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  • Quantitative Systems Pharmacology

    Models and Model-Based Systems with Applications
    • 1st Edition
    • Volume 42
    • Davide Manca
    • English
    Quantitative Systems Pharmacology: Models and Model-Based Systems with Applications, Volume 42, provides a quantitative approach to problem-solving that is targeted to engineers. The book gathers the contributions of doctors, pharmacists, biologists, and chemists who give key information on the elements needed to model a complex machine like the human body. It presents information on diagnoses, administration and release of therapeutics, distribution metabolism and excretion of drugs, compartmental pharmacokinetics, physiologically-base... pharmacokinetics, pharmacodynamics, identifiability of models, numerical methods for models identification, design of experiments, in vitro and in vivo models, and more. As the pharma community is progressively acknowledging that a quantitative and systematic approach to drug administration, release, pharmacokinetics and pharmacodynamics is highly recommended to understand the mechanisms and effects of drugs, this book is a timely resource.

  • Evaluating Environmental and Social Impact Assessment in Developing Countries

    • 2nd Edition
    • Salim Momtaz + 1 more
    • English
    Evaluating Environmental and Social Impact Assessment in Developing Countries, Second Edition, outlines an evaluation framework that supports environmental professionals, researchers and academics in evaluating the effectiveness of impact assessment within limited budgets, promotes standardization across the field, and helps determine if Environmental Impact Assessment (EIA) is achieving its intended goal of sustainable development. Using Bangladesh as a case study, the book discusses key processes, highlights the need for an integrated, holistic approach, outlines the current institutional framework, and discusses environmental impact, social impact, community participation, and the implementation of mitigation measures. This new edition provides a fully updated picture of both recent changes and ongoing development in process, such as the growth in social wellbeing, community participation and enhanced auditing. Finally, the challenges still facing EIA and SIA evaluation are addressed as robustly as possible.

  • Smart, Resilient and Transition Cities

    Emerging Approaches and Tools for A Climate-Sensitive Urban Development
    • 1st Edition
    • Adriana Galderisi + 1 more
    • English
    Smart, Resilient and Transition Cities: Emerging Approaches and Tools for Climate-Sensitive Urban Development starts with a presentation of three widespread Urban Metaphors, which are gaining increasing attention from urban planners and decision-makers: Smart City, Resilient City and Transition Towns, being all of them focused on the need for enhancing cities’ capacities to cope with the multiple and heterogeneous challenges threatening contemporary cities and their future development and, above all, with climate issues. Then, the Authors provide an overview of current large-scale and urban strategies to counterbalance climate change so far undertaken in different geographical contexts (Europe, United States, China, Africa and Australia), shedding light on the different approaches, on the different weights assigned to mitigation and adaptation issues as well as on the main barriers hindering their effectiveness and translation into measurable outcomes. Opportunities and criticalities arising from the rich, ‘sprawled’ and ‘blurred’ landscape of current strategies and initiatives in the face of climate change pave the way to a discussion on the lessons learnt from current initiatives and provide new hints for developing integrated climate strategies, capable to guide planners and decision makers towards a climate sensitive urban development Smart, Resilient and Transition Cities: Emerging Approaches and Tools for Climate-Sensitive Urban Development merges a scientific approach with a pragmatic one. Through a case study approach, the Authors explore strengths and weaknesses of institutional and informal practices to foreshadow innovative paths for an adaptive process of urban governance in the face of climate change. The book guides the reader along new governance paths, characterized by continuous learning and close cooperation and communication among different actors and stakeholders and, in so doing, helps them to overcome current ‘siloed’ approaches to climate issues.

  • Urban Geomorphology

    Landforms and Processes in Cities
    • 1st Edition
    • Mary J Thornbush + 1 more
    • English
    Urban Geomorphology: Landforms and Processes in Cities addresses the human impacts on landscapes through occupation (urbanization) and development as a contribution to anthropogenic geomorphology or "anthropogeomorpholo... This includes a focus on land clearance, conservation issues, pollution, decay and erosion, urban climate, and anthropogenic climate change. These topics, as well as others, are considered to shed more light on the human transformation of natural landscapes and the environmental impacts and geomorphological hazards that environmental change can encompass. Its multidisciplinary approach is appropriate for audiences from a range of disciplines and professions, from geologists, conservationists, and land-use planners to architects and developers. Urban Geomorphology not only transcends disciplines, but also covers varied spatial-temporal frameworks and presents a diverse set of approaches and solutions to human impacts and geomorphological hazards within urban landscapes.

  • Bone Marrow Failure, An Issue of Hematology/Oncology Clinics of North America

    • 1st Edition
    • Volume 32-4
    • Colin A Sieff
    • English
    This issue of Hematology/Oncology Clinics, edited by Dr. Colin A. Sieff, will focus on Bone Marrow Failure. Topics include, but are not limited to, Acquired and Inherited Bone Marrow Failure; Kickapoo Joy Juice and Somatic Mutations in the Pathogenesis of AA; Somatic Mutations in Aplastic Anemia; Recent Advances and Long-term Results of Medical Treatment of AA; Upfront Matched Unrelated Donor Transplantation in AA; Significance of Clonal Mutations in the Diagnosis and Management of Myelodysplastic Syndrome; Alternate (Haploidental) Donor Transplantation in AA; Management of Diamond Blackfan Anemia and Prospects for Novel Treatment; MDS, AML and Cancer Surveillance in Fanconi Anemia; Diagnosis, Treatment and Molecular Pathology of Shwachman Diamond Syndrome; Clinical Implications of Clonal Hematopoiesis in Dyskeratosis congenita; and Germline GATA2 Mutations and Bone Marrow Failure.

  • Muscle Over-activity in Upper Motor Neuron Syndrome: Assessment and Problem Solving for Complex Cases, An Issue of Physical Medicine and Rehabilitation Clinics of North America

    • 1st Edition
    • Volume 29-3
    • Miriam Segal
    • English
    This issue of Physical Medicine and Rehabilitation Clinics, guest edited by Dr. Miriam Segal, will cover the important topic of Muscle Overactivity in Upper Motor Neuron Syndrome, including assessment and problem-solving for complex cases. Topics discussed in the volume will include: Functional/problem based assessment in patients with spinal cord injury; Special considerations in pediatric assessment; Special considerations and assessment of spasticity and multiple sclerosis; Pharmacologic treatment tools; Peripheral neurolysis; The role of physical and occupational therapy; Neurosurgical approaches; The neuro-orthopedic approach; Upper extremity problem-solving: Challenging cases; Lower extremity problem-solving: Challenging cases; and Emerging therapies.

  • The Right Heart - Pulmonary Circulation Unit, An Issue of Heart Failure Clinics

    • 1st Edition
    • Volume 14-3
    • Eduardo Bossone + 1 more
    • English
    This issue of Heart Failure Clinics--edited by Dr. Eduardo Bossone--will cover The Right Heart Pulmonary Circulation Unit. Topics include Pathophysiology, Increased Systemic versus Increased Pulmonary Pressures, Pulmonary Arterial Hypertension, Right Heart Pulmonary Circulation Unit in Connective Tissue Disease, Right Heart Pulmonary Circulation Unit in Congenital Heart Diseases, Pulmonary Hypertension and Heart Failure, Right Heart Pulmonary Circulation Unit in Cardiomyopathies and Storage Diseases, Pulmonary Hypertension, Right Heart Pulmonary Circulation Unit at High Altitude, Chronic Thromboembolic Pulmonary Hypertension, Combining Invasive and Non-Invasive Evaluation for the Diagnosis of Pulmonary Hypertension, Imaging the Right Heart Pulmonary Circulation Unit: The Role of Ultrasound, Imaging the Right Heart Pulmonary Circulation Unit: The Role of CT and MRI, Biomarkers in Pulmonary Hypertension, Pulmonary Hypertension Related to Diffuse Parenchymal Lung Disease, Chronic Right Heart Failure, Exercise Training and Rehabilitation in Pulmonary Hypertension, and Right Heart Circulation Unit and Left Heart Valvular Diseases.

  • Imaging in Intervention, An Issue of Interventional Cardiology Clinics

    • 1st Edition
    • Volume 7-3
    • Jorge Álvaro Gonzalez-Martinez + 1 more
    • English
    This issue of Interventional Cardiology Clinics, edited by Jorge Gonzalez and Matthew Price, will span a number of essential topics surrounding Imaging in Intervention. Subjects discussed include: Multimodality Imaging for Transcatheter Mitral Valve Replacement; CT Assessment for Transcatheter Aortic Valve Replacement; Imaging Evaluation and Interpretation for Vascular Access for TAVR; Imaging Evaluation for the Detection of Leaflet Thrombosis after TAVR; CT Imaging Guidance for WATCHMAN LAA Closure; Myocardial viability testing to guide coronary revascularization; Intravascular Ultrasound For Guidance and Optimization of Percutaneous Coronary Intervention; CT-FFR to guide coronary angiography and intervention; Multimodality imaging of the tricuspid valve for assessment and guidance of transcatheter repair; and Three-dimensional printing for structural heart intervention planning, among others.

  • Current Controversies in the Management of Temporomandibular Disorders, An Issue of Oral and Maxillofacial Surgery Clinics of North America

    • 1st Edition
    • Volume 30-3
    • Daniel M. Laskin + 1 more
    • English
    This issue of Oral and Maxillofacial Surgery Clinics of North America focuses on Current Controversies in the Management of Temporomandibular Disorders, and is edited by Drs. Daniel Laskin and Shravan Kumar Renapurkar. Articles will include: The role of imaging in diagnosis of TMJ pathology; The use of synovial fluid analysis for diagnosis of TMJ disorders; The use of occlusal equilibration in the treatment of TMDs; The use of occlusal appliances in the management of TMDs; The efficacy of pharmacologic treatment of TMDs; The use of Botox to treat myofascial pain; Surgical versus non-surgical management of degenerative joint disease; Orthodontics as a treatment for TMD; Orthognathic surgery as a treatment for TMD; Arthroscopy versus arthrocentesis for treating internal derangements; Discectomy versus discoplasty for treating internal derangements; Costochondral graft versus total alloplastic joint for TMJ reconstruction; Injectable agents versus surgery for recurrent TMJ dislocation; Combined or staged TMJ and Orthognathic surgery for patients with internal derangement and a skeletal disharmony; Treatment for idiopathic condylar resorption: Orthognathic surgery versus total TMJ replacement; The role of stress in the etiology of oral parafunction and myofascial pain; and more!

  • MR Imaging of the Pancreas, An Issue of Magnetic Resonance Imaging Clinics of North America

    • 1st Edition
    • Volume 26-3
    • Kumar Sandrasegaran + 1 more
    • English
    This issue of MRI Clinics of North America focuses on MR Imaging of the Pancreas, and is edited by Drs. Kumar Sandrasegaran and Dushyant V. Sahani. Articles will include: Advanced MRI Techniques for Pancreas Imaging; PET/MRI for Pancreatic Diseases; The Role of MRI in Pancreas Cancer; Genetics of Pancreatic Neoplasms and Role of Screening; Cystic Pancreatic Tumors; Rare Pancreatic Tumors; Autoimmune Pancreatitis; Routine MRI for Pancreas; Neuroendocrine Tumors; Acute Pancreatitis: How Can MRI Help; Chronic Pancreatitis: What the Clinician Wants to Know from MRI; and more!

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