medical data, enhancing diagnostics, and fortifying the security of interconnected healthcare networks.
  • PACAP

    From Discovery to Function
    • 1st Edition
    • David Vaudry + 1 more
    • English
    PACAP: From Discovery to Function in Health and Disease serves as a comprehensive review covering all aspects of PACAP and its receptors, from expression to function in healthy tissues and disease models. The book introduces the biochemical, pharmacological and signaling properties of PACAP before exploring the biological actions of PACAP in normal health and pathological conditions. It considers PACAP in relation to various aspects, including pain, stress, brain injury, tumor cells and neurodegenerative disease. Effect on peripheral organs is also covered, from the gastrointestinal tract and cardiovascular system to immune cells and bones, among others. Therapeutic potential is also explored. This is a volume in the Molecular Mediators in Health and Disease book series, and provides a complete analysis of PACAP and the latest research in the field. Thus it is an ideal guide for researchers interested in PACAP and its impact across health and disease.
  • Natural Language Processing for Healthcare

    The Rise of Intelligent Assistants
    • 1st Edition
    • Laxmi Shaw + 2 more
    • English
    Natural Language Processing for Healthcare: The Rise of Intelligent Assistants addresses the critical gap between cutting-edge AI research and its practical application in healthcare, offering an accessible yet comprehensive guide tailored to the unique challenges of medical environments. It highlights how NLP technologies are revolutionizing patient care, medical documentation, and clinical decision-making, while emphasizing ethical, legal, and interoperability considerations. Structured into four sections, the book begins by laying foundational knowledge in NLP and healthcare data, covering crucial concepts such as tokenization, medical ontologies like UMLS and SNOMED CT, machine learning models including BioBERT and ClinicalBERT, and the emerging impact of large language models like GPT. The applications section explores real-world implementations of intelligent assistants, such as virtual health chatbots, clinical documentation tools, conversational AI for patient engagement, and voice recognition integrated into electronic health records. Technical chapters provide insights into system architectures, evaluation metrics, data privacy, security, and interoperability standards like FHIR. The final section looks ahead to future directions including multilingual NLP, federated learning for privacy preservation, and the evolving landscape of AI-driven healthcare assistants. This book is an indispensable resource for a broad audience. Healthcare professionals and clinicians will find practical insights into streamlining patient care and diagnostics. Biomedical researchers and data scientists can deepen their understanding of NLP methods tailored to medical data. Students, educators, technology developers, and healthcare administrators alike will benefit from the book’s balanced coverage of theory, implementation, and regulation, empowering them to innovate and responsibly deploy intelligent assistants that enhance healthcare delivery worldwide.
  • Seldin and Giebisch's The Kidney

    Physiology and Pathophysiology
    • 6th Edition
    • Robert J. Alpern + 3 more
    • English
    Seldin and Giebisch’s The Kidney: Physiology and Pathophysiology, Sixth Edition provides a common language for nephrology researchers, fellows, and practicing nephrologists to discuss normal and abnormal renal physiology and the development and diagnosis of a wide range of renal diseases. Guided by a team of four distinguished authorities in nephrology, experts from all areas of renal research and practice take readers from the structure and function of the normal kidney, to the specific cellular and molecular mechanisms underlying disease development, and into the management of renal disease through physiologic regulation. This classic nephrology reference for nearly 30 years combines basic and clinical sciences that provides authoritative, concise, and readily accessible information. Academic, medical, and pharma researchers save valuable time by quickly accessing the very latest details on renal physiology and pathophysiology as opposed to searching through thousands of journal articles.
  • Laboratory Animal Medicine

    • 4th Edition
    • James G. Fox + 4 more
    • English
    Laboratory Animal Medicine, Fourth Edition—a volume in the American College of Laboratory Animal Medicine (ACLAM) blue book series—is the authoritative reference on the biology, health, and care for species involved in research. Edited by recognized veterinary, operational, and research experts and endorsed as the official material for veterinary specialty certification by ACLAM, this work defines the standard for all aspects of humane laboratory animal care and science with animal models.This new edition contains significant changes in content and organization to reflect the evolution of the field. The animal welfare chapter has been moved to the beginning of the book to highlight this subject’s importance. Other chapters have either been consolidated to encourage the reader to recognize commonalities such as those between guinea pigs, gerbils and hamsters, or separated out in recognition of expansions in knowledge and cross-species complexity as illustrated by separate new and old world primate chapters. Advances in practice, technology, and knowledge are highlighted in the chapters on genetically modified organisms, with updates on new techniques in genetic engineering and consideration of non-rodent genetically modified models; microbiological monitoring, with an increased emphasis on environmental monitoring and sentinel free colony health monitoring methods; regulatory compliance, with a comprehensive chapter on birds; employee health and safety, with expanded consideration of compassion fatigue; and animal models in biomedical research, with increased emphasis on experimental design and rigor. New chapters on animal models for microbiome, infectious disease, and transplant research have been added to serve as a reference for the community.This book is an excellent reference for veterinarians and research scientists, as well as program directors and facility managers employed in a variety of academic and corporate settings. This edition continues the tradition of this text in setting standards for the research animal science community as well as expanding and updating relevant and essential topics for this specialty field.
  • Retinoic Acids in Cancer Therapy

    Mechanisms of Sensitivity, Resistance, and Methods of Delivery
    • 1st Edition
    • Volume 23
    • Saeid Ghavami + 2 more
    • English
    Retinoic Acids in Cancer Therapy: Mechanisms of Sensitivity, Resistance, and Methods of Delivery, Volume 21 offers a detailed exploration of how All Trans Retinoic Acid (ATRA) functions to kill cancer cells, as well as the survival mechanisms of certain cells when treated with this drug. This comprehensive book delves into the specific cell pathways and compartments that are involved in the action of retinoic acids (RAs) in inhibiting cell proliferation across various cancers, providing invaluable insights for continued research and improved therapeutic approaches in oncology.The book comprises 16 chapters that address the molecular structure and biological properties of ATRA, elucidate the mechanisms of resistance to ATRA, and evaluate its efficiency in treating seven different cancers. Additionally, it discusses strategies to enhance ATRA cancer treatment and offers future perspectives on its applications. As a vital resource for health professionals, researchers, and students alike, this volume aims to expand the collective understanding of ATRA's therapeutic potential and inspire the development of new, more effective cancer treatments.