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Elsevier

Tendon Regeneration

Understanding Tissue Physiology and Development to Engineer Functional Substitutes

  • 1st Edition - August 8, 2015
  • Newer edition is available
  • Editors: Manuela E. Gomes, Rui L. Reis, Márcia T. Rodrigues
  • Language: English

Tendon Regeneration: Understanding Tissue Physiology and Development to Engineer Functional Substitutes is the first book to highlight the multi-disciplinary nature of this spec… Read more

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Description

Tendon Regeneration: Understanding Tissue Physiology and Development to Engineer Functional Substitutes

 is the first book to highlight the multi-disciplinary nature of this specialized field and the importance of collaboration between medical and engineering laboratories in the development of tissue-oriented products for tissue engineering and regenerative medicine (TERM) strategies.

Beginning with a foundation in developmental biology, the book explores physiology, pathology, and surgical reconstruction, providing guidance on biological approaches that enhances tendon regeneration practices.

Contributions from scientists, clinicians, and engineers who are the leading figures in their respective fields present recent findings in tendon stem cells, cell therapies, and scaffold treatments, as well as examples of pre-clinical models for translational therapies and a view of the future of the field.

Key features

  • Provides an overview of tendon biology, disease, and tissue engineering approaches
  • Presents modern, alternative approaches to developing functional tissue solutions discussed
  • Includes valuable information for those interested in tissue engineering, tissue regeneration, tissue physiology, and regenerative medicine
  • Explores physiology, pathology, and surgical reconstruction, building a natural progression that enhances tendon regeneration practices
  • Covers recent findings in tendon stem cells, cell therapies, and scaffold treatments, as well as examples of pre-clinical models for translational therapies and a view of the future of the field

Readership

Scientists and Engineers working on tissue engineering and regeneration. Undergraduate and postgraduate students, professors, and scientists working in the biosciences, biomedicine, biotechnology, bioengineering, and materials sciences.

Table of contents

  • Preface
  • Section 1. Biology and Physiology of Tendons
    • Chapter 1. Tendon Physiology and Mechanical Behavior: Structure–Function Relationships
      • 1. Tendon Structure and Composition
      • 2. Tendon Mechanics
      • 3. Multiscale Mechanics and Structure–Function Characterization
      • 4. Mechanical and Compositional Variations in Tendons with Different Functions
      • List of Abbreviations
      • Glossary
    • Chapter 2. Tendon Resident Cells—Functions and Features in Section I—Developmental Biology and Physiology of Tendons
      • 1. Introduction
      • 2. Tendon Cells—Origin and Specification
      • 3. Tendon Cells—ECM Synthesis, Assembly, and Tissue Maturation
      • 4. Cell–ECM Interactions
      • 5. Mechanoregulation of Tendon Cells
      • 6. Conclusion
      • List of Abbreviations
      • Glossary
    • Chapter 3. Mechanobiology of Embryonic and Adult Tendons
      • 1. Introduction
      • 2. Embryonic Tendon
      • 3. Postnatal Tendon
      • 4. Mechanical Cues Experienced by Embryonic, Postnatal, and Adult Tendons
      • 5. Studies in the Embryo Suggest Mechanical Factors Influence Embryonic Tendon Development
      • 6. In Vitro Studies Suggest Mechanical Factors Influence Embryonic Tendon Development
      • 7. Exercise Studies Examine the Influence of Mechanics in Adult Tendon
      • 8. In Vitro Studies Suggest Mechanical Factors Influence Adult Tendon Homeostasis
      • 9. Potential Mechanisms of Tendon Cell Mechanotransduction
      • 10. Conclusions
      • List of Abbreviations
  • Section 2. Pathologies and Repair of Tendons
    • Chapter 4. Tendinopathy I: Understanding Epidemiology, Pathology, Healing, and Treatment
      • 1. Introduction
      • 2. Anatomical Diagnosis
      • 3. Pathology
      • 4. Epidemiology
      • 5. Pathophysiology
      • 6. Healing and Repair
      • 7. Nonsurgical Treatment
      • 8. Surgical Treatment
      • 9. Conclusion
      • List of Abbreviations
      • Glossary
    • Chapter 5. Tendinopathy II: Etiology, Pathology, and Healing of Tendon Injury and Disease
      • 1. Epidemiology
      • 2. Definitions
      • 3. Tendinopathy Etiology
      • 4. Pathology
      • 5. Summary and Conclusions
      • List of Abbreviations
      • Glossary
  • Section 3. Tendon Regenerative Medicine Approaches
    • Chapter 6. Cell-Based Approaches for Tendon Regeneration
      • 1. Introduction
      • 2. Tendon Endogenous Regeneration
      • 3. Isolation Procedures of Tendon Resident Cells
      • 4. Alternative Stem Cells Sources for Cell-Based Tendon Tissue Engineering
      • 5. Moving Cell Therapies into the Clinics
      • 6. Conclusion
      • List of Abbreviations
      • Glossary
    • Chapter 7. The Role of Growth Factors in Tendon Stimulation
      • 1. Introduction
      • 2. Growth Factors
      • 3. Platelet-Rich Plasma
      • 4. Conclusions
      • List of Abbreviations
  • Section 4. Scaffolds-Based Approaches
    • Chapter 8. Engineering Anisotropic 2D and 3D Structures for Tendon Repair and Regeneration
      • 1. Introduction
      • 2. Anisotropic Sponges
      • 3. Anisotropic Self-Assembled Fibers
      • 4. Anisotropic Electrospun Fibers
      • 5. Anisotropic Imprinted Substrates
      • 6. Conclusive Remarks
      • List of Abbreviations
      • Glossary
    • Chapter 9. Biologic- and Synthetic-Based Scaffolds for Tendon Regeneration
      • 1. Tendon Injuries
      • 2. Tendon Repair and Tissue Engineering Strategies
      • 3. Criteria and Requirements for Tendon Tissue Engineering Scaffolds
      • 4. Types for Tendon Tissue Engineering Scaffolds
      • 5. Scaffold Architecture and Design
      • 6. Functional and Bioactive Scaffolds
      • 7. Conclusions
      • List of Abbreviations
  • Section 5. Tendon Tissue Engineering
    • Chapter 10. Fabrication of Hierarchical and Biomimetic Fibrous Structures to Support the Regeneration of Tendon Tissues
      • 1. Introduction
      • 2. Spinning Techniques for Tendon TE Scaffolding
      • 3. Rapid Prototyping Technique
      • 4. Electrochemically Aligned Collagen
      • 5. Microengineered Hydrogels
      • 6. Assembly of Fibrous Biomaterials into Higher Hierarchical Structures
      • 7. Concluding Remarks and Future Perspectives
      • List of Abbreviations
      • Glossary
    • Chapter 11. Multifactorial Tendon Tissue Engineering Strategies
      • 1. Introduction
      • 2. Cells, Scaffolds, and Mechanical Stimulation
      • 3. Approaches for Different Anatomical Regions
      • 4. Design of Custom Bioreactors
      • 5. Concluding Remarks
      • List of Abbreviations
      • Glossary
    • Chapter 12. Tendon Tissue Engineering: Combined Tissue Engineering Approach for the Regeneration of Tendons
      • 1. Introduction
      • 2. Functional Tendon Tissue Engineering
      • 3. Tendon Tissue Engineering Bioreactors and Construct Stimulation
      • 4. Conclusions
      • List of Abbreviations
      • Glossary
    • Chapter 13. Biomaterial Scaffolds for Tendon Tissue Engineering
      • 1. Motivation: Tendon Injury and Repair Mechanism
      • 2. Introduction to Tissue Engineering
      • 3. Cell–Biomaterial Interactions
      • 4. Clinical Translation and Adaptation to Complex Musculoskeletal Injury Models
      • 5. Conclusions
      • List of Abbreviations
      • Glossary
    • Chapter 14. Engineered Tendon Repair and Regeneration
      • 1. Introduction
      • 2. Cell Sources in Tendon Engineering and Regeneration
      • 3. Scaffold Materials for Tendon Engineering
      • 4. In Vivo, In Vitro, and Ex Vivo Tendon Engineering
      • 5. Conclusion
      • List of Abbreviations
      • Glossary
    • Chapter 15. Scaffold Design for Integrative Tendon–Bone Repair
      • 1. Introduction
      • 2. Rotator Cuff Tendon Augmentation Grafts
      • 3. Integrative Rotator Cuff Tendon–Bone Repair
      • 4. Summary and Future Directions
      • List of Abbreviations
  • Index

Product details

About the editors

MG

Manuela E. Gomes

Manuela E. Gomes is Associate Professor and Vice-President of the Research Institute for Biomaterials, Biodegradable and Biomimetics at the University of Minho. Dr. Gomes is also on the Board of Directors of the Portuguese Associate Laboratory that gathers the Institute for Life and Health Sciences of the University of Minho and the 3B´s Research Group and was responsible for the implementation of the Quality Management System at the 3B’s. She is a board member of the Doctoral Program on Tissue Engineering Regenerative Medicine and Stem Cells and has been part of numerous European and national/regional projects as PI/member. She was awarded a Consolidator Grant and a PoC from the European Research Council that started in 2018 and 2022, respectively. She has edited 2 books, 1 encyclopedia, and is author of 43 book chapters, 226 scientific papers in journals with international peer-review, 9 patents and over 344 communications in international conferences.
Affiliations and expertise
Associate Professor and Vice President, Research Institute for Biomaterials, Biodegradable and Biomimetics, University of Minho 3B’s Research Group, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, Avepark – Parque de Ciência e Tecnologia, Zona Industrial da Gandra, Barco GMR, Portugal

RR

Rui L. Reis

Dr. Rui Reis is Vice-President for Research and Innovation of University of Minho, Portugal, Director of 3B’s Research Group and Director of ICVS/3B´s Associate Laboratory, both of UMinho. He’s the CEO of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, the Coordinator of the Discoveries Centre for Regenerative and Precision Medicine, the Global Past-President of the Tissue Engineering and Regenerative Medicine International Society and the Editor-in-chief of the Journal of Tissue Engineering and Regenerative Medicine. He’s edited 18 books, 10 special issue journals, 280 book chapters and has more than 1225 published works listed on ISI Web of Knowledge, being an inventor of around 70 patents. He’s been awarded many important international prizes, including the TERMIS-EU contributions to the literature Award and the TERMIS-EU Career Achievement Award, and recently the UNESCO- International Life Sciences Award and the IET A. F. Harvey Engineering Research Prize.
Affiliations and expertise
President of Institute 3B’s, University of Minho; Director of the Associated Laboratory ICVS/3B’s and of the European Institute of Excellence in Tissue Engineering and Regenerative Medicine (EXPERTISSUES); Full Professor of Tissue Engineering, Regenerative Medicine and Stem Cells, University of Minho, Barco, Portugal

MR

Márcia T. Rodrigues

Márcia T. Rodrigues is an Assistant Researcher the Research Institute for Biomaterials, Biodegradable and Biomimetics at the University of Minho. Her research is focused on strategies to study persistent inflammation cues and associated pathways that impair tissue healing and regeneration. Dr. Rodrigues has mentored and supervised several PhD, MSc, and BSc students. Currently, she supervises 1 PhD student and mentors 3 post-doctoral fellows. She has also been part of the scientific committee and organization of 8 international scientific events and acts as a peer reviewer in > 20 major international journals in the field. She is also a member of the Editorial Board of IJMS and editor of 2 special issues for IJMS and Adv Drug Deliv Rev (2022). Dr. Rodrigues co-edited one scientific book Tendon Regeneration (Elsevier), authored 13 book chapters, 1 Encyclopedia chapter, 48 papers in international refereed journals, 3 featured articles, and 4 corresponding author papers.
Affiliations and expertise
Assistant Researcher, Research Institute on Biomaterials, Biodegradables and Biomimetics of University of Minho 3B's Research Group,eadquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, Avepark – Parque de Ciência e Tecnologia, Zona Industrial da Gandra, Guimarães, Portugal.

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