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Elsevier

Books in Life sciences

  • Chromatin Signaling and Diseases

    • 2nd Edition
    • Olivier Binda + 2 more
    • English
    Chromatin Signaling and Diseases, Second Edition, a volume in the Translational Epigenetics series, covers the molecular mechanisms that regulate gene expression, which governs embryonic development, growth, and human pathologies associated with aging, such as cancer. Although human genome sequencing continues to improve, molecular mechanisms regulating gene expression remain largely misunderstood. The impact of gene expression defects associated with malfunctioning chromatin signaling are considered in this update. In addition, this new edition has addresses developments in the field, from phase separation of membrane-less organelles and local segregation of factors to chromatinization of naked foreign DNA and cancer evolution as regulated by chromatin signaling.Chromatin signaling proposes that small protein domains recognize chemical modifications on the genome scaffolding histone proteins, facilitating the nucleation of enzymatic complexes at specific loci that then open up or shut down the access to genetic information, thereby regulating gene expression. The addition and removal of chemical modifications on histones, as well as the proteins that specifically recognize these are also considered.

  • Snake Venom and Human Health

    Translating Nature’s Toxins into Therapeutics
    • 1st Edition
    • Subir Chandra Dasgupta + 2 more
    • English
    Snake Venom and Human Health: Translating Nature’s Toxins into Therapeutics offers a detailed exploration of the burgeoning field of venom-derived therapeutics. As biomedical research continues to uncover potential applications of snake venom, this book serves as an essential resource that bridges fundamental science and clinical application and examines how these potent biological substances are being transformed into innovative treatments for a wide array of health conditions, including cancer, infectious and parasitic diseases, cardiovascular issues, neurodegenerative disorders, diabetes, and autoimmune diseases. Starting with an overview of venom classification and structural insights, the book is organized into detailed chapters that cover the biochemical basis of snake venom, its therapeutic applications, and the emerging technologies supporting its development. Subsequent chapters explore specific medical applications—from anticancer and antimicrobial therapies to treatments for cardiovascular, neurological, dermatological, and metabolic disorders. It goes on to explore innovative topics as well as the regulatory and sustainability issues and ongoing challenges—such as safety concerns, ethical considerations, and scalability that surrounding venom research.Enriched by contributions from international experts in the field, Snake Venom and Human Health aims to provide researchers, clinicians, and industry professionals a thorough understanding of both the scientific foundations and the translational aspects of venom-based therapeutics.

  • Mitochondrial Intoxication

    • 2nd Edition
    • Marcos Roberto de Oliveira
    • English
    Mitochondrial Intoxication, Second Edition, offers a comprehensive and fully updated exploration of the impact of toxic molecules on mitochondrial physiology and the diseases that result from their dysfunction. Divided into three sections, the book opens with a detailed overview of mitochondrial physiology, molecular markers of mitochondrial intoxication, and challenges of mitochondrial profiling during pre-clinical studies. The book then focuses on endogenous toxicants and their impact on mitochondria, including new chapters on lipids, glucose and microbiota-derived toxicants. Amyloid-β peptide and its impact on mitochondrial dysfunction is also a new addition to this book, as well as inflammation-induced mitochondrial intoxication.The final section explores exogenous toxicants, such as pollutants, food additives, illicit and pharmaceutical drugs, pesticides, and heavy metals. The effects of micro- and nanoplastics on mitochondrial function are newly covered. Furthermore, the latest computational tools in mitochondrial toxicity research are investigated. Incorporating the latest advances in the field, this new release offers cutting-edge insights on mitochondrial toxicity, serving as an invaluable resource for researchers and advanced students in cell biology, molecular biology, toxicology, biochemistry, pharmacology, and related fields.

  • Antimicrobial Resistance, Sepsis, and the Invisible Threats to Women’s Health

    • 1st Edition
    • Uzma Syed + 1 more
    • English
    Antimicrobial Resistance, Sepsis, and the Invisible Threats to Women’s Health focuses on the burden of antimicrobial resistance (AMR) and sepsis on women's health, providing the latest information to educate both global researchers and healthcare professionals. The book begins by introducing the fundamental concepts of antimicrobial resistance and sepsis, setting the stage for a deeper exploration of their impact on women's health. It examines the epidemiology of sepsis and antimicrobial resistance in women, highlighting key risk factors, research gaps, reproductive health, antimicrobial resistance, and sepsis in detail, and further emphasizing their disproportionate impact on women's health.Additional coverage includes strategies for recruiting women in clinical trials and research studies, exploring the One Health approach integrating women's health into the broader context of AMR and sepsis and the role of artificial intelligence and technology in combating AMR and sepsis. The book concludes with case studies of female patients and their families affected by AMR and sepsis.

  • Memory Loss, Alzheimer's Disease, and Dementia

    A Practical Guide for Clinicians
    • 4th Edition
    • Andrew E. Budson + 1 more
    • English
    An essential, practical guide for neurologists, psychiatrists, geriatricians, and others who work with the elderly, Memory Loss, Alzheimer's Disease, and Dementia: A Practical Guide for Clinicians, 4th Edition, provides up-to-date information on detection, diagnosis, and treatment—including recent, significant medical advancements, drug therapies, and research. Drs. Andrew E. Budson and Paul R. Solomon focus on the day-to-day tools clinicians need, thoroughly covering the essentials of physical and cognitive examinations plus laboratory and imaging studies for dementia and related illnesses. This fully revised edition is particularly timely in a field that is experiencing tremendous progress and change in numerous areas, and contains authoritative, real-world guidance to help you make accurate diagnosis and treatment decisions with confidence.

  • Analytics and Laboratory Testing Protocols for Halal Food and Non-Food Products

    • 1st Edition
    • Syed Ghulam Musharraf
    • English
    Analytics and Laboratory Testing Protocols for Halal Food and Non-Food Products is a comprehensive exploration of the diverse field of Halal research and laboratory testing that dives into the scientific advancements necessary for ensuring compliance with Halal standards. The book introduces readers to methodologies and technologies used in laboratory testing, equipping them with the knowledge needed to adopt best practices and ensure compliance with Halal standards. It offers guidance on quality assurance measures and testing protocols, enabling readers to uphold the highest standards of Halal authenticity and enhance consumer confidence and brand reputation.This is an essential resource for graduate students and researchers in food sciences, analytical chemistry, and pharmaceutical sciences who want to check non-Halal ingredients and stay up-to-date with the latest developments in Halal assurance and quality control.

  • Resource Evaluation and Deep Processing of Edible Insects

    • 1st Edition
    • Jun Wang + 1 more
    • English
    Resource Evaluation and Deep Processing of Edible Insects: Silk peptide and protein for advanced applications presents the latest progress in the processing, analysis, and application of edible insect resources, mainly focusing on the resource evaluation and deep processing methods to retrieve valuable products from the constituents of the by-products of edible insects. The book combines discursive chapters that bring the latest in resource evaluation, with discussions on novel extraction techniques, biological approaches, microbial transformations, green chemistry and microfluidic technologies. It also covers analytical and biological systems, step-by-step and readily reproducible biological and chemical protocols for analyzing edible insect resources.Edible insect resources as raw materials for the food industry for sustainability are also outlined in this book. These techniques support the latest progress in cross-disciplinary research that integrates the different scales of biotechnological and biological complexity. Edited by a team of experts in the field, this book is an excellent resource for researchers with a background in biotechnology, biological and chemical engineering, agriculture, and food chemistry, and covers a broad range of topics in agriculture sustainability and food production.

  • Nonchicken Poultry Production

    • 1st Edition
    • Caven Mguvane Mnisi + 2 more
    • English
    Non-chicken Poultry Production focuses on the modern production of non-chicken poultry birds as alternatives to diversify animal protein options and complement conventional chicken production. The book offers a general review of the sustainable production of non-chicken birds followed by nutritional considerations for each bird of interest. Various strategies to improve the nutrition, welfare, and health of the birds are covered, with an emphasis on long-term economic viability and sustainability. It ultimately examines the future outlook for establishing long-term, sustainable production systems, helping aid academic and industry researchers meet the demand of growing populations and contributing to global food security.Demand for chicken and eggs has surged with population growth, rising income levels, and urbanization. Meeting the demand has proved a challenge for farmers and other stakeholders.

  • Thiamine, Thiamine Pyrophosphate and Thiamine Pyrophosphate-Dependent Enzymes Part B

    • 1st Edition
    • Volume 736
    • English
    Thiamine Pyrophosphate (TPP)-Dependent Enzymes, Volume 736 in the Methods in Enzymology series covers this diverse group of ubiquitous enzymes with timely chapters on Methods for Studying ThDP-dependent Mycobacterial MenDs (SEPHCHC Synthases), Mammalian 2-hydroxyacyl-CoA lyases, discovery and assays, Anti-infective target 1-deoxy-d-xylulose-5... synthase (DXS) and drug design for enzyme inhibition, Expression, Purification, and Mechanistic Studies of DXP synthases from Deinococcus radiodurans, Plasmodium falciparum, and Plasmodium vivax, Comparison of the catalysis of ThPP-dependent enzymes AHAS, ALS, and DXS, and much more.Additional sections cover Plant and fungal acetohydroxyacid synthases (AHAS): Methods for heterologous expression, kinetic characterization, and structural analysis, Biochemical and Structural characterization of novel ‘split-gene’ archeal transketolases, 4-Hydroxybenzoylform... decarboxylase enzymes from Rhodococcus jostii RHA1 and Pseudomonas fluorescens Pf-5: characterization and involvement in bacterial lignin degradation, Engineering of phosphoketolase from Bifidobacterium adolescentis for increased activity on non-phosphorylated substrates and application in a cell-free reaction system for ATP regeneration, Repurposing TPP-dependent enzymes with anodic oxidation for the conversion of aldehydes to enantioenriched carboxylic acids, and much more.

  • Laser Polarization and Autofluorescence Imaging for Biomedical and Clinical Applications

    • 1st Edition
    • Alexander Ushenko
    • English
    Laser Polarization and Autofluorescence Imaging for Biomedical and Clinical Applications addresses the cutting-edge research area of laser and autofluorescence polarimetric visualization combined with sophisticated multi-algorithm digital analysis. The book’s content spans ten detailed sections, covering fundamental theories of Mueller-matrix polarimetry, azimuth-invariant mapping methods, advanced Fourier and wavelet transformations, singular analysis, laser-induced autofluorescence polarimetry, and biomedical system architectures. It culminates with clinical application examples demonstrating early diagnostics of malignancies, type 2 diabetes, albuminuria, cholelithiasis, septic conditions, and forensic determinations such as cause and time of death.This reference offers significant benefits to researchers, biomedical engineers, and medical data analysts by delivering a pioneering synthesis of the latest theoretical concepts and multifunctional digital imaging methods. It equips the audience with objective, highly sensitive digital markers essential for accurate, rapid preclinical diagnostics, thereby advancing precision medicine and evidence-based clinical practice in biomedical optics.

  • Foundations of Antiviral Research and African Ethnomedicinal Knowledge

    • 1st Edition
    • Volume 120
    • English
    Advances in Botanical Research series, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.

  • Moving Toward Nonanimal Approaches in Medical Research and Testing

    • 1st Edition
    • Gail A. Van Norman + 1 more
    • English
    Moving Toward Nonanimal Approaches in Medical Research and Testing pioneers a single-source guide for researchers regarding nonanimal research tools and methodologies and their many advantages and applications in place of animals. This book is presented in three parts: historical, ethical, legislative, and scientific contexts on the need to shift away from animal-based research and testing; the latest advances in nonanimal tools and methods for biomedical research and testing of human therapeutics and other compounds, including microphysiological systems, bioprinting, biobanks, and artificial intelligence; and achieving a practical shift toward these powerful approaches, including advocacy for legal, regulatory, and policy change, securing funding for nonanimal studies, and how to overcome bias against nonanimal methods. This book, primarily directed to researchers in biomedicine, human medical therapeutics, and toxicology, will also appeal to researchers in industry, providing overview and insights about the latest applications of nonanimal research tools and methods for product development and testing. Clinicians who wish to understand the reliability of testing therapeutics with nonanimal versus animal methods, as well as advocacy groups seeking an up-to-date understanding of ethical, economic, political, and scientific considerations in moving toward nonanimal approaches, will also find significant value in this text. Finally, legislators and those involved in regulatory review and oversight will benefit from this single comprehensive source for developing a basic understanding of nonanimal research and human safety.

  • Threats to Pollinator Abundance and Diversity

    • 1st Edition
    • Scott A. Elias
    • English
    Threats to Pollinator Abundance and Diversity, the first release in the Pollinators in Peril series, covers the latest research on insect pollinators, the threats to their survival, declining populations, and what conservation actions should be taken. The book demonstrates that most threats to pollinators are either directly or indirectly human-caused, such as chemicals, land alteration, and habitat loss due to agricultural practices, as well as climate change and its many ripple effects. Covering everything from honeybee pathogens to butterfly range changes, this book covers concepts that are both crucial for researchers in entomology, upper-level students, governmental and non-governmental organizations, and adjacent fields.Pollinating insects are among the most crucial species groups on earth. Without them, much of the earth’s vegetation would not survive and the elaborate ecosystems they sustain would collapse. Today, pollinator declines have reached critical levels in most regions of the world.

  • Beer and Brewing

    Current Advances and Future Outlook
    • 1st Edition
    • Charles W. Bamforth
    • English
    Beer and Brewing: Current Advances and Future Outlook addresses key changes and challenges facing breweries today, and with an eye to the future. The book offers the latest in scientific research and technology for novel methods and ingredients, such as genetically modified yeasts. In response to the climate crisis and consumer demand for sustainable products, information on brewing process changes for lower waste and reduced impact will also be covered. Due to shifting consumer preferences, new product types such as spiked cider, low-alcohol, and alcohol-free beers will be discussed in addition to traditional beer.Edited by a true pillar of the field, the book approaches brewing on the basis of driving forces that are impacting the industry now and into the future. Researchers interested in applied brewing science, skilled small-scale brewers and other industry stakeholders will gain invaluable insight from Dr. Bamforth's latest work.

  • Nutritional Strategies, Predictive Models, and Sustainable Policies

    • 1st Edition
    • Sandeep K. Panda + 2 more
    • English
    Nutritional Strategies, Predictive Models, and Sustainable Policies brings together scientists, professors, and policymakers from over 10 countries to cover strategies and approaches to improve human health by focusing on the nutritional needs of children, pregnant women, and patients from around the world. Sections cover existing policies in specific geographical areas, critical reviews on the scientific updates of maternal, pediatric, and geriatric nutrition and how the Pandemic disrupted nutritional strategies, review predictive models on different nutrition categories for certain diseases and cancers, and highlight international and regional policies related to nutrition in war affected countries.

  • Nutraceutical Applications in Food Processing and Preservation

    • 1st Edition
    • M. Anuradha + 1 more
    • English
    Nutraceutical Applications in Food Processing and Preservation addresses the urgent need for healthier and safer food processing methods by integrating nutraceuticals as natural alternatives to conventional additives. The book explores the intersection of food science, nutrition, and biotechnology to seek innovative solutions to enhance food safety and nutritional value amid rising consumer health consciousness. The contents encompass an in-depth analysis of food additives and their evolution, a detailed coverage of various nutraceutical types such as phytochemicals and probiotics, and practical applications across beverages, snacks, dairy, bakery, and meat alternatives.The book also includes case studies that showcase successful nutraceutical substitutions, discussions on regulatory compliance, sustainability, and market trends that affect product development and food safety. By providing regulatory insights, scientific advancements, and consumer trend analyses, this reference fosters the creation of safer, health-promoting food products. It will equip food scientists, technologists, product developers, and academic researchers with actionable knowledge to innovate and improve food processing practices.

  • Conceptual Breakthroughs in Comparative Animal Physiology

    • 1st Edition
    • James Hicks + 1 more
    • English
    Conceptual Breakthroughs in Comparative Animal Physiology tells a story of innate human curiosity about the natural world, and a deeply creative discipline, shaped by varied environments, unusual organisms, elegant experiments, and the persistent effort to understand how animals work and why they work the way they do—along the way discovering “adaptations and mechanisms of the most surprising character”.Written by two leading experts in the field, each chapter reflects on the origins of ideas and the approach of turning natural diversity into experimental design. From deserts to oceans, from the anoxia-tolerant animals to endothermic insects, from deep-diving mammals to the integration of “omics,” each chapter follows the discoveries and people who were compelled to modify their view of “what life can do.” The chapters also highlight the long-term influence of key conceptual breakthroughs, demonstrating how insights from comparative physiology have shaped not only the field itself but also, ecology, evolution, and engineering.As scientists strive to understand the complexity of living systems, the book underscores the inherent integrative nature of comparative physiology, revealing a process that strives to connect genes to organisms and organisms to environments, and providing a framework for understanding the diversity of life. This is an essential resource for undergraduates, graduate students and researchers interested in physiology with its comprehensive synopsis on the field’s foundational history and significant advances.

  • Advances in Marine Biology

    • 1st Edition
    • Volume 104
    • English
    Advances in Marine Biology, Volume 104, the latest release in this serial that highlights new advances in the field, includes comprehensive chapters written by an international board of authors. Chapters in this new release explore Integrative Fish Biomechanics and Advancing marine invertebrate biodiversity in South Africa: Addressing gaps in taxonomy and genetic knowledge.

  • Step-by-step Approach to the Radiological Evaluation of Arthritis, 12-Month Access, eBook

    • 1st Edition
    • Muthusamy Chandramohan + 1 more
    • English

  • Utilities in the Food Factories

    Unit Operations and Processing Equipment in the Food Industry
    • 1st Edition
    • Seid Mahdi Jafari + 1 more
    • English
    Utilities in the Food Factories: Unit Operations and Processing Equipment in the Food Industry, a volume in the Unit Operations and Processing Equipment in the Food Industry series, explains the processing operations and equipment necessary for utilities within food production factories. These processes and unit operations are very important in terms of providing enough resources for production lines. The book's chapters analyze, in detail, the importance of food industry utilities, such as boilers, compressors, electricity generators, refrigeration systems, water and wastewater treatment facilities, cleaning in place (CIP), automation and control, fire extinguishing and emergency, Lightening, Aeration, ventilation, and air conditioning systems. Written by experts in the field of food engineering, in a simple and dynamic way, this book targets industrial Engineers working in the field of food processing and within food factories to make them more familiar with the particular food processing operations and equipment. It will serve as a single reference summarizing the utilities in the industrial sector.

  • Biochemical, Physiological, and Molecular Aspects of Human Nutrition

    • 5th Edition
    • Martha H. Stipanuk + 5 more
    • English
    Gain a complete understanding of nutrition’s role in health and disease! With its comprehensive, easy-to-read format, Biochemical, Physiological, and Molecular Aspects of Human Nutrition, 5th Edition, provides clear, concise coverage of advanced nutrition concepts at the molecular, cellular, tissue, and whole-body levels. Written by a team of nutrition experts, this edition address nutrients by classification, and describes macronutrient function from digestion to metabolism. Fully updated artwork and new features such as bolded summary headings and additional boxes and tables enhance readability and present new research and findings in an easily digestible format.

  • Zero-Waste Technologies in Aquaculture

    Global Perspectives and Methods toward a Circular Economy
    • 1st Edition
    • Soibam Khogen Singh + 3 more
    • English
    Zero-Waste Technologies in Aquaculture: Global Perspectives and Methods toward a Circular Economy addresses the crucial aspects of waste management, available strategies for attaining a circular economy, and novel technologies to improve the sustainability of the aquaculture industry. As global demand for fish and fish products grows, commercial aquaculture operations must optimize resource utilization and reduce environmental impacts to ensure sustainable scaleup. This book discusses promising technologies like biofloc, aquaponics, recirculating aquaculture systems, integrated multi-trophic aquaculture, microbial fermentation, insect-mediated bioconversion, and algal-based waste utilization. Written and edited by a diverse team of experts, Zero-Waste Technologies in Aquaculture bridges disciplines in aquaculture, biology, and environmental engineering. It opens by addressing the recent history, significance, and challenges of global aquaculture expansion to provide context for these diverse audiences. Subsequent chapters explore proven, novel, and emerging technologies for wastewater treatment, solid waste recovery and valorization, and sustainable, environmentally conscious system scaleup. This is an essential read for aquaculturists, aquatic biologists, environmental scientists, and those interested in the economics of fish production.

  • Blood-Based Biomarkers for Alzheimer's and Parkinson's Disease – Part A

    • 1st Edition
    • Volume 191
    • English
    Blood-Based Biomarkers for Alzheimer’s and Parkinson’s Disease, Volume 191 in the International Review of Neurobiology series, presents current advances and comprehensive reviews on the development and application of circulating biomarkers in neurodegenerative disorders. It brings together contributions from an international panel, highlighting emerging strategies for early detection, diagnosis, and monitoring of Alzheimer’s and Parkinson’s diseases. Chapters explore a wide range of topics, including the Diagnostic Potential of Exosomes in Neurodegenerative Diseases and Cancer, Blood Biomarkers of Oxidative Stress and Mitochondrial Dysfunction in Alzheimer’s and Parkinson’s Diseases, GFAP and the Genetic Code of Astrocyte Activation in Alzheimer’s Disease, and much more.Additional chapters cover Blood-Based Emerging Biomarkers in Early Detection and Diagnosis of Alzheimer’s Disease, Advances in Nanomaterial-Based Biomarker Detection for Neurodegenerative Diseases, Blood-Based Biomarkers in Alzheimer’s and Parkinson’s Disease: From Molecular Pathology to Therapeutic Potential, Blood-Based Biomarkers and Their Role in AD/PD Diagnosis, The Emerging Landscape of Circulatory Biomarkers in Alzheimer’s Disease, Biofluid-Based Biosensors, Biomarkers of Vascular Dementia and Alzheimer’s Disease, Silent Clues in Blood: Proteomic Approach for Alzheimer’s Disease, and more.

  • Advances in Virus Research

    • 1st Edition
    • Volume 125
    • English
    Advances in Virus Research, Volume 125 in this ongoing series, highlights new advances in the field, with this new volume presenting interesting chapters surrounding online resource hubs for modeling viruses/databases to support virology communities

  • Biological Fluid–Mediated Transport Mechanisms for Targeted Drug Delivery in Next-Generation Cancer Immunotherapy

    • 1st Edition
    • Khemraj Deshmukh + 3 more
    • English
    Biological Fluid-Mediated Transport Mechanisms for Targeted Drug Delivery in Next-Generation Cancer Immunotherapy addresses the critical need for innovative therapeutic platforms that improve efficacy and reduce toxicity in cancer treatment. The volume explores how natural biofluids and derived carriers, like exosomes and extracellular vesicles, can serve as highly biocompatible vehicles for delivering immunotherapeutics. It emphasizes their roles in overcoming barriers such as immune evasion, rapid clearance, and systemic side effects, while also leveraging biofluid signatures for real-time diagnostics through liquid biopsies. The book encompasses topics from the composition and biomolecular content of biofluids to the engineering strategies for functionalization, targeting, and controlled release, integrating cutting-edge nanotechnologies and microfluidics.This reference book supports the advancement of next-generation precision cancer immunotherapies by providing insights into biofluid dynamics, bioresponsive carriers, and personalized approaches. It bridges basic science with translational potential, fostering innovation in nanomedicine, immunology, and biomedical engineering, and aims to accelerate the clinical impact of biofluid-inspired drug delivery systems.

  • Pharmacological Foundations of Parkinson’s Disease

    From Mechanisms to Clinical Practice
    • 1st Edition
    • Wael Mohamed
    • English
    Pharmacological Foundations of Parkinson's Disease: From Mechanisms to Clinical Practice provides a comprehensive guide on the pharmacological treatment of Parkinson's Disease, offering students and clinicians a combination of foundational knowledge and advanced clinical insights. The book bridges theoretical concepts with real-world clinical scenarios and equips readers with the tools necessary to effectively manage Parkinson's Disease in practice. Offering a detailed review of symptoms, treatment gaps, and emerging therapies, this book delves into the pathogenesis the disease, along with dopaminergic treatments and management of motor and non-motor symptoms.Providing updates on emerging therapies, including innovative treatment approaches, this book serves as a valuable reference for continuous learning and staying current with evolving practices and research in Parkinson's Disease management.

  • Navigating Health Research

    From Fundamentals to Advanced Practices in Biostatistics and Study Design
    • 1st Edition
    • Aliaa Rehan Youssef + 3 more
    • English
    Navigating Health Research: From Fundamentals to Advanced Practices in Biostatistics and Study Design is an essential resource for students, scientists, and clinicians embarking on their research journeys. This book clarifies research methodology and regulation while providing foundational knowledge in biostatistics through clear explanations and illustrative examples. Covering both classical and modern advancements in health research, it addresses topics such as health economics, artificial intelligence, and bioinformatics. The book offers a step-by-step guide through the research lifecycle, tackling challenges like study design flaws and ethical compliance. Emphasizing open-source software and freely available resources, it ensures accessibility for researchers from diverse socioeconomic backgrounds. With a multi-generational and multicultural perspective, this book enhances its relevance for a broad audience. By simplifying complex topics and promoting best practices, it empowers early-career researchers and clinicians to improve their skills, elevate the quality of their work, and contribute meaningfully to evidence-based practice in health research.

  • The Matrix Metalloproteinases

    • 1st Edition
    • Volume 60
    • English
    The Matrix Metalloproteinases, Volume 60 in The Enzymes series, explores recent advances in the study of matrix metalloproteinases (MMPs), a critical family of enzymes involved in extracellular matrix remodeling and numerous physiological and pathological processes. This volume presents a comprehensive collection of chapters covering key aspects of MMP biology, including their structure, function, regulation, and detection through activity-based probes.Chapters in this release examine classical and selective MMP inhibitors, including specific targeting strategies for MMP-13, as well as the role of endogenous tissue inhibitors of metalloproteinases. Additional contributions explore the involvement of MMPs in various biological and disease contexts, including oral diseases, neurodegenerative disorders, neutrophil biology, and cancer progression.The volume also addresses current challenges and opportunities in the design of MMP-targeted therapeutics, highlighting advances in drug development and pharmacological applications. Together, these chapters provide valuable insights into the biochemical, physiological, and clinical significance of MMPs, making this volume an essential reference for researchers in enzymology, biochemistry, molecular biology, and biomedical sciences.

  • Carrier-Free Enzyme Immobilization

    Fundamentals and Innovations in Biocatalysis
    • 1st Edition
    • Mehdi Mohammadi + 1 more
    • English
    Carrier-Free Enzyme Immobilization: Fundamentals and Innovations in Biocatalysis explores innovative techniques for immobilizing enzymes without the use of inert carriers, highlighting their advantages, applications, and integration into modern biocatalytic processes. The book begins by introducing the concept of enzyme immobilization and the transition from traditional carrier-bound methods to innovative carrier-free techniques. It discusses the fundamental principles behind carrier-free immobilization, including the types of cross-linkers used and the advantages in enhancing enzyme stability and activity. The book also covers various methods for the structural characterization of carrier-free immobilized enzymes.With a strong focus on practical implementation, it examines the applications of carrier-free immobilized enzymes across different industries, highlighting the pros and cons of the method. It explores novel approaches for producing carrier-free immobilized biocatalysts and provides a comparative analysis of carrier-free versus traditional carrier-bound immobilization techniques. The book also addresses the challenges associated with implementing carrier-free immobilization in industrial processes and proposes potential solutions to overcome these obstacles. It is an essential resource for biochemists, chemical engineers, and researchers in biotechnology who are involved in enzyme research and development.

  • Autophagy – Part C

    • 1st Edition
    • Volume 406
    • English
    Autophagy, Part C, Volume 406 dives cellular housekeeping, weaving together the mechanistic precision of modern biology with the larger questions of health, aging, and resilience. Building on the foundations laid in Parts A and B, this book takes the reader from the microscopic machinery inside a single cell to the sweeping implications for organisms, ecosystems, and medicine. Chapters cover Lysosomal Function and Homeostasis: From Cellular Adaptation to Disease Pathogenesis, Autophagy Meets Plant Virology: From Molecular Crosstalk to Outstanding Challenges, Impact of mitophagy on obesity-affected tissues, Autophagy in Endothelial Cells: a gatekeeper of immune cell trafficking and function, and much more.Additional sections cover Viral Trafficking: The Role of Autophagy in the Release of Virus-Loaded Extracellular Vesicles and Sex matters in macroautophagy: sex-driven differences in autophagic function in aging and aging related-diseases.

  • Microbial Biofilms and Cancer - Part A

    • 1st Edition
    • Volume 224
    • English
    Microbial Biofilms and Cancer - Part A provides a comprehensive and multidisciplinary exploration of the emerging biological connection between microbial biofilms, chronic infection, genetic instability, and cancer development and progression. Moving beyond the traditional perception of biofilms as merely microbial communities associated with antimicrobial resistance, the book examines biofilms as dynamic biological ecosystems capable of influencing host signaling, immune responses, genome stability, epigenetic regulation, cellular metabolism, and oncogenic processes.The opening chapters establish the molecular and genetic foundations of biofilm-associated carcinogenesis. The role of horizontal gene transfer within biofilms and its potential oncogenic consequences is examined alongside genetic profiling of biofilm-associated cancers. Particular emphasis is placed on the signaling pathways that may be hijacked by biofilms and the epigenetic mechanisms governing biofilm biology and host–microbe interactions. The book further explores how biofilms can modulate antitumor immunity and contribute to cancer progression, while genetic instability and biofilm-driven mutations are considered as potential mechanisms linking persistent microbial colonization with malignant transformation.A further dimension of the book focuses on the therapeutic and translational potential of biofilm biology. Bacterial metabolites are examined as emerging sources of anticancer molecules and as potential tools for developing innovative cancer chemotherapeutics. At the same time, the book critically addresses the dual nature of biofilms, considering their potential applications alongside associated biological risks, environmental consequences, biosafety concerns, and legal challenges.The latter part of the book introduces an emerging AI- and nanotechnology-enabl... paradigm for infection–cancer surveillance and diagnostics. Advanced nanostructured biosensors, AI-assisted multiplexed platforms, metaheuristic optimization, and integrated surveillance technologies are presented as approaches for simultaneous detection and monitoring of infectious and cancer-associated biomarkers. The application of AI to wastewater surveillance further expands the discussion toward a One Health framework, connecting environmental pathogen monitoring with potential cancer-risk assessment.The final contribution integrates genomics, metagenomics, and artificial intelligence to investigate infection-associated genomic signatures in Bacteroides fragilis, demonstrating how multi-omics and computational approaches can facilitate biomarker discovery and improve understanding of infection–cancer relationships.Collec... the book brings together microbiology, molecular oncology, genomics, epigenetics, immunology, metabolomics, nanotechnology, biosensing, artificial intelligence, environmental surveillance, and One Health. It provides an integrated perspective on the emerging biofilm–infection–ca... axis, highlighting both fundamental mechanisms and opportunities for diagnosis, prevention and therapeutic intervention.The book is intended for researchers, academicians, clinicians, biotechnologists, microbiologists, cancer biologists, bioinformaticians, nanotechnologists, environmental scientists, and advanced postgraduate students interested in the rapidly evolving interface between microbial biology and cancer.

  • Thiamine and Thiamine-Pyrophosphate (TPP) Riboswitches

    • 1st Edition
    • Volume 735
    • English
    Thiamine and Thiamine-Pyrophospha... (TPP) Riboswitches is devoted to the cofactor thiamine, also known as vitamin B1, and its phosphorylated derivatives. The biosynthesis of thiamine is discussed in terms of key enzymes and their regulation, the evolution of metabolic pathways, and its importance in plant and yeast metabolism. The importance of quantifying and distinguishing between phosphorylated and unphosphorylated thiamine in animal and human tissues using chromatographic, enzymatic, and nanopore methods is also discussed. In addition to these methods, thiamine riboswitches are a major focus of this book, covering everything from their identification in plants and the elucidation of their structure to their application in detection.This book presents state-of-the-art methods and detailed protocols intended for all researchers interested in thiamine metabolism or its detection.

  • Advances in Agronomy

    • 1st Edition
    • Volume 200
    • English
    Advances in Agronomy, Volume 200, the latest release in this leading reference on agronomy, contains a variety of updates and highlights new advances in the field, each written by an international board of authors.

  • The Handbook of Autobiographical Memory

    From Basic to Applied Perspectives
    • 1st Edition
    • Mohamad El Haj + 2 more
    • English
    The Handbook of Autobiographical Memory: From Basic to Applied Perspectives offers a comprehensive view on autobiographical memory from a multidisciplinary approach. The book explores contemporary advances in understanding both cognitive and neural processes, including historical contexts on autobiographical memory theory and assessment. The book further synthesizes insights from cognitive, developmental, and social aspects of autobiographical functioning while also covering departures from norms in terms of autobiographical memory dysfunction. A section on applications equips readers with essential information regarding the assessment and detection of autobiographical memory dysfunction in neurological and psychiatric populations. How such processes evolve over the lifespan, and how deviations from healthy memory function can be supported through novel rehabilitation practices are also covered.

  • Molecular Insights into Proteinopathies

    Increased Scope from Neurodegeneration to other Pathologies of the Brain
    • 1st Edition
    • Eva Žerovnik + 1 more
    • English
    Molecular Insights into Proteinopathies: Increased Scope from Neurodegeneration to other Pathologies of the Brain investigates the molecular events that lead to various diseases. The book is divided into four parts, the first of which delves into protein aggregation across a range of diseases, including Alzheimer’s disease, Parkinson’s disease, schizophrenia, and neuropsychiatric diseases. It then moves on to discuss signaling pathways and biomarkers of disease, including oxidative stress, mitochondrial decline, and dysregulated molecular pathways. The third part explores small molecules as modulators of key processes in the pathogenesis of proteinopathies, including antioxidants, polyphenol compounds, metal chelators, and repurposed drugs that modulate proteinopathies.The final section considers biophysical methods, molecular dynamics, and machine learning approaches in the study of these aspects. The book provides a detailed overview of protein dysfunction and its implications for health and disease, aiding understanding of protein condensates and aggregates, protein misfolding, co-chaperoning and toxicity of pre-amyloid aggregates. By understanding the fundamental properties underlying these, the book paves the way for investigating how proteinopathies could be treated.

  • Bioplastics for Food Packaging

    Materials, Procedures, and Applications
    • 1st Edition
    • Mehran Ghasemlou + 1 more
    • English
    Bioplastics for Food Packaging: Materials, Procedures, and Applications offers a comprehensive overview of the fundamentals and recent developments in the field of bioplastics tailored specifically for food packaging applications. Covering critical topics such as the environmental impact of plastic waste and the regulatory landscape driving the adoption of bioplastics in the food industry, this book discusses the unique benefits and drawbacks associated with different types of bioplastics. It explores practical applications of bioplastic flexible films, containers, coatings, and more, and showcases real-world success stories and industry insights.This is a valuable reference for those looking to understand the application of bioplastics in the food industry and stay updated on the latest trends and innovations in bioplastics for food packaging purposes.

  • Sugarcane Research: From Molecular Insights to Field Applications

    • 1st Edition
    • Volume 119
    • English
    Advances in Sugarcane Research: From Molecular Insights to Field Applications presents a comprehensive and integrative overview of contemporary sugarcane science, bridging fundamental discoveries with crop modeling and climate change. As one of the world’s most important crops for sugar and bioenergy production.This volume brings together leading experts to explore advances across multiple scales of research—from genomics, molecular biology, and genetic improvement to plant physiology, stress responses, and crop management. Emerging approaches such as omics technologies, artificial intelligence, and functional genomics are addressed as a way to transform sugarcane breeding and accelerating the development of climate-resilient cultivars. In addition to molecular and physiological perspectives, the book addresses key aspects of agronomy, including plant nutrition, soil constraints, root system dynamics, and sustainable management practices. Special attention is given to abiotic stresses such as drought and ozone, as well as their underlying mechanisms and implications for sugarcane growth. The integration of crop modeling and agrometeorology further provides tools for predicting crop performance and supporting decision-making under limiting environmental conditions. Overall, this volume aims to serve as a key reference for understanding current progress and future directions in sugarcane research.

  • International Review of Neurobiology

    • 1st Edition
    • Volume 190
    • English
    International Review of Neurobiology, Volume 190 highlights new advances in the field, with this volume presenting an in-depth chapter on imaging the glymphatic system in Huntington’s disease. This contribution explores the benefits of multimodal imaging approaches and their clinical implications, offering insights into disease mechanisms and potential diagnostic strategies.This volume provides a focused and up-to-date perspective on neurobiological research, serving as a valuable resource for researchers and clinicians interested in neurodegenerative disorders and advanced imaging techniques.

  • Alternative Proteins

    • 1st Edition
    • Volume 154
    • English
    Alternative Proteins, Volume 154 provides a comprehensive overview of alternative proteins, exploring their sources, production technologies, nutritional profiles, and potential to transform the global food system. Covering plant-based, microbial, insect, and cultured (cell-based) proteins, the book examines the scientific advances, market trends, regulatory challenges, and sustainability implications of these innovative protein sources. Chapters in this new release include Introduction to Alternative Proteins, Molecular Properties of Plant-Based Proteins for Alternative Proteins, The Science of Alternative Proteins: Comparing Animal and Plant-Based Sources, Blue Proteins: Marine-Derived Alternatives for Sustainable Nutrition and Climate-Resilient Food Systems, and much more. Additional sections cover Insect Proteins for Alternative Proteins: Sustainable Solutions with Molecular Efficiency, Plant-Based Proteins: Key Sources and Production Methods, Fungal proteins as Eco-friendly Alternate Proteins, Algae and Microbial Proteins for Alternative Proteins: Untapped Molecular Resources, Integrating Siddha Dietary Principles with Alternative Protein Systems: A Pathway Toward Sustainable and Functional Nutrition, Alternative Proteins: Structure and Functional Properties, and a variety of extensive and timely topics.

  • Evaluating Oral Probiotics and Prebiotics

    • 1st Edition
    • Amir M. Mortazavian + 2 more
    • English
    Evaluating Oral Probiotics and Prebiotics reviews emerging applications of new probiotic strains, postbiotics, and production of key synbiotic generations. The book discusses successes and failures of viable probiotic ingestion, new trends and strains including genetically engineered probiotics, assessment of nonviable probiotics (postbiotics) and microflora benefits of prebiotic and synbiotic ingestion over probiotics.

  • Microbial Exopolysaccharides

    An Integrated Approach to Green Applications
    • 1st Edition
    • Onkar Nath Tiwari + 2 more
    • English
    Microbial Exopolysaccharides: An Integrated Approach to Green Applications provides a comprehensive overview of natural exopolysaccharides (EPS) obtained from different microbial species and marine resources. Featuring contributions by an interdisciplinary group of experts in academia, research, and industry, this book offers a detailed introduction and exploration of natural microbial exopolysaccharides. It offers detailed discussions on topics such as the extraction and characterization of EPS, their role in health-promoting formulations and probiotic potential, their utilization in therapeutics, their use in food technologies and packaging, and their impact in the environmental and medical sectors.The book offers in-depth insights into the principles of EPS and their wide range of applications as sustainable solutions to challenges in the food, health, environmental, and biotechnology sectors.With a focus on green technology and sustainable practices, this book offers cost-effective utilization of natural EPS, their application in diverse sectors, and serves as an informative resource for those interested in the innovative application of natural bio-macromolecules.

  • Advancing Sustainable Agriculture Through Arbuscular Mycorrhizal Fungi

    • 1st Edition
    • Allah Ditta + 2 more
    • English
    Advancing Sustainable Agriculture Through Arbuscular Mycorrhizal Fungi provides a comprehensive view of AMF-focused approaches that support biodiversity, ecosystem services, and soil health. The book addresses the topic from the basis of symbiosis to the latest research and future directions of AMF use in agriculture. It provides a thorough overview of the role that AM fungi play in promoting agricultural sustainability and synthesizes current knowledge on the biology, ecology, and applications of AM fungi in sustainable agriculture, highlighting best practices for promoting AM fungi in agricultural ecosystems, such as crop selection, soil management, and fertilizer use. In addition, the book identifies research gaps and priorities for the advancement of the understanding of AM fungi in sustainable agriculture. Among the major issues confronting agriculture are soil erosion, water shortages, climate change, and dwindling biodiversity. In response to these issues, the need for sustainable farming methods that support ecosystem services, biodiversity, and soil health is rising. As the soil microbiome is largely composed of arbuscular mycorrhizal (AM) fungi, which are essential for preserving soil health and encouraging plant development, this book is a welcomed resource.

  • Advances in Parasitology

    • 1st Edition
    • Volume 134
    • English
    Advances in Parasitology series, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.

  • Modeling of Unit Operations in the Food Industry

    Unit Operations and Processing Equipment in the Food Industry
    • 1st Edition
    • Seid Mahdi Jafari + 1 more
    • English
    Modeling of Unit Operations in the Food Industry: Unit Operations and Processing Equipment in the Food Industry, a volume in the Unit Operations and Processing Equipment in the Food Industry series, explains the fundamentals and techniques necessary for modelling of different food processing operations, including heat transfer and thermal food processes, non-thermal food processes, mass transfer food processes, and other operations.All the chapters emphasize basic texts relating to experimental, theoretical, computational, and/or applications of food engineering principles and the relevant modelling techniques, such as the modelling of drying, frying, baking, sterilization, evaporation, extraction, high pressure, radio frequency, and many more.Written by experts in the field of food engineering, in a simple and dynamic way, this book targets industrial Engineers working in the field of food processing and within food factories to make them more familiar with the food processing operations and equipment.

  • Pharmacological Approaches in Cancer Treatment

    A Comprehensive Guide
    • 1st Edition
    • Sadhna Aggarwal + 1 more
    • English
    Pharmacological Approaches in Cancer Treatment: A Comprehensive Guide presents an in-depth exploration of pharmacological approaches utilized in cancer treatment. The book's overarching theme revolves around understanding the intricate mechanisms and applications of various therapies, ranging from targeted treatments to immunotherapies. Through examination and analysis, the content sheds light on emerging trends and breakthroughs in the field, providing a comprehensive overview of cancer pharmacology. Sections target therapies, chemotherapy agents, immunotherapy, personalized medicine, combination therapies, drug resistance, novel drug delivery systems, palliative care in oncology, adverse effects of cancer pharmacotherapy, and preclinical studies.Each chapter provides the nuances of its respective subject matter, providing readers with a thorough understanding of the scientific underpinnings and practical applications of cancer pharmacology. Designed to cater to both oncology professionals and patients, this book serves as a valuable resource for enhancing understanding and informing treatment decisions.

  • Nanotechnology in Photosynthesis

    Innovations for Global Food Sustainability
    • 1st Edition
    • Vishnu D. Rajput + 1 more
    • English
    Nanotechnology in Photosynthesis: Innovations for Global Food Sustainability explores how cutting-edge nanotechnology can revolutionize agriculture to combat rising food insecurity. This book highlights the urgent need for innovative solutions that combine nanoscale science with natural photosynthesis to enhance crop resilience, efficiency, and resource use, thus ensuring a sustainable food future. The volume covers key topics such as the fundamentals of nanotechnology, nanoscale transformations in plants, nanoparticle-based nutrient delivery, and engineered nanomaterials that boost photosynthesis. It also discusses environmental, ethical and policy considerations, along with real-world applications and future prospects for climate-resilient crops.Designed for scientists, policymakers, and agricultural practitioners, this book demonstrates how tiny technological advances can significantly impact food production. By illustrating the potential of nanotechnology to improve crop yields and sustainability, it aims to inspire collective efforts toward a resilient, food-secure world.

  • Nitric Oxide in Plant Resilience to Abiotic Stress

    • 1st Edition
    • Ravi Gupta + 2 more
    • English
    Nitric Oxide in Plant Resilience to Abiotic Stress offers a detailed examination of this essential gasotransmitter’s pivotal role in bolstering plant defenses against environmental stressors. Part of the Plant Gasotransmitters and Molecules with Hormonal Activity series, the volume investigates the molecular mechanisms of nitric oxide (NO) biosynthesis and signaling, emphasizing how post-translational modifications like S-nitrosylation and tyrosine nitration govern key targets to activate adaptive stress responses. It systematically examines NO’s properties, detection techniques, and its regulation under both optimal and adverse conditions, providing a comprehensive understanding of how it modulates plant functions.Expanding beyond fundamental processes, the volume highlights NO’s crucial involvement across a spectrum of abiotic stresses—drought, salinity, temperature extremes, heavy metals, and UV radiation—unveiling its capacity to mitigate damage and strengthen plant resilience. It also discusses the crosstalk between NO and other signaling molecules, such as phytohormones and emerging growth regulators, revealing synergistic pathways that underpin sustainable agriculture.Designed for researchers, advanced students, and plant scientists worldwide, this work illuminates the potential of NO to drive innovations in breeding strategies, enabling crop improvement to overcome the challenges posed by a changing climate and expanding environmental pressures.

  • Exploring Health Benefits of Phenolic Compounds in Food By-Products and Functional Foods

    • 1st Edition
    • Abdur Rauf + 1 more
    • English
    Exploring Health Benefits of Phenolic Compounds in Food By-Products and Functional Foods investigates the diverse sources of bioactive compounds found in various foods and their physiological effects on the human body. This comprehensive volume emphasizes the chemical structures that maximize nutritional benefits, offering insights into how different phenolic compounds can improve health and manage diseases. From fruits and vegetables to marine sources and microbial fermentation, this book highlights new developments in phenolic compounds and functional food research.The book also delves into the functional attributes of ingredients like mushrooms and pomegranates, exploring the potential of flavonoids and antibacterial agents in certain fruits and vegetables to promote healing and overall health. Chapter authors discuss the role of bioactive compounds in areas such as weight management, gut health, sports nutrition, cardiovascular health, and more.

  • Erythropoiesis/Hematopoiesis

    • 1st Edition
    • Volume 170
    • English
    Erythropoiesis/Hemat... Volume 170 provides a comprehensive overview of erythropoiesis and hematopoiesis—the processes by which blood cells are formed, developed, and maintained in the body. The book covers the molecular, cellular, and physiological mechanisms that regulate the formation of red blood cells (erythropoiesis) and all other blood cell lineages (hematopoiesis), including stem cell biology, signaling pathways, and genetic regulation. Timely chapters in this new release include Ribosomal RNA transcription in normal and leukemic hematopoiesis, Regulation of erythroid development by iron metabolism, Mediator at the Helm: Coordinating Transcription and Biomolecular Condensates in Hematopoiesis, and much more.Additional chapters explore Cell fate decision and lineage specification mechanisms in hematopoiesis, Hijacking the Host: Red Blood Cell Remodeling and Extracellular Vesicle Release During Babesia Infection, How advances in chromosome conformation capture methods are reshaping our understanding of gene regulation in haematopoiesis, Post-transcriptional regulation in erythropoiesis, Erythropoiesis resolved through spatial omics, and Transcription elongation mechanisms that control gene expression in erythropoiesis.

  • Neuroscience for Sleep Medicine, Part C

    • 1st Edition
    • Volume 301
    • English
    Neuroscience for Sleep Medicine, Part C offers a comprehensive and forward-looking integration of cutting-edge neuroscience with clinical sleep science, bridging molecular, circuit-level, and behavioral perspectives on sleep and its disorders. The volume explores neural mechanisms, cognitive-affective processes, and emerging neurotechnologies that shape both normal sleep and pathological conditions. With a strong translational emphasis, it advances a bench-to-bedside framework that informs precision diagnostics, innovative therapeutics, and future directions in sleep medicine and neuropsychiatry.

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