Books in Toxicology

Polydrug Abuse

1st Edition
October 22, 2013
Donald R. Wesson + 2 more
English
eBook
9 7 8 1 4 8 3 2 7 6 4 5 8

Polydrug Abuse: The Results of a National Collaborative Study reports on the findings of a national study of polydrug users, initiated and organized by the Special Action Office of Drug Abuse Prevention. This book provides a comprehensive demographic, sociological, psychological, and medical study of polydrug cases. The chapters in the text cover the varieties and classification of polydrug abusers; an estimation of the magnitude of polydrug abuse; certain central nervous system consequences to chronic drug use; and the impact of polydrug abuse on physicians and other deliverers of health care. Physicians, epidemiologists, drug enforcers, and government policy makers will find the book interesting.

Cardiac Pharmacology

1st Edition
October 22, 2013
R. Douglas Wilkerson
English
eBook
9 7 8 1 4 8 3 2 7 6 4 1 0

Cardiac Pharmacology aims to interface basic and clinical knowledge of those interventions used or being studied for use in the treatment of heart disease. The book is divided into four major sections which address intrinsic and neural control of cardiac function, pharmacologic modification of cardiac contractility and cardiac output, the genesis and control of cardiac arrhythmias, and pharmacologic manipulation of myocardial oxygen supply and demand. The last three sections contain a chapter describing the techniques employed in the study of that particular aspect of cardiac function and its alterations by pharmacologic interventions. Cardiologists, pharmacologists, physiologists, and those interested in the area of cardiovascular medicine will find the book insightful.

Mechanisms of Drug Resistance in Neoplastic Cells

1st Edition
October 22, 2013
Paul V. Woolley + 1 more
English
eBook
9 7 8 1 4 8 3 2 2 0 7 5 8

Bristol-Myers Cancer Symposia, Volume 9: Mechanisms of Drug Resistance in Neoplastic Cells provides information on both basic scientific and clinical studies on the causes and implications of tumor cell resistance to common antineoplastic agents. The book describes the colon cancer as a model for resistance to antineoplastic drugs; mathematical modeling of drug resistance; and the mechanism of induced gene amplification in mammalian cells. The text also discusses the cellular concomitants of multidrug resistance; resistance to alkylating agents; and the phosphoprotein and protein kinase C changes in human multidrug-resistant cancer cells. Novel drugs that affect glutathione metabolism; the regulation of genes encoding drug-metabolizing enzymes in normal and preneoplastic tissues; and the relevance of glutathione S-transferases to anticancer drug resistance are also considered. The book further tackles the cellular resistance to cyclophosphamide; the preclinical and clinical experiences with drug combinations designed to inhibit DNA repair in resistant human tumor cells; and the modification of the cytotoxicity of DNA-directed chemotherapeutic agents by polyamine depletion. The text also demonstrates multidrug resistance and the circumvention of resistance. Oncologists, molecular biologists, biochemists, geneticists, and pharmacologists will find the book invaluable.

Drugs in Psychiatric Practice

1st Edition
October 22, 2013
Sam Stuart
English
eBook
9 7 8 1 4 8 3 1 9 1 9 3 5

Drugs in Psychiatric Practice present a comprehensive examination of the drug treatment in psychiatry. It discusses certain ways in which drugs behaved. It addresses the advances in pharmacology and the basis of prescription. Some of the topics covered in the book are the classification of psychotropic drugs; basic principles of pharmacokinetics and drug metabolism; anti-schizophrenic drugs; evaluation of psychotropic drugs; unconventional chemotherapy; anti-parkinsonian and anti-dyskinetic drugs; introduction of amitriptyline; and tricyclic antidepressants. The role of tricyclic drugs in the treatment of enuresis and the drug treatment of organic brain syndrome are fully covered. An in-depth account of the monoamine oxidase inhibitors and amine precursors are provided. The tolerance and pharmacological dependence on alcohol are completely presented. A chapter is devoted to the factors involve in ethanol metabolism. Another section focuses on the unwanted effects of psychotropic drugs. The book can provide useful information to doctors, pharmacists, psychologists, students, and researchers.

Aspirin and the Salicylates

1st Edition
October 22, 2013
K. D. Rainsford
English
eBook
9 7 8 1 4 8 3 1 9 1 9 9 7

Aspirin and the Salicylates focuses principally on aspirin. Topics ranging from analytical chemistry and pediatric medicine, taxonomy and cartels, enzymology and toxicity, to renal functions and rheumatology are also included in this compilation. This book emphasizes that salicylates are polycompetent drugs that influence a large number and variety of biological processes. Their multifactorial actions, in relation to the known therapeutic and toxic effects are clearly described. This text likewise provides a refreshing multidisciplinary approach to aspirins that cover the whole extent from chemical to clinical aspects. This publication is a good reference for clinicians, pharmacists, and students intending to acquire general knowledge of the aspirin and salicylates.

Basic Pharmacology

2nd Edition
October 22, 2013
R W Foster
English
eBook
9 7 8 1 4 8 3 1 4 2 0 9 8

Basic Pharmacology, Second Edition, similar to the first edition, talks about the relationship between the human body and therapeutic drugs. A large part of this book discusses the nervous system and the way certain drugs operate and affect it. The first part of this book covers the importance of having a firm understanding of the organ system, especially the nervous system. Understanding the systems is the initial step in learning how a drug affects the body, both internally and externally. This book also clarifies that a drug's impact occurs when it comes in contact with a chemical component of the body (enzymes, hormones, membranes, etc.). The next sections of this book discuss miscellaneous topics of the human anatomy, such as the brain, eyes, lungs, and various muscles. This edition also explains how a drug acts on each of those body parts. This book serves as a great reference to students affiliated in the anatomy, biology, pharmacy, and related fields.

The Actions and Uses of Ophthalmic Drugs

3rd Edition
October 22, 2013
P. H. O'Connor Davies + 2 more
English
eBook
9 7 8 1 4 8 3 1 9 2 0 4 8

The Actions and Uses of Ophthalmic Drugs, Third Edition discuses the application and discrimination in the use of ophthalmic drugs. The book reviews the general pharmacological principles including drug nomenclature, pharmacological classification, pharmacokinetics, pharmacodynamics, and the use of these drugs. Ophthalmic drugs (cycloplegics, mydriatics, miotics) directly or indirectly, stimulate or inhibit a part of the autonomic nervous system connected to the intra-ocular muscles. The text investigates in detail the structure and function of this involuntary nervous system in the orbital region as it is affected by these drugs. The book explains the different drug classifications, their therapeutic and diagnostic purposes, including the ideal properties, indications, contra-indications, mode of action, or adverse effects of cycloplegics, of mydriatics, and of miotics. The book also describes the uses and characteristics of local anesthetics, stains, anti-infective agents, and miscellaneous agents (antihistamines, vasoconstrictors). The text explains the different types of contact lens solutions, application of ocular first aid, as well as, the possible adverse ocular reactions that can occur during ophthalmic drug therapy. This book is suitable for optometrists, pharmacists, pharmacologists, students and professors related to the discipline of optometry and general medicine.

Drug Therapy During Pregnancy

1st Edition
October 22, 2013
Tom K. A. B. Eskes + 1 more
English
eBook
9 7 8 1 4 8 3 1 6 2 9 8 0

Drug Therapy During Pregnancy is a collection of papers dealing with the risks and benefits of drug treatment for both mother and fetus. One paper notes that the total use of medication during pregnancy in the Netherlands has decreased from 82.7 % to 71.7 %. The paper also points out the lack of a relationship between the number or type of congenital anomalies and the use of medication. Another paper assesses fetal drug exposure in two ways: firstly, through the physicochemical characteristics of the drug and the way it is handled by the mother in order to estimate placental passage and fetal exposure. Secondly, through the utilization of pharmacokinetic models estimating the probable time course of drug concentrations in the feto-maternal unit. One paper investigates the effects of hypertension during pregnancy, in which the etiology of hypertension, a group of disorders with one common abnormality, remains unsolved with a clinical diagnosis that is not always accurate. Treatment differs widely depending on the type: chronic hypertension, albuminuric hypertension, and hypertensive crises during pregnancy. One paper suggests that to prove any environmental exposure to a particular substance affecting pregnancy, the exact timing of exposure must be established, large samples are necessary, possibly on a national or international scale. The paper cites as example the four-year documentation period of the 50% to 80% incidence of malformations due to thalidomide. General medicine practitioners, obstetricians, gynecologists, and researchers dealing with pharmacology, pharmocokinetics, toxicology, or embryology will find the collection valuable.

Presystemic Drug Elimination

1st Edition
October 22, 2013
Charles F. George + 1 more
English
eBook
9 7 8 1 4 8 3 1 6 3 6 0 4

Butterworths International Medical Reviews, Clinical Pharmacology and Therapeutics 1: Presystemic Drug Elimination explores the principles of presystemic drug metabolism in human based on animal studies. This book is divided into four sections encompassing 10 chapters that specifically describe the extent of metabolism occurring in the gastrointestinal tract, liver, and lung. Section 1 focuses on presystemic elimination by the gastrointestinal tract. This section discusses the enzymatic biotransformation in the gastrointestinal mucosa and the ability of the microflora to metabolize drugs. Section 2 considers the contribution of the liver to presystemic drug elimination, with a particular emphasis on the physiological factors, which determine the rate of breakdown of drugs in vivo. This section also deals with the effects of hepatic cirrhosis on presystemic drug elimination. Section 3 presents first a brief outline of the knowledge of pulmonary structure and relevant physiology, followed by a discussion on “first-pass” metabolism of endogenous substrates and drugs across the pulmonary circulation and of environmental chemicals after inhalation. This section also provides the methods for distinguishing between the contribution of the various sites to presystemic drug elimination and the problems associated with attempts to analyze available pharmacokinetic data. This work is an ideal source for clinical pharmacologists and researchers.

The Actions and Uses of Ophthalmic Drugs

2nd Edition
October 22, 2013
P. H. O'Connor Davies
English
eBook
9 7 8 1 4 8 3 1 9 2 2 0 8

The Actions and Uses of Ophthalmic Drugs: A Textbook for Students and Practitioners, Second Edition provides pertinent information in relation to concepts in pharmacology, the formulation and application of ophthalmic drugs, and adverse ocular effects of systemic medication. This book discusses the preparations used in contact lens practice. Organized into 17 chapters, this edition begins with an overview of the primary systems of drug classification according to their actions or effects, or on the basis of their chemistry. This text then presents a detailed discussion on the actions and uses of ophthalmic autonomic drugs. Other chapters consider the structure and function of the involuntary nervous system in the orbital region. This book discusses as well the two main classifications of ophthalmic drugs, namely, therapeutic and diagnostic. The final chapter deals with the clinical significance of medication-induced ocular adverse effects. This book is a valuable resource for ophthalmologists, students, and practitioners.

Life Sciences

Physical Sciences & Engineering

Social Sciences & Humanities

Health

Books in Toxicology

Polydrug Abuse

Cardiac Pharmacology

Mechanisms of Drug Resistance in Neoplastic Cells

Drugs in Psychiatric Practice

Aspirin and the Salicylates

Basic Pharmacology

The Actions and Uses of Ophthalmic Drugs

Drug Therapy During Pregnancy

Presystemic Drug Elimination

The Actions and Uses of Ophthalmic Drugs