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Elsevier

Elsevier

  • Strategies and Tactics in Organic Synthesis

    • 1st Edition
    • Volume 11
    • Michael Harmata
    • English
    Strategies and Tactics in Organic Synthesis provides a forum for investigators to discuss their approach to the science and art of organic synthesis. Rather than a simple presentation of data or a secondhand analysis, this classic provides stories that vividly demonstrate the power of the human endeavor known as organic synthesis and the creativity and tenacity of its practitioners. Firsthand accounts of each project tell of the excitement of conception, the frustration of failure, and the joy experienced when either rational thought or good fortune gives rise to the successful completion of a project. This book series shows how synthesis is really done. Readers will be educated, challenged, and inspired by these accounts, which portray the idea that triumphs do not come without challenges. This innovative approach also helps illustrate how challenges to further advance the science and art of organic synthesis can be overcome, driving the field forward to meet the demands of society by discovering new reactions, creating new designs, and building molecules with atom and step economies that provide functional solutions to create a better world.

  • Neonatal Hematology and Transfusion Medicine, An Issue of Clinics in Perinatology

    • 1st Edition
    • Volume 42-3
    • Robert D. Christensen
    • English
    Recent advances in neonatal hematology, largely made by the authors of these chapters, are likely to generate wide spread and long-term improvements in outcomes, as well as reductions in costs of care. Publication of these advances in a single volume will facilitate dissemination of these techniques and practices. The advances include neuroprotection from erythropoietic stimulators, improved guidelines for platelet transfusions, evidence-based guidelines for FFP administration, improved diagnostic methods for genetic causes of severe neonatal jaundice, more accurate definitions of hematological perturbations in necrotizing enterocolitis and sepsis, and reduction in transfusions and in IVH rates by cord milking/delayed clamping.

  • A Practical Approach to Musculoskeletal Medicine

    Assessment, Diagnosis, Treatment
    • 4th Edition
    • Elaine Atkins + 2 more
    • English
    This refreshing fourth edition of the established evidence-based textbook by Elaine Atkins, Jill Kerr and Emily Goodlad continues to uphold the Cyriax approach to clinical reasoning, assessment, diagnosis and treatment of musculoskeletal conditions.Renamed A Practical Approach to Musculoskeletal Medicine, to reflect globally understood terminology, it focuses on the principles and practice of musculoskeletal medicine, providing practical guidance and tips for clinical practice based on extensive clinical experience and evidence.The book is split into three sections. Section 1 presents the theory underpinning musculoskeletal medicine. The histology and behaviour of the soft tissues follow, with a review of the healing process, to enhance understanding of the effects of injury on the soft tissues. The first section ends with the principles of treatment as applied in musculoskeletal medicine and discusses the techniques of mobilization and injection, aims and application, and indications for use.Section 2 adopts a regional approach. Anatomy is presented, including useful tips on surface marking to locate commonly injured anatomical structures. Assessment, lesions and treatment techniques are discussed for each region as appropriate for the stage in the healing process.Section 3 provides resources to support the recording of assessment and to ensure safety, especially whilst learning the musculoskeletal medicine approach.A Practical Approach to Musculoskeletal Medicine comprehensively and critically discusses current literature. It is a complete reference source for students and postgraduate medical practitioners, physiotherapists, osteopaths and other allied health professionals, including occupational therapists and podiatrists. It is essential reading.

  • Evidence-Based Treatment Guidelines for Treating Injured Workers, An Issue of Physical Medicine and Rehabilitation Clinics of North America

    • 1st Edition
    • Volume 26-3
    • Andrew S. Friedman
    • English
    Medical treatment guidelines are written from a clinical perspective, to guide clinical care. The review criteria that will be included in this issue of Physical Medicine & Rehabilitation Clinics are evidence based and are developed by practicing physicians and advisors who work in physical medicine and rehabilitation. Health care providers are expected to be familiar with the guidelines and follow the recommendations. Good medical judgment is important in deciding how to use and interpret this information.

  • Function Preservation in Laryngeal Cancer, An Issue of Otolaryngologic Clinics of North America

    • 1st Edition
    • Volume 48-4
    • Babak Sadoughi
    • English
    Cancers of the larynx, while survival outcomes increase, result in massive treatment damage from radiation and surgery. Patients often lose ability to speak and to eat. Preserving the larynx is a fine balance of cancer eradication, life extension, and quality of life. This issueof Otolaryngologic Clinics led by Dr Babak Sadoughi should be of interest to Otolaryngologists, Oncologists, Radiologists, and Speech Therapists. The issue approach reaches all the most important aspects of diagnosing and treating the patient with laryngeal cancer with a focus on preserving the voice in early laryngeal cancer and preserving and restoring function in advanced laryngeal cancer. Topics include: Functional Anatomy and Oncological Barriers of the Larynx; Evaluation of the Dysphonic Patient; Role of Advanced Laryngeal Imaging in Glottic Cancer; Laryngeal Function after Radiation Therapy; Management of Dysphonia after Radiation Therapy; Contemporary Surgical Management of Early Glottic Cancer; Voice Prognosis after Transoral Laser Microsurgery of the Larynx; Voice Rehabilitation after Transoral Laser Microsurgery of the Larynx; Quality of Life after Conservation Surgery for Laryngeal Cancer; Salvage Conservation Surgery of the Larynx; Airway Preservation in Ablative Laryngeal Surgery; Voice Restoration after Total Laryngectomy. A special article for Residents, written by a Resident, emphasizes essential "take home messages" for laryngeal function preservation diagnosis and treatment.

  • Exergy Analysis of Heating, Refrigerating and Air Conditioning

    Methods and Applications
    • 1st Edition
    • Ibrahim Dincer + 1 more
    • English
    Improve and optimize efficiency of HVAC and related energy systems from an exergy perspective. From fundamentals to advanced applications, Exergy Analysis of Heating, Air Conditioning, and Refrigeration provides readers with a clear and concise description of exergy analysis and its many uses. Focusing on the application of exergy methods to the primary technologies for heating, refrigerating, and air conditioning, Ibrahim Dincer and Marc A. Rosen demonstrate exactly how exergy can help improve and optimize efficiency, environmental performance, and cost-effectiveness. The book also discusses the analysis tools available, and includes many comprehensive case studies on current and emerging systems and technologies for real-world examples. From introducing exergy and thermodynamic fundamentals to presenting the use of exergy methods for heating, refrigeration, and air conditioning systems, this book equips any researcher or practicing engineer with the tools needed to learn and master the application of exergy analysis to these systems.

  • Personalized Immunosuppression in Transplantation

    Role of Biomarker Monitoring and Therapeutic Drug Monitoring
    • 1st Edition
    • Michael Oellerich + 1 more
    • English
    Personalized Immunosuppression in Transplantation: Role of Biomarker Monitoring and Therapeutic Drug Monitoring provides coverage of the various approaches to monitoring immunosuppressants in transplant patients, including the most recently developed biomarker monitoring methods, pharmacogenomics approaches, and traditional therapeutic drug monitoring. The book is written for pathologists, toxicologists, and transplant surgeons who are involved in the management of transplant patients, offering them in-depth coverage of the management of immunosuppressant therapy in transplant patients with the goal of maximum benefit from drug therapy and minimal risk of drug toxicity. This book also provides practical guidelines for managing immunosuppressant therapy, including the therapeutic ranges of various immunosuppressants, the pitfalls of methodologies used for determination of these immunosuppressants in whole blood or plasma, appropriate pharmacogenomics testing for organ transplant recipients, and when biomarker monitoring could be helpful.

  • Fundamentals and Analytical Applications of Multiway Calibration

    • 1st Edition
    • Volume 29
    • English
    Fundamentals and Analytical Applications of Multi-Way Calibration presents researchers with a set of effective tools they can use to obtain the maximum information from instrumental data. It includes the most advanced techniques, methods, and algorithms related to multi-way calibration and the ways they can be applied to solve actual analytical problems. This book provides a comprehensive coverage of the main aspects of multi-way analysis, including fundamentals and selected applications of chemometrics that can resolve complex analytical chemistry problems through the use of multi-way calibration.

  • Pancreatic Cancer, An Issue of Hematology/Oncology Clinics of North America

    • 1st Edition
    • Volume 29-4
    • Brian M. Wolpin
    • English
    This issue of Hematology/Oncology Clinics of North America is devoted to Pancreatic Cancer. Guest Editor Brian Wolpin, MD has assembled a group of expert authors to review the following topics: Biology and genetics of pancreatic adenocarcinoma; Mouse models of pancreatic adenocarcinoma; Epidemiology and inherited predisposition for sporadic pancreatic adenocarcinoma; Familial pancreatic adenocarcinoma; Imaging and endoscopic approaches to pancreatic cancer; Diagnosis and management of pancreatic cystic neoplasms; Surgical management of pancreatic cancer; Peri-operative therapy for surgically resectable pancreatic adenocarcinoma; Diagnosis and management of borderline resectable pancreatic adenocarcinoma; Treatment approaches to locally advanced pancreatic adenocarcinoma; Therapeutic approaches for metastatic pancreatic adenocarcinoma; Supportive and end-of-life care for patients with pancreatic adenocarcinoma; and Novel therapeutics for pancreatic adenocarcinoma.

  • Emergency Neuro-Otology: Diagnosis and Management of Acute Dizziness and Vertigo, An Issue of Neurologic Clinics

    • 1st Edition
    • Volume 33-3
    • David E. Newman-Toker
    • English
    The focus of this publication on Neuro-Otology in Neurologic Clinics is on the patient presenting for urgent or emergent care with a chief complaint of new, previously-undiagnos... dizziness or vertigo. Intent is to emphasize throughout the issue five primary components of initial diagnosis and management: (1) Epidemiology, differential diagnosis, and disease definitions; (2) Bedside clinical features that differentiate dangerous from benign causes; (3) Appropriate use of advanced diagnostic tests (including imaging, vestibular tests) and consultations; (4) Application of early treatments (manipulative, pharmacologic, rehabilitative); and (5) Acute disposition strategies, including determining need for admission and urgency of follow-up. Articles have a consistent architecture to highlight key points: 1) Case Scenario (with a representative case example; videos are presented with many of these); 2) Prevalence & Pathomechanisms; 3) Definitions & Diagnostic Criteria; 4) Bedside & Laboratory Diagnostic Tests; 5) Acute Treatment Options (including manipulative, pharmacologic, rehabilitative); and 6) Triage & Disposition (including referrals and follow-up). The articles are presented with four major parts: Overall approach to acute dizziness and vertigo; Episodic vertigo and dizziness; Acute, continuous vertigo and dizziness; and Case unknowns. Among the topics covered are: Bedside evaluation; Transient ischemic attacks; Vestibularl neuritis and labyrinthitis; Stroke; Novel approach to diagnosing the acutely dizzy patient. David Newman-Toker leads this publication with associate editors renown in their fields - Kevin Kerber, William J. Meurer, Rodney Omron, and Jonathan Edlow.

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