Books in Neuropathology

Brain Metastases from Primary Tumors, Volume 3

1st Edition
April 7, 2016
M. A. Hayat
English
Hardback
9 7 8 0 1 2 8 0 3 5 0 8 5
eBook
9 7 8 0 1 2 8 0 3 5 5 9 7

Brain Metastases from Primary Tumors Volume Three: Epidemiology, Biology, and Therapy of Melanoma and Other Cancers provides a comprehensive overview of the metastasis of cancer, the main cause of approximately 90% of cancer associated deaths, yet the mechanisms governing this clinically important process remain poorly understood. Melanoma is the third most common diagnosis among patients with brain metastases, after lung and breast cancer. Approximately 75% of patients with metastatic melanoma develop brain metastases during the course of their disease. Although tumorigenesis of melanoma remains poorly understood, recent advances in gene expression profiling have revealed molecular mechanisms of this deadly disease. In addition, high-throughput gene expression has many advantages over techniques in cancer transcriptomic studies and has led to the discovery of numerous diagnostic, prognostic, and therapeutic targets, which are also detailed in this book. The book discusses the link between primary tumors and brain metastasis of melanoma, including molecular mechanisms, treatment options, prognosis, and general applications. Comprehensive chapters discuss systemic therapy, integrin inhibitors, stereotaxic radiosurgery, and more, making this book a great resource for neurooncologists, neurosurgeons, neurologists, and cancer researchers.

Neuropathology of Drug Addictions and Substance Misuse Volume 1

1st Edition
March 7, 2016
Victor R Preedy
English
Hardback
9 7 8 0 1 2 8 0 0 2 1 3 1
eBook
9 7 8 0 1 2 8 0 0 3 7 6 3

Neuropathology of Drug Addictions and Substance Misuse, Volume One: Foundations of Understanding, Tobacco, Alcohol, Cannabinoids, Opioids and Emerging Addictions provides the latest research in an area that shows that the neuropathological features of one addiction are often applicable to those of others. The book also details how a further understanding of these commonalties can provide a platform for the study of specific addictions in greater depth, all in an effort to create new modes of understanding, causation, prevention, and treatment. The three volumes in this series address new research and challenges, offering comprehensive coverage on the adverse consequences of the most common drugs of abuse, with each volume serving to update the reader’s knowledge on the broader field of addiction, while also deepening our understanding of specific addictive substances. Volume One addresses tobacco, alcohol, cannabinoids, and opioids, with each section providing data on the general, molecular/cellular, and structural/functiona... neurological aspects of a given substance, along with a focus on the adverse consequences of addictions.

Gliomas

1st Edition
Volume 134
March 2, 2016
Mitchel S. Berger + 1 more
English
Hardback
9 7 8 0 1 2 8 0 2 9 9 7 8
eBook
9 7 8 0 1 2 8 0 3 0 0 7 3

Researchers’ knowledge of gliomas continues to advance rapidly at both the basic and translational levels, and Gliomas provides a thorough overview of the evolving fields of tumor biology and clinical medicine as they relate to our understanding of brain tumors. Gliomas reviews the current paradigms that underlie these fields, beginning with the molecular epidemiology of glioma susceptibility and prognosis through population-based science and genome-wide association studies. The book’s discussion of imaging modalities extends beyond advances in anatomical imaging to include metabolic and physiological studies. This work provides thorough discussion of the clinical view of tumors, ranging from the presentation of the patient to surgical management, and covers all therapeutic options for patient care, including chemotherapy, targeted molecular therapies, immunotherapies, and even personalized approaches to impact the set of lesions. Additionally, the book discusses radiotherapy with regard to the many options available to treat patients using myriad fractionated techniques with various sources. Finally, Gliomas reviews issues specific to the quality of life for patients, and techniques for maximizing the effect of caregivers. Edited and authored by premier researchers from around the world, Gliomas is a comprehensive reference for clinicians and researchers seeking the most up-to-date information on gliomas, and a guide to the best ways to effectively manage glioma patients and their care.

Genes, Environment and Alzheimer's Disease

1st Edition
February 25, 2016
Orly Lazarov + 1 more
English
Hardback
9 7 8 0 1 2 8 0 2 8 5 1 3
eBook
9 7 8 0 1 2 8 0 2 8 8 5 8

Genes, Environment and Alzheimer's Disease discusses the role that activities such as exercise can play in cardiovascular health, while also highlighting the fact that the last 10 years have brought great discoveries in the strong environmental component of brain disorders, neurodegeneration, and cognitive decline. It is now clear that brain insult is an environmental risk factor for AD, while on the other hand, lifestyle components such as exercise and level of education may play a protective role, delaying the onset and/or severity of the disease. Evidence from experiments in rodent models of Alzheimer’s disease contributes major insight into the molecular mechanisms by which the environment plays its role in AD. Additionally, there are diseases related to lifestyle that may lead to AD. This volume reviews new discoveries related to all these factors, serving as a translational tool for clinicians and researchers interested in genetic and environmental risk factors for the disease.

Intracellular Consequences of Amyloid in Alzheimer's Disease

1st Edition
February 17, 2016
Michael R. D'Andrea
English
Paperback
9 7 8 0 1 2 8 0 4 2 5 6 4
eBook
9 7 8 0 1 2 8 0 4 3 3 0 1

Consequences of Intracellular Amyloid in Alzheimer’s Disease addresses one of the more currently unresolved aspects confounding Alzheimer’s research, the significance of intraneuronal amyloid. It seeks to explain some of the unresolved questions concerning intracellular amyloid and its origin, entry, and toxicity. Following up on Dr. D’Andrea’s first book, Bursting Neurons and Fading Memories: An Alternative Hypothesis for the Pathogenesis of Alzheimer’s Disease, this book further examines the Inside-Out or Bursting alternative hypothesis of how amyloid escapes the circulatory system to ultimately enter neurons, also examining whether there is a relationship between intracellular amyloid, amyloid plaques, and cognitive impairment. Through a comprehensive explanation of the currently relevant scientific research on intracellular amyloid compiled in this handy reference, readers will better understand the mechanisms that lead to neuron death.

Essential Clinically Applied Anatomy of the Peripheral Nervous System in the Head and Neck

1st Edition
February 11, 2016
Paul Rea
English
Paperback
9 7 8 0 1 2 8 0 3 6 3 3 4
eBook
9 7 8 0 1 2 8 0 3 6 6 4 8

Essential Clinically Applied Anatomy of the Nerves in the Head and Neck presents the reader with an easy access format to clinically-applied peripheral nervous system (PNS) anatomy. Perfect for a quick reference to essential details. The chapters review nerves of the head and neck, the origin(s), course, distribution and relevant pathologies affecting each are given, where relevant. The pathologies present typical injuries to the nerves of the PNS, as well as clinical findings on examination and treatments. It details modern clinical approaches to the surgery and other treatments of these nerve pathologies, as applicable to the clinical scenario.

Diseases of the Nervous System

1st Edition
March 6, 2015
Harald Sontheimer
English
Hardback
9 7 8 0 1 2 8 0 0 2 4 4 5
eBook
9 7 8 0 1 2 8 0 0 4 0 3 6

The study of the brain continues to expand at a rapid pace providing fascinating insights into the basic mechanisms underlying nervous system illnesses. New tools, ranging from genome sequencing to non-invasive imaging, and research fueled by public and private investment in biomedical research has been transformative in our understanding of nervous system diseases and has led to an explosion of published primary research articles. Diseases of the Nervous System summarizes the current state of basic and clinical knowledge for the most common neurological and neuropsychiatric conditions. In a systematic progression, each chapter covers either a single disease or a group of related disorders ranging from static insults to primary and secondary progressive neurodegenerative diseases, neurodevelopmental illnesses, illnesses resulting from nervous system infection and neuropsychiatric conditions. Chapters follow a common format and are stand-alone units, each covering disease history, clinical presentation, disease mechanisms and treatment protocols. Dr. Sontheimer also includes two chapters which discuss common concepts shared among the disorders and how new findings are being translated from the bench to the bedside. In a final chapter, he explains the most commonly used neuroscience jargon. The chapters address controversial issues in current day neuroscience research including translational research, drug discovery, ethical issues, and the promises of personalized medicine. This book provides an introduction for course adoption and an introductory tutorial for students, scholars, researchers and medical professionals interested in learning the state of the art concerning our understanding and treatment of diseases of the nervous system.

Bursting Neurons and Fading Memories

1st Edition
October 10, 2014
Michael R. D'Andrea
English
Paperback
9 7 8 0 1 2 8 0 1 9 7 9 5
eBook
9 7 8 0 1 2 8 0 1 9 8 8 7

Advances in Alzheimer’s disease (AD) research have been challenging and without major breakthroughs in understanding its pathological basis. The reigning hypothesis suggests AD is the result of extracellular amyloid deposition that seed to form amyloid plaques, which then grow and kill neighboring neurons. However, there are several inconsistencies with this hypothesis, not to mention the inability to show clinical benefit in several failed clinical trials by pharmaceuticals (i.e., from Pfizer, Eli Lilly, etc.), and it is in the field’s best interest to explore and test multiple hypotheses for pathology rather than drive the majority of research on this single amyloid theory. Reviewing many scientifically peer-reviewed publications, this book describes the "Inside-Out" hypothesis on how amyloid escapes the circulatory system through a dysfunctional blood-brain barrier to bind to the alpha 7 nicotinic acetylcholine receptor on pyramidal neurons. Over time, excessive amounts of amyloid appear to be internalized, resulting in neuron death and lysis. This simple mechanism readily explains plaque composition, size, shape, and location. Based on the current direction of research in the field, this hypothesis appears years from any research and development.

Forensic Neuropathology

1st Edition
August 23, 2007
Hideo H. Itabashi MD + 4 more
English
Hardback
9 7 8 0 1 2 0 5 8 5 2 7 4
eBook
9 7 8 0 0 8 0 5 4 9 8 4 2

Forensic Neuropathology provides superior visual examples of the more commonly encountered conditions in forensic neuropathology and answers questions that arise regarding neuropathological findings. The work includes values for frequently-encounter... clinical assessments, and contains a more comprehensive summary of aging/dating of various neuropathological processes than is available in any other single current source. General pathology residents, forensic pathology and neuropathology fellows, and general pathologists and clinicians involved in referred cases will find this book extremely useful, as will individuals in allied fields such as law enforcement officers and attorneys. Forensic Neuropathology aims to: (1) provide a concise summary of practical information frequently needed in forensic neuropathology cases; (2) include selected material previously known but perhaps not significantly emphasized in current literature; and (3) where possible, to suggest aging/dating parameters for certain neuropathological findings relevant to forensic neuropathology testimony. As a selective reference, the volume emphasizes practical issues and focuses on the most commonly encountered issues among neuropathology and medical examiner professionals.

Diagnostic Atlas of Gastroesophageal Reflux Disease

1st Edition
July 11, 2007
Parakrama T. Chandrasoma
English
Hardback
9 7 8 0 1 2 3 7 3 6 0 5 5
eBook
9 7 8 0 0 8 0 8 7 8 0 3 4

Gastroesophageal reflux is one of the most common maladies of mankind. Approximately 40% of the adult population of the USA suffers from significant heartburn and the numerous antacids advertised incessantly on national television represents a $8 billion per year drug market. The ability to control acid secretion with the increasingly effective acid-suppressive agents such as the H2 blockers (pepcid, zantac) and proton pump inhibitors (nexium, prevacid) has given physicians an excellent method of treating the symptoms of acid reflux.Unfortunately... this has not eradicated reflux disease. It has just changed its nature. While heartburn, ulceration and strictures have become rare, reflux-induced adenocarcinoma of the esophagus is becoming increasingly common. Adenocarcinoma of the esophagus and gastric cardia is now the most rapidly increasing cancer type in the Western world.At present, there is no histologic test that has any practical value in the diagnosis of reflux disease. The only histologic diagnostic criteria are related to changes in the squamous epithelium which are too insensitive and nonspecific for effective patient management. It is widely recognized that columnar metaplasia of the esophagus (manifest histologically as cardiac, oxyntocardiac and intestinal epithelia) is caused by reflux. However, except for intestinal metaplasia, which is diagnostic for Barrett esophagus, these columnar epithelia are not used to diagnose reflux disease in biopsies. The reason for this is that these epithelial types are indistinguishable from "normal" "gastric" cardiac mucosa. In standard histology texts, this "normal gastric cardia" is 2-3 cm long.In the mid-1990s, Dr. Chandrasoma and his team at USC produced autopsy data suggesting that cardiac and oxyntocardiac mucosa is normally absent from this region and that their presence in biopsies was histologic evidence of reflux disease. From this data, they determined that the presence of cardiac mucosa was a pathologic entity caused by reflux and could therefore be used as a highly specific and sensitive diagnostic criterion for the histologic diagnosis of reflux disease. They call this entity "reflux carditis". In addition, the length of these metaplastic columnar epithelia in the esophagus was an accurate measure of the severity of reflux disease in a given patient.At present, there is some controversy over whether cardiac mucosa is totally absent or present normally to the extent of 0-4 mm. While this should not be a deterrent to changing criteria which are dependent on there normally being 20-30 cm of cardiac mucosa, there has been little mainstream attempt to change existing endoscopic and pathologic diagnostic criteria in the mainstream of either gastroenterology or pathology. The ATLAS will be the source of easily digestible practical information for pathologists faced with biopsies from this region. It will also guide gastroenterologists as they biopsy these patients.

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