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Elsevier

  • Comprehensive Medicinal Chemistry IV

    • 4th Edition
    • David Rotella + 1 more
    • English
    Comprehensive Medicinal Chemistry, Fourth Edition, Four Volume Set provides a contemporary and forward-looking critical analysis and summary of recent developments, emerging trends, and recently identified new areas where medicinal chemistry is having an impact. The discipline of medicinal chemistry continues to evolve as it adapts to new opportunities and strives to solve new challenges. These include drug targeting, biomolecular therapeutics, development of chemical biology tools, data collection and analysis, in silico models as predictors for biological properties, identification and validation of new targets, approaches to quantify target engagement, new methods for synthesis of drug candidates such as green chemistry, development of novel scaffolds for drug discovery, and the role of regulatory agencies in drug discovery. A list of new areas covered includes: - newer assays, techniques, applications in medicinal chemistry - use of artificial intelligence and machine learning in drug discovery and development (prediction of drug efficacy, toxicity, and ADME properties, identification of new drug targets; design of novel drug candidates) - big data - chemical biology - degradation technologies - Precision medicine (targeted therapies; the use of biomarkers to guide drug development)

  • Tenable Engineering for a Sustainable Future

    Integrating SDGs and Natural Resource Utilization
    • 1st Edition
    • David S-K. Ting + 1 more
    • English
    Tenable Engineering for a Sustainable Future: Integrating SDGs and Natural Resource Utilization offers a comprehensive exploration of sustainable resource management. It delves into how natural resources can help achieve the United Nations Sustainable Development Goals (SDGs). This book highlights innovative ideas and technologies to encourage sustainable development and responsible resource utilization. To offer innovative solutions, each chapter will include experts from diverse disciplines as they examine eco-friendly practices across various global regions.

  • Polymer, Metal, and Ceramic Composites Manufacturing

    Material Fundamentals and Conventional and Additive Manufacturing Techniques
    • 1st Edition
    • Kuldeep Agarwal
    • English
    Polymer, Metal, and Ceramic Composites Manufacturing: Material Fundamentals and Conventional and Additive Manufacturing Techniques offers a detailed comparative analysis of the various techniques that can be used to create these materials, from the conventional to the cutting-edge. It provides insight into the fundamentals of composite materials, covering their properties and applications, then discusses options for their manufacture, highlighting challenges, solutions, and best-use applications. Conventional techniques such as vacuum bagging, filament winding, powder metallurgy, solid state welding, and more are outlined. Additive manufacturing techniques covered include fused deposition modeling, stereolithography, selective laser sintering, digital light processing, and more. The book also provides a comparative analysis of these manufacturing techniques, discussing the material properties, manufacturing process efficiency, and environmental impact of both conventional and additive manufacturing of these materials. Case studies, quality control and testing methods, and future trends are each included as well.

  • Hematological Insights and Clinical Implications of Platelet Functions in Lymphatic Filariasis

    • 1st Edition
    • Jyotsna Kailashiya
    • English
    Hematological Insights and Clinical Implications of Platelet Functions in Lymphatic Filariasis is a groundbreaking resource that delves into the impact of filarial parasites on platelet functions in humans. This comprehensive work explores the intricate signaling and immunological pathways affected by these interactions, filling a significant gap in the existing literature. The book is particularly valuable for researchers, scientists, and clinicians involved in the management and study of lymphatic filariasis, commonly known as elephantiasis; and also human platelets. With limited prior information on the interplay between human platelets and filarial parasites, this text offers a fresh perspective that could enhance patient management strategies. By understanding these interactions, healthcare professionals may unlock new avenues for effective treatment and prevention of lymphatic filariasis. This book is essential for anyone looking to deepen their understanding of the disease and contribute to its potential elimination.

  • Community Trees and Forests

    Improving Environmental and Human Well-Being
    • 1st Edition
    • David J. Nowak
    • English
    Improving Environmental and Human Health with Community Trees and Forests provides the latest and most comprehensive information on community forests globally, how these trees improve human health and well-being, the value of community trees, and what local land managers, from the lot to regional scale, could do to improve the benefits provided by community trees. It offers a complete understanding of the benefits and costs associated with trees in cities and how these benefits occur. This book facilitates the creation of sustainable community forests that provide optimal benefits to individuals and society.It takes a systems approach, focusing on the forest population rather than the individual tree, and providing information on the best tree species and designs to produce optimal effects. The book is divided into three major sections: The Basics, Urban Forest Benefits, and Improving the Urban Environment with Trees. It covers how cities affect our local environment, the monetary value of trees, and specific steps that land managers should follow to manage and improve their local tree and forest population. This comprehensive resource is valuable for city forest and park managers, policy makers, regional managers, and non-profit groups.

  • Cheminformatic Modeling and Data Gap Filling for a Green and Sustainable Environment

    • 1st Edition
    • Kunal Roy + 1 more
    • English
    Cheminformatic Modelling and Data Gap Filling for a Green and Sustainable Environment covers the theory and practices of chemical informatics, focusing on modeling various properties and endpoints related to chemicals for improved chemical management and the design of safer chemicals to promote environmental sustainability.Acros... four sections, this book outlines modeling techniques such as quantitative structure–property relationship (QSPR), read-across, and machine learning for modeling environmental endpoints of chemicals. OECD guidelines are discussed and considered for model development and validation, documentation using the QSAR modeling reporting format (QMRF), and regulatory requirements for result presentation. This book offers full datasets, algorithm information, and real-world case studies for all models, along with worked examples.This book will serve as an essential resource for chemists and environmental scientists working in green and sustainable chemistry, as well as for students and academics at graduate level and above studying cheminformatics. This book will also be of interest to researchers developing new and sustainable chemicals and to decision-makers looking to make industrial processes more sustainable.

  • Epigenetic Mechanisms in Brain Physiology and Disorders

    • 1st Edition
    • Moshe Szyf + 1 more
    • English
    Epigenetic Mechanisms in Brain Physiology and Disorders provides a comprehensive summary of epigenetic mechanisms in brain development, from embryogenesis to aging, brain physiology and pathology. It discusses the role DNA methylation plays in regulating genomic functions, which in turn guide brain function. The book explores the epigenetic role in cell type differentiation, epigenetic processes in memory, learning, and neuronal functioning, the role of DNA methylation and other epigenetic mechanisms in sleep, feeding and metabolic control, sex, temperature regulation, and cardiovascular and blood pressure regulation. It further explores the role of epigenetic processes in neuropsychiatry disorders, neurological disease and behavioral disorders, as well as epigenetic diagnostics and therapeutics.

  • Cheminformatics with Python

    • 1st Edition
    • Zhimin Zhang + 2 more
    • English
    Cheminformatics with Python provides a ground-up, practical introduction that helps reader make effective use of the software. In four parts, including programming, data, methods, and applications, the book provides a brief introduction to Python language and related scientific computing, cheminformatics, machine learning, and deep learning packages and presents a systematic study of the representation of instrumental data, including molecular structures and common chemical databases. The methods section covers analytical signal processing, multivariate calibration, multivariate resolution, classical machine learning, and deep learning methods. Finally, the application section presents case studies of successful applications of cheminformatics in analytical chemistry, metabolomics, drug discovery, and more.A supporting appendix section and the necessary mathematical, statistical, and information theory-related theories are provided, along with practical tips such as code editors and source code management. Online coding materials on GitHub and an individual Jupyter notebook for each chapter further support practical learning. This book will be a great resource for senior undergraduate students, graduate students, post-docs, and professors primarily in the field of computational and analytical chemistry.

  • Biotemplated Catalysts

    Synthesis, Properties and Applications
    • 1st Edition
    • Mohammad Amin Makarem + 2 more
    • English
    Biotemplated Catalysts: Synthesis, Properties and Applications is a comprehensive guide to the field of biotemplated catalysis, providing a systematic exploration of synthesis and characterization methods. The book compiles state-of-the-art research, methodologies, case studies, and practical insights, serving as a valuable resource for readers seeking a deeper understanding of biotemplated catalysts. It presents clear explanations of key concepts, detailed discussions of synthesis methods and characterization techniques, and real-world examples of biotemplated catalysts in action. Additionally, the book highlights the relevance and potential impact of biotemplated catalysis in various industries, bridging the gap between fundamental research and practical applications.Readers will find this to be a comprehensive resource that empowers them to explore new avenues for research, innovation, and collaboration in this dynamic field.

  • Advances in Thermal Engineering

    Innovations for Sustainable Solutions
    • 1st Edition
    • G. Sriharan + 2 more
    • English
    Advances in Thermal Engineering: Innovations for Sustainable Solutions takes readers on a journey through cutting-edge thermal engineering innovations and sustainable solutions in this comprehensive reference book. From advanced heat transfer technologies to environmental sustainability initiatives, the book delves into a diverse array of topics, providing insights into the latest advancements in thermal sciences and engineering. It covers a wide range of topics in thermal engineering, including advanced heat transfer technologies, innovative cooling systems, sustainable energy solutions, and emerging materials. Readers will explore practical applications, case studies, and discussions on environmental sustainability, thermal management in various systems, and the latest advancements.From fundamental principles to cutting-edge research, this book provides a comprehensive overview of thermal engineering innovations and their applications in diverse industries. It will equip readers -- from researchers, engineers, educators, students, industry professionals, and environmentalists -- with the knowledge and tools needed to address challenges and innovate in the ever-evolving field of thermal engineering.

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