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Books in Pharmaceutical chemistry

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21-30 of 48 results in All results

Significant Pharmaceuticals Reported in US Patents

  • 1st Edition
  • May 2, 2007
  • Thomas F. DeRosa
  • English
  • eBook
    9 7 8 - 0 - 0 8 - 0 4 8 0 9 1 - 6
Significant Pharmaceuticals Reported in US Patents identifies the next generation of pharmaceuticals reported in US Patents. This "hands-on" title provides explicit laboratory methods for preparing the most recent and effective medications. Each entry documents the biological testing protocols used to evaluate a drug and the significance of the current treatment agent over previous methods. Pharmaceuticals are included in this review only if at least two of the following criteria were met: Effectiveness in treating an illness, Innovative, ease of preparation, synergy with existing Medications. Pharmaceuticals are reported for 27 separate classes of illness, including: AIDS, Alzheimer's Disease, Cardiovascular Disorders, Diabetes, Epilepsy, Hepatitis C, Osteoporosis, Obesity and Sleep Disorders. Significant Pharmaceuticals Reported in US Patents has been designed to be used as both a reference and synthetic guide for pharmaceutical, medicinal and organic chemists and graduate students. Researchers working in other areas will also find the information valuable as in many instances intermediates or the next generation pharmaceutical are readily convertible into other industrial products including: anti-oxidants, chemical additives, herbicides, polymer precursors, water purification agents. Clear structural depictions of reagents and chemical transformations have been supplied to permit the identification of other future applications.

Progress in Medicinal Chemistry

  • 1st Edition
  • Volume 45
  • February 19, 2007
  • F.D. King + 1 more
  • English
  • Hardback
    9 7 8 - 0 - 4 4 4 - 5 2 8 0 8 - 7
  • eBook
    9 7 8 - 0 - 0 8 - 0 4 7 1 3 1 - 0
The success of any drug discovery project relies upon the quality of the lead that initiates the lead optimization process. What defines a ‘quality lead’, where these ‘quality leads’ come from and how one discovers them has been the subject of intense debate within the pharmaceutical industry, relies upon defining those properties that historically have led to successful drug discovery. This volume addresses these questions and specifically discusses diabetes, obesity and tuberculosis.

Progress in Medicinal Chemistry

  • 1st Edition
  • Volume 44
  • April 25, 2006
  • F.D. King + 1 more
  • English
  • Hardback
    9 7 8 - 0 - 4 4 4 - 5 1 7 3 7 - 1
  • eBook
    9 7 8 - 0 - 0 8 - 0 4 6 2 1 0 - 3
The perceived lack of drug discovery productivity in recent times has led to much debate in the pharmaceutical/biotechnology industry as escalating R&D costs are not being matched by increased output. Few observers doubt that selecting the right targets, ie those which are critical to disease pathology and are ‘druggable’, is the best starting point for improved productivity.The seven chapters of this volume describe recent progress towards drugs acting at a range of ‘druggable’ targets. One chapter addresses kinases, one covers an ion channel, two proteases are featured and three of the chapters cover G-protein coupled receptors, which has historically perhaps been the most fruitful area for medicinal chemists.

Surface Activity in Drug Action

  • 1st Edition
  • Volume 21
  • March 1, 2005
  • R.C. C. Srivastava + 1 more
  • English
  • eBook
    9 7 8 - 0 - 0 8 - 0 4 5 6 1 1 - 9
Surface activity is present in living systems; for example in body fluid or cell soup and molecules of surface-active nature are crucial to living matter and its organization. Surface Activity in Drug Action proposes "a liquid membrane hypothesis of drug action" for surface-active drugs. Chapters 1-7 contains an account of the hypothesis and chapter 8 contains a general account of the application of surface activity in therapeutics. The methodology and presentation of the information makes Surface Activity in Drug Action valuable reading for students and researchers interested in surface activity.

Designer Drugs Directory

  • 1st Edition
  • October 16, 1998
  • K. Valter + 1 more
  • J-C. Landry
  • English
  • eBook
    9 7 8 - 0 - 0 8 - 0 5 3 0 3 2 - 1
This book is intended to serve as quick reference handbook on so-called designer drugs. These new, mainly synthetic compounds are also often referred to as analogues of controlled substances. This new work provides a unique directory of 104 designer drugs. This class of drugs is rapidly growing in variety and number of compounds. Although identification, toxicology and other properties have been thoroughly investigated, their analogues and derivatives remain poorly documented. This book fills the gap.Data which is available is often contradictory and confused. This directory provides a critical treatment of the subject which is thoroughly indexed including both the subject index and an index listing more that 230 street names of the described designer drugs.Divided into two parts; the first section describes aspects of designer drug manufacture, new abuse trends, sources of information and terminology. The second, descriptive part, classifies the drugs into ten main categories according to their chemical structure and prevalent pharmacological action. A separate chapter is devoted to each category, followed by a set of corresponding data sheets, street names and eventual synonyms, Toxicological data, short notes on the history of drugs as well as the most pertinent bibliographic references are included.

Chemistry and Pharmacology

  • 1st Edition
  • Volume 49
  • June 16, 1997
  • Geoffrey A. Cordell
  • English
  • eBook
    9 7 8 - 0 - 0 8 - 0 8 6 5 7 3 - 7
Internationally acclaimed for more than 40 years, this Series, founded by the late Professor R.H.F. Manske, continues to provide outstanding coverage of the rapidly expanding field of the chemotaxonomy, structure elucidation, synthesis, biosynthesis, and biology of all classes of alkaloids from higher and lower plants, marine organisms, or various terrestrial animals. Each volume provides, through its distinguished authors, up-to-date and detailed coverage of particular classes or sources of alkaloids. Over the years, this Series has become the standard in natural product chemistry to which all other book series aspire. The Alkaloids: Chemistry and Pharmacology endures as an essential reference for all naturalproduct chemists and biologists who have an interest in alkaloids, their diversity, and their unique biological profile.

Chemistry and Pharmacology

  • 1st Edition
  • Volume 48
  • June 21, 1996
  • Geoffrey A. Cordell
  • English
  • eBook
    9 7 8 - 0 - 0 8 - 0 8 6 5 7 2 - 0
Internationally acclaimed for more than forty years, this Series, founded by the late Professor R.H.F. Manske, continues to provide outstanding coverage of the rapidly expanding field of the chemotaxonomy, structureelucidation, synthesis, biosynthesis, and biology of all classes of alkaloids from higher and lower plants, marine organisms, or various terrestrial animals. Each volume provides, through its distinguished authors, up-to-date and detailed coverage of particular classes or sources of alkaloids. Over the years, this Series has become the standard in natural product chemistry to which all other book series aspire. The Alkaloids: Chemistry and Pharmacology endures as an essential reference for all natural product chemists and biologists who have an interest in alkaloids, their diversity, and their unique biological profile.

Chemistry and Pharmacology

  • 1st Edition
  • Volume 45
  • May 12, 1994
  • Geoffrey A. Cordell + 1 more
  • English
  • eBook
    9 7 8 - 0 - 0 8 - 0 8 6 5 6 9 - 0
Internationally acclaimed for more than 40 years, this serial, founded by the late Professor R.H.F. Manske, continues to provide outstanding coverage of the rapidly expanding field of the chemotaxonomy, structure elucidation, synthesis, biosynthesis, and biology of all classes of alkaloids from higher and lower plants, marine origins, or various terrestrial animals. Each volume provides, through its distinguished authors, up-to-date and detailed coverage of particular classes or sources of alkaloids. Over the years, this series has become the standard in natural product chemistry to which all other book series aspire. The Alkaloids, Chemistry and Pharmacology endures as an essential reference for all natural product chemists and biologists who have an interest in alkaloids, their diversity, and their unique biological profile.

Chemistry and Pharmacology

  • 1st Edition
  • Volume 42
  • August 19, 1992
  • Geoffrey A. Cordell
  • English
  • eBook
    9 7 8 - 0 - 0 8 - 0 8 6 5 6 6 - 9
This volume deals for the most part, with current status of four groups of alkaloids of substantial biological releavance. Chapter 1 by Lounasmaa and Tolvanen, focuses on the "Eburanmine-Vincamine Alkaloids," and discusses the new alkaloids, and the extensive synthetic and pharmacologic work that has been conducted since the last review in 1981. Clark and Hufford present a review which focuses on the "Antifungal Alkaloids," especially those compounds that might be important as lead structures for the development of agents usefulin treating the opportunistic infections associated with AIDS. Wang and Liang bring up-to-date the area of the diterpenoid alkaloids from a chemical perspective. Over the years this large group of alkaloids has produced a fascinating array of molecular gyrations. Finally, Wrobel and Wojtasiewicz revisit the topic of "Sulfur-Containing Alkaloids" (which was last covered in Volume 26) from a chemical and biological perspective.