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Elsevier

Elsevier

  • The World of Nano-Biomechanics

    • 2nd Edition
    • Atsushi Ikai
    • English
    The World of Nano-Biomechanics, Second Edition, focuses on the remarkable progress in the application of force spectroscopy to molecular and cellular biology that has occurred since the book's first edition in 2008. The initial excitement of seeing and touching a single molecule of protein/DNA is now culminating in the development of various ways to manipulate molecules and cells almost at our fingertips, enabling live cell operations. Topics include the development of molecular biosensors, mechanical diagnosis, cellular-level wound healing, and a look into the advances that have been made in our understanding of the significance of mechanical rigidity/flexibility of protein/DNA structure for the manifestation of biological activities. The book begins with a summary of the results of basic mechanics to help readers who are unfamiliar with engineering mechanics. Then, representative results obtained on biological macromolecules and structures, such as proteins, DNA, RNA, polysaccharides, lipid membranes, subcellular organelles, and live cells are discussed. New to this second edition are recent developments in three important applications, i.e., advanced AFM-data analysis, high-resolution mechanical biosensing, and the use of cell mechanics for medical diagnosis.

  • Mountain Ice and Water

    Investigations of the Hydrologic Cycle in Alpine Environments
    • 1st Edition
    • Volume 21
    • John F. Shroder + 1 more
    • English
    Mountain Ice and Water: Investigations of the Hydrologic Cycle in Alpine Environments is a new volume of papers reviewed and edited by John Shroder, Emeritus Professor of Geography and Geology at the University of Nebraska at Omaha, USA, and Greg Greenwood, Director of the Mountain Research Initiative from Bern, Switzerland. Chapters in this book were derived from research papers that were delivered at the Perth III Conference on Mountains of our Future Earth in Scotland in October 2015. The conference was established to help develop the knowledge necessary to respond effectively to the risks and opportunities of global environmental change and to support transformations toward global sustainability in the coming decades. To this end, the conference and book have investigated the future situation in mountains from three points of view. (1) Dynamic Planet: Observing, explaining, understanding, and projecting Earth, environmental, and societal system trends, drivers, and processes and their interactions to anticipate global thresholds and risks, (2) Global Sustainable Development: Increasing knowledge for sustainable, secure, and fair stewardship of biodiversity, food, water, health, energy, materials, and other ecosystem services, and (3) Transformations towards Sustainability: Understanding transformation processes and options, assessing how these relate to human values, emerging technologies and social and economic development pathways, and evaluating strategies for governing and managing the global environment across sectors and scales.

  • Psychologically Informed Physiotherapy

    Embedding psychosocial perspectives within clinical management
    • 1st Edition
    • Stuart Porter
    • English
    Psychologically Informed Physiotherapy is a key new textbook for those who need a trusted and comprehensive resource to guide them in applying psychosocial perspectives to their physiotherapy practice. The first of its kind, this textbook brings together an international and interdisciplinary team of leading experts in the field. Together they present an evidence-based range of ideas and concepts around the psychologically informed practice framework, bringing psychosocial aspects of physiotherapy to the fore alongside the established biomedical model. By applying these aspects to screening, exploration and triaging, physiotherapists are better able to identify the origins of pain and barriers to rehabilitation; and so are more likely to achieve consistently good clinical outcomes for their patients. Throughout, clinical case studies ensure that the theory is then grounded in a variety of practical scenarios after which some reflective exercises and clinically relevant scenarios reinforce learning and understanding. Chapters on: Psychology of professional identity in health care The biopsychosocial model Screening for red flags Adapting interactions with others to form empowering relationships and influence behavioural change Neuro-immune-endocri... interactions and clinical practice in stress, pain and recovery Care of the anxious patient through cognitive and person-centred strategies Alternative and evolving models of practice, including the clinical flag system The psychology of the athlete from the physiotherapist’s perspective Using counselling and psychological strategies within physiotherapy Making evidence-based decisions and measuring effectiveness in practice Using psychological interventions as a student or new graduate

  • Toxicology and Drug Testing, An Issue of Clinics in Laboratory Medicine

    • 1st Edition
    • Volume 36-4
    • Martin H. Bluth
    • English
    This issue of Clinics in Laboratory Medicine, edited by Dr. Martin Bluth, will cover a wide array of topics related to drug testing and toxicology. Experts will discuss common drugs in analgesia, toxicology techniques, errors and interferences in toxicology testing, toxicology considerations in pain and addiction medicine, toxicology in reproductive endocrinology, forensic toxicology, and toxicology in emergency medicine, among others.

  • Drug Hepatotoxicity, An Issue of Clinics in Liver Disease

    • 1st Edition
    • Volume 21-1
    • Vinod K. Rustgi
    • English
    Dr. Rustgi has assembled the leading experts in the management of Heptatitis B to present the current treatment and clinical course for diagnosis and management of the disease. Articles are devoted to: Drug metabolism in the liver; Mechanism of Liver Damage including the RUCAM scale; Drug-induced acute liver failure; Epidemiology and genetic risk factors; Adverse drug reactions: type A (intrinsic or pharmacological) or type B (idiosyncratic); Pathology of injury including phenotypes; The clinical course of drug-induced liver disease; Environmental factors of drug hepatotoxicity; Newer agents in drug hepatotoxicity; Drug hepatotoxicity: herbal products; Drug hepatotoxicity: models including “human on a chip” and zebrafish; Acute and chronic liver failure from drugs: impact on the kidney; and Management of acute hepatotoxicity including medical agents and liver support systems. Readers will come away with the cutting edge science behind the latest innovations in the treatment of Hepatitis B.

  • Advances in Mechanical Ventilation, An Issue of Clinics in Chest Medicine

    • 1st Edition
    • Volume 37-4
    • Neil R. MacIntyre
    • English
    This issue of Clinics in Chest Medicine focuses on Advances in Mechanical Ventilation. Articles include: Mechanical Ventilation Design Features; Assessing Respiratory System Mechanical Function; Ventilator Induced Lung Injury; Managing Acute Lung Injury; Patient-Ventilator Interactions; Extracorporeal Gas Exchange; Preventing Ventilator Associated Infections; Ventilator Discontinuation Process; Ventilator Management of the Non-injured Lung; Non-invasive Ventilation; and more!

  • Advanced Machining Processes of Metallic Materials

    Theory, Modelling, and Applications
    • 2nd Edition
    • Wit Grzesik
    • English
    Advanced Machining Processes of Metallic Materials: Theory, Modelling and Applications, Second Edition, explores the metal cutting processes with regard to theory and industrial practice. Structured into three parts, the first section provides information on the fundamentals of machining, while the second and third parts include an overview of the effects of the theoretical and experimental considerations in high-level machining technology and a summary of production outputs related to part quality. In particular, topics discussed include: modern tool materials, mechanical, thermal and tribological aspects of machining, computer simulation of various process phenomena, chip control, monitoring of the cutting state, progressive and hybrid machining operations, as well as practical ways for improving machinability and generation and modeling of surface integrity. This new edition addresses the present state and future development of machining technologies, and includes expanded coverage on machining operations, such as turning, milling, drilling, and broaching, as well as a new chapter on sustainable machining processes. In addition, the book provides a comprehensive description of metal cutting theory and experimental and modeling techniques, along with basic machining processes and their effective use in a wide range of manufacturing applications. The research covered here has contributed to a more generalized vision of machining technology, including not only traditional manufacturing tasks, but also potential (emerging) new applications, such as micro and nanotechnology.

  • Pathophysiology of Human His-Purkinje System, An Issue of Cardiac Electrophysiology Clinics

    • 1st Edition
    • Volume 8-4
    • Masood Akhtar
    • English
    This issue of the Cardiac Electrophysiology, edited by Dr. Masood Akhtar, will cover the physiological and pathological aspects of the His-Purkinje System in depth. This content will be supported by a variety of clinical cases that explore various aspects of and issues encountered involving the His-Purkinje System compliment the pathology and physiology.

  • Non-Invasive Ventilation, An Issue of Clinics in Perinatology

    • 1st Edition
    • Volume 43-4
    • Bradley Yoder + 1 more
    • English
    Preterm birth interrupts the normal developmental progression of most organs, particularly when birth occurs at the lowest level of viability. An immediate task is to successfully transition to a post-natal life without a placental circulation. To do this demands careful management of the cardiorespiratory systems. To best help the fragile preterm infant at this demanding time, care-givers must remember two most pressing goals. These are first to maintain adequacy of gas exchange and delivery, while simultaneously minimizing any secondary injury to the fragile preterm lung. However, after these immediate priorities in the delivery room, the longer term effects of an immature lung development and its associated problems come to the forefront. These problems include the inflammation of perinatal infection, oxygen, and invasive mechanical ventilation. Both the immaturity itself, and secondary lung injury and its inflammation – collectively will often lead to the condition termed bronchopulmonary dysplasia (BPD). Although many of these infants may eventually be discharged to home without a need for oxygen supplementation or pulmonary medications, the long-term impact of interrupted lung development and secondary lung injury remain serious concerns. It is now well recognized that mechanical ventilation is pivotal to developing secondary lung injury and BPD. Consequently, a great deal of time and effort has been put into the development and application of non-invasive ventilator (NIV) approaches to supporting respiratory function in neonates. Since the landmark publication by Gregory and colleagues in 1967, nasal continuous positive airway pressure (nCPAP) has been the most commonly applied approach to NIV. This approach has been supported by the recent generation of randomized controlled trials. However, cumulatively these trials have shown only a small reduction in rates of BPD. Outside of the trial data, despite the wider application of nCPAP, rates of BPD remain relatively unchanged over recent years. This has led to investigations of other NIV approaches including nasal ventilation and high flow nasal cannula therapy. Not only have available modes increased, but so have the interfaces through which these modes may be applied. In the issue of Clinic in Perinatology, readers will find an up-to-date review of non-invasive approaches to supporting preterm respiratory function. This draws on the expertise of leading investigators in the field. This issue reviews the physiologic mechanisms by which the various approaches to NIV may support respiratory function; the evidence base supporting different NIV approaches; and adjunctive aspects of NIV therapy including their use during neonatal transport and the application of other supportive therapies such as inhaled NO.

  • Investigating Seafloors and Oceans

    From Mud Volcanoes to Giant Squid
    • 1st Edition
    • Antony Joseph
    • English
    Investigating Seafloors and Oceans: From Mud Volcanoes to Giant Squid offers a bottom-to-top tour of the world’s oceans, exposing the secrets hidden therein from a variety of scientific perspectives. Opening with a discussion of the earth’s formation, hot spots, ridges, plate tectonics, submarine trenches, and cold seeps, the text goes on to address such topics as the role of oceans in the origin of life, tidal bore, thermal effects, ecosystem services, marine creatures, and nutraceutical and pharmaceutical resources. This unique reference provides insight into a wide array of questions that researchers continue to ask about the vast study of oceans and the seafloor. It is a one-of-a-kind examination of oceans that offers important perspectives for researchers, practitioners, and academics in all marine-related fields.

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