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Books in Life sciences

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    • Cellular Imaging Techniques for Neuroscience and Beyond

      • 1st Edition
      • August 8, 2012
      • Floris G. Wouterlood
      • English
      • Hardback
        9 7 8 0 1 2 3 8 5 8 7 2 6
      • eBook
        9 7 8 0 1 2 3 8 5 8 7 3 3
      The imaging of small cellular components requires powerful instruments, and an entire family of equipment and techniques based on the confocal principle has been developed over the past 30 years. Such methods are commonly used by neuroscience researchers, but the majority of these users do not have a microscopy or a cell biology backgrounds and do can encounter difficulties in obtaining and interpreting results. This volume brings experts in high-resolution optical microscopy applications in neuroscience and cell biology together to document the state of the art. Outlining what is currently possible, the volume also discusses promising developments for the future and aids readers in selecting the most scientifically meaningful approach to solve their questions. Each chapter discusses instrumentation and technology in relationship to application in research. All of the common and cutting edge trends are covered - fluorescence / laser electron / nonlinear microscopy, infrared fluorescence, multiphoton imaging, tomography, FRAP, live imaging, STED, PALM/STORM, etc.

    • Cardiac Muscle: The Regulation Of Excitation And Contraction

      • 1st Edition
      • December 2, 2012
      • Richard Nathan
      • English
      • Paperback
        9 7 8 0 1 2 4 3 1 7 1 2 3
      • eBook
        9 7 8 0 3 2 3 1 5 5 1 8 2
      Cardiac Muscle: The Regulation of Excitation and Contraction is a 12-chapter text that covers the research studies on characterizing the ionic and molecular mechanisms that regulate excitation and contraction of cardiac muscle. This book describes first the ionic currents underlying diastolic depolarization and pacing of the heart. The discussions then shift to the mechanisms of action of calcium-channel antagonists; the regulation of calcium influx by indigenous factors, such as voltage- or calcium-mediated inactivation; the identification of fixed negative charges on the surface of the sarcolemma; and the regulation of gating and permeability of ion channels by these charges. These topics are followed by examining the molecular and ionic mechanisms that underlie the electrophysiologic actions of adrenergic and cholinergic neurotransmitters and peptide hormones. This text further explores the theoretical and experimental studies of the sodium-calcium exchange process, its stoichiometry, and how the exchanger might contribute to current flow during or after the action potential. Other chapters consider the mechanism of twitch and tonic tension regulation by cardiac glycosides and intracellular sodium and how toxic concentrations induce cardiac arrhythmias. A chapter highlights the identification of sarcolemmal binding sites for calcium, the likelihood that such binding or the release of calcium from the sarcoplasmic reticulum plays a role in the regulation of contraction and the release of calcium from the sarcoplasmic reticulum. The remaining chapters deal with the structural similarities among calcium-binding proteins of the contractile apparatus and the calcium channel, and the regulation of contraction by calcium-binding proteins. Physiologists, pathophysiologists, clinicians, researchers, and students who are interested in heart’s function will find this book invaluable.

    • Comparative Endocrinology V2

      • 1st Edition
      • December 2, 2012
      • U.S. Von Euler
      • English
      • Paperback
        9 7 8 0 1 2 4 3 3 3 9 3 2
      • eBook
        9 7 8 0 3 2 3 1 5 7 0 5 6
      Comparative Endocrinology: A Treatise in Two Volumes, Volume II, Part One: Invertebrate Hormones, Part Two: Tissue Hormones focuses on animal physiology, morphology, and chemistry and systematic and comprehensive explanation of endocrine principles from the comparative point of view. The selection first offers information on hormones controlling reproduction and molting in invertebrates and the structure of neurosecretory systems in invertebrates. Discussions focus on protozoa, crustacea, insects, and neurosecretory systems of the head, thorax, and abdomen. The text then ponders on bradykinin, angiotensin, and substance P and heparin. The publication examines physiologically active lipid anions and 5-hydroxytryptamine. Topics include biologically active unsaturated fatty acids without alcoholic hydroxyl groups, prostaglandin, endometrial acids in menstrual fluid, turnover rate, and biosynthesis and fate. The manuscript also tackles cholinergic neurohormones and adrenergic neurohormones. The selection is a dependable source of data for readers interested in invertebrate and tissue hormones.

    • Methods of Enzymatic analysis V4

      • 2nd Edition
      • December 2, 2012
      • Hans-UIrich Bergmeyer
      • English
      • Paperback
        9 7 8 0 1 2 4 3 3 7 9 1 6
      • eBook
        9 7 8 0 3 2 3 1 6 1 3 2 9
      Methods of Enzymatic Analysis, Volume 4 reviews developments in the use of enzymes as tools in analytical biochemistry, including advances in assay techniques. It discusses the principles and methods for the elucidation of structures of enzymes, such as peptides, proteins, amino acids, fatty acid metabolites, lipids, steroids, nucleic acids, purines, pyrimidines, nucleosides, and coenzymes. It also considers the isolation and characterization of active centers in enzymes. This volume is divided into four parts, each discussing a group of enzymes and their determination. Part I focuses on proteins, peptides, and amino acids including amines and amides. Part II is concerned with fatty acid metabolites, lipids, and steroids ranging from polyunsaturated fatty acids and lecithin to choline, acetylcholine, triglycerides, glycerol, acetoacetate, triacetate, fumarylacetoacetate, 20-ketosteroids, prostaglandins, bile acids, and cholesterol. Part III discusses nucleic acids, purines, pyrimidines, nucleosides, coenzymes, and related compounds, whereas Part IV looks at other substrates and effectors such as inorganic phosphate. The book concludes with a chapter on metabolites and their concentrations in animal tissues. Biochemists as well as students and researchers working in the field of analytical biochemistry will find this book highly informative.

    • Plant Physiology 6C

      • 1st Edition
      • December 2, 2012
      • F.C. Steward
      • English
      • Paperback
        9 7 8 0 1 2 4 1 4 6 0 0 6
      • eBook
        9 7 8 0 3 2 3 1 4 9 1 9 8
      Plant Physiology: A Treatise, Volume VIC: Physiology of Development: From Seeds to Sexuality deals with the physiology of development in angiosperms, from seeds to sexuality. This book treats germination and cell division, growth, and development from a single point of view, emphasizing the problems of early development in flowering plants. This volume begins with an introduction to the process of germination, focusing on the dispersal unit that emerges at some stage in the life cycle of plants, seed viability and dormancy, and properties of seed components. The following chapters discuss cell division in higher plants, the importance of cell expansion for the growth of the whole plant, and the sexuality of angiosperms. Topics such as meiosis in the anther and the ovule, male spores and gametophytes, and the embryo sac are discussed in detail. This book concludes with problems that arise, and points of view that emerge, as development is considered in the light of genetics. This book is a valuable resource for researchers, students, and specialists in related fields who wish to gain insights on the concepts and research trends in the physiology of development in flowering plants.

    • Biological Basis of Detoxication

      • 1st Edition
      • December 2, 2012
      • John Caldwell
      • English
      • Paperback
        9 7 8 0 1 2 4 3 1 2 1 2 8
      • eBook
        9 7 8 0 3 2 3 1 5 0 1 0 1
      Biological Basis of Detoxication focuses on the biological processes involved in detoxication, with emphasis on the biochemistry of the removal of xenobiotics from an organism. Topics range from the formation of toxic metabolites and compounds that are not metabolized at all to the tissue distribution and nutritional considerations, the kinetics and mechanisms of the metabolic and excretory processes, and the integration of xenobiotic metabolism in the activation and detoxication of carcinogens. Organized into 14 chapters, this book begins with an overview of the enzymatic basis for the metabolic activation of foreign compounds in forming reactive chemical intermediates. The first few chapters discuss the identification of reactive electrophiles derived from xenobiotics, intratissue distribution of activating and detoxicating enzymes, enzymatic and non-enzymatic modes of xenobiotic metabolism, and unmetabolized compounds. The middle chapters explore the biological basis of detoxication of oxygen free radicals, physiologic and kinetic aspects of the fate of xenobiotics, excretion of xenobiotics, and effects of nutrition on detoxication. The remaining chapters look at the relationships between the enzymes of detoxication and host defense mechanisms, metabolic basis of target organ toxicity, the enzymatic factor in selective toxicity, and intraindividual and interindividual variations in rates of hepatic metabolism of exogenous chemicals. Pharmacologists, toxicologists, and biochemists will find this book highly informative.

    • Orexin/Hypocretin System

      • 1st Edition
      • Volume 198
      • July 27, 2012
      • English
      • Hardback
        9 7 8 0 4 4 4 5 9 4 8 9 1
      • eBook
        9 7 8 0 4 4 4 5 9 4 9 0 7
      Leading authors review the state-of-the-art in their field of investigation, and provide their views and perspectives for future research. Chapters are extensively referenced to provide readers with a comprehensive list of resources on the topics covered. All chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist.

    • Bioinformatics of Behavior: Part 2

      • 1st Edition
      • Volume 104
      • December 3, 2012
      • English
      • Hardback
        9 7 8 0 1 2 3 9 8 3 2 3 7
      • eBook
        9 7 8 0 1 2 3 9 8 3 1 0 7
      This issue of International Review of Neurobiology is split over 2 volumes, bringing together cutting-edge research on Bioinformatics of Behavior. The 2 volumes review current knowledge and understanding, provide a starting point for researchers and practitioners entering the field, and build a platform for further research and discovery.

    • Emerging Horizons in Neuromodulation

      • 1st Edition
      • Volume 107
      • December 11, 2012
      • English
      • Hardback
        9 7 8 0 1 2 4 0 4 7 0 6 8
      • eBook
        9 7 8 0 1 2 4 0 5 1 8 0 5
      This issue of International Review of Neurobiology brings together cutting-edge research on neuromodulation. It reviews current knowledge and understanding, provides a starting point for researchers and practitioners entering the field, and builds a platform for further research and discovery.

    • Nanomedicine

      • 1st Edition
      • Volume 509
      • May 23, 2012
      • English
      • Hardback
        9 7 8 0 1 2 3 9 1 8 5 8 1
      • eBook
        9 7 8 0 1 2 3 9 1 8 7 0 3
      This volume in the Methods in Enzymology series comprehensively covers Infectious Diseases, Immunotheraphy, Gene Medicine, Diagnostics and Toxicology of Nanomedicine. With an international board of authors, this volume is split into sections that cover subjects such as Nanomedicines in Immunotherapy, Nanomedicine toxicity, and Diagnostic Nanomedicine.

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