Nonclinical Assessment of Abuse Potential for New Pharmaceuticals offers a complete reference on the current international regulatory guidelines and details best practice methodology for the three standard animal models used to evaluate abuse potential: physical dependence, self-administration and drug discrimination. This book also includes chapters on alternative models and examples of when you should use these alternatives. Case histories are provided at the end of the book to show how the data generated from the animal models play a pivitol role in the submission package for a new drug. By incorporating all of this information into one book, Nonclinical Assessment of Abuse Potential for New Pharmaceuticals is your single resource for everything you need to know to understand and implement the assessment of abuse liability.
Our contemporary era has witnessed the remarkable development of China-ASEAN relations. Both sides have pledged to establish and develop a comprehensive cooperation. However, any development of international relations is governed by international legal principles, norms and rules, such as the Charter of the United Nations and general international law. There is no exception for China-ASEAN relations. The book discusses and explains China-ASEAN relations from an international law perspective and covers a wide range of legal topics and legal issues.
The first book to comprehensively analyze the regulation of dirty industry migration - a global issue that has complex economic, environmental and social implications. The book examines the mechanisms of regulation of dirty industry migration under internal trade, investment, environment and human rights laws. Other than international law, the host and home country regulation of dirty industry migration in the context of domestic laws and policies are examined. Finally, this book critically evaluates the voluntary codes relating to corporate environmental citizenship and social responsibility which bear implications on the regulation of dirty industry migration.