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Books in Medicinal chemistry

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21-30 of 110 results in All results

Third Generation EGFR Inhibitors

  • 1st Edition
  • November 27, 2018
  • Harun M. Patel + 2 more
  • English
  • Paperback
    9 7 8 - 0 - 0 8 - 1 0 2 6 6 1 - 8
  • eBook
    9 7 8 - 0 - 0 8 - 1 0 2 6 6 2 - 5
Third Generation EGFR Inhibitors: Overcoming EGFR Resistance and Toxicity Problems reviews current issues relating to the design of reversible and irreversible third generation EGFR inhibitors, highlighting the types of mutation responsible for resistance, and providing different chemical starting points for researchers to optimize and develop in designing the next generation of drugs. Beginning with an introduction to EGFR inhibitors and a review of inhibitors currently approved or in clinical trials, the book goes on to discuss current approaches in the development of both covalent irreversible and covalent reversible EGFR Inhibitors. In addition, mechanisms of resistance to third generation inhibitors, and discovery of fourth generation allosteric C797S inhibitors are explored before a discussion of potential future trends. This comprehensive coverage of the design and development of improved analogues to overcome the problems of resistance and toxicity associated with third generation EGFR inhibitors makes Third Generation EGFR Inhibitors a crucial resource for medicinal chemists, drug developers, and researchers investigating cancer therapeutics.

Chemistry and Bioactivity of Boswellic Acids and Other Terpenoids of the Genus Boswellia

  • 1st Edition
  • September 19, 2018
  • Ahmed Al-Harrasi + 3 more
  • English
  • Paperback
    9 7 8 - 0 - 0 8 - 1 0 2 4 4 1 - 6
  • eBook
    9 7 8 - 0 - 0 8 - 1 0 2 4 4 8 - 5
Exhibiting a wealth of interesting activities and novel structures, Boswellic acid and the other terpenoids of the genus Boswellia (from which frankincense is derived) are a growing source of interest for the natural product drug discovery community. Chemistry and Bioactivity of Boswellic Acids and Other Terpenoids of the Genus Boswellia presents, in a single volume for the first time, key research into their structures, synthesis and potential as starting points for the development of medicinal agents. Drawing on the authors’ expert knowledge, this volume is an interesting insight into the identification of novel compounds from endemic plant sources, and is a useful tool for all researchers involved in the discovery and development of bioactive structures from natural products.

Key Heterocycle Cores for Designing Multitargeting Molecules

  • 1st Edition
  • June 11, 2018
  • Om Silakari
  • English
  • Paperback
    9 7 8 - 0 - 0 8 - 1 0 2 0 8 3 - 8
  • eBook
    9 7 8 - 0 - 0 8 - 1 0 2 1 0 5 - 7
Key Heterocycle Cores for Designing Multitargeting Molecules provides a helpful overview of current developments in the field. Following a detailed introduction to the manipulation of heterocycle cores for the development of dual or multitargeting molecules, the book goes on to describe specific examples of such developments, focusing on compounds such as Benzimidazole, Acridine, Flavones, Thiazolidinedione and Oxazoline. Drawing on the latest developments in the field, this volume provides a valuable guide to current approaches in the design and development of molecules capable of acting on multiple targets. Adapting the heterocyclic core of a single-target molecule can facilitate its development into an agent capable of acting on multiple targets. Such multi-targeting drugs have the potential to become essential components in the design of novel, holistic treatment plans for complex diseases, making the design of such active agents an increasingly important area of research.

Synthesis of Medicinal Agents from Plants

  • 1st Edition
  • April 17, 2018
  • Ashish Tewari + 1 more
  • English
  • Paperback
    9 7 8 - 0 - 0 8 - 1 0 2 0 7 1 - 5
  • eBook
    9 7 8 - 0 - 0 8 - 1 0 2 2 7 4 - 0
Synthesis of Medicinal Agents from Plants highlights the importance of synthesizing medicinal agents from plants and outlines methods for performing it effectively. Beginning with an introduction to the significance of medicinal plants, the book goes on to provide a historical overview of drug synthesis before exploring how this can be used to successfully replicate and adapt the active agents from natural sources. Chapters then explore the medicinal properties of a number of important plants, before concluding with a discussion of the future of drugs from medicinal plants. Illustrated with real-world examples, it is a practical resource for researchers in this field. In an age of rapid environmental destruction, hundreds of medicinal plants are at risk of extinction from overexploitation and deforestation, limiting the natural resources available for active agent extraction, thereby threatening the discovery of future cures for diseases. Simultaneously, with the increasing population and advances in medical sciences, the demand for drugs is continuously increasing and cannot be met with just plants. The ability to synthetically replicate the active compounds from these plants is essential in creating an ecologically-aware, sustainable future for drug design

Himalayan Phytochemicals

  • 1st Edition
  • April 10, 2018
  • Sumira Jan + 1 more
  • English
  • Paperback
    9 7 8 - 0 - 0 8 - 1 0 2 2 2 7 - 6
  • eBook
    9 7 8 - 0 - 0 8 - 1 0 2 2 3 6 - 8
Himalayan Phytochemicals: Sustainable Options for Sourcing and Developing Bioactive Compounds provides a detailed review of the important medicinal plants which have already been discovered in the Himalayan region, outlining their discovery, activity and underlying chemistry. In addition, it supports a global shift towards sustainable sourcing of natural products from delicate ecosystems. Across the world, environmental destruction and overharvesting of medicinal plants are reducing and destroying multiple important sources and potential leads before researchers have the chance to discover, explore or synthesize them effectively. By identifying this problem and discussing its impact on the Himalayan region, Himalayan Phytochemicals: Sustainable Options for Sourcing and Developing Bioactive Compounds frames the ongoing global struggle and highlights the key factors that must be considered and addressed when working with phytochemicals from endemic plant sources.

Vicinal Diaryl Substituted Heterocycles

  • 1st Edition
  • March 14, 2018
  • M. R. Yadav + 2 more
  • English
  • Paperback
    9 7 8 - 0 - 0 8 - 1 0 2 2 3 7 - 5
  • eBook
    9 7 8 - 0 - 0 8 - 1 0 2 2 4 9 - 8
Vicinal Diaryl-Substituted Heterocycles: A Gold Mine for the Discovery of Novel Therapeutic Agents draws together all of the key information about these compounds in one place for the first time. Following an informative overview of the importance of these structures to the discovery of potential therapeutic agents, the text goes on to outline the main compound types, with each chapter focusing on the activities of a different structure. Designed to support researchers by consolidating this important information in a single, practical guide, the authors hope to encourage further advancement and development in the discovery of novel therapeutic agents. As flexible building blocks for the production of novel compounds, vicinal diaryl-substituted heterocycles are a rich source of leads for the development of new drugs. Their adaptability means that they can be used to produce structures with a broad range of attractive characteristics, and a large number of vicinal diaryl-substituted heterocyclic compounds have already been synthesized and investigated by medicinal chemists as promising lead molecules.

Water Extraction of Bioactive Compounds

  • 1st Edition
  • September 20, 2017
  • Herminia Dominguez + 1 more
  • English
  • Paperback
    9 7 8 - 0 - 1 2 - 8 0 9 3 8 0 - 1
  • eBook
    9 7 8 - 0 - 1 2 - 8 0 9 6 1 5 - 4
Water Extraction of Bioactive Compounds: From Plants to Drug Development draws together the expert knowledge of researchers from around the world to outline the essential knowledge and techniques required to successfully extract bioactive compounds for further study. The book is a practical tool for medicinal chemists, biochemists, pharmaceutical scientists and academics working in the discovery and development of drugs from natural sources. The discovery and extraction of bioactive plant compounds from natural sources is of growing interest to drug developers, adding greater fuel to a simultaneous search for efficient, green technologies to support this. Particularly promising are aqueous based methods, as water is a cheap, safe and abundant solvent. Water Extraction of Bioactive Compounds: From Plants to Drug Development is a detailed guide to the fundamental concepts and considerations needed to successfully undertake such processes, supported by application examples and highlighting the most influential variables. Beginning with an introduction to plants as sources of drugs, the book highlights the need for a move towards both more rational and greener techniques in the field, and presents multiple innovative water-based strategies for the discovery and extraction of bioactive constituents of botanicals. A broad range of available techniques are reviewed, including conventional and pressurized hot water extraction techniques, intensified processes such as microwave-assisted, ultrasound-assisted processes, and enzyme assisted extraction, and processes using combined techniques.

Piperidine-Based Drug Discovery

  • 1st Edition
  • June 12, 2017
  • Ruben Vardanyan
  • English
  • Paperback
    9 7 8 - 0 - 1 2 - 8 0 5 1 5 7 - 3
  • eBook
    9 7 8 - 0 - 1 2 - 8 1 3 4 2 8 - 3
Piperidine-Based Drug Discovery outlines the complexities of Piperidine scaffold use in drug discovery, including derivative chemistry, structural properties, methods of synthesis and practical implementations. Piperidine scaffolds are the cornerstones of over 70 commercialized drugs (including multiple blockbusters). Designed as a guide for both experts and students working in this and related areas, it is hoped that this volume will encourage and inspire the continued design and development of novel pharmaceuticals based on Piperidine and its derivatives. Heterocyclic compounds are of central importance to medicinal chemistry, as demonstrated by the high percentage of marketable drugs that feature heterocyclic fragments in their structures. As starting points for drug discovery they offer a broad range of attractive properties, and a detailed understanding of the particular characteristics of each is of great benefit to researchers. The most commonly used heterocycle among US FDA approved pharmaceuticals, Piperidine is an extremely important building block in the synthesis of medicinal agents. This heterocycle and its derivatives exhibit a number of important functionalities and have been employed variously as CNS modulators, antiaggregants, anticoagulants, antihistamines, anti-cancer drugs and analgesics.

Comprehensive Medicinal Chemistry III

  • 3rd Edition
  • June 3, 2017
  • Samuel Chackalamannil + 2 more
  • English
  • Hardback
    9 7 8 - 0 - 1 2 - 8 0 3 2 0 0 - 8
  • eBook
    9 7 8 - 0 - 1 2 - 8 0 3 2 0 1 - 5
Comprehensive Medicinal Chemistry III, Eight Volume Set provides a contemporary and forward-looking critical analysis and summary of recent developments, emerging trends, and recently identified new areas where medicinal chemistry is having an impact. The discipline of medicinal chemistry continues to evolve as it adapts to new opportunities and strives to solve new challenges. These include drug targeting, biomolecular therapeutics, development of chemical biology tools, data collection and analysis, in silico models as predictors for biological properties, identification and validation of new targets, approaches to quantify target engagement, new methods for synthesis of drug candidates such as green chemistry, development of novel scaffolds for drug discovery, and the role of regulatory agencies in drug discovery.

Dehydroacetic Acid and Its Derivatives

  • 1st Edition
  • March 31, 2017
  • Santhosh Penta
  • English
  • Paperback
    9 7 8 - 0 - 0 8 - 1 0 1 9 2 6 - 9
  • eBook
    9 7 8 - 0 - 0 8 - 1 0 1 9 2 7 - 6
Dehydroacetic Acid and Its Derivatives: Useful Synthons in Organic Synthesis outlines the use of DHA and its derivatives for the synthesis of pharmacologically active heterocyclic compounds. Beginning with an introduction to the chemistry and reactivity of Dehydroacetic Acid, the book goes on to outline the key ring transformation reactions of DHA. The synthesis of various derivatives is then discussed, before a wide range of metal complexes of DHA are explored in detail. The book then concludes with a review of DHA’s biological importance and its impressive range of pharmacological activities, including anti-cancer, anti-bacterial, anti-fungal and analgesic properties. For those researching the synthesis of bioactive heterocyclic compounds, this book is a valuable guide on the fundamental knowledge needed to facilitate and enhance the successful synthesis of lead molecules.