LIMITED OFFER
Save 50% on book bundles
Immediately download your ebook while waiting for your print delivery. No promo code needed.
Systemic Lupus Erythematosus
- 5th Edition - October 29, 2010
- Editors: Robert G. Lahita, George C. Tsokos, Jill P Buyon, Takao Koike
- Language: English
- Hardback ISBN:9 7 8 - 0 - 1 2 - 3 7 4 9 9 4 - 9
- eBook ISBN:9 7 8 - 0 - 0 8 - 0 9 6 1 7 1 - 2
Systemic lupus erythematosus (S.L.E.), commonly called lupus, is a chronic autoimmune disorder that can affect virtually any organ of the body. In lupus, the body's immune sy… Read more
Purchase options
Institutional subscription on ScienceDirect
Request a sales quoteSystemic lupus erythematosus (S.L.E.), commonly called lupus, is a chronic autoimmune disorder that can affect virtually any organ of the body. In lupus, the body's immune system, which normally functions to protect against foreign invaders, becomes hyperactive, forming antibodies that attack normal tissues and organs, including the skin, joints, kidneys, brain, heart, lungs, and blood. Lupus is characterized by periods of illness, called flares, and periods of wellness, or remission.
Because its symptoms come and go and mimic those of other diseases, lupus is difficult to diagnose. There is no single laboratory test that can definitively prove that a person has the complex illness.
To date, lupus has no known cause or cure. Early detection and treatment is the key to a better health outcome and can usually lessen the progression and severity of the disease. Anti-inflammatory drugs, anti-malarials, and steroids (such as cortisone and others) are often used to treat lupus. Cytotoxic chemotherapies, similar to those used in the treatment of cancer, are also used to suppress the immune system in lupus patients.
A new edition of this established and well regarded reference which combines basic science with clinical science to provide a translational medicine model. Systemic Lupus Erythematosus is a useful reference for specialists in the diagnosis and management of patients with SLE, a tool for measurement of clinical activity for pharmaceutical development and basic research of the disease and a reference work for hospital libraries.
- Highly illustrated and in full color throughout
- Basic science section expanded to allow the reader to focus on the newest techniques in molecular medicine and its effects on disease expression and treatment
- Clinical aspects and new drugs will be covered in great detail providing a useful reference to both experienced clinicians and physicians with an interest in lupus in their clinical practice
Basic scientists and clinicians who are interested in SLE including rheumatologists, dermatologists, nephrologists, immunologists and allergists. Residents and fellows in training, primary internists with an interest in the disease and medical libraries
Section I: Basis of Disease Pathogenesis
A. Genetics
1 Major histocompatibility complex class II
Michelle M.A. Fernando and Timothy J. Vyse
2 Genetic susceptibility and class III complement genes
John P. Atkinson, Peter M. Schneider and C. Yung Yu
3 Constitutive genes and lupus
Betty P. Tsao and Yun Deng
4 Genetics of lupus in mice
Dwight H. Kono and Argyrios N. Theofilopoulos
B. Cellular Pathogenesis
5 Tolerance and autoimmunity
Shiv Pillai and Kendra N. Taylor
6 Dendritic cells in SLE
Gerlinde Obermoser, Karolina Palucka, Hideki Ueno, Jacques Banchereau, and Virginia Pascual
7 T cells and systemic lupus erthematosus
Jose C. Crispin and George C. Tsokos
8 B-lymphocyte biology in SLE
Mark J. Mamula
9 Polymorhonuclear and endothelial cells
Robert Clancy
10 Mechanisms and consequences of mitochondrial dysfunction and oxidative stress in T cells of patients with SLE
Andras Perl
11 Cell cycle regulation and systemic lupus erythematosus
Dimitrios Balomenos
12 The role of reactive nitrogen and oxygen intermediates in systemic lupus erythematosus
Ahmad K. Mashmoushi, Gary S. Gilkeson and Jim C. Oates
C. Humoral Pathogenesis
13 Origins of antinuclear antibodies
Westley H. Reeves, Yuan Xu, Haoyang Zhuang, Yi Li and Lijun Yang
14 Anti-DNA antibodies: Structure, regulation and pathogenicity
Cynthia Aranow, Dun Zhou and Betty Diamond
15 Extractable nuclear antigens and SLE: specificity and role in disease pathogenesis
Mary Keogan, Grainne Kearns and Caroline A. Jefferies
16 Antihistone and antispliceosomal antibodies
Minoru Satoh, Marvin J. Fritzler, and Edward K.L. Chan
17 Toll-like receptors in SLE
Terry K. Means
18 Interferon-alpha in systemic lupus erythematosus
Mary K. Crow
19 Immune complexes in systemic lupus erythematosus
Mark H. Wener
20 Complement and tissue injury in SLE
Chau-Ching Liu and Joseph Ahearn
21 Humoral pathogenesis: Fc receptors in autoimmunity and end-organ damage
T. Ernandez and T.N. Mayadas
D. Environmental Aspects of Pathogenesis
22 Drug-induced lupus mechanisms
Raymond L. Yung and Bruce C. Richardson
23 Gender and age in lupus
Robert G. Lahita
24 Roles for infections in systemic lupus erythematosus pathogenesis
Evan S. Vista, A. Darise Farris and Judith A. James
25 Systemic lupus erythematosus in domestic animals
Michael J. Day
E. Mechanisms of Tissue Injury
26 Pathogenesis of lupus nephritis
Yong Du and Chandra Mohan
27 Tissue injury and the skin
Annegret Kuhn, Markus Bohm and Thomas A. Luger
28 Neuropsychiatric systemic lupus erythematosus: Mechanisms of injury
Meggan Mackay, Aziz M. Ulug and Bruce T. Volpe
29 Atherosclerosis and tissue injury in systemic lupus erythematosus
Ingrid Avalos and C. Michael Stein
Section II: Clinical Aspects of Disease
A. Clinical Presentation
30 The clinical presentation of systemic lupus erythematosus
Robert G. Lahita
31 Neonatal lupus
Jill P. Buyon and Deborah M. Friedman
32 SLE in children
Rina Mina and Hermine I. Brunner
33 Drug-induced disease
Anne-Barbara Mongey and Evelyn V. Hess
34 Laboratory evaluation of patients with systemic lupus erythematosus
Peter H. Schur
35 Pregnancy and reproductive concerns in systemic lupus erythematosus
Carl Laskin, Karen Spitzer and Christine A. Clark
36 Epidemiology of systemic lupus erythematosus
Catia Duarte, Maura Couto, Luis Ines and Matthew H. Liang
37 Monitoring disease activity
Kenneth C. Kalunian and Joan T. Merrill
38 Incomplete lupus erythematosus
Johannes C. Nossent and Tom J.G. Swaak
39 Design of clinical trials for SLE
Joan T. Merrill, Ken Kalunian and Jill P. Buyon
B. Organ Systems
40 The nervous system and lupus
John G. Hanly
41 Skin
Victoria P. Werth, Cristian Vera-Kellet and Jan P. Dutz
42 Kidney
Brad H. Rovin and Isaac E. Stillman
43 Heart
Kathleen Macsimowicz-McKinnon and Susan Manzi
44 Vasculitis
Barri Fessler and Gary S. Hoffman
45 Lung
Aryeh Fischer and Roland M. du Bois
46 Gastrointestinal: Liver
Ian R. Mackay
47 Gastrointestinal: Nonhepatic
Lloyd Mayer
48 Cellular hematology
Seetha U. Monrad and Mariana J. Kaplan
49 Musculoskeletal system: Articular disease, bone metabolism
Diane Horowitz, Galina Marder and Richard Furie
Section III: Anti-Phospholipid Syndrome
A. Pathogenesis
50 Antiphospholipid antibody: Pathogenesis
Takao Koike, Tatsuya Atsumi and Olga Amengual
51 Endothelial cell damage and atherosclerosis
Joan T. Merrill
B. Clinical
52 Laboratory testing for antiphospholipid syndrome
Steven Krilis and Yiannia Ioannou
53 Clinical presentation of antiphospholipid syndrome
Munther A. Khamashta
54 Pregnancy and antiphospholipid syndrome
Kristina Milan and D. Ware Branch
55 Treatment of antiphospholipid syndrome
Gerard Espinosa and Richard Cervera
Section IV: Treatment
56 Steroids and nonsteroidal anti-inflammatory drugs
Olga Dvorkina and Ellen M. Ginzler
57 Antimalarials
Nathalie Costedoat-Chalumeau, Gaelle Leroux, Jean-Charles Piette and Zahir Amoura
58 Cytotoxic agents
Eva D. Papadimitraki, George Bertsias, George Chamilos and Dimitrios T. Boumpas
59 Biological agents
Vasileios C. Kyttaris
- No. of pages: 1154
- Language: English
- Edition: 5
- Published: October 29, 2010
- Imprint: Academic Press
- Hardback ISBN: 9780123749949
- eBook ISBN: 9780080961712
RL
Robert G. Lahita
Dr. Robert Lahita is Clinical Professor of Medicine at Rutgers University, and the Director of the Institute for Autoimmune and Rheumatic Diseases. He is a fellow of the ACP and the Royal College, and a master of the ACR. Dr. Lahita is the author of more than 16 books and 150 scientific publications in the field of autoimmunity. He is the editor of the standard textbook Systemic Lupus Erythematosus and the Senior Editor of the Textbook of Autoimmunity, and the author of Lupus: Q and A for patients and Autoimmunity in Women.
Affiliations and expertise
Professor of Medicine, Adjunct Professor of Biochemistry and Molecular Biology UMDNJ, New Jersey Medical School Vice President and Chairman of Medicine Newark Beth Israel Medical Center Newark, NJ, USAGT
George C. Tsokos
George C. Tsokos, MD, is a Professor of Medicine at Harvard Medical School and Chief of Rheumatology and Clinical Immunology at Beth Israel Deaconess Medical Center. Dr Tsokos has served as President of the Clinical Immunology Society, on the boards of directors for the American College of Rheumatology and the Lupus Foundation of America, member/chair of multiple federal study sections, and editor/member of the editorial boards for top scientific journals. He has received several awards, including a MERIT from NIH, the Lee C. Howley Sr. Prize, the Evelyn V. Hess, the Distinguished Basic Investigator Award from the American College of Rheumatology, the Lupus Insight Prize from the Lupus Research Alliance, and the Carol Nachman Prize for Rheumatology. He is a Master of the American College of Physicians and the American College of Rheumatology, a member of American Association of Physicians and Fellow of AAAS.
Affiliations and expertise
Professor of Medicine at Harvard Medical School and Chief of Rheumatology and Clinical Immunology at Beth Israel Deaconess Medical CenterJB
Jill P Buyon
Affiliations and expertise
Lady Va and Sir Deryck Maughan Professor of Medicine, Division of Rheumatology, New York University School of Medicine, New York, New YorkRead Systemic Lupus Erythematosus on ScienceDirect