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Books in Analytical separations

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41-50 of 120 results in All results

Capillary Electrophoresis Methods for Pharmaceutical Analysis

  • 1st Edition
  • Volume 9
  • August 5, 2008
  • Satinder Ahuja + 1 more
  • English
  • eBook
    9 7 8 - 0 - 0 8 - 0 5 5 9 6 1 - 2
Capillary electrophoresis (CE) is a powerful analytical technique that is widely used in research and development and in quality control of pharmaceuticals. Many reports of highly efficient separations and methods have been published over the past 15 years. CE offers several advantages over high-pressure or high-performance liquid chromatography (HPLC). These include simplicity, rapid analysis, automation, ruggedness, different mechanisms for selectivity, and low cost. Moreover, EC requires smaller sample size and yet offers higher efficiency and thus greater resolution power over HPLC. These characteristics are very attractive in research and development, even more so in pharmaceutical quality control (QC) and stability monitoring (SM) studies. This book will provide busy pharmaceutical scientists a complete yet concise reference guide for utilizing the versatility of CE in new drug development and quality control.

Fluorine and Health

  • 1st Edition
  • April 24, 2008
  • Alain Tressaud + 1 more
  • English
  • Hardback
    9 7 8 - 0 - 4 4 4 - 5 3 0 8 6 - 8
  • eBook
    9 7 8 - 0 - 0 8 - 0 5 5 8 1 1 - 0
Fluorine and Health presents a critical multidisciplinary overview on the contribution of fluorinated compounds to resolve the important global issue of medicinal monitoring and health care. The involved subjects are organized in three thematic parts devoted to Molecular Imaging, Biomedical Materials and Pharmaceuticals. Initially the key-position of partially fluorinated low molecular weight compounds labelled either with the natural 19F-isotope for Magnetic Resonance Imaging (MRI) or labelled with the radioactive [18F]-isotope for Positron Emission Tomography (PET) is highlighted. Both non-invasive methods belong to the most challenging in vivo imaging techniques in oncology, neurology and in cardiology for the diagnosis of diseases having the highest mortality in the industrialized countries. The manifold facets of fluorinated biomaterials range from inorganic ceramics to perfluorinated organic molecules. Liquid perfluorocarbons are suitable for oxygen transport and as potential respiratory gas carriers, while fluorinated polymers are connected to the pathology of blood vessels. Another important issue concerns the application of highly fluorinated liquids in ophthalmology. Moreover, fluorine is an essential trace element in bone mineral, dentine and tooth enamel and is applied for the prophylaxis and treatment of dental caries. The various origins of human exposure to fluoride species is detailed to promote a better understanding of the effect of fluoride species on living organisms.Medicinally relevant fluorinated molecules and their interactions with native proteins are the main focus of the third part. New molecules fluorinated in strategic position are crucial for the development of pharmaceuticals with desired action and optimal pharmacological profile. Among the hundreds of marketed active drug components there are more than 150 fluorinated compounds. The chapters will illustrate how the presence of fluorine atoms alters properties of bioactive compounds at various biochemical steps, and possibly facilitate its emergence as pharmaceuticals. Finally the synthetic potential of a fluorinase, the first C-F bond forming enzyme, is summarized.

Magnetic Cell Separation

  • 1st Edition
  • Volume 32
  • September 28, 2007
  • Maciej Zborowski + 1 more
  • English
  • Hardback
    9 7 8 - 0 - 4 4 4 - 5 2 7 5 4 - 7
  • eBook
    9 7 8 - 0 - 0 8 - 0 5 5 3 5 0 - 4
Cell separation is at the core of current methods in experimental biology and medicine. Its importance is illustrated by the large number of physical and biochemical principles that have been evaluated for application to cell separation. The development of cell separation methods is driven by the needs of biological and medical research, and the ever-increasing demands for sensitivity, selectivity, yield, timeliness and economy of the process. The interdisciplinary nature of research in this area and the volume of information available in research publications and conferences necessitates a basic description of the fundamental processes involved in magnetic cell separation that may help the user in navigating this wealth of information available online and in scientific publications. This book will appeal to researchers in many areas utilizing this technique, including those working in cell biology, clinical research, inorganic chemistry, biochemistry, chemical engineering, materials science, physics and electrical engineering.

HPLC Method Development for Pharmaceuticals

  • 1st Edition
  • Volume 8
  • May 15, 2007
  • Satinder Ahuja + 1 more
  • English
  • Hardback
    9 7 8 - 0 - 1 2 - 3 7 0 5 4 0 - 2
  • eBook
    9 7 8 - 0 - 0 8 - 0 5 5 4 1 9 - 8
High pressure, or high performance, liquid chromatography (HPLC) is the method of choice for checking purity of new drug candidates, monitoring changes during scale up or revision of synthetic procedures, evaluating new formulations, and running control/assurance of the final drug product. HPLC Method Development for Pharmaceuticals provides an extensive overview of modern HPLC method development that addresses these unique concerns. Includes a review and update of the current state of the art and science of HPLC, including theory, modes of HPLC, column chemistry, retention mechanisms, chiral separations, modern instrumentation (including ultrahigh-pressure systems), and sample preparation. Emphasis has been placed on implementation in a pharmaceutical setting and on providing a practical perspective. HPLC Method Development for Pharmaceuticals is intended to be particularly useful for both novice and experienced HPLC method development chemists in the pharmaceutical industry and for managers who are seeking to update their knowledge.

Liquid Chromatography of Natural Pigments and Synthetic Dyes

  • 1st Edition
  • Volume 71
  • October 19, 2006
  • Tibor Cserháti
  • English
  • eBook
    9 7 8 - 0 - 0 8 - 0 4 6 5 7 6 - 0
This latest volume in the series entitled Liquid Chromatography of Natural Pigments and Synthetic Dyes presents an overview of the latest developments in the field while critically evaluating this method of analysis and providing comparisons of the various liquid chromatographic separation techniques that are currently available. Natural pigments and synthetic dyes are extensively used in various fields of everyday life including food production, textile industry, paper production, agricultural practice and research and water science and technology. Besides their capacity for increasing the marketability of products, natural pigments have shown advantageous biological activity as antioxidants and anticancer agents. On the negative side, synthetic pigments have a significant impact on the environment and can cause adverse toxicological side effects. Both pigment classes exhibit considerable structural diversity. As the stability of the pigments against hydrolysis, oxidation and other environmental and technological conditions is markedly different, the exact determination of the pigment composition may help for the prediction of the shelf-life of products and the assessment of the influence of technological steps on the pigment fractions resulting in more consumer friend processing methods. Furthermore, the qualitative determination and identification of the pigments may contribute to the establishment of the provenance of the product. The unique separation capacity of liquid chromatographic (LC) techniques makes it a method of preference for the analysis of pigments in any complicated accompanying matrices.

Modern Instrumental Analysis

  • 1st Edition
  • Volume 47
  • October 17, 2006
  • Satinder Ahuja + 1 more
  • English
  • eBook
    9 7 8 - 0 - 0 8 - 0 4 6 7 2 2 - 1
Modern Instrumental Analysis covers the fundamentals of instrumentation and provides a thorough review of the applications of this technique in the laboratory. It will serve as an educational tool as well as a first reference book for the practicing instrumental analyst. The text covers five major sections:1. Overview, Sampling, Evaluation of Physical Properties, and Thermal Analysis2. Spectroscopic Methods 3. Chromatographic Methods 4. Electrophoretic and Electrochemical Methods 5. Combination Methods, Unique Detectors, and Problem Solving Each section has a group of chapters covering important aspects of the titled subject, and each chapter includes applications that illustrate the use of the methods. The chapters also include an appropriate set of review questions.

Fundamentals of Preparative and Nonlinear Chromatography

  • 2nd Edition
  • February 10, 2006
  • Georges Guiochon + 2 more
  • English
  • Hardback
    9 7 8 - 0 - 1 2 - 3 7 0 5 3 7 - 2
  • eBook
    9 7 8 - 0 - 0 8 - 0 4 5 7 2 2 - 2
Fundamentals of Preparative and Nonlinear Chromatography, Second Edition is devoted to the fundamentals of a new process of purification or extraction of chemicals or proteins widely used in the pharmaceutical industry and in preparative chromatography. This process permits the preparation of extremely pure compounds satisfying the requests of the US Food and Drug Administration. The book describes the fundamentals of thermodynamics, mass transfer kinetics, and flow through porous media that are relevant to chromatography. It presents the models used in chromatography and their solutions, discusses the applications made, describes the different processes used, their numerous applications, and the methods of optimization of the experimental conditions of this process.

Analysis and Detection by Capillary Electrophoresis

  • 1st Edition
  • Volume 45
  • September 6, 2005
  • Maria Luisa Marina + 2 more
  • English
  • eBook
    9 7 8 - 0 - 0 8 - 0 4 5 6 2 3 - 2
Capillary Electrophoresis (CE) is a powerful analytical technique used to separate compounds and is increasingly being used in routine analytical laboratories. Analysis and Detection by Capillary Electrophoresis presents developments enabling the enhancement of the detection sensitivity in CE, including the different strategies used to achieve sensitivity requirements. It describes techniques allowing sample preconcentration and sensitive continuous detection systems and looks at recent developments such as chiral analysis in CE and electrochemical detection in microchips. UV-Vis absorbance detection, as the most widely used detection system in CE, is also presented. Analysis and Detection by Capillary Electrophoresis delves into the practical approaches used in the field and will greatly benefit analytical chemists, as well as students, teachers, technical analysts, scientists and researchers involved in capillary electrophoresis.

Quantitation of Amino Acids and Amines by Chromatography

  • 1st Edition
  • Volume 70
  • June 27, 2005
  • Ibolya Molnár-Perl
  • English
  • eBook
    9 7 8 - 0 - 0 8 - 0 4 5 8 4 5 - 8
Quantitation of Amino Acids and Amines by Chromatography: Methods and Protocols is intended to serve as a ready-to-use guide for the identification and quantification of amino acids and amines in various matrices, providing an overview on the theory and protocol of available methods. It presents chromatograms with exact elution programs enabling visual analysis and compares the advantages-disadvantages of various chromatographic techniques. In accordance with the chronological order of the development of chromatographic methods, different techniques are discussed: The possibilities of gas chromatography (GC), followed by those of the high performance liquid chromatography (HPLC) and the most recent techniques capillary electrophoresis (CE), capillary, electrochromatography (CEC).The characteristics of the given chromatographic procedure, relating to the topic in question, are classified according to the preliminary preparation/derivatization process(es), which means the simple methods, suitable for the analysis of the selected compound(s) in natural form, are followed by various derivatization proposals. Detailed protocols provide the reader with guidance in beginning tasks and on how to improve current methods. This book appeals to a wide audience and is recommended for those looking towards the wider reaches of identification and quantification of amino acids and amines.

Handbook of Isoelectric Focusing and Proteomics

  • 1st Edition
  • Volume 7
  • May 9, 2005
  • David Garfin + 1 more
  • English
  • Hardback
    9 7 8 - 0 - 1 2 - 0 8 8 7 5 2 - 1
  • eBook
    9 7 8 - 0 - 0 8 - 0 5 3 3 6 2 - 9
Isoelectric focusing (IEF) is a high-resolution, stand-alone technique that can be used as an analytical method or tool for protein purification. The only current book on the market, the Handbook of Isoelectric Focusing and Proteomics is the ideal 'one-stop' source for germane information in this discipline. This highly practical book also contains chapters on alternative methods that may pave the way in the search for efficient techniques for fractionating and purifying proteins. Complete with the history of IEF focusing to authors' insights and practical tips, this book is a must for anyone working in proteomics.