Sustainability in the Manufacturing of Pharmaceutical serves as a critical reference for an industry in need of a substantial shift towards more sustainable practices. Currently lagging behind other manufacturing segments, the production of pharmaceuticals requires changes in critical areas such as manufacturing methods, waste management, packaging, and supply-chain. This book offers content from leading researchers around the world providing scientific insights and innovative strategies to revolutionize sustainability in pharmaceuticals. The chapters explore the transformative potential of circular economy and life cycle management, optimization of resource utilization for maximum efficiency and minimal environmental impact. The green chemistry chapter highlights alternative solvents and methods for drug production. Additionally, the book explores novel approaches such as microfluidic and additive manufacturing methods using bio-based sustainable polymers and materials, pointing to promising greener methods for drug discovery, development, and scaling processes. Sustainability in Pharmaceutical Manufacturing provides cutting-edge research across all stages of the production cycle, enabling researchers in academia and industry to make appropriate choices to improve their manufacturing practices. The book provides resources to pharmaceutical industry managers to thinking about the future and importance of sustainability in the pharmaceutical sector.
Geometric Morphometrics for Biologists: A Primer, Third Edition explores how these geometric methods allow for the study of biological shape by incorporating the geometry of organisms throughout data analyses. Novel content on phylogenetic comparative methods, evolutionary morphology, analyses of disparity, genetics of shape, and simulating shape data is included. This edition delivers step-by-step guidance on how to effectively utilize updated analytical software while also providing guidance on important methodologies that remain relevant to the field to ensure clear and effective instruction to audiences new to this branch of data analysis.It succeeds the second edition as the primary resource for teaching modern geometric methods of shape analysis to students, researchers, and practicing scientists in the field of organismal biology. Users will find it to be an immensely valuable introduction for students and practicing biologists interested in learning applications of multivariate statistics and matrix algebra to organismal biology.
Medications for Older Persons: Recommendations, Harms, Evidence provides a comprehensive resource detailing the benefits of medications for older individuals. It also addresses the potential harms associated with the prescription of potentially inappropriate medications or omissions in prescribing and examines how many adverse events, rehospitalizations, and deaths can be attributed to these medications. The book opens with a summary of medications that most benefit older patients, followed by the impact of older persons’ alcohol consumption, self-medication, and medication list accuracy and how these factors correlate to health outcomes.The remainder of the book is devoted to the assessment of medication groups focusing on Numbers Needed to Treat, Numbers Needed to Harm, and characteristics and numbers of adverse events. Medication groups covered include cardiovascular, central nervous system, renal, gastrointestinal, musculoskeletal, respiratory, endocrine, pain, and fall prevention.
Future Fat Alternatives: Concepts, Structuring and Food Application takes a deep dive into the strategies for the development of fat alternatives for food applications. It covers all structuring strategies, including oleogels, emulsion gels and foamed gels as well as cell-cultured fats. In addition, it details other applications such as additive manufacturing, and fat alternatives in different food applications and discusses their nutritional benefits. Divided into eight sections, “Future Fat Alternatives: Concepts, Structuring and Food Application, begins with an overview of the structural-properties relationship in traditional fats then segues into the benefits and challenges of fat alternatives, the prospects and challenges of cell-cultured fats, the additive manufacturing of fat analogues and how they pave the way towards novel food development. The applications of different fat replacers and their nutritional benefits in bakery, meat, chocolate, and cheese products as well as nutraceutical delivery systems will also be discussed.
Temperate Tree Fruits and Nuts presents up-to-date information regarding economically important temperate fruit crops in a comprehensive manner. It explains the history, genetic improvements, and production physiology of growth and cropping. It delves into orchard establishment and management, and harvest considerations for sustainable fruit crop production under temperate conditions. This textbook functions as a one-stop standalone resource that provides all relevant information considered essential to the field of Pomology. Temperate Tree Fruits and Nuts is targeted toward undergraduate and postgraduate students and professionals in the field of pomology (fruit crops). It is broadly useful for students pursuing degrees in horticulture, agricultural science, plant science, or related fields. Additionally, it is an essential resource for researchers, researchers, farmers, consultants, industrial stakeholders, and agribusiness professionals involved in critical aspects of fruit and nut production, and orchard management. Each chapter is focused on a specific temperate fruit crop and authored by an expert for that crop. The outline of each chapter will include an introduction, and information on origin-spread and economic importance. It will offer an exposition of the botany and relevant species of the crop, and details on orchard management (fertilization, irrigation, pruning, thinning), propagation, rootstocks, cultivars, and main diseases and their management. Lastly each chapter will delineate the main pests attacking the fruit crop, and their management, as well as ripening, harvest criteria, postharvest physiology, and technology of the fruit crop. This textbook incorporates supplementary resources in the form of high-quality graphic illustrations for students and a question bank for instructors.
Atlas of Endoscopy Imaging in Inflammatory Bowel Disease, Second Edition, serves as a comprehensive guide to the latest advancements in IBD. This new edition keeps readers updated with cutting-edge medical treatments, state-of-the-art endoscopy, and imaging technologies, as well as the evolution of interventional IBD. It explores the latest advancements in IBD diagnosis and management, including the most recent endoscopy instruments for measuring disease activity and the transformative world of image-enhanced endoscopy. Additionally, it delves into the groundbreaking application of Artificial Intelligence (AI) in IBD, revolutionizing diagnosis, disease monitoring, and dysplasia surveillance. New content introduces a range of topics to stay at the forefront of Inflammatory Bowel Disease (IBD) knowledge. These include Intestinal Ultrasound, Device-Associated Enteroscopy in Crohn’s Disease, insights into IBD-Like Conditions (Autoinflammatory Disorders), and the value of Intraoperative Endoscopy in IBD procedures. The book also integrates New Consensus Guidelines for Endoscopy Imaging in IBD, explores the Applications of Artificial Intelligence (AI) in IBD diagnosis and monitoring, addresses the intersection of COVID, COVID Vaccines, and IBD, and presents New Applications of Interventional IBD techniques. This second edition serves as a dynamic repository of state-of-the-art information, providing invaluable insights on differential diagnosis, advanced endoscopy, and imaging technologies, with a pronounced focus on AI. It also offers updated guidelines for disease activity assessment and the latest advancements in endoscopic therapy modalities. Designed to cater to a diverse range of medical professionals, it stands as an indispensable reference, fostering a comprehensive and up-to-date understanding of Inflammatory Bowel Disease (IBD). Within these pages,Gastroenterologists and IBD specialists will discover a wealth of resources to aid their pursuit of cutting-edge treatments and AI-driven insights. Primary care clinicians will find an expanded list of differential diagnoses that enables more accurate early-stage identification. Surgeons can elevate their expertise by delving into the intricacies of interventional IBD techniques, while pathologists and radiologists can enhance their diagnostic skills through AI and image-enhanced endoscopy. This comprehensive resource ensures that medical professionals across various disciplines are well-equipped to navigate the evolving landscape of IBD diagnosis, treatment, and management.
Curcumin Bioavailability and Sustainability as Therapeutic Agent: Strategies for Sustained Release Curcumin is a comprehensive reference on techniques to enhance the bioavailability of curcumin, while also covering sustainability aspects across its production cycle. This book focuses on the information needs of pharmaceutical scientists aiming at developing drug delivery systems and formulations that can maximize the therapeutic impact of curcumin drugs. After an introduction to curcumin therapeutic properties, the authors delve into the bioavailability challenges confronted by curcumin, discussing influencing factors, pharmacokinetic pathways, and formulations to augment its bioaccessibility. Chapter 3 explores innovative formulation paradigms, encompassing nanoparticle-based delivery systems and lipidic matrices, tailored to overcome solubility limitations and increase absorptive efficacy. Chapter 4 covers delivery systems, encompassing prodrug strategies, encapsulation modalities, and nanocarrier technologies. Chapter 5 investigates sustainable sourcing and production, raising awareness to ethical cultivation practices, eco-friendly extraction methodologies, and proficient waste management techniques within curcumin production processes. In Chapter 6 discusses balancing bioavailability augmentation with sustainability principles including case studies. Chapter 7 navigates the domain of pharmacokinetic studies and clinical trials, providing an overview of bioaccessibility and bioavailable formulations. Chapter 8 explores safety profiles, regulatory requirements, and quality benchmarks, encompassing product labeling and claims concerning curcumin's bioavailability and sustainability. Chapter 9 casts a future view contemplating nascent technologies for bioavailability and sustainability optimization. The final chapter concludes the book with the author's observations on its central themes. Curcumin Bioavailability and Sustainability as Therapeutic Agent: Strategies for Sustained Release Curcumin provides practical strategies to be explored by pharmaceutical scientists in increasing bioavailability of curcumin formulations. Research physicians and nutritionists may also benefit from the evidence-based information on curcumin's therapeutic activities provided across the book.
Age-Related Hearing Loss, Brain Health, and Dementia reviews the effects of hearing loss on the brain and examines the most up-to-date perspectives on the possible causal relation between hearing loss and cognitive impairment. Through this synthesis, the book will explore the links between hearing loss and the brain to improve understanding and promote better hearing for better brain health.
Extracellular Mitochondria in Health and Disease covers this new and significant area of research, shedding light on their roles in intercellular communication and disease pathology. These tiny powerhouses, traditionally known for their intracellular functions, are now recognized for their extracellular activities that impact various physiological and pathological processes. The book delves into a range of topics, including cellular mechanisms of mitochondrial transfer, metabolic signaling, and the crosstalk between extracellular vesicles and mitochondria. It serves as a comprehensive guide for scientists, researchers, and students eager to explore these novel findings and their potential implications.Other sections examine the roles of extracellular mitochondria in immune regulation and inflammation, neurodegeneration and neuroprotection, and their therapeutic potential. By bridging gaps in existing literature, this resource offers up-to-date research and discoveries, providing valuable insights into how extracellular mitochondria could revolutionize medical advancements and improve patient outcomes.
Drug Metabolism in Diseases: Leveraging Drug Metabolism and Disposition in Precision Medicine and Therapeutic Development, now in second edition, provides pharmaceutical scientists and biologists with the needed foundational knowledge required to understand the interplay between diseases and physiological conditions, how they impact drug metabolism and disposition, and its implications in personalized treatment. The book has been expanded with six new chapters, and completely updated with the scientific findings since the first edition published in 2016. The new chapters in the book cover drug metabolism in metabolic syndrome , transplant patients, geriatric patients, the developmental regulation of drug metabolism and disposition, the effect of gut microbiota on xenobiotic and endobiotic metabolism, the regulation of expression of drug-metabolizing enzymes by oncogenic signaling pathways, and drug metabolism in HIV patients. All other chapters in the first edition like drug metabolism in pregnancy, pediatric patients, patients of cardiovascular disease, and kidney diseases were completely updated to include the latest research results and references. Drug Metabolism in Diseases: Leveraging Drug Metabolism and Disposition in Precision Medicine and Therapeutic Development is a comprehensive reference on the mutual effect between drug metabolism and diseases, which has great implications in precision medicine and therapeutic development. Pharmaceutical scientists and drug metabolism researchers in academia and corporate R&D departments will benefit from the expanded coverage provided by expert authors. Research physicians interested in better understand the impact of diseases in drug metabolism will also benefit from the comprehensive overview of the area.