Skip to main content
Elsevier
View Cart
openUserAccount

Books in Life sciences

BooksJournals
481-490 of 14739 results in All results

Current Advances and Future Trends in Vascular Neurology, An Issue of Neurologic Clinics

  • 1st Edition
  • Volume 42-3
  • June 27, 2024
  • Michael J. Schneck
  • English
  • Hardback
    9 7 8 - 0 - 3 2 3 - 9 3 8 6 5 - 5
  • eBook
    9 7 8 - 0 - 3 2 3 - 9 3 8 6 6 - 2
In this issue of Neurologic Clinics, guest editor Dr. Michael J. Schneck brings his considerable expertise to the topic of Current Advances and Future Trends in Vascular Neurology. Top experts discuss biomarkers in ischemic and hemorrhagic stroke; AI and other computer prediction tools in stroke; cardioembolic stroke; small vessel disease; advances and future trends in the diagnosis and management of subarachnoid hemorrhage; and more.

Evolving Landscape of Molecular Diagnostics

  • 1st Edition
  • June 27, 2024
  • Mrutyunjay Suar + 2 more
  • English
  • Paperback
    9 7 8 - 0 - 3 2 3 - 9 9 3 1 6 - 6
  • eBook
    9 7 8 - 0 - 3 2 3 - 9 9 3 1 7 - 3
Evolving Landscape of Molecular Diagnostics: Applications and Techniques presents cutting-edge reviews on current and emerging technologies in the diagnosis of microbial infections. The book discusses the fundamentals of Molecular Diagnostics for bacteria, fungi, viruses and a variety of state-of-the-art diagnostics tools and techniques for obtaining qualitative and quantitative results. It includes topics such as Next generation sequencing and application of "OMICS" for early disease diagnosis. Sections cover the entire spectrum of emerging diagnostic tools and techniques, as well as the principles, pros and cons of each method and applications for diagnosis of infectious disease in plants, humans and veterinary. This is a resource for both researchers and students working in clinical microbiology, infectious biology, applied life sciences and scientists working in the clinical diagnostic industry.

Pili in Mycobacterium Tuberculosis

  • 1st Edition
  • June 27, 2024
  • Ali Akbar Velayati + 1 more
  • English
  • Paperback
    9 7 8 - 0 - 4 4 3 - 2 1 7 1 2 - 8
  • eBook
    9 7 8 - 0 - 4 4 3 - 2 1 7 1 3 - 5
Pili in Mycobacterium Tuberculosis: Structure, Function, and Therapeutic Advances discusses the types of pili produced by the tuberculosis-causing bacterium, Mycobacterium tuberculosis (MTB). The book examines the structure of pili shown under electron and atomic force microscopy and, by using whole genome sequencing, outlines the importance of pili in MTB. It also explores the role of pili in bacteria–host interactions and in drug development and delivery.The book provides an overview of the structure, synthesis, and function of pili in bacteria. This includes taxonomy and the role of pili in diseases. It also examines the structure of pili and the preparation of MTB for electronic and atomic microscopy. It explores the various life cycles of pili, the susceptibility patterns of MTB, the differences of pili formation in MTB, and their role in increase surveillance. It goes on to discuss the expression and function of pili using whole genome sequencing and PCR-based methods and delves into bacteria–host interactions. Lastly, it explores the development of new drugs and their therapeutic delivery by pili.

Macrophages Biology and Tissue Inflammation in Health and Disease

  • 1st Edition
  • June 26, 2024
  • Stuart Goodman + 2 more
  • English
  • Paperback
    9 7 8 - 0 - 1 2 - 8 2 1 7 5 4 - 2
  • eBook
    9 7 8 - 0 - 1 2 - 8 2 1 7 6 2 - 7
Macrophages Biology and Tissue Inflammation in Health and Disease outlines the important role of macrophages—keys cells in the innate immune system—as regulators and orchestrators of inflammation and repair in health and disease. It contains chapters by leading authors on the basic and translational aspects of macrophage biology, covering how to maintained tissue homeostatis and how to deal with internal and external biological threats.

Biochemical and Molecular Pharmacology in Drug Discovery

  • 1st Edition
  • June 26, 2024
  • Mithun Rudrapal + 2 more
  • English
  • Paperback
    9 7 8 - 0 - 4 4 3 - 1 6 0 1 3 - 4
  • eBook
    9 7 8 - 0 - 4 4 3 - 1 6 0 1 4 - 1
Biochemical and Molecular Pharmacology in Drug Discovery comprises fundamental biochemical and molecular aspects of drug discovery and basic understanding of modern drug discovery approaches, along with certain key topics related to molecular pharmacology of drugs and therapeutics. The book explains the phenomena of drug-target interactions, considering different biochemical systems and cellular strategies. With the advent of technologies, current advances, and research trends move toward molecular and/or target-based drug design and discovery. Through this book, readers will gain skills and knowledge with a thorough understanding of the subject of biochemical and molecular pharmacology in a comprehensive and systematic manner.Molecular pharmacology has gained significant momentum among researchers, scientists, and academicians because of its increasing interest in drug discovery research across the globe. Molecular pharmacology involves a fundamental understanding of drug actions at the molecular level with the help of several tools and techniques of biochemical and molecular biology.

Revealing Uncharted Biology with Single Cell Multiplex Proteomic Technologies

  • 1st Edition
  • June 25, 2024
  • Wendy Fantl
  • English
  • Paperback
    9 7 8 - 0 - 1 2 - 8 2 2 2 0 9 - 6
  • eBook
    9 7 8 - 0 - 1 2 - 8 2 2 2 1 0 - 2
Revealing Uncharted Biology with Single Cell Multiplex Proteomic Technologies: Platforms. Understanding the intricate coordination of highly diverse cell types within healthy tissues and organs is essential for grasping their functionality. This coordination, often disrupted in disease, hinges on proteins—the primary drivers of cellular function. By examining protein abundance and activation states in single cells, researchers can identify key cell populations involved in both healthy and diseased states, including those influencing disease initiation, progression, and therapeutic responses. Single-cell multiplex proteomic platforms have recently emerged as powerful tools for biomedical research. Their strengths lie in revealing cell types that are rare or subtly different and would otherwise go undetected in bulk cellular analyses. This unique capability enables deeper insights into cellular behavior and disease mechanisms.This book offers comprehensive overviews of technologies developed for multiplex single-cell proteomic analyses. It begins with the pioneering work from Professors Scott Tanner, Mitchell Winnick and Garry Nolan resulting in the development and early application of the mass cytometer, (CyTOF). The instrument merges flow cytometry with time-of-flight mass spectrometry and analyzes cells labelled with metal tagged antibodies. These components work together to enable CyTOF to perform highly multiplexed protein analysis at the single-cell level, offering a powerful tool for understanding complex cellular behaviors and interactions.Recognizing that cellular organization is critical for tissue function, subsequent chapters explore advanced multiplex imaging platforms including Imaging Mass Cytometry (IMC), Multiplexed Ion Beam Imaging (MIBI), CODetection by InDExing, and Chip Cytometry. Later chapters present recent advances in these imaging platforms and data analysis approaches - Combined Nucleic Acid and Protein Quantification in situ, Tissue Schematics, and High-definition CODEX for 3D Multiplex Spatial Cell Phenotyping. These techniques integrate deep phenotyping with spatial mapping to provide unprecedented insights into cellular interactions within tissues. The book also highlights computational approaches essential for managing and interpreting the vast datasets generated by these technologies. Revealing Uncharted Biology with Single Cell Multiplex Proteomic Technologies: Platforms help researchers in many fields, including developmental biology, cancer biology, immunology, neuroscience, and drug discovery gain an understanding about the theories and detailed methodologies behind these technologies. Integrating proteomics with genetic, epigenetic, and transcriptomic platforms, this book aims to inspire new research opportunities, ultimately advancing the development of reliable biomarkers and improving patient outcomes.

Revealing Uncharted Biology with Single Cell Multiplex Proteomic Technologies

  • 1st Edition
  • June 25, 2024
  • Wendy Fantl
  • English
  • Paperback
    9 7 8 - 0 - 1 2 - 8 2 2 2 1 3 - 3
  • eBook
    9 7 8 - 0 - 1 2 - 8 2 2 2 1 4 - 0
Revealing Uncharted Biology with Single Cell Multiplex Proteomic Technologies: ApplicationsHealthy tissues and organs rely on the precise coordination of diverse cell types, each responding to external and internal signals. Disease disrupts this coordination. Since proteins drive cellular function, analyzing their abundance and activation states in single cells helps identify key cell populations in health and disease. Bulk protein analyses mask critical differences between individual cells. Additionally, the arrangement of cells into neighborhoods through cell-cell interactions is essential for tissue function. Over the last decade, single-cell proteomic phenotyping combined with positional information has become crucial for understanding biology in health and disease. This has led to the development of multiple technology platforms, profoundly impacting fields including developmental biology, cancer biology, immunology, neuroscience, and drug discovery. This book focuses on the application of single-cell multiplex proteomic platforms to various biological systems. These platforms have proved to be essential in biomedical research, advancing our understanding of complex biological systems at the cellular level. Compelling studies where authors use these technologies to answer previously unanswerable questions are featured. Exploring this "Uncharted Biology" opens new avenues for scientific inquiry and clinical translation, covering areas including oncology, immunology, metabolomics, stem cell research, preclinical models, and translational research. The initial chapters discuss incorporating these technologies into core facilities and consortia, providing access for multiple users and integrating datasets from other omics technologies. The following chapters cover applications in diverse areas such as muscle stem cell function in skeletal muscle regeneration, metabolic regulome profiling, translational studies, developing predictive biomarkers for patients receiving immune checkpoint inhibitors, and pre-clinical studies of lung cancer. These applications demonstrate how advanced single cell proteomic technologies are reshaping our understanding of complex biological systems and enhancing clinical translation. Revealing Uncharted Biology with Single Cell Multiplex Proteomic Technologies: Applications highlights the transformative benefits of single-cell proteomics, offering insights into cellular mechanisms underlying health and disease and inspiring further exploration into "Uncharted Biology." It is an essential resource for researchers, clinicians, and students aiming to advance biomedical science and improve therapeutic outcomes.

Transpathology

  • 1st Edition
  • June 25, 2024
  • Mei Tian
  • English
  • Paperback
    9 7 8 - 0 - 3 2 3 - 9 5 2 2 3 - 1
  • eBook
    9 7 8 - 0 - 3 2 3 - 9 5 2 2 4 - 8
Transpathology: Molecular Imaging-Based Pathology is a multidisciplinary reference on molecular imaging and pathology. The book is intended for professionals in the fields of molecular imaging, nuclear medicine, radiology, and pathology as well as students and clinical residents. The book describes the importance of non-invasive diagnosis-based precision medicine and presents a detailed description of current transpathological approaches in different aspects essential for the future development of precision medicine. It is molecular imaging approach to experimental research and clinical practice which will drive the field forward and improve research outcomes.

On Epigenetics and Evolution

  • 1st Edition
  • June 25, 2024
  • Carlos M. Guerrero-Bosagna
  • English
  • Paperback
    9 7 8 - 0 - 4 4 3 - 1 9 0 5 1 - 3
  • eBook
    9 7 8 - 0 - 4 4 3 - 1 9 0 5 2 - 0
On Epigenetics and Evolution, a new volume in the Translational Epigenetics series, introduces key themes from current epigenetic evolution research, with contributions from leading scientists around the world that investigate the role of epigenetic mechanisms in evolution from a variety of different angles, with each contribution combining theory, current research overviews, and applications. This book gives researchers, students, and clinicians a better understanding of the origin of genotypic and phenotypic variability, the role of epigenetics in development and inheritance, how epigenetics may affect speciation, and the evolution of epigenetic mechanisms in different taxa, and helps them apply their learnings across new research. Other modalities and subtopics explored include epigenetics in neutral and also adaptive evolution; epigenetic evolution in plants, invertebrates, and vertebrates; and the role of epigenetics in human evolution and its societal impact.

Resilient Health

  • 1st Edition
  • June 24, 2024
  • Judy Kuriansky + 1 more
  • English
  • Paperback
    9 7 8 - 0 - 4 4 3 - 1 8 5 2 9 - 8
  • eBook
    9 7 8 - 0 - 4 4 3 - 1 8 5 3 0 - 4
Resilient Health: Leveraging Technology and Social Innovations to Transform Healthcare for COVID-19 Recovery and Beyond presents game-changing and disruptive technological innovations and social applications in physical and mental healthcare around the world for the post-COVID age and beyond, addressing the urgent need for care. In this first-of-its kind comprehensive volume, experts and stakeholders from all sectors - government and the public and private sectors - offer models and frameworks for policy, programming, and financing to transform healthcare, address inequities, close the treatment gap, and “build back better,” especially for under-resourced vulnerable communities globally, to “leave no one behind” and advance development globally. Contributions from world experts cover 8 essential parts: The context and challenges for resilient health systems to shape the future; developments and directions (AI, VR, MR, IVAs and more); an innovations toolbox, also targeted for special populations and settings (women, youth, ageing, migrants, disabled persons, indigenous peoples, in the workplace); the role of stakeholders (governments, the United Nations bodies, and the public and private sector); forums and networks; innovative financing; resources, lessons learned and the way forward.

Related subjects

Agricultural and biological sciences

Drug discovery

Immunology

Microbiology and virology

Neuroscience

Pharmaceutical sciences

Pharmacology

Toxicology