Skip to main content
Elsevier
View Cart
openUserAccount

Books in Neuropathology

BooksJournals
21-28 of 28 results in All results

Genes, Environment and Alzheimer's Disease

  • 1st Edition
  • February 25, 2016
  • Orly Lazarov + 1 more
  • English
  • Hardback
    9 7 8 - 0 - 1 2 - 8 0 2 8 5 1 - 3
  • eBook
    9 7 8 - 0 - 1 2 - 8 0 2 8 8 5 - 8
Genes, Environment and Alzheimer's Disease discusses the role that activities such as exercise can play in cardiovascular health, while also highlighting the fact that the last 10 years have brought great discoveries in the strong environmental component of brain disorders, neurodegeneration, and cognitive decline. It is now clear that brain insult is an environmental risk factor for AD, while on the other hand, lifestyle components such as exercise and level of education may play a protective role, delaying the onset and/or severity of the disease. Evidence from experiments in rodent models of Alzheimer’s disease contributes major insight into the molecular mechanisms by which the environment plays its role in AD. Additionally, there are diseases related to lifestyle that may lead to AD. This volume reviews new discoveries related to all these factors, serving as a translational tool for clinicians and researchers interested in genetic and environmental risk factors for the disease.

Intracellular Consequences of Amyloid in Alzheimer's Disease

  • 1st Edition
  • February 17, 2016
  • Michael R. D'Andrea
  • English
  • Paperback
    9 7 8 - 0 - 1 2 - 8 0 4 2 5 6 - 4
  • eBook
    9 7 8 - 0 - 1 2 - 8 0 4 3 3 0 - 1
Consequences of Intracellular Amyloid in Alzheimer’s Disease addresses one of the more currently unresolved aspects confounding Alzheimer’s research, the significance of intraneuronal amyloid. It seeks to explain some of the unresolved questions concerning intracellular amyloid and its origin, entry, and toxicity. Following up on Dr. D’Andrea’s first book, Bursting Neurons and Fading Memories: An Alternative Hypothesis for the Pathogenesis of Alzheimer’s Disease, this book further examines the Inside-Out or Bursting alternative hypothesis of how amyloid escapes the circulatory system to ultimately enter neurons, also examining whether there is a relationship between intracellular amyloid, amyloid plaques, and cognitive impairment. Through a comprehensive explanation of the currently relevant scientific research on intracellular amyloid compiled in this handy reference, readers will better understand the mechanisms that lead to neuron death.

Essential Clinically Applied Anatomy of the Peripheral Nervous System in the Head and Neck

  • 1st Edition
  • February 11, 2016
  • Paul Rea
  • English
  • Paperback
    9 7 8 - 0 - 1 2 - 8 0 3 6 3 3 - 4
  • eBook
    9 7 8 - 0 - 1 2 - 8 0 3 6 6 4 - 8
Essential Clinically Applied Anatomy of the Nerves in the Head and Neck presents the reader with an easy access format to clinically-applied peripheral nervous system (PNS) anatomy. Perfect for a quick reference to essential details. The chapters review nerves of the head and neck, the origin(s), course, distribution and relevant pathologies affecting each are given, where relevant. The pathologies present typical injuries to the nerves of the PNS, as well as clinical findings on examination and treatments. It details modern clinical approaches to the surgery and other treatments of these nerve pathologies, as applicable to the clinical scenario.

Bursting Neurons and Fading Memories

  • 1st Edition
  • October 10, 2014
  • Michael R. D'Andrea
  • English
  • Paperback
    9 7 8 - 0 - 1 2 - 8 0 1 9 7 9 - 5
  • eBook
    9 7 8 - 0 - 1 2 - 8 0 1 9 8 8 - 7
Advances in Alzheimer’s disease (AD) research have been challenging and without major breakthroughs in understanding its pathological basis. The reigning hypothesis suggests AD is the result of extracellular amyloid deposition that seed to form amyloid plaques, which then grow and kill neighboring neurons. However, there are several inconsistencies with this hypothesis, not to mention the inability to show clinical benefit in several failed clinical trials by pharmaceuticals (i.e., from Pfizer, Eli Lilly, etc.), and it is in the field’s best interest to explore and test multiple hypotheses for pathology rather than drive the majority of research on this single amyloid theory. Reviewing many scientifically peer-reviewed publications, this book describes the "Inside-Out" hypothesis on how amyloid escapes the circulatory system through a dysfunctional blood-brain barrier to bind to the alpha 7 nicotinic acetylcholine receptor on pyramidal neurons. Over time, excessive amounts of amyloid appear to be internalized, resulting in neuron death and lysis. This simple mechanism readily explains plaque composition, size, shape, and location. Based on the current direction of research in the field, this hypothesis appears years from any research and development.

Forensic Neuropathology

  • 1st Edition
  • August 23, 2007
  • Hideo H. Itabashi MD + 4 more
  • English
  • Hardback
    9 7 8 - 0 - 1 2 - 0 5 8 5 2 7 - 4
  • eBook
    9 7 8 - 0 - 0 8 - 0 5 4 9 8 4 - 2
Forensic Neuropathology provides superior visual examples of the more commonly encountered conditions in forensic neuropathology and answers questions that arise regarding neuropathological findings. The work includes values for frequently-encountered clinical assessments, and contains a more comprehensive summary of aging/dating of various neuropathological processes than is available in any other single current source. General pathology residents, forensic pathology and neuropathology fellows, and general pathologists and clinicians involved in referred cases will find this book extremely useful, as will individuals in allied fields such as law enforcement officers and attorneys. Forensic Neuropathology aims to: (1) provide a concise summary of practical information frequently needed in forensic neuropathology cases; (2) include selected material previously known but perhaps not significantly emphasized in current literature; and (3) where possible, to suggest aging/dating parameters for certain neuropathological findings relevant to forensic neuropathology testimony. As a selective reference, the volume emphasizes practical issues and focuses on the most commonly encountered issues among neuropathology and medical examiner professionals.

Diagnostic Atlas of Gastroesophageal Reflux Disease

  • 1st Edition
  • July 11, 2007
  • Parakrama T. Chandrasoma
  • English
  • Hardback
    9 7 8 - 0 - 1 2 - 3 7 3 6 0 5 - 5
  • eBook
    9 7 8 - 0 - 0 8 - 0 8 7 8 0 3 - 4
Gastroesophageal reflux is one of the most common maladies of mankind. Approximately 40% of the adult population of the USA suffers from significant heartburn and the numerous antacids advertised incessantly on national television represents a $8 billion per year drug market. The ability to control acid secretion with the increasingly effective acid-suppressive agents such as the H2 blockers (pepcid, zantac) and proton pump inhibitors (nexium, prevacid) has given physicians an excellent method of treating the symptoms of acid reflux.Unfortunately, this has not eradicated reflux disease. It has just changed its nature. While heartburn, ulceration and strictures have become rare, reflux-induced adenocarcinoma of the esophagus is becoming increasingly common. Adenocarcinoma of the esophagus and gastric cardia is now the most rapidly increasing cancer type in the Western world.At present, there is no histologic test that has any practical value in the diagnosis of reflux disease. The only histologic diagnostic criteria are related to changes in the squamous epithelium which are too insensitive and nonspecific for effective patient management. It is widely recognized that columnar metaplasia of the esophagus (manifest histologically as cardiac, oxyntocardiac and intestinal epithelia) is caused by reflux. However, except for intestinal metaplasia, which is diagnostic for Barrett esophagus, these columnar epithelia are not used to diagnose reflux disease in biopsies. The reason for this is that these epithelial types are indistinguishable from "normal" "gastric" cardiac mucosa. In standard histology texts, this "normal gastric cardia" is 2-3 cm long.In the mid-1990s, Dr. Chandrasoma and his team at USC produced autopsy data suggesting that cardiac and oxyntocardiac mucosa is normally absent from this region and that their presence in biopsies was histologic evidence of reflux disease. From this data, they determined that the presence of cardiac mucosa was a pathologic entity caused by reflux and could therefore be used as a highly specific and sensitive diagnostic criterion for the histologic diagnosis of reflux disease. They call this entity "reflux carditis". In addition, the length of these metaplastic columnar epithelia in the esophagus was an accurate measure of the severity of reflux disease in a given patient.At present, there is some controversy over whether cardiac mucosa is totally absent or present normally to the extent of 0-4 mm. While this should not be a deterrent to changing criteria which are dependent on there normally being 20-30 cm of cardiac mucosa, there has been little mainstream attempt to change existing endoscopic and pathologic diagnostic criteria in the mainstream of either gastroenterology or pathology. The ATLAS will be the source of easily digestible practical information for pathologists faced with biopsies from this region. It will also guide gastroenterologists as they biopsy these patients.

Functional Neuroanatomy of the Nitric Oxide System

  • 1st Edition
  • Volume 17
  • June 30, 2000
  • H.W.M. Steinbusch + 2 more
  • English
  • eBook
    9 7 8 - 0 - 0 8 - 0 5 3 2 0 8 - 0
This volume of the Handbook of Neuroanatomy is concerned with nitric oxide synthase. In this volume different research areas are presented together, which adds up to the first major review volume on the localization of nitric oxide synthase in the nervous system. The subjects range from developmental aspects in vertebrates to a functional neuroanatomy of the nervous system in vertebrates. This presentation gives an impressive look on the overwhelming presence of NOS in animal organism and the significance of NO - cGMP signaling. By clearly stating the limitations of our present knowledge the book is also a stimulant for further research. This book presents for the first time an overview of NOS and NO-cGMP signaling in the retina and urogenital system. In addition the effects if injuries on the expression of NOS are summarized in a number of models, which has not been done before.The frame of the book is a classical neuroanatomic description of the localization of NOS. Several authors give detailed advice to prevent pitfalls which may occur when different methods to locate NOS are used. In addition, several chapters detail the target structures for NO while describing the localization of NOS at the same time.All these points together make this volume very timely, i.e. overviewing a decade of NO research.

Chemical Factors in Neural Growth, Degeneration and Repair

  • 1st Edition
  • December 17, 1996
  • C. Bell
  • English
  • eBook
    9 7 8 - 0 - 0 8 - 0 5 2 9 0 3 - 5
This volume provides an up-to-date survey of current thinking concerning the actions of chemical factors in the regulation of neuronal behaviour under normal and pathological conditions. The book is divided into four sections, dealing with chemical factors involved with the formation of axon pathways, factors involved with neuronal survival and specialization during normal development, factors involved in normal maintenance and repair of adult neurons and, finally, factors that have been implicated as mediators of degenerative changes in neurological and neuropsychiatric disorders.