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    • Pathology of Domestic Animals

      • 4th Edition
      • December 2, 2012
      • English
      • Paperback
        9 7 8 0 1 2 3 9 6 0 9 7 9
      • eBook
        9 7 8 0 3 2 3 1 3 9 4 9 6
      The all-new Fourth Edition of Pathology of Domestic Animals comprehensively covers the biology and pathology of diseases of domestic animals on a systemic basic. Updated and expanded to reflect the current knowledge of the study of domestic animal diseases, this three-volume set appeals to veterinarians, veterinary students, trainee veterinary pathologists learning the scope of their field, and practicing pathologists confronted with diagnostic problems.

    • Control of Membrane Function: short-term and long-term

      • 1st Edition
      • December 2, 2012
      • J.M. Ritchie + 2 more
      • English
      • Paperback
        9 7 8 0 4 4 4 5 6 7 1 4 7
      • eBook
        9 7 8 0 4 4 4 6 0 0 9 3 6
      A critical factor in cell-to-cell interactions is the presence in the cell membrane of highly specific ion channels controlled by specific receptors that are bound to, and activated by, a gamut of external hormones and neurotransmitters. Through both this action on ion channels, and action on other membrane components (such as G-proteins), extracellular signals alter intracellular events, usually through the mediation of second messengers, and so provide the basis for the transduction mechanism connecting extracellular signals with intracellular effectors. This volume deals with the various ways that such membrane function is controlled.

    • Immune Biology of Allogeneic Hematopoietic Stem Cell Transplantation

      • 1st Edition
      • December 6, 2012
      • Gerard Socie + 1 more
      • English
      • Hardback
        9 7 8 0 1 2 4 1 6 0 0 4 0
      • eBook
        9 7 8 0 1 2 3 9 1 4 6 5 1
      Immune Biology of Allogeneic Hematopoietic Stem Cell Transplantation provides clinical and scientific researchers with a deep understanding of the current research in this field and the implications for translational practice. By providing an overview of the immune biology of HSCT, an explanation of immune rejection, and detail on antigens and their role in HSCT success, this book embraces biologists and clinicians who need a broad view of the deeply complex processes involved. It then moves on to discuss the immunobiology mechanisms that influence graft-versus-host disease (GVHD), graft-versus-leukemi... (GVL) effect, and transplantation success. Using illustrative figures, highlighting key issues, describing recent successes and discussing unanswered questions, this book sums up the current state of HSCT to enhance the prospects for the future. Allogeneic HSCT is a medical procedure in which a patient receives blood-forming stem cells from a genetically similar but not identical donor. This procedure is commonly performed for people with diseases of the blood, bone marrow, or certain cancers, but it remains risky with many possible complications. As such, experimental practice is reserved for preclinical animal models including the mouse and dog. These animal models have been essential in developing transplant protocols, including preclinical testing of conditioning regimens, treatment of GVHD, and understanding the pathology of GVHD as well as the immunological mechanisms of GVHD and GVL effect. However, recent research has revealed significant species differences between humans and animal models that must be considered when relating animal model studies to clinical allogeneic HSCT scenarios.

    • Lipids

      • 1st Edition
      • Volume 108
      • February 16, 2012
      • English
      • Hardback
        9 7 8 0 1 2 3 8 6 4 8 7 1
      • eBook
        9 7 8 0 1 2 3 8 6 4 8 8 8
      Lipids are a broad group of naturally occurring molecules which includes fats, waxes, sterols, fat-soluble vitamins (such as vitamins A, D, E and K), monoglycerides, diglycerides, phospholipids, and others. The main biological functions of lipids include energy storage, as structural components of cell membranes, and as important signaling molecules.This volume of Methods in Cell Biology covers such areas as Membrane structure and dynamics, Imaging, and Lipid Protein Interactions. It will be an essential tool for researchers and students alike.

    • Comparative Biochemistry V7

      • 1st Edition
      • December 2, 2012
      • Marcel Florkin
      • English
      • Paperback
        9 7 8 0 1 2 4 1 4 4 9 2 7
      • eBook
        9 7 8 0 3 2 3 1 4 8 1 1 5
      Comparative Biochemistry: A Comprehensive Treatise, Volume VII: Supplementary Volume focuses on the processes, methodologies, and approaches involved in molecular biochemistry. The selection first offers information on expressions of the pentose phosphate cycle, including description, criteria for the presence of the pentose phosphate cycle, chordates, segmented worms, mollusks, echinoderms, roundworms, flatworms, algae, and higher plants. The text then ponders on chitin and mucosubstances, as well as the distribution and biochemistry of chitin, molecular structure and function of chitin, and chitin in relation to mucosubstances. The publication reviews the cellular aspects of active transport and hormones and behavior. Topics include relations between inorganic ions, sugar, amino acids, fatty acids, and bioelectric potentials; aspects of the regulation of the intracellular pool of free amino acids; hormones and permeability characteristics of living cellular membranes; and chemical nature of the structure responsible for the permeability characteristics of living membranes. The recording and measurement of behavior, role of hormones in the patterning of behavior, and hormones influencing behavior and the behavior most subject to hormonal influence and control are also discussed. The selection is a dependable source of data for readers interested in the processes, methodologies, approaches involved in biochemistry.

    • Antimalarial Agents

      • 1st Edition
      • December 2, 2012
      • Poul Thompson
      • English
      • Paperback
        9 7 8 0 1 2 4 3 1 3 6 7 5
      • Hardback
        9 7 8 0 1 2 6 8 8 9 5 0 5
      • eBook
        9 7 8 0 3 2 3 1 5 1 6 8 9
      Medicinal Chemistry, Volume 12: Antimalarial Agents: Chemistry and Pharmacology presents the essentials of both biology and chemistry pertinent to the chemotherapy of malaria. This book discusses the nature of the disease, the physiology and biochemistry of the plasmodia, and the mode of action of drugs. Organized into 19 chapters, this volume begins with an overview of the most intensive efforts to develop synthetic antimalarial drugs. This text then examines how drugs are evaluated as well as the specific chemotherapy in malaria. Other chapters consider the diversity of chemical structures exhibiting antimalarial activity with emphasis on structure–activity relationships and methods of synthesis. This book discusses as well the plasmodial effects by quinine in vivo. The final chapter deals with the miscellaneous structures known to have activity against some types of plasmodial infection in animals. This book is a valuable resource for chemists and biologists involved in the development of antimalarial drugs.

    • Lipoprotein (a)

      • 1st Edition
      • December 2, 2012
      • Angelo Scanu
      • English
      • Paperback
        9 7 8 0 1 2 4 3 3 6 2 8 5
      • eBook
        9 7 8 0 3 2 3 1 5 9 4 4 9
      Lipoprotein(a) presents the proceedings of the International Symposium, held in Chicago, Illinois, on December 2–3, 1988. It discusses the different aspects of the research on lipoprotein(a), commonly referred to as Lp(a). It covers a wide range of topics, including comparative biology, metabolism, structure, epidemiology, and treatment. Comprised of 15 chapters, the book starts with an overview of the role of Lp(a) in atherosclerotic cardiovascular disease (ASCVD), followed by a discussion on recent findings and developments. It then considers the relationship between elevated plasma Lp(a) and the inherited risk factor for the development of coronary heart disease. The reader is also introduced to the various components of Lp(a), which include neutral lipids, polar lipids, apoprotein(a), and apoprotein B. Other chapters discuss the specific functions of apolipoproteins in plasma lipid metabolism, which determine the fate of the various lipoprotein particles in plasma. This book will be of benefit to cardiologists and medical practitioners.

    • Efferent Organization and The Integration of Behavior

      • 1st Edition
      • December 2, 2012
      • Jack Maser
      • English
      • Paperback
        9 7 8 0 1 2 4 3 1 5 0 1 3
      • Hardback
        9 7 8 0 1 2 4 7 6 9 5 0 2
      • eBook
        9 7 8 0 3 2 3 1 5 3 0 3 4
      Efferent Organization and the Integration of Behavior is a nine-chapter text that discusses the hypotheses and alternative conceptualizations of efferent mechanisms, as well as the neural basis of patterned movement. The opening chapters examine several behavioral categories, the neural mediation of movement, and the distinction between efferent response and efferent motor processes. These chapters also present a revised theory of the role of the motor system in physiological regulation and neural-metabolic integration in energy production for behavior. These topics are followed by considerable chapters devoted to efferent organization of specific brain sections, including the motor cortex, pyramidal system, globus pallidus, substantia nigra, diencephalon, hippocampus, and neocortex. This text also deals with the instrumental conditioning based on alimentary or food reinforcements. A chapter discusses the constraints on theoretical interpretations of neuroanatomical circuitry functions of noradrenergic and cholinergic brain systems. The concluding chapter describes the relationship between the motor integration systems of extrapyramidal structures and the motivational systems of limbic structures. This chapter also looks into the anatomical organization of self-stimulation and the microelectrode data, which delineate the response of single neurons to stimulation at hypothalamic self-stimulation sites.

    • Molecular Biology of the Fission Yeast

      • 1st Edition
      • December 2, 2012
      • English
      • Paperback
        9 7 8 0 1 2 4 1 2 0 2 6 6
      • eBook
        9 7 8 0 3 2 3 1 4 0 0 6 5
      This highly researched yeast, which represents a system used by cell biologists, geneticists and molecular biologists, has been given only minimal coverage in the literature. Its properties make it an excellent organism for DNA and related biotechnology reseach. This book, which is the first attempt to collate existing information in one source, will be an invaluable aid to those initiating projects with this organism.

    • Reproductive Pathology of Domestic Mammals

      • 1st Edition
      • December 2, 2012
      • Mark McEntee
      • English
      • eBook
        9 7 8 0 3 2 3 1 3 8 0 4 8
      This book evolved from a series of lectures and laboratories given by Dr. Kenneth McEntee to students at Cornell University, the University of Illinois, and Tufts University and is based on tissues from over 20,000 cases of reproductive disease in the International Registry of Reproductive Pathology, founded by Dr. McEntee. Dr. McEntee brings into sharp focus what is known of reproductive pathology in North America and abroad. His book will be an invaluable text and reference for those working on the diagnosis, prevention, and treatment of reproductive failures of all kinds.

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